研究者詳細 - 久松　隆史

論文 - 久松　隆史

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Isolated systolic hypertension and 29-year cardiovascular mortality risk in Japanese adults aged 30--49 years. 査読国際誌

Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Aya Kadota, Keiko Kondo, Yoshikuni Kita, Takehito Hayakawa, Hideyuki Kanda, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

Journal of hypertension 38 ( 11 ) 2230 - 2236 2020年11月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

OBJECTIVE: The prognostic implication of isolated systolic hypertension (ISH), defined as SBP at least 140 mmHg and DBP less than 90 mmHg, among young-to-middle-aged adults remains controversial. We examined the association of ISH with cardiovascular disease (CVD) risk in adults aged 30-49 years. METHODS: In a prospective cohort of representative Japanese general populations from the NIPPON DATA80 (1980-2009), we studied 4776 participants (mean age, 39.4 years; 55.4% women) without clinical CVD or antihypertensive medication. Participants were classified as follows: normal blood pressure (BP) (SBP/DBP, <120/<80 mmHg), high-normal BP (120-129/<80 mmHg), elevated BP (130-139/80-89 mmHg), ISH, isolated diastolic hypertension (IDH) (<140/≥90 mmHg), and systolic--diastolic hypertension (SDH) (≥140/≥90 mmHg). RESULTS: ISH was observed in 389 (8.1%) participants. During the 29-year follow-up, 115 participants died of CVD, 28 of coronary heart disease, and 49 of stroke. Cox proportional hazards models adjusted for demographics and CVD risk factors showed that participants with ISH had higher risk of CVD mortality than those with normal BP [hazard ratio (confidence interval), 4.10 (1.87-9.03)]. The magnitude of CVD mortality risk related to ISH was comparable with that related to IDH [3.38 (1.31-8.72)] and not as great as that related to SDH [5.41 (2.63-11.14)]. We found significant associations of ISH with coronary and stroke mortality. The association of ISH with CVD mortality was consistent across men and women and those aged 30-39 and 40-49 years. CONCLUSION: ISH among young-to-middle-aged Japanese adults was independently associated with higher risk of CVD mortality later in life.

DOI： 10.1097/HJH.0000000000002533

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Intracranial Artery Stenosis and Its Association With Conventional Risk Factors in a General Population of Japanese Men. 査読国際誌

Satoshi Shitara, Akira Fujiyoshi, Takashi Hisamatsu, Sayuki Torii, Sentarou Suzuki, Takahiro Ito, Hisatomi Arima, Akihiko Shiino, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

Stroke 50 ( 10 ) 2967 - 2969 2019年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background and Purpose- Few community-based studies have reported the prevalence of intracranial artery stenosis (ICAS) assessed with magnetic resonance angiography. The aim was to determine the prevalence of ICAS using magnetic resonance angiography in a general population of Japanese men and to investigate the associations between ICAS and conventional cardiovascular risk factors. Methods- The Shiga Epidemiological Study of Subclinical Atherosclerosis randomly recruited and examined participants from Kusatsu City, Shiga, Japan, in 2006 to 2008 (baseline); 740 men returned for follow-up and underwent 1.5 T brain magnetic resonance angiography in 2012 to 2015. Participants were categorized as having no-ICAS, mild-ICAS (1 to <50%), or severe-ICAS (≥50%) in any of the arteries examined. After excluding the men with a history of stroke, 709 men were analyzed using multivariable logistic regression to assess independent associations of conventional cardiovascular risk factors with reference to the no-ICAS group. Results- The participants' mean age was 68.0 years. The age-standardized prevalences of mild and severe-ICAS were 20.7% and 4.5%, respectively (with the population of the 2010 Japanese vital statistics as the reference). Age, hypertension, diabetes mellitus, and dyslipidemia were associated with a higher prevalence of severe-ICAS after simultaneous adjustment for conventional cardiovascular risk factors. Conclusions- In a community-based sample of Japanese men, ICAS was estimated to be present in 25.2%, and related to metabolic risk factors, in addition to hypertension and age. These results support the importance of comprehensive management of conventional cardiovascular risk factors for stroke prevention.

DOI： 10.1161/STROKEAHA.119.025964

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Association between excessive supraventricular ectopy and subclinical cerebrovascular disease: a population-based study. 査読国際誌

T Hisamatsu, K Miura, A Fujiyoshi, A Kunimura, T Ito, I Miyazawa, S Torii, A Shiino, K Nozaki, H Kanda, H Arima, T Ohkubo, H Ueshima

European journal of neurology 26 ( 9 ) 1219 - 1225 2019年9月

Coronary Artery Calcium Progression Among the US and Japanese Men. 査読

Takashi Hisamatsu

Circulation. Cardiovascular imaging 12 ( 2 ) 2019年2月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

Background The risk of coronary heart disease remains low in Japan, although distributions of several coronary risk factors have become comparable with those in the United States. We prospectively compared coronary atherosclerosis burden, measured with coronary artery calcium (CAC) progression, between men in the 2 countries. Methods In 2 population-based samples of 1712 US White, Black, Hispanic, Chinese men (baseline, 2000-2002) and 697 Japanese men in Japan (2006-2008) aged 45-74 years without clinical cardiovascular disease, we quantified CAC progression by serial computed tomography with medians of 3.4 and 5.2 years between scans, respectively. Results Among White, Black, Hispanic, Chinese, and Japanese men free of baseline CAC, CAC incidence was observed in 35.2%, 26.9%, 29.2%, 18.9%, and 29.2%, respectively. After adjustment for times between scans, demographics, behaviors, coronary risk factors, and their changes between scans, White men had significantly higher CAC incidence than Japanese men (relative risk, 1.68; 95% CI, 1.13-2.50). Among those with detectable baseline CAC, after similar adjustments, all the US race/ethnic groups had significantly greater annual changes in CAC score (mean [95% CI]: 39.4 [35.2-43.6] for White, 26.9 [21.4-32.4] for Black, 30.6 [24.7-36.5] for Hispanic, and 30.2 [22.6-37.8] for Chinese men) than Japanese men (15.9 [10.1-21.8]). Conclusions We found a higher CAC incidence among US White men and greater increases in existing CAC among all the US race/ethnic groups than among Japanese men in Japan. These differences persisted despite adjustment for differences in coronary risk factors.

DOI： 10.1161/circimaging.118.008104

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Control Rates of Systolic and Diastolic Blood Pressure among Hypertensive Adults in Korea 招待査読

Takashi Hisamatsu

Korean Circulation Journal 49 ( 11 ) 1049 - 1049 2019年1月

担当区分：筆頭著者,　最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Korean Society of Cardiology

DOI： 10.4070/kcj.2019.0197

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その他リンク： https://synapse.koreamed.org/DOIx.php?id=10.4070/kcj.2019.0197

Home blood pressure variability and subclinical atherosclerosis in multiple vascular beds 査読国際誌

Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Hisatomi Arima, Akira Fujiyoshi, Atsushi Satoh, Aya Kadota, Maryam Zaid, Naoyuki Takashima, Seiko Ohno, Minoru Horie, Hirotsugu Ueshima

Journal of Hypertension 36 ( 11 ) 2193 - 2203 2018年11月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

OBJECTIVE: The mechanism by which higher blood pressure (BP) variability causes cardiovascular events remains unclear. Experimental results indicate that alterations in vessel wall tension related to BP variability may initiate atherosclerosis through oscillatory shear stress. We examined associations of home BP variability with subclinical atherosclerosis at four anatomically distinct vascular beds. METHODS: In a cross-sectional population-based study of 1033 Japanese (mean age, 64.0 years; men, 88.7%) without known cardiovascular disease, we defined SBP and DBP variability as variability independent of the mean (VIM) across self-measured home BP values during seven consecutive days and quantified coronary and aortic artery calcification (CAC and AAC) by computed tomography, carotid intima-media thickness (CIMT) by ultrasonography, and ankle-brachial index (ABI). RESULTS: In multivariable adjusted models including mean SBP, higher VIM of SBP was associated with CIMT greater than1.0 mm [relative risk (95% confidence interval) fourth versus first quartile, 1.71 (1.15-2.54)], AAC score greater than 0 [1.08 (1.02-1.15)], and ABI less than 1.1 [1.49 (1.12-1.97)], and linear trends were also statistically significant. However, there was no significant association between VIM of SBP and CAC score greater than 0. Meanwhile, higher VIM of DBP was associated only with AAC score greater than 0. The associations were similar when modeling subclinical atherosclerosis severity as continuous outcomes and were consistent across subgroups based on demographics, behavioural, and cardiovascular risk factors. CONCLUSION: Higher variability in home BP, particularly in home SBP, was associated with greater carotid, aortic, and peripheral but not coronary atherosclerosis burdens independent of the mean home BP.

DOI： 10.1097/hjh.0000000000001810

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Relationship of serum irisin levels to prevalence and progression of coronary artery calcification: A prospective, population-based study 査読

Takashi Hisamatsu, Katsuyuki Miura, Hisatomi Arima, Akira Fujiyoshi, Aya Kadota, Sayaka Kadowaki, Maryam Zaid, Naoko Miyagawa, Atsushi Satoh, Ayako Kunimura, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group

International Journal of Cardiology 267 177 - 182 2018年9月

Serum magnesium, phosphorus, and calcium levels and subclinical calcific aortic valve disease: A population-based study 査読

Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Atsushi Satoh, Maryam Zaid, Takashi Yamamoto, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group

Atherosclerosis 273 145 - 152 2018年6月

Increased Aortic Calcification Is Associated With Arterial Stiffness Progression in Multiethnic Middle-Aged Men 査読

Jingchuan Guo, Akira Fujiyoshi, Bradley Willcox, Jina Choo, Abhishek Vishnu, Takashi Hisamatsu, Vasudha Ahuja, Naoyuki Takashima, Emma Barinas-Mitchell, Aya Kadota, Rhobert W. Evans, Katsuyuki Miura, Daniel Edmundowicz, Kamal Masaki, Chol Shin, Lewis H. Kuller, Hirotsugu Ueshima, Akira Sekikawa

Hypertension 69 ( 1 ) 102 - 108 2017年1月

客観的に評価された歩数値とメタボリックシンドローム発症との関連:地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA) 査読

久松隆史, 久松隆史, 三浦克之, 三浦克之, 渋川武志, 藤吉朗, 有馬久富, 有馬久富, 門田文, 門田文, 宮川尚子, 鳥居さゆ希, 近藤慶子, 宮澤伊都子, 鈴木仙太朗, 佐藤敦, 山添正博, 柳田昌彦, 前川聡, 上島弘嗣, 上島弘嗣

日本循環器病予防学会誌 52 ( 1 ) 20 - 28 2017年

Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men 査読

Hisamatsu Takashi, Miura Katsuyuki, Arima Hisatomi, Kadota Aya, Kadowaki Sayaka, Torii Sayuki, Suzuki Sentaro, Miyagawa Naoko, Sato Atsushi, Yamazoe Masahiro, Fujiyoshi Akira, Ohkubo Takayoshi, Yamamoto Takashi, Murata Kiyoshi, Robert D. Abbott, Sekikawa Akira, Horie Minoru, Ueshima Hirotsugu, the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group

Journal of the American Heart Association 5 ( 9 ) e003738 2016年8月

Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome Components 査読国際誌

Masahiro Yamazoe, Takashi Hisamatsu, Katsuyuki Miura, Sayaka Kadowaki, Maryam Zaid, Aya Kadota, Sayuki Torii, Itsuko Miyazawa, Akira Fujiyoshi, Hisatomi Arima, Akira Sekikawa, Hiroshi Maegawa, Minoru Horie, Hirotsugu Ueshima

Arteriosclerosis, Thrombosis, and Vascular Biology 36 ( 8 ) 1703 - 1708 2016年8月

Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population 査読国際誌

Takashi Hisamatsu, Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Aya Kadota, Sayaka Kadowaki, Takashi Kadowaki, Takashi Yamamoto, Naoko Miyagawa, Maryam Zaid, Sayuki Torii, Naoyuki Takashima, Yoshitaka Murakami, Tomonori Okamura, Minoru Horie, Hirotsugu Ueshima

Atherosclerosis 236 ( 2 ) 237 - 243 2014年10月

High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: A 24-year follow-up of Japanese general population 査読

Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima

JOURNAL OF CARDIOLOGY 64 ( 3-4 ) 218 - 224 2014年9月

Interaction between dietary marine-derived n-3 fatty acids intake and J-point elevation on the risk of cardiac death: a 24-year follow-up of Japanese men 査読

Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Yasuhiro Matsumura, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima

Heart 99 ( 14 ) 1024 - 1029 2013年7月

Association between J-Point elevation and death from coronary artery disease 査読

Hisamatsu T, Ohkubo T, Miura K, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Nagasawa SY, Kita Y, Murakami Y, Okayama A, Horie M, Okamura T, Ueshima H, for the NIPPON DATA, Research Group

Circ J. 77 ( 5 ) 1260 - 1266 2013年

Asymptomatic intracranial vascular lesions and cognitive function in a general population of Japanese men: Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Takahiro Ito, Akira Fujiyoshi, Takayoshi Ohkubo, Akihiko Shiino, Satoshi Shitara, Naoko Miyagawa, Sayuki Torii, Takashi Hisamatsu, Hiroyoshi Segawa, Keiko Kondo, Aya Kadota, Ikuo Tooyama, Yoshiyuki Watanabe, Kazumichi Yoshida, Kazuhiko Nozaki, Katsuyuki Miura

Cerebrovascular Diseases 2025年6月

Nicotine dependence based on the tobacco dependence screener among heated tobacco products users in Japan, 2022-2023: The JASTIS study. 査読国際誌

Takuma Kitajima, Takashi Hisamatsu, Hideyuki Kanda, Takahiro Tabuchi

Neuropsychopharmacology reports 45 ( 1 ) e12512 2025年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

Heated tobacco products (HTPs) are nicotine-containing products similar to cigarettes and are widely used in Japan. However, there has been insufficient research on nicotine dependence associated with HTP use. This study investigated the association of the types of individuals who smoked with the prevalence of nicotine dependence. We utilized data from the Japan Survey on Tobacco and Health (JASTIS). A total of 7969 participants who currently smokes was selected from the 2022 and 2023 survey respondents for the analysis. Nicotine dependence was defined as a score of 5 or higher on the Tobacco Dependence Screener (TDS). The prevalence of nicotine dependence was 43.0% (3473/8077) among all participants who smoked, 42.9% (1479/3447) among those who used cigarettes, 44.2% (760/1720) among those who used two products, and 43.0% (1206/2802) among those who used HTPs. The prevalence of nicotine dependence was statistically higher in the participants who used two products than in cigarettes (odds ratio [OR], 1.17; 95% confidence interval [CI], 1.04-1.33). When classified by temperature, participants who used of two products (high-temp and low-temp) and those using participants who used HTPs (high-temp) had higher ORs for prevalent nicotine dependence (OR, 1.31 [95% CI, 1.14-1.51]) and (OR, 1.12 [95% CI, 1.00-1.25], respectively) compared to participants who used cigarettes. Additionally, the ORs for prevalent nicotine dependence increased with the number of tobacco sticks smoked per day. These results suggest that HTP use, particularly high-temperature HTPs use, and a higher number of tobacco sticks smoked is associated with nicotine dependence.

DOI： 10.1002/npr2.12512

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SCN5A variant type-dependent risk prediction in Brugada syndrome 査読国際誌

Takanori Aizawa, Takeru Makiyama, Hai Huang, Tomohiko Imamura, Megumi Fukuyama, Keiko Sonoda, Koichi Kato, Takashi Hisamatsu, Yuko Nakamura, Kenji Hoshino, Junichi Ozawa, Hiroshi Suzuki, Kazushi Yasuda, Hisaaki Aoki, Takashi Kurita, Yoko Yoshida, Tsugutoshi Suzuki, Yoshihide Nakamura, Yoshiharu Ogawa, Shintaro Yamagami, Hiroshi Morita, Shinsuke Yuasa, Masakazu Fukuda, Makoto Ono, Hidekazu Kondo, Naohiko Takahashi, Seiko Ohno, Yoshihisa Nakagawa, Koh Ono, Minoru Horie

Europace 27 ( 2 ) 2025年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

AIMS: The variant in SCN5A with the loss of function (LOF) effect in the cardiac Na+ channel (Nav1.5) is the definitive cause for Brugada syndrome (BrS), and the functional analysis data revealed that LOF variants are associated with poor prognosis. However, which variant types (e.g. missense or non-missense) affect the prognoses of those variant carriers remain unelucidated. METHODS AND RESULTS: We defined SCN5A LOF variants as all non-missense and missense variants that produce peak INa < 65% of wild-type previously confirmed by patch-clamp studies. The study population consisted of 76 Japanese BrS patients (74% patients were male and the median age [IQR] at diagnosis was 28 [14-45] years) with LOF type of SCN5A variants: 40 with missense and 36 with non-missense variants. Non-missense variant carriers presented significantly more severe cardiac conduction disorder compared to the missense variant carriers. During follow-up periods of 9.0 [5.0-14.0] years, compared to missense variants, non-missense variants were significant risk factors of lifetime lethal arrhythmia events (LAEs) (P = 0.023). When focusing only on the missense variants that produce no peak INa, these missense variant carriers exhibited the same clinical outcomes as those with non-missense (log-rank P = 0.325). After diagnosis, however, both variant types were comparable in risk of LAEs (P = 0.155). CONCLUSION: We identified, for the first time, that SCN5A non-missense variants were associated with higher probability of LAE than missense variants in BrS patients though it did not change significantly after diagnosis.

DOI： 10.1093/europace/euaf024

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Toward personalized exercise prescriptions for blood pressure management: insights from a comprehensive meta-analysis. 招待査読国際誌

Takashi Hisamatsu

Hypertension research : official journal of the Japanese Society of Hypertension 48 ( 3 ) 1228 - 1230 2024年12月

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