研究者詳細 - 久松　隆史

論文 - 久松　隆史

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The association between objectively measured physical activity and home blood pressure: a population-based real-world data analysis 査読国際誌

Minako Kinuta, Takashi Hisamatsu, Kaori Taniguchi, Mari Fukuda, Noriko Nakahata, Hideyuki Kanda

Journal of Human Hypertension 2025年4月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Few studies have examined the association of objectively measured habitual physical activity (PA) and sedentary behavior with out-of-office blood pressure (BP). We investigated the associations of objectively measured PA intensity time, sedentary time, and step count with at-home BP. Using accelerometer-recorded PA indices and self-measured BP in 368 participants (mean age, 53.8 years; 58.7% women), we analyzed 115,575 records of each parameter between May 2019 and April 2024. PA intensities were categorized as light (2.0-2.9 metabolic equivalents [METs]); moderate (3.0-5.9 METs); vigorous (≥6.0 METs), or sedentary (<2.0 METs): the median [interquartile ranges] for these variables was 188 [146-232], 83 [59-114], 1 [0-2], 501 [428-579] minutes, respectively, and for step count, was 6040 [4164-8457]. Means [standard deviations] for systolic and diastolic BP were 116.4 [14.2] and 75.2 [9.3] mmHg, respectively. A mixed-effect model adjusted for possible confounders showed that 1-h longer in vigorous PA was associated with lower systolic and diastolic BP (-1.69 and -1.09 mmHg, respectively). A 1000-step increase in step count was associated with lower systolic and diastolic BP (-0.05 and -0.02 mmHg, respectively). Associations were more pronounced among men and participants aged <60 years. Sedentary time was positively associated with BP in men and participants aged <60 years, but inversely associated with BP in women and participants aged ≥60 years. Our findings suggest that more PA and less sedentary behavior were associated with BP reduction, particularly among men and participants aged <60 years. However, the clinical relevance of this effect remains uncertain because of its modest magnitude.

DOI： 10.1038/s41371-025-01014-8

Effectiveness of self-monitoring devices measuring the urinary sodium-to-potassium ratio, urinary salt (sodium) excretion, or salt concentration in foods for blood pressure management: a systematic review and meta-analysis. 査読国際誌

Takashi Hisamatsu, Kohei Ueda, Kimika Arakawa, Shintaro Minegishi, Yukiko Okami, Minako Kinuta, Keiko Kondo, Hiroshige Jinnouchi, Maho Ishihara, Makiko Abe, Atsushi Sakima, Katsuyuki Miura, Hisatomi Arima

Hypertension research : official journal of the Japanese Society of Hypertension 2025年2月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Self-monitoring devices that measure the urinary sodium-to-potassium (Na/K) ratio, urinary salt or sodium excretion, or salt concentration in foods have emerged as tools that can guide dietary adjustments for blood pressure (BP) control. This systematic review and meta-analysis investigated whether these self-monitoring devices can help to control BP in adults. The PubMed, Cochrane Library, and Ichushi-Web databases were searched to identify randomized controlled trials that compared the effect of these devices (with or without additional dietary education) plus usual care on BP with that of usual care alone. The pooled effect of weighted mean difference between the intervention and control groups at the end of follow-up was estimated by random-effects meta-analysis. The primary outcome was the change in BP. Secondary outcomes included changes in the urinary Na/K ratio, and sodium and potassium excretions. Of 1525 studies screened, eight (with 1442 participants) were eligible for inclusion. Meta-analysis showed greater reductions in systolic BP by 2.45 (95% confidence interval, 0.04, 4.86) mmHg and diastolic BP by 1.38 (-0.15, 2.90) mmHg in the intervention vs. control groups. However, heterogeneity was high (I² = 69.4% for systolic BP and 65.1% for diastolic BP). The BP-lowering effect was not statistically different across different follow-up durations (4 weeks or 2-6 months) and intervention approaches (self-monitoring alone or combined with dietary education) (all p values for heterogeneity >0.1). Reductions in the urinary Na/K ratio and sodium excretion were greater in the intervention group. Self-monitoring devices may assist with BP reduction by promoting decreased sodium intake and increased potassium intake.

DOI： 10.1038/s41440-025-02124-z

ChatGPT Responses to Clinical Questions in the Japan Atherosclerosis Society Guidelines for Prevention of Atherosclerotic Cardiovascular Disease 2022. 査読

Takashi Hisamatsu, Mari Fukuda, Minako Kinuta, Hideyuki Kanda

Journal of atherosclerosis and thrombosis 2024年10月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

AIMS: Artificial intelligence is increasingly used in the medical field. We assessed the accuracy and reproducibility of responses by ChatGPT to clinical questions (CQs) in the Japan Atherosclerosis Society Guidelines for Prevention Atherosclerotic Cardiovascular Diseases 2022 (JAS Guidelines 2022). METHODS: In June 2024, we assessed responses by ChatGPT (version 3.5) to CQs, including background questions (BQs) and foreground questions (FQs). Accuracy was assessed independently by three researchers using six-point Likert scales ranging from 1 ("completely incorrect") to 6 ("completely correct") by evaluating responses to CQs in Japanese or translated into English. For reproducibility assessment, responses to each CQ asked five times separately in a new chat were scored using six-point Likert scales, and Fleiss kappa coefficients were calculated. RESULTS: The median (25th-75th percentile) score for ChatGPT's responses to BQs and FQs was 4 (3-5) and 5 (5-6) for Japanese CQs and 5 (3-6) and 6 (5-6) for English CQs, respectively. Response scores were higher for FQs than those for BQs (P values ＜0.001 for Japanese and English). Similar response accuracy levels were observed between Japanese and English CQs (P value 0.139 for BQs and 0.586 for FQs). Kappa coefficients for reproducibility were 0.76 for BQs and 0.90 for FQs. CONCLUSIONS: ChatGPT showed high accuracy and reproducibility in responding to JAS Guidelines 2022 CQs, especially FQs. While ChatGPT primarily reflects existing guidelines, its strength could lie in rapidly organizing and presenting relevant information, thus supporting instant and more efficient guideline interpretation and aiding in medical decision-making.

DOI： 10.5551/jat.65240

Practical use and target value of urine sodium-to-potassium ratio in assessment of hypertension risk for Japanese: Consensus Statement by the Japanese Society of Hypertension Working Group on Urine Sodium-to-Potassium Ratio. 査読国際誌

Takashi Hisamatsu, Mana Kogure, Yasuharu Tabara, Atsushi Hozawa, Atsushi Sakima, Takuya Tsuchihashi, Katsushi Yoshita, Hitomi Hayabuchi, Koichi Node, Yukari Takemi, Takayoshi Ohkubo, Katsuyuki Miura

Hypertension research : official journal of the Japanese Society of Hypertension 47 ( 12 ) 3288 - 3302 2024年10月

担当区分：筆頭著者記述言語：英語

Epidemiological studies have demonstrated that the urine sodium-to-potassium (Na/K) ratio is more positively associated with high blood pressure and cardiovascular disease risk than either urine sodium or potassium excretion alone. In this consensus statement, we recommend using the average Na/K ratio of casual urines randomly taken in various times on at least four days a week for a reliable individual estimate because of high day-to-day and intraday variability of casual urine Na/K ratio within individuals. Although a continuous positive association exists between the Na/K ratio and high blood pressure or cardiovascular disease risk, for clinical and public health decision making for Japanese, we recommend using an average urine Na/K ratio of 2 as an optimal target value because this aligns with recommendations for both sodium and potassium intake in the Dietary Reference Intakes for Japanese, 2020, considering a typical Japanese dietary pattern. We also suggest that an average urine Na/K ratio of 4 is a feasible target value to achieve a temporary goal of being below the mean values of the urine Na/K ratio across Japanese general populations. These recommendations apply mainly for apparently healthy individuals, but not for patients with specific conditions due to the lack of supporting data. Current evidence for the usefulness of measuring the urine Na/K ratio for the prevention or control of hypertension remains inconclusive and warrants further investigation.

DOI： 10.1038/s41440-024-01861-x

Five-year findings from the home blood pressure management study using IoT technology and future perspectives based on a time-series big data and AI analysis : the Masuda Study 査読

Takashi Hisamatsu, Minako Kinuta, Mari Fukuda, Kaori Taniguchi, Noriko Nakahata, Hideyuki Kanda

Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 136 ( 2 ) 57 - 62 2024年8月

Home blood pressure measurement days and changes in urinary sodium-to-potassium ratio, estimated salt and potassium intakes and blood pressure: 1-year prospective study. 査読国際誌

Minako Kinuta, Takashi Hisamatsu, Mari Fukuda, Kaori Taniguchi, Noriko Nakahata, Hideyuki Kanda

Blood pressure monitoring 29 ( 4 ) 188 - 194 2024年8月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

Objective

Current international guidelines recommend home blood pressure (BP) measurement and low sodium and high potassium intakes for the management of hypertension. We hypothesized that increased home BP measurement may result in more effective management of sodium and potassium intakes and BP.

Methods

We examined associations of home BP measurement days with changes in the urinary sodium-to-potassium (Na/K) ratio, estimated salt and potassium intakes and BP. We included 209 healthy participants (mean age, 55.9 years; 56.5% women) from a prospective cohort study. We examined 1-year data on self-measured home BP and spot urine samples.

Results

Median (interquartile range) days of home BP measurement was 324 (225–358) over 1-year. Baseline mean (SD) Na/K ratio, salt and potassium intakes, morning and evening SBP, and morning and evening DBP were 3.8 (2.3), 8.5 (1.9) g/day, 1833.5 (416.5) mg/day, 120.4 (14.0) mmHg, 118.2 (14.2) mmHg, 79.2 (10.1) mmHg, and 76.2 (10.1) mmHg, respectively. In multivariable-adjusted linear regression , β (standard error) per 10 days increase in number of home BP measurement were −0.031 (0.017) for Na/K ratio, −0.036 (0.015) for salt intake, −1.357 (2.797) for potassium intake, −0.178 (0.064) for morning SBP, −0.079 (0.041) for morning DBP, −0.109 (0.067) for evening SBP and −0.099 (0.045) for evening DBP. Additionally, relationships persisted for men and women, but changes in salt intake were more pronounced among participants taking antihypertensive medication (interaction P = 0.002).

Conclusion

Continuous measurement of home BP may lead not only to self-monitoring of BP, but also to declines in salt intakes and some BP indices.

DOI： 10.1097/MBP.0000000000000705

Epidemiology and control of hypertension in Japan: a comparison with Western countries. 招待査読国際誌

Takashi Hisamatsu, Katsuyuki Miura

Journal of human hypertension 38 ( 6 ) 469 - 476 2024年6月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Based on data from national surveys, the prevalence of hypertension rests at 40-60% in Japan, the USA, and in European countries. This suggests there has been little progress in the prevention of hypertension in even high-income countries despite their well-functioning health systems. In particular, compared with the USA and European countries, the improvement in awareness, treatment, and control of hypertension has been relatively low in Japan. For example, the rates of hypertension awareness, treatment, and control were observed, respectively, in 60-70%, 50-60%, and 20-30% of Japanese compared with 80-90%, 70-80%, and 50-60% of US citizens in the years around 2015. The lower proportions in Japan might be explained by the slower progress in lowering the accepted thresholds for diagnosis of hypertension and initiation of treatment compared with Western countries; however, the underlying reasons for the differences warrant further study. The high prevalence (>40%) of uncontrolled hypertension in even high-income countries has major implications for the prevention of cardiovascular disease. Health policy and research on early control of high blood pressure at the individual and public health levels will contribute to decreases in the prevalence of hypertension. Furthermore, proactive treatment and strict adherence to intensified antihypertensive treatment guidelines will more effectively achieve targeted blood pressure levels. In this context, it is important to continue to carefully monitor and compare trends in hypertension across countries.

DOI： 10.1038/s41371-021-00534-3

その他リンク： http://www.nature.com/articles/s41371-021-00534-3

High blood pressure and colorectal cancer mortality in a 29-year follow-up of the Japanese general population: NIPPON DATA80. 査読国際誌

Takashi Hisamatsu, Aya Kadota, Takehito Hayakawa, Yoshikuni Kita, Akiko Harada, Yukiko Okami, Keiko Kondo, Takayoshi Ohkubo, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima, Katsuyuki Miura

Hypertension research : official journal of the Japanese Society of Hypertension 47 ( 1 ) 206 - 214 2023年11月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Onco-hypertension has been proposed, although associations of high blood pressure (BP) with cancer risk remain inconsistent. We examined associations of high BP with risk of mortality from stomach, lung, colorectal, liver, and pancreatic cancers independent of possible confounders in an analysis that excluded deaths within the first 5 years of follow-up to consider the reverse causality. In a prospective cohort representative of the general Japanese population (1980-2009), we studied 8088 participants (mean age, 48.2 years; 56.0% women) without clinical cardiovascular disease or antihypertensive medication at baseline. Fine-Gray competing risks regression was used to estimate hazard ratios for 10 mmHg higher BP adjusted for confounders including smoking, alcohol-drinking, obesity, and diabetes mellitus. During 29-year follow-up, 159 (2.0%), 159 (2.0%), 89 (1.1%), 86 (1.1%), and 68 (0.8%) participants died from stomach, lung, colorectal, liver, and pancreatic cancers, respectively. We observed a positive association of high BP with risk of colorectal cancer mortality but not with mortality risks from any other cancers. The association with colorectal cancer mortality for systolic and diastolic BP was evident in those aged 30-49 years (hazard ratios 1.43 [95% confidence interval, 1.22-1.67] and 1.86 [1.32-2.62], respectively) but not in those aged 50-59 years and ≥60 years (P for age interaction <0.01 for systolic and diastolic BP). The associations with colorectal cancer mortality were similar in the analyses stratified by smoking, alcohol-drinking, obesity, and diabetic status. In conclusion, high BP among young to middle-aged adults was independently associated with risk of colorectal cancer mortality later in life.

DOI： 10.1038/s41440-023-01497-3

Alcohol Consumption and Cerebral Small- and Large-Vessel Diseases: A Mendelian Randomization Analysis. 査読

Takashi Hisamatsu, Yasuharu Tabara, Aya Kadota, Sayuki Torii, Keiko Kondo, Yuichiro Yano, Akihiko Shiino, Kazuhiko Nozaki, Tomonori Okamura, Hirotsugu Ueshima, Katsuyuki Miura

Journal of atherosclerosis and thrombosis 31 ( 2 ) 135 - 147 2023年8月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

AIMS: It remains inconclusive regarding alcohol intake and stroke risk because determining risk factors depends on the specific pathogenesis of stroke. We used the variant rs671 in the aldehyde dehydrogenase 2 gene (ALDH2) as an instrument to investigate the causal role of alcohol intake in cerebral small- and large-vessel diseases. METHODS: We studied 682 men (mean age, 70.0 years), without stroke, in a cross-sectional Mendelian randomization analysis. We assessed small-vessel diseases (SVDs), which comprised lacunar infarcts, white matter hyperintensities (WMHs), and cerebral microbleeds, and large intracranial artery stenosis (ICAS) on brain magnetic resonance imaging. RESULTS: The median (25%tiles, 75%tiles) alcohol consumption by ALDH2-rs671 inactive A allele (n=313 [45.9%]) and non-A allele (n=369 [54.1%]) carriers was 3.5 (0.0, 16.0) and 32.0 (12.9, 50.0) g/day, respectively. Non-A allele carriers had higher prevalent hypertension and lower low-density lipoprotein cholesterol concentrations than A allele carriers. In age-adjusted ordinal logistic regression for graded burden, odds ratios (95% confidence intervals) for total SVDs, lacunar infarcts, WMHs, cerebral microbleeds, and ICAS in non-Aallele carriers were 1.46 (1.09-1.94), 1.41 (0.95-2.08), 1.39 (1.05-1.85), 1.69 (1.06-2.69), and 0.70 (0.50-0.98), respectively, compared with A allele carriers. These associations attenuated to statistical non-significance after considering covariates and amount of alcohol intake. CONCLUSIONS: Our findings suggest a positive association of alcohol consumption with risk of cerebral SVDs and its inverse association with risk of large-vessel disease through intermediaries, such as hypertension or low-density lipoprotein cholesterol. These findings provide insight into potential causal mechanisms linking alcohol consumption with stroke risk.

DOI： 10.5551/jat.64222

Association of Anthropometric and CT-Based Obesity Indices with Subclinical Atherosclerosis. 査読

Yosuke Higo, Takashi Hisamatsu, Yoshihisa Nakagawa, Yuichi Sawayama, Yuichiro Yano, Aya Kadota, Akira Fujiyoshi, Sayaka Kadowaki, Sayuki Torii, Keiko Kondo, Yoshiyuki Watanabe, Hirotsugu Ueshima, Katsuyuki Miura

Journal of atherosclerosis and thrombosis 31 ( 1 ) 48 - 60 2023年8月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

AIM: Few studies have compared the strength in the associations of anthropometric and computed tomography (CT)-based obesity indices with coronary artery calcification (CAC), aortic artery calcification (AoAC), and aortic valve calcification (AVC). METHODS: We assessed cross-sectcional associations of anthropometric and CT-based obesity indices with CAC, AoAC, and AVC. Anthropometric measures included body mass index (BMI), waist circumference, hip ircumference, waist-to-hip circumference ratio, and waist-to-height ratio in 931 men (mean age, 63.7 years) from a population-based cohort. CT images at the L4/5 level were obtained to calculate the areas of abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), total adipose tissue (TAT), VAT-to-SAT ratio (VSR), and VAT-to-TAT ratio (VTR). CAC, AoAC, and AVC were quantified using the Agatston score based on CT scanning. RESULTS: CAC, AVC, and AoAC were present in 348 (62.6%), 173 (18.6%), and 769 (82.6%) participants, respectively. In multivariable models adjusting for age, lifestyle factors, and CT types (electron beam CT and multidetector row CT), anthropometric and CT-based obesity indices were positively associated with CAC (p＜0.01). Conversely, VAT-to-SAT ratio and VAT-to-TAT ratio were positively associated with AoAC (p＜0.01). Any obesity indices were not associated with AVC. CONCLUSIONS: The strength of the associations of obesity indices with subclinical atherosclerosis varied according to the anatomically distinct atherosclerotic lesions, among men.

DOI： 10.5551/jat.64096

Associations of indoor and outdoor temperatures and their difference with home blood pressure: The Masuda Study 査読国際誌

Minako Kinuta, Takashi Hisamatsu, Mari Fukuda, Kaori Taniguchi, Sho Komukai, Noriko Nakahata, Hideyuki Kanda

Hypertension Research 46 ( 1 ) 200 - 207 2022年10月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Ambient temperature and blood pressure (BP) are closely related; however, few studies have examined the association of out-of-office BP with indoor or outdoor temperature. The effect of the difference between indoor and outdoor temperatures on BP also remains unknown. Therefore, this study aimed to investigate the association of indoor and outdoor temperatures and their difference with home BP. We studied healthy 352 participants (mean age, 49.8 years; 46.0% women) from a population-based cohort using 2-year data on temperature and self-measured home BP. We measured home BP and indoor temperature at the same time in the morning and evening every day. Outdoor temperature during the same period was based on national data. We observed 82,900 home BP measurements in the morning and 66,420 in the evening. In the mixed-effects model adjusted for age, sex, and possible confounders, indoor temperature was inversely associated with systolic and diastolic BP in the morning and evening. A 1 °C increase in indoor temperature reduced systolic and diastolic BP by 0.37 and 0.22 mmHg, respectively, in the morning and by 0.45 and 0.30 mmHg, respectively, in the evening (all P-values<0.001). The magnitude of associations was stronger for indoor than outdoor temperature. Similarly, a 1 °C increase in indoor temperature above outdoor temperature decreased systolic and diastolic BP by 0.33 and 0.12 mmHg, respectively, in the morning and by 0.45 and 0.26 mmHg, respectively, in the evening independent of outdoor temperature (all P-values <0.001). In conclusion, controlling indoor temperature is important to stabilize home BP levels.

DOI： 10.1038/s41440-022-01059-z

その他リンク： https://www.nature.com/articles/s41440-022-01059-z

Alcohol consumption and subclinical and clinical coronary heart disease: A Mendelian randomization analysis 査読国際誌

Hisamatsu T, Miura K, Tabara Y, Sawayama Y, Kadowaki T, Kadota A, Torii S, Kondo K, Yano Y, Fujiyoshi A, Yamamoto T, Nakagawa Y, Horie M, Kimura T, Okamura T, Ueshima H, for the SESSA, ACCESS Research Groups

European Journal of Preventive Cardiology 29 ( 15 ) 2006 - 2014 2022年7月

Association of ambulatory blood pressure with aortic valve and coronary artery calcification. 査読国際誌

Yuichi Sawayama, Takashi Hisamatsu, Aya Kadota, Sayuki Torii, Keiko Kondo, Akira Fujiyoshi, Yosuke Higo, Akiko Harada, Yoshiyuki Watanabe, Yoshihisa Nakagawa, Katsuyuki Miura, Hirotsugu Ueshima

Journal of hypertension 40 ( 7 ) 1344 - 1351 2022年7月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: We aimed to investigate the effect of ambulatory blood pressure (BP) on aortic valve calcification (AVC) and coronary artery calcification (CAC), which are subclinical atherosclerotic diseases. METHODS: In this population-based, cross-sectional study, we assessed office BP, mean ambulatory BP (24-h, awake, and asleep), and variability of ambulatory BP, as determined by the coefficient of variation (awake and asleep). AVC and CAC were quantified using an Agatston score (>0) based on computed tomography scanning. We calculated relative risks (RRs) and 95% confidence intervals (CIs) with a 1-standard deviation increment in each BP index for the presence of AVC and CAC using a multivariate-adjusted Poisson regression with robust error variance. RESULTS: Of 483 participants (mean age: 66.8 years), 154 (31.9%) and 310 (64.2%) had AVC and CAC, respectively. The presence of AVC was associated with office systolic BP (SBP; RR, 1.15; 95% CI, 1.03-1.28), awake diastolic BP (DBP) variability (RR, 1.12; 95% CI, 1.01-1.25), and asleep SBP variability (RR, 1.14; 95% CI, 1.03-1.27). The presence of CAC was associated with office SBP (RR, 1.08; 95% CI, 1.01-1.15), mean 24-h SBP (RR, 1.10; 95% CI, 1.04-1.16), mean awake SBP (RR, 1.11; 95% CI, 1.04-1.17), mean asleep SBP (RR, 1.07; 95% CI, 1.01-1.13), and asleep SBP variability (RR, 1.07; 95% CI, 1.01-1.13). CONCLUSION: These findings highlight the association of ambulatory BP indices with both AVC and CAC, but with different effects on their presences.

DOI： 10.1097/HJH.0000000000003147

Ventricular Premature Complexes and Their Associated Factors in a General Population of Japanese Men. 査読国際誌

Sabrina Ahmed, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Hiroyoshi Segawa, Sayuki Torii, Naoyuki Takashima, Keiko Kondo, Yoshihisa Nakagawa, Hirotsugu Ueshima, Katsuyuki Miura

The American journal of cardiology 169 51 - 56 2022年4月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Increased ventricular premature complexes (VPCs) are associated with a higher risk of cardiac morbidities. However, little information is available on the risk factors of Western general populations. Therefore, we aimed to assess the frequency and associated factors of VPCs in healthy general Japanese men. We conducted a population-based cross-sectional study in 517 men, aged 40 to 79 years, using 24-hour Holter electrocardiography. Age, body mass index, height, low-density lipoprotein cholesterol, triglycerides, high-density lipoprotein cholesterol, resting heart rate, diabetes mellitus, hypertension, physical activity, smoking, alcohol consumption, lipid-lowering therapy were included in multivariable negative binomial regression to assess independent correlates for the number of VPCs per hour. We observed at least 1 VPC in 1 hour in 429 men (83%). In multivariable negative binomial regression adjusted for all covariates simultaneously, age (risk ratio [95% confidence interval] 1.91 [1.56 to 2.33] per 1-SD increment), height (1.17 [1.04 to 1.49] per 1-SD increment), resting heart rate(1.34 [1.02 to 1.77] per 1-SD increment), diabetes mellitus (2.36 [1.17 to 4.76] ), hypertension (1.90 [1.03 to 3.50]), physical activity (0.67 [0.47 to 0.97] ), current smoking (4.23 [1.86 to 9.60] ), past smoking (2.08 [1.03 to 4.19] ), current light alcohol consumption (0.16 [0.04 to 0.64] ), and lipid-lowering therapy (0.47 [0.23 to 0.96] ) were independently associated with VPCs frequency. In conclusion, VPCs frequency was independently associated with age, height, resting heart rate, diabetes mellitus, hypertension, physical activity, smoking, alcohol consumption, and lipid-lowering therapy.

DOI： 10.1016/j.amjcard.2021.12.046

The association between problematic Internet use and neck pain among Japanese schoolteachers 査読国際誌

Tanabe R, Hisamatsu T, Fukuda M, Tsumura H, Tsuchie R, Suzuki M, Sugaya N, Nakamura K, Takahashi K, Kanda H

63 ( 1 ) e12298 - 9 of 9 2021年11月

Urinary sodium and potassium excretions in young adulthood and blood pressure by middle age: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. 査読国際誌

Takashi Hisamatsu, Donald M Lloyd-Jones, Laura A Colangelo, Kiang Liu

Journal of hypertension 39 ( 8 ) 1586 - 1593 2021年8月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: Data are sparse regarding the impact of sodium and potassium intakes on serial blood pressure (BP) levels during long-term follow-up. METHODS: Among 1007 Coronary Artery Risk Development in Young Adults participants (mean age, 30.2 years; 53% blacks; 57% women) who had at least two 24-h urine samples collected at year 5 (Y5) examination, we assessed associations of urinary sodium and potassium excretions with BP trends and incident hypertension in the subsequent 25 years. Participants were classified by sex-specific medians for averaged 24-h urinary excretions: lower sodium and higher potassium (Na-Lo-K-Hi); higher sodium and lower potassium (Na-Hi-K-Lo); and others. RESULTS: In the adjusted generalized estimating equation model, SBP and DBP greatly increased in the Na-Hi-K-Lo group (n = 185) compared with the Na-Lo-K-Hi group (n = 185), with statistically significant BP differences at Y20, Y25, and Y30 (mean SBP, 3.93, 4.94, and 4.88 mmHg, respectively; and mean DBP, 4.70, 4.95, and 4.59 mmHg, respectively). During 25-year follow-up, among 926 participants without prevalent hypertension by Y5, 381 (41.1%) developed hypertension. In the adjusted Cox proportional hazards model, the Na-Hi-K-Lo group had hazard ratio (95% confidence interval), 1.45 (1.00-2.10) for incident hypertension compared with the Na-Lo-K-Hi group. The association with incident hypertension was predominant in blacks and white women (race--sex interaction, P = 0.03). Sodium-to-potassium ratio and sodium excretion were positively, whereas potassium excretion was inversely, associated with incident hypertension (all P trend <0.05). CONCLUSION: Our findings highlight the importance of dietary sodium reduction and higher potassium intake for hypertension prevention among young adults.

DOI： 10.1097/HJH.0000000000002802

Association of self-measured home, ambulatory, and strictly measured office blood pressure and their variability with intracranial arterial stenosis. 査読国際誌

Takashi Hisamatsu, Takayoshi Ohkubo, Atsushi Hozawa, Akira Fujiyoshi, Sayuki Torii, Hiroyoshi Segawa, Keiko Kondo, Aya Kadota, Naoyuki Takashima, Satoshi Shitara, Hisatomi Arima, Yoshihisa Nakagawa, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

Journal of hypertension Publish Ahead of Print ( 10 ) 2030 - 2039 2021年6月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

OBJECTIVE: Hypertension and intracranial artery stenosis (ICAS) are closely related; however, few studies have compared the strength of the relationship between strictly measured office and out-of-office blood pressure (BP) measurements. The relationship of day-by-day or short-term variability in BP to asymptomatic ICAS also remains unclear. METHODS: In apparently healthy 677 men (mean age, 70 years) from a population-based cohort, we examined the association of strictly measured office BP and 7-day home BP with ICAS on magnetic resonance angiography. We conducted 24-h ambulatory BP monitoring in 468 of the men. Variability indices included day-by-day, daytime, and night-time variability, nocturnal decline, and morning pressor surge. Any ICAS was defined as either mild (1-49%) or severe (≥50%) stenosis. RESULTS: We observed mild and severe ICAS in 153 (22.6%) and 36 (5.3%) participants, respectively. In multivariable-adjusted Poisson regression with robust error variance, higher SBP in office, home, or ambulatory BP monitoring was associated with the presence of any or severe ICAS. The associations with ICAS were comparable between office, home, and ambulatory SBP (all heterogeneity P values >0.1). Independent of mean SBP, greater nocturnal decline or morning pressor surge, but not day-by-day, daytime, or night-time variability, in SBP was associated with higher burden of any or severe ICAS. CONCLUSION: The magnitude of association of strictly measured office BP for asymptomatic ICAS was comparable with that of BP measured at home or in ambulatory BP monitoring. Circadian BP variation based on ambulatory BP monitoring was positively associated with asymptomatic ICAS burden.

DOI： 10.1097/HJH.0000000000002900

Relationship between insomnia with alcohol drinking before sleep (Ne-Zake) or in the morning (Mukae-Zake) among Japanese farmers. 査読国際誌

Rie Sato, Takashi Hisamatsu, Hideki Tsumura, Mari Fukuda, Kaori Taniguchi, Haruo Takeshita, Hideyuki Kanda

Alcohol (Fayetteville, N.Y.) 93 57 - 62 2021年6月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Ne-Zake is the drinking of alcohol before sleeping for helping to fall asleep and sleep well, and Mukae-Zake is the drinking of alcohol in the morning for "calming down" or "curing hangovers". OBJECTIVE: We sought to examine the relationship of insomnia with Ne-Zake and Mukae-Zake among healthy middle-aged Japanese farmers. METHODS: In a cross-sectional study of 746 participants (mean age, 59.5 years; women, 25.9%), Ne-Zake and Mukae-Zake were defined based on a self-administered questionnaire. Insomnia was defined as the Athens Insomnia Scale Japanese version ≥6 or usage of sleeping pills in the previous year. Logistic regression was used to calculate odds ratio (OR) of insomnia related to Ne-Zake and Mukae-Zake adjusting for sex, age, presence of sleep-related disorders, frequency of alcohol consumption, and quantity of alcohol consumed per one occasion. RESULTS: We observed insomnia, Ne-Zake, and Mukae-Zake in 174 (23.3%), 140 (18.8%), and 37 (5.0%) participants, respectively. After adjustment for demographic and confounding factors, participants with Ne-Zake had a significantly higher prevalence of insomnia (OR 2.00 [95% confidence interval, 1.27-3.16]), compared to those without Ne-Zake. Mukae-Zake was also independently associated with a higher prevalence of insomnia among men (OR 3.26 [1.55-6.87]). Participants with both Ne-Zake and Mukae-Zake had a highly significant association with insomnia (OR 4.77 [2.01-11.3]) than those with neither Ne-Zake nor Mukae-Zake. Additionally, for insomnia, the association of Mukae-Zake was more pronounced than that of Ne-Zake (OR 4.09, 95% CI 1.14-14.7, p = 0.031; and OR 1.81, 95% CI 1.08-3.06, p = 0.026, respectively). CONCLUSION: Ne-Zake and Mukae-Zake were associated with insomnia independent of the quantity and frequency of alcohol consumption among Japanese farmers. This finding can be used for stratifying individuals with insomnia not only to improve sleep hygiene but also to prevent alcohol dependence by informing the general population that alcohol has a negative effect on sleep, contrary to popular beliefs.

DOI： 10.1016/j.alcohol.2020.11.005

Effect of Coronavirus Disease 2019 Pandemic on Physical Activity in a Rural Area of Japan: The Masuda Study. 査読

Takashi Hisamatsu, Kaori Taniguchi, Mari Fukuda, Minako Kinuta, Noriko Nakahata, Hideyuki Kanda

Journal of epidemiology 31 ( 3 ) 237 - 238 2021年3月

Epidemiology of hypertension in Japan: beyond the new 2019 Japanese guidelines 招待査読

Takashi Hisamatsu, Hiroyoshi Segawa, Aya Kadota, Takayoshi Ohkubo, Hisatomi Arima, Katsuyuki Miura

Hypertension Research 43 ( 12 ) 1344 - 1351 2020年12月

Isolated systolic hypertension and 29-year cardiovascular mortality risk in Japanese adults aged 30--49 years. 査読国際誌

Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Aya Kadota, Keiko Kondo, Yoshikuni Kita, Takehito Hayakawa, Hideyuki Kanda, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

Journal of hypertension 38 ( 11 ) 2230 - 2236 2020年11月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

OBJECTIVE: The prognostic implication of isolated systolic hypertension (ISH), defined as SBP at least 140 mmHg and DBP less than 90 mmHg, among young-to-middle-aged adults remains controversial. We examined the association of ISH with cardiovascular disease (CVD) risk in adults aged 30-49 years. METHODS: In a prospective cohort of representative Japanese general populations from the NIPPON DATA80 (1980-2009), we studied 4776 participants (mean age, 39.4 years; 55.4% women) without clinical CVD or antihypertensive medication. Participants were classified as follows: normal blood pressure (BP) (SBP/DBP, <120/<80 mmHg), high-normal BP (120-129/<80 mmHg), elevated BP (130-139/80-89 mmHg), ISH, isolated diastolic hypertension (IDH) (<140/≥90 mmHg), and systolic--diastolic hypertension (SDH) (≥140/≥90 mmHg). RESULTS: ISH was observed in 389 (8.1%) participants. During the 29-year follow-up, 115 participants died of CVD, 28 of coronary heart disease, and 49 of stroke. Cox proportional hazards models adjusted for demographics and CVD risk factors showed that participants with ISH had higher risk of CVD mortality than those with normal BP [hazard ratio (confidence interval), 4.10 (1.87-9.03)]. The magnitude of CVD mortality risk related to ISH was comparable with that related to IDH [3.38 (1.31-8.72)] and not as great as that related to SDH [5.41 (2.63-11.14)]. We found significant associations of ISH with coronary and stroke mortality. The association of ISH with CVD mortality was consistent across men and women and those aged 30-39 and 40-49 years. CONCLUSION: ISH among young-to-middle-aged Japanese adults was independently associated with higher risk of CVD mortality later in life.

DOI： 10.1097/HJH.0000000000002533

Intracranial Artery Stenosis and Its Association With Conventional Risk Factors in a General Population of Japanese Men. 査読国際誌

Satoshi Shitara, Akira Fujiyoshi, Takashi Hisamatsu, Sayuki Torii, Sentarou Suzuki, Takahiro Ito, Hisatomi Arima, Akihiko Shiino, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

Stroke 50 ( 10 ) 2967 - 2969 2019年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background and Purpose- Few community-based studies have reported the prevalence of intracranial artery stenosis (ICAS) assessed with magnetic resonance angiography. The aim was to determine the prevalence of ICAS using magnetic resonance angiography in a general population of Japanese men and to investigate the associations between ICAS and conventional cardiovascular risk factors. Methods- The Shiga Epidemiological Study of Subclinical Atherosclerosis randomly recruited and examined participants from Kusatsu City, Shiga, Japan, in 2006 to 2008 (baseline); 740 men returned for follow-up and underwent 1.5 T brain magnetic resonance angiography in 2012 to 2015. Participants were categorized as having no-ICAS, mild-ICAS (1 to <50%), or severe-ICAS (≥50%) in any of the arteries examined. After excluding the men with a history of stroke, 709 men were analyzed using multivariable logistic regression to assess independent associations of conventional cardiovascular risk factors with reference to the no-ICAS group. Results- The participants' mean age was 68.0 years. The age-standardized prevalences of mild and severe-ICAS were 20.7% and 4.5%, respectively (with the population of the 2010 Japanese vital statistics as the reference). Age, hypertension, diabetes mellitus, and dyslipidemia were associated with a higher prevalence of severe-ICAS after simultaneous adjustment for conventional cardiovascular risk factors. Conclusions- In a community-based sample of Japanese men, ICAS was estimated to be present in 25.2%, and related to metabolic risk factors, in addition to hypertension and age. These results support the importance of comprehensive management of conventional cardiovascular risk factors for stroke prevention.

DOI： 10.1161/STROKEAHA.119.025964

Association between excessive supraventricular ectopy and subclinical cerebrovascular disease: a population-based study. 査読国際誌

T Hisamatsu, K Miura, A Fujiyoshi, A Kunimura, T Ito, I Miyazawa, S Torii, A Shiino, K Nozaki, H Kanda, H Arima, T Ohkubo, H Ueshima

European journal of neurology 26 ( 9 ) 1219 - 1225 2019年9月

Coronary Artery Calcium Progression Among the US and Japanese Men. 査読

Takashi Hisamatsu

Circulation. Cardiovascular imaging 12 ( 2 ) 2019年2月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

Background The risk of coronary heart disease remains low in Japan, although distributions of several coronary risk factors have become comparable with those in the United States. We prospectively compared coronary atherosclerosis burden, measured with coronary artery calcium (CAC) progression, between men in the 2 countries. Methods In 2 population-based samples of 1712 US White, Black, Hispanic, Chinese men (baseline, 2000-2002) and 697 Japanese men in Japan (2006-2008) aged 45-74 years without clinical cardiovascular disease, we quantified CAC progression by serial computed tomography with medians of 3.4 and 5.2 years between scans, respectively. Results Among White, Black, Hispanic, Chinese, and Japanese men free of baseline CAC, CAC incidence was observed in 35.2%, 26.9%, 29.2%, 18.9%, and 29.2%, respectively. After adjustment for times between scans, demographics, behaviors, coronary risk factors, and their changes between scans, White men had significantly higher CAC incidence than Japanese men (relative risk, 1.68; 95% CI, 1.13-2.50). Among those with detectable baseline CAC, after similar adjustments, all the US race/ethnic groups had significantly greater annual changes in CAC score (mean [95% CI]: 39.4 [35.2-43.6] for White, 26.9 [21.4-32.4] for Black, 30.6 [24.7-36.5] for Hispanic, and 30.2 [22.6-37.8] for Chinese men) than Japanese men (15.9 [10.1-21.8]). Conclusions We found a higher CAC incidence among US White men and greater increases in existing CAC among all the US race/ethnic groups than among Japanese men in Japan. These differences persisted despite adjustment for differences in coronary risk factors.

DOI： 10.1161/circimaging.118.008104

Control Rates of Systolic and Diastolic Blood Pressure among Hypertensive Adults in Korea 招待査読

Takashi Hisamatsu

Korean Circulation Journal 49 ( 11 ) 1049 - 1049 2019年1月

担当区分：筆頭著者,　最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Korean Society of Cardiology

DOI： 10.4070/kcj.2019.0197

その他リンク： https://synapse.koreamed.org/DOIx.php?id=10.4070/kcj.2019.0197

Home blood pressure variability and subclinical atherosclerosis in multiple vascular beds 査読国際誌

Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Hisatomi Arima, Akira Fujiyoshi, Atsushi Satoh, Aya Kadota, Maryam Zaid, Naoyuki Takashima, Seiko Ohno, Minoru Horie, Hirotsugu Ueshima

Journal of Hypertension 36 ( 11 ) 2193 - 2203 2018年11月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

OBJECTIVE: The mechanism by which higher blood pressure (BP) variability causes cardiovascular events remains unclear. Experimental results indicate that alterations in vessel wall tension related to BP variability may initiate atherosclerosis through oscillatory shear stress. We examined associations of home BP variability with subclinical atherosclerosis at four anatomically distinct vascular beds. METHODS: In a cross-sectional population-based study of 1033 Japanese (mean age, 64.0 years; men, 88.7%) without known cardiovascular disease, we defined SBP and DBP variability as variability independent of the mean (VIM) across self-measured home BP values during seven consecutive days and quantified coronary and aortic artery calcification (CAC and AAC) by computed tomography, carotid intima-media thickness (CIMT) by ultrasonography, and ankle-brachial index (ABI). RESULTS: In multivariable adjusted models including mean SBP, higher VIM of SBP was associated with CIMT greater than1.0 mm [relative risk (95% confidence interval) fourth versus first quartile, 1.71 (1.15-2.54)], AAC score greater than 0 [1.08 (1.02-1.15)], and ABI less than 1.1 [1.49 (1.12-1.97)], and linear trends were also statistically significant. However, there was no significant association between VIM of SBP and CAC score greater than 0. Meanwhile, higher VIM of DBP was associated only with AAC score greater than 0. The associations were similar when modeling subclinical atherosclerosis severity as continuous outcomes and were consistent across subgroups based on demographics, behavioural, and cardiovascular risk factors. CONCLUSION: Higher variability in home BP, particularly in home SBP, was associated with greater carotid, aortic, and peripheral but not coronary atherosclerosis burdens independent of the mean home BP.

DOI： 10.1097/hjh.0000000000001810

Relationship of serum irisin levels to prevalence and progression of coronary artery calcification: A prospective, population-based study 査読

Takashi Hisamatsu, Katsuyuki Miura, Hisatomi Arima, Akira Fujiyoshi, Aya Kadota, Sayaka Kadowaki, Maryam Zaid, Naoko Miyagawa, Atsushi Satoh, Ayako Kunimura, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group

International Journal of Cardiology 267 177 - 182 2018年9月

Serum magnesium, phosphorus, and calcium levels and subclinical calcific aortic valve disease: A population-based study 査読

Takashi Hisamatsu, Katsuyuki Miura, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Atsushi Satoh, Maryam Zaid, Takashi Yamamoto, Minoru Horie, Hirotsugu Ueshima, for the SESSA Research Group

Atherosclerosis 273 145 - 152 2018年6月

Increased Aortic Calcification Is Associated With Arterial Stiffness Progression in Multiethnic Middle-Aged Men 査読

Jingchuan Guo, Akira Fujiyoshi, Bradley Willcox, Jina Choo, Abhishek Vishnu, Takashi Hisamatsu, Vasudha Ahuja, Naoyuki Takashima, Emma Barinas-Mitchell, Aya Kadota, Rhobert W. Evans, Katsuyuki Miura, Daniel Edmundowicz, Kamal Masaki, Chol Shin, Lewis H. Kuller, Hirotsugu Ueshima, Akira Sekikawa

Hypertension 69 ( 1 ) 102 - 108 2017年1月

客観的に評価された歩数値とメタボリックシンドローム発症との関連:地域住民5年前向き研究(滋賀動脈硬化疫学研究SESSA) 査読

久松隆史, 久松隆史, 三浦克之, 三浦克之, 渋川武志, 藤吉朗, 有馬久富, 有馬久富, 門田文, 門田文, 宮川尚子, 鳥居さゆ希, 近藤慶子, 宮澤伊都子, 鈴木仙太朗, 佐藤敦, 山添正博, 柳田昌彦, 前川聡, 上島弘嗣, 上島弘嗣

日本循環器病予防学会誌 52 ( 1 ) 20 - 28 2017年

Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men 査読

Hisamatsu Takashi, Miura Katsuyuki, Arima Hisatomi, Kadota Aya, Kadowaki Sayaka, Torii Sayuki, Suzuki Sentaro, Miyagawa Naoko, Sato Atsushi, Yamazoe Masahiro, Fujiyoshi Akira, Ohkubo Takayoshi, Yamamoto Takashi, Murata Kiyoshi, Robert D. Abbott, Sekikawa Akira, Horie Minoru, Ueshima Hirotsugu, the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group

Journal of the American Heart Association 5 ( 9 ) e003738 2016年8月

Relationship of Insulin Resistance to Prevalence and Progression of Coronary Artery Calcification Beyond Metabolic Syndrome Components 査読国際誌

Masahiro Yamazoe, Takashi Hisamatsu, Katsuyuki Miura, Sayaka Kadowaki, Maryam Zaid, Aya Kadota, Sayuki Torii, Itsuko Miyazawa, Akira Fujiyoshi, Hisatomi Arima, Akira Sekikawa, Hiroshi Maegawa, Minoru Horie, Hirotsugu Ueshima

Arteriosclerosis, Thrombosis, and Vascular Biology 36 ( 8 ) 1703 - 1708 2016年8月

Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population 査読国際誌

Takashi Hisamatsu, Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Aya Kadota, Sayaka Kadowaki, Takashi Kadowaki, Takashi Yamamoto, Naoko Miyagawa, Maryam Zaid, Sayuki Torii, Naoyuki Takashima, Yoshitaka Murakami, Tomonori Okamura, Minoru Horie, Hirotsugu Ueshima

Atherosclerosis 236 ( 2 ) 237 - 243 2014年10月

High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: A 24-year follow-up of Japanese general population 査読

Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima

JOURNAL OF CARDIOLOGY 64 ( 3-4 ) 218 - 224 2014年9月

Interaction between dietary marine-derived n-3 fatty acids intake and J-point elevation on the risk of cardiac death: a 24-year follow-up of Japanese men 査読

Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Yamamoto, Akira Fujiyoshi, Naoko Miyagawa, Aya Kadota, Naoyuki Takashima, Nagako Okuda, Yasuhiro Matsumura, Katsushi Yoshita, Yoshikuni Kita, Yoshitaka Murakami, Yasuyuki Nakamura, Tomonori Okamura, Minoru Horie, Akira Okayama, Hirotsugu Ueshima

Heart 99 ( 14 ) 1024 - 1029 2013年7月

Association between J-Point elevation and death from coronary artery disease 査読

Hisamatsu T, Ohkubo T, Miura K, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Nagasawa SY, Kita Y, Murakami Y, Okayama A, Horie M, Okamura T, Ueshima H, for the NIPPON DATA, Research Group

Circ J. 77 ( 5 ) 1260 - 1266 2013年

Asymptomatic intracranial vascular lesions and cognitive function in a general population of Japanese men: Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Takahiro Ito, Akira Fujiyoshi, Takayoshi Ohkubo, Akihiko Shiino, Satoshi Shitara, Naoko Miyagawa, Sayuki Torii, Takashi Hisamatsu, Hiroyoshi Segawa, Keiko Kondo, Aya Kadota, Ikuo Tooyama, Yoshiyuki Watanabe, Kazumichi Yoshida, Kazuhiko Nozaki, Katsuyuki Miura

Cerebrovascular Diseases 2025年6月

Nicotine dependence based on the tobacco dependence screener among heated tobacco products users in Japan, 2022-2023: The JASTIS study. 査読国際誌

Takuma Kitajima, Takashi Hisamatsu, Hideyuki Kanda, Takahiro Tabuchi

Neuropsychopharmacology reports 45 ( 1 ) e12512 2025年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

Heated tobacco products (HTPs) are nicotine-containing products similar to cigarettes and are widely used in Japan. However, there has been insufficient research on nicotine dependence associated with HTP use. This study investigated the association of the types of individuals who smoked with the prevalence of nicotine dependence. We utilized data from the Japan Survey on Tobacco and Health (JASTIS). A total of 7969 participants who currently smokes was selected from the 2022 and 2023 survey respondents for the analysis. Nicotine dependence was defined as a score of 5 or higher on the Tobacco Dependence Screener (TDS). The prevalence of nicotine dependence was 43.0% (3473/8077) among all participants who smoked, 42.9% (1479/3447) among those who used cigarettes, 44.2% (760/1720) among those who used two products, and 43.0% (1206/2802) among those who used HTPs. The prevalence of nicotine dependence was statistically higher in the participants who used two products than in cigarettes (odds ratio [OR], 1.17; 95% confidence interval [CI], 1.04-1.33). When classified by temperature, participants who used of two products (high-temp and low-temp) and those using participants who used HTPs (high-temp) had higher ORs for prevalent nicotine dependence (OR, 1.31 [95% CI, 1.14-1.51]) and (OR, 1.12 [95% CI, 1.00-1.25], respectively) compared to participants who used cigarettes. Additionally, the ORs for prevalent nicotine dependence increased with the number of tobacco sticks smoked per day. These results suggest that HTP use, particularly high-temperature HTPs use, and a higher number of tobacco sticks smoked is associated with nicotine dependence.

DOI： 10.1002/npr2.12512

SCN5A variant type-dependent risk prediction in Brugada syndrome 査読国際誌

Takanori Aizawa, Takeru Makiyama, Hai Huang, Tomohiko Imamura, Megumi Fukuyama, Keiko Sonoda, Koichi Kato, Takashi Hisamatsu, Yuko Nakamura, Kenji Hoshino, Junichi Ozawa, Hiroshi Suzuki, Kazushi Yasuda, Hisaaki Aoki, Takashi Kurita, Yoko Yoshida, Tsugutoshi Suzuki, Yoshihide Nakamura, Yoshiharu Ogawa, Shintaro Yamagami, Hiroshi Morita, Shinsuke Yuasa, Masakazu Fukuda, Makoto Ono, Hidekazu Kondo, Naohiko Takahashi, Seiko Ohno, Yoshihisa Nakagawa, Koh Ono, Minoru Horie

Europace 27 ( 2 ) 2025年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

AIMS: The variant in SCN5A with the loss of function (LOF) effect in the cardiac Na+ channel (Nav1.5) is the definitive cause for Brugada syndrome (BrS), and the functional analysis data revealed that LOF variants are associated with poor prognosis. However, which variant types (e.g. missense or non-missense) affect the prognoses of those variant carriers remain unelucidated. METHODS AND RESULTS: We defined SCN5A LOF variants as all non-missense and missense variants that produce peak INa < 65% of wild-type previously confirmed by patch-clamp studies. The study population consisted of 76 Japanese BrS patients (74% patients were male and the median age [IQR] at diagnosis was 28 [14-45] years) with LOF type of SCN5A variants: 40 with missense and 36 with non-missense variants. Non-missense variant carriers presented significantly more severe cardiac conduction disorder compared to the missense variant carriers. During follow-up periods of 9.0 [5.0-14.0] years, compared to missense variants, non-missense variants were significant risk factors of lifetime lethal arrhythmia events (LAEs) (P = 0.023). When focusing only on the missense variants that produce no peak INa, these missense variant carriers exhibited the same clinical outcomes as those with non-missense (log-rank P = 0.325). After diagnosis, however, both variant types were comparable in risk of LAEs (P = 0.155). CONCLUSION: We identified, for the first time, that SCN5A non-missense variants were associated with higher probability of LAE than missense variants in BrS patients though it did not change significantly after diagnosis.

DOI： 10.1093/europace/euaf024

Toward personalized exercise prescriptions for blood pressure management: insights from a comprehensive meta-analysis. 招待査読国際誌

Takashi Hisamatsu

Hypertension research : official journal of the Japanese Society of Hypertension 48 ( 3 ) 1228 - 1230 2024年12月

Optimal timing for measuring the casual urine Na/K ratio using a single sample: insights from a comparison with 24-h urine samples. 招待査読国際誌

Takashi Hisamatsu

Hypertension research : official journal of the Japanese Society of Hypertension 48 ( 2 ) 849 - 851 2024年12月

CTG repeat length underlying cardiac events and sudden death in myotonic dystrophy type 1 査読国際誌

Hideki Itoh, Takashi Hisamatsu, Kazuhiko Segawa, Toshiaki Takahashi, Takumi Sato, Hiroto Takada, Satoshi Kuru, Chizu Wada, Mikiya Suzuki, Takuhisa Tamura, Shugo Suwazono, Koichi Kimura, Tsuyoshi Matsumura, Masanori P Takahashi

European Heart Journal Open 4 ( 5 ) oeae078 2024年8月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

AIMS: Myotonic dystrophy Type 1 (DM1) is caused by the expansion of CTG repeats (CTGn) in the DM1 protein kinase (DMPK) gene, while it remains unclear whether CTGn may be associated with the incidence of cardiac events or sudden death in Japan as well as Europe. The aim of this study was to investigate the association between CTGn and cardiac involvements. METHODS AND RESULTS: This cohort study included patients with DM1 who were retrospectively recruited from nine Japanese hospitals specializing in neuromuscular diseases. A total of 496 patients with DM1 who underwent a genetic test in the DMPK gene were analysed. Patients with congenital form or under 15 years old were excluded and patients were assigned into the quartiles. When we compared the incidence of cardiac events including advanced/complete atrioventricular block, pacemaker implantation, and ventricular tachycardias or mortality among four groups, patients with 1300 or longer CTGn experienced composite cardiac events [hazard ratio (HR): 3.19, 95% confidence interval (CI): 1.02-9.99, P = 0.014] more frequently and had significantly higher mortality rate (HR: 6.79, 95% CI: 2.05-22.49, P < 0.001) than those under 400 CTGn while the rate of sudden death was not significantly different. CONCLUSION: Regarding the cardiac events and mortality in patients with DM1, patients with 1300 or longer CTGn are at especially high risk.

DOI： 10.1093/ehjopen/oeae078

IoT技術を用いた家庭血圧管理研究の5年間の成果と時系列ビックデータ・AIを活用した今後の展望益田研究査読

久松隆史, 絹田皆子, 福田茉莉, 谷口かおり, 中畑典子, 神田秀幸

岡山医学会雑誌 136 ( 2 ) 57 - 62 2024年8月

Low-density lipoprotein particle profiles compared with standard lipids measurements in the association with asymptomatic intracranial artery stenosis. 査読国際誌

Thien Vu, Yuichiro Yano, Huy Kien Tai Pham, Rajib Mondal, Mizuki Ohashi, Kaori Kitaoka, Mohammad Moniruzzaman, Sayuki Torii, Akihiko Shiino, Atsushi Tsuji, Takashi Hisamatsu, Tomonori Okamura, Keiko Kondo, Aya Kadota, Yoshiyuki Watanabe, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

Scientific reports 14 ( 1 ) 10765 - 10765 2024年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

The Shiga Epidemiological Study of Subclinical Atherosclerosis was conducted in Kusatsu City, Shiga, Japan, from 2006 to 2008. Participants were measured for LDL-p through nuclear magnetic resonance technology. 740 men participated in follow-up and underwent 1.5 T brain magnetic resonance angiography from 2012 to 2015. Participants were categorized as no-ICAS, and ICAS consisted of mild-ICAS (1 to < 50%) and severe-ICAS (≥ 50%) in any of the arteries examined. After exclusion criteria, 711 men left for analysis, we used multiple logistic regression to examine the association between lipid profiles and ICAS prevalence. Among the study participants, 205 individuals (28.8%) had ICAS, while 144 individuals (20.3%) demonstrated discordance between LDL-c and LDL-p levels. The discordance "low LDL-c-high LDL-p" group had the highest ICAS risk with an adjusted OR (95% CI) of 2.78 (1.55-5.00) in the reference of the concordance "low LDL-c-low LDL-p" group. This was followed by the concordance "high LDL-c-high LDL-p" group of 2.56 (1.69-3.85) and the discordance "high LDL-c-low LDL-p" group of 2.40 (1.29-4.46). These findings suggest that evaluating LDL-p levels alongside LDL-c may aid in identifying adults at a higher risk for ICAS.

DOI： 10.1038/s41598-024-59523-4

Heart Rate Fragmentation, Ambulatory Blood Pressure, and Coronary Artery Calcification: A Population-Based Study. 査読国際誌

Yuichi Sawayama, Yuichiro Yano, Takashi Hisamatsu, Akira Fujiyoshi, Aya Kadota, Sayuki Torii, Keiko Kondo, Sayaka Kadowaki, Yosuke Higo, Akiko Harada, Yoshiyuki Watanabe, Yoshihisa Nakagawa, Katsuyuki Miura, Hirotsugu Ueshima

JACC. Asia 4 ( 3 ) 216 - 225 2024年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Little is known regarding whether ultra-rapid patterns of heart rate variability (eg, heart rate fragmentation [HRF]) are associated with coronary artery calcification (CAC) in a general population. OBJECTIVES: This study aimed to assess the association between HRF and CAC, and whether these associations are independent of systolic blood pressure (SBP) levels. METHODS: From SESSA (the Shiga Epidemiological Study of Subclinical Atherosclerosis), we used data from 24-hour ambulatory blood pressure monitoring to identify awake and asleep SBP levels, and data from concurrent 24-hour Holter monitoring to quantify HRF using the awake and asleep percentage of inflection points (PIP). CAC on computed tomography scanning was quantified using an Agatston score. We used multivariable binomial logistic regression to assess the associations of PIP and ambulatory SBP with the presence of CAC, as defined by Agatston score >0. RESULTS: Of the 508 participants in this study (mean age: 66.5 ± 7.3 years), 325 (64%) had CAC and 183 (36%) did not. In fully adjusted models of prevalent CAC that also included office SBP, the ORs with 95% CIs for awake PIP, awake SBP, asleep PIP, and asleep SBP were 1.23 (95% CI: 0.99-1.54), 1.40 (95% CI: 1.11-1.77), 1.31 (95% CI: 1.05-1.62), and 1.28 (95% CI: 1.02-1.60), respectively. There was no evidence of interaction between PIP and ambulatory SBP in association with CAC. Results were similar when other HRF indices instead of PIP were used. CONCLUSIONS: Higher HRF and SBP levels during sleep are each associated with the presence of CAC in a general male population.

DOI： 10.1016/j.jacasi.2023.10.004

Relationship Between Hemoglobin Concentration and Cardiovascular Disease Mortality in a 25-Year Follow-up Study of a Japanese General Population - NIPPON DATA90. 査読

Megumi Kawashima, Takashi Hisamatsu, Akiko Harada, Aya Kadota, Keiko Kondo, Yukiko Okami, Takehito Hayakawa, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura, Katsuyuki Miura

Circulation journal : official journal of the Japanese Circulation Society 88 ( 5 ) 742 - 750 2024年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Deviations of hemoglobin from normal levels may be a factor in cardiovascular disease (CVD) risk; however, conclusive evidence is lacking. In addition, preclinical conditions may influence hemoglobin concentrations, but studies focusing on reverse causation are limited. Thus, we examined the relationship between hemoglobin concentrations and CVD mortality risk, considering reverse causation.Methods and Results: In a prospective cohort representative of the general Japanese population (1990-2015), we studied 7,217 individuals (mean age 52.3 years; 4,219 women) without clinical CVD at baseline. Participants were categorized into sex-specific hemoglobin quintiles (Q1-Q5) and data were analyzed using the Cox proportional hazards model adjusted for possible confounders. During a 25-year follow-up, 272 men and 334 women died from CVD. Adjusted hazard ratios for CVD mortality across sex-specific quintiles, using Q3 as the reference, were significantly higher for Q1 (1.40; 95% confidence interval [CI] 1.08-1.82) and Q5 (1.49; 95% CI 1.14-1.96), and remained significant after excluding deaths within the first 5 years of follow-up to consider reverse causation (1.35 [95% CI 1.02-1.79] and 1.45 [95% CI 1.09-1.94], respectively). A similar U-shaped association was seen between transferrin saturation levels and CVD mortality, but after excluding deaths within the first 5 years the association was significant only for Q1. CONCLUSIONS: Low and high hemoglobin concentrations were associated with an increased risk of CVD mortality.

DOI： 10.1253/circj.CJ-23-0725

Association of step counts with cognitive function in apparently healthy middle-aged and older Japanese men. 査読国際誌

Takeshi Shibukawa, Akira Fujiyoshi, Mohammad Moniruzzaman, Naoko Miyagawa, Aya Kadota, Keiko Kondo, Yoshino Saito, Sayaka Kadowaki, Takashi Hisamatsu, Yuichiro Yano, Hisatomi Arima, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura

Preventive medicine reports 38 102615 - 102615 2024年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Increasing physical activity may prevent cognitive decline. Previous studies primarily focused on older adults and used self-reported questionnaires to assess physical activity. We examined the relationship between step count, an objective measure of physical activity, and cognitive function in community-based middle-aged and older Japanese men. METHODS: The Shiga Epidemiological Study of Subclinical Atherosclerosis randomly recruited community-dwelling healthy men aged 40-79 years from Shiga, Japan, and measured their step counts over 7 consecutive days using a pedometer at baseline (2006-2008). Among men who returned for follow-up (2009-2014), we assessed their cognitive function using the Cognitive Abilities Screening Instrument (CASI) score. We restricted our analyses to those with valid 7-day average step counts at baseline and those who remained free of stroke at follow-up (n = 676). Using analysis of covariance, we calculated the adjusted means of the CASI score according to the quartiles of the average step counts. RESULTS: The mean (standard deviation) of age and unadjusted CASI score were 63.8 (9.1) years and 90.8 (5.8), respectively. The CASI score was elevated in higher quartiles of step counts (90.2, 90.4, 90.6, and 91.8 from the lowest to the highest quartile, respectively, [p for trend = 0.004]) in a model adjusted for age and education. Further adjustment for smoking, drinking, and other cardiovascular risk factors resulted in a similar pattern of association (p for trend = 0.005). CONCLUSION: In apparently healthy middle-aged and older Japanese men, a greater 7-day average step count at baseline was associated with significantly higher cognitive function score.

DOI： 10.1016/j.pmedr.2024.102615

全国の一般地域住民における最近の循環器疾患発症率 NIPPON DATA2010

門田文, 大久保孝義, 原田亜紀子, 高嶋直敬, 有馬久富, 二宮利治, 秦淳, 寳澤篤, 中村幸志, 東山綾, 大澤正樹, 久松隆史, 鳥居さゆ希, 岡見雪子, 近藤慶子, 宮本恵宏, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

Journal of Epidemiology 34 ( Suppl. ) 122 - 122 2024年1月

High blood pressure in childhood and adolescence. 招待査読国際誌

Takashi Hisamatsu, Minako Kinuta

Hypertension research : official journal of the Japanese Society of Hypertension 47 ( 1 ) 203 - 205 2023年10月

The gut microbiota and coronary artery calcification in Japanese men. 査読国際誌

Yukiko Okami, Hisatomi Arima, Keiko Kondo, Zhang Hexun, Yuichiro Yano, Aya Kadota, Sayuki Torii, Takashi Hisamatsu, Akira Fujiyoshi, Sayaka Kadowaki, Yoshiyuki Watanabe, Akira Andoh, Yoshihisa Nakagawa, Hirotsugu Ueshima, Katsuyuki Miura for the SESSA Research Group

American heart journal 267 12 - 21 2023年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The gut microbiota differs between patients with coronary artery disease (CAD) and healthy controls; however, it currently remains unclear whether these differences exist prior to the onset of CAD. We herein investigated the gut microbiota associated with subclinical coronary artery calcification (CAC) in a Japanese population. METHODS: A total of 663 Japanese men were enrolled in this cross-sectional study. Computed tomography and gut microbiology tests were performed, and CAC scores were calculated using the Agatston method. Participants were categorized into four groups based on their CAC scores: CAC = 0, 0 <CAC ≤100, 100 <CAC, and with a CAD history. The bacterial 16S ribosomal RNA gene was amplified, and DNA sequencing was conducted on a MiSeq System. QIIME2 and LEfSe were used to analyze the gut microbiota, and the results obtained were compared among the four CAC categories. RESULTS: The mean age of participants was 68.4 years (46-83 years). The numbers of participants in CAC = 0, 0 <CAC ≤100, 100 <CAC, and with a CAD history were 219, 200, 193, and 51, respectively. The medians of the Firmicutes to Bacteroidota ratio were 1.50, 1.52, 1.67, and 1.80 for each CAC category (P = 0.020). One standard deviation higher phylum Firmicutes, class Bacilli, and order Lactobacillales were associated with a 1.3- to 1.4-fold higher risk of CAD. These taxa were also associated with a higher CAC score category. The family Streptococcaceae and genus Streptococcus showed a higher risk of CAD. The order Enterobacterales and family Enterobacteriaceae correlated with CAC scores. The genus Blautia showed a preventive direction for CAD, but did not correlate with CAC scores. CONCLUSIONS: The gut microbiota significantly differed from the phylum to genus level in a manner that was dependent on CAC scores, even before the onset of CAD.

DOI： 10.1016/j.ahj.2023.09.009

Long-Term Effect of Smoking Ban Legislation on Hospitalization for Acute Coronary Syndrome. 招待査読

Takashi Hisamatsu, Minako Kinuta

Circulation journal : official journal of the Japanese Circulation Society 87 ( 11 ) 1686 - 1688 2023年9月

At-risk internet addiction and related factors among senior high school teachers in Japan based on a Nationwide survey. 査読国際誌

Mari Fukuda, Mohammad Chowdhury, Tanvir Turin Chowdhury, Hideki Tsumura, Rina Tsuchie, Minako Kinuta, Takashi Hisamatsu, Hideyuki Kanda

Neuropsychopharmacology reports 43 ( 4 ) 553 - 560 2023年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Internet addiction (IA) has been drawing attention to mental health. However, few reports have been found on the related factors of at-risk IA among regular workers by a nationwide survey. The study aimed to evaluate the characteristics of at-risk IA and identify related factors among senior high school teachers in Japan. METHODS: This survey was a cross-sectional survey of high schools across Japan in 2017. There were 3189 teachers (2088 males and 1098 female) who participated in this survey. The questionnaire asked about their devices, both the time and the activities of using their internet, and sociodemographic factors. IA was measured by the internet addiction test (IAT) by which 40-79 points were classified as at-risk IA, and more as IA. We compared the related factors of at-risk IA and non-IA using descriptive analysis and multivariable regression analysis. RESULTS: The rates of IA and at-risk IA were 0.09% (n = 3) and 6.91% (n = 220), respectively. At-risk IA was positively associated with activities on the internet for gaming, entertainment, net-surfing, and younger ages. In addition, the at-risk IA group had a longer time spent on the internet than the non-IA group. CONCLUSIONS: Around 7% of high school teachers are at-risk IA in this survey, though they have regular work. Our results suggest that at-risk IA may be reinforced not only by the active internet use such as gaming, but also by purposeless behaviors, such as net-surfing. Managing time on the internet may support preventing at-risk IA among senior high school teachers.

DOI： 10.1002/npr2.12350

Relationships of rapid eating with visceral and subcutaneous fat mass and plasma adiponectin concentration. 査読国際誌

Hideki Tsumura, Mari Fukuda, Takashi Hisamatsu, Rie Sato, Rina Tsuchie, Hideyuki Kanda

Scientific reports 13 ( 1 ) 11491 - 11491 2023年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

Rapid eating has been demonstrated to be associated with obesity and overweight. However, few studies have characterized the separate relationships of eating speed with visceral and subcutaneous fat mass or circulating adiponectin concentration. We hypothesized that rapid eating is associated with the larger visceral fat tissue (VFT) area and lower adiponectin concentration, but not with the subcutaneous fat tissue (SFT) area in men and women. We performed a cross-sectional study of 712 adults aged 20-86 years (528 men and 184 women; mean ± SD age 59.36 ± 13.61 years). The participants completed a self-reported questionnaire, and underwent anthropometric and laboratory measurements and computed tomographic imaging of the abdomen as a part of annual medical check-ups. Multivariate linear regression analyses revealed that rapid eating was associated with larger visceral (B = 24.74; 95% CI 8.87-40.61, p = 0.002) and subcutaneous fat areas (B = 31.31; 95% CI 12.23-50.38, p = 0.001), lower adiponectin concentration (B = - 2.92; 95% CI - 4.39- - 1.46, p < 0.001), higher body mass index (BMI) (B = 2.13; 95% CI 1.02-3.25, p < 0.001), and larger waist circumference (B = 5.23; 95% CI 2.16-8.30, p < 0.001) in men, which is partially consistent with the hypothesis. In contrast, rapid eating was found to be associated only with BMI, and not with abdominal adipose area or adiponectin concentration in women, which is a result that is not consistent with the hypothesis. These results suggest that there is no difference in the association of rapid eating with VFT and SFT areas.

DOI： 10.1038/s41598-023-38623-7

Coronary Artery Calcium in Assessment of Atherosclerotic Cardiovascular Disease Risk and its Role in Primary Prevention. 招待査読

Takashi Hisamatsu, Minako Kinuta

Journal of atherosclerosis and thrombosis 30 ( 10 ) 1289 - 1302 2023年7月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Coronary artery calcium (CAC), which is detected using computed tomography scanning, is a well-established indicator of subclinical atherosclerosis. The CAC score is independently associated with atherosclerotic cardiovascular disease (ASCVD) outcomes and provides improved predictive values for estimating the risk of ASCVD beyond traditional risk factors. Thus, CAC is considered to have important implications for reclassification as a decision aid among individuals in the preclinical phase and as the primary prevention of ASCVD. This review is focused on epidemiological evidence on CAC in asymptomatic population-based samples from Western countries and Japan. We also discuss the usability of CAC as a tool for assessing ASCVD risk and its role in the primary prevention of ASCVD. A lack of evidence for the CAC score in ASCVD risk assessment beyond traditional risk factors in populations other than those in Western countries (including Japan) warrants further investigation. Clinical trials are also necessary to demonstrate the usefulness and safety of CAC screening in the primary prevention of ASCVD.

DOI： 10.5551/jat.RV22009

Association of Arterial Stiffness and Atherosclerotic Burden With Brain Structural Changes Among Japanese Men. 査読国際誌

Nazar M Azahar, Yuichiro Yano, Aya Kadota, Akihiko Shiino, Ali H Syaifullah, Naoko Miyagawa, Keiko Kondo, Mohammad Moniruzzaman, Sayuki Torii, Hiroyoshi Segawa, Takashi Hisamatsu, Akira Fujiyoshi, Kazuhiko Nozaki, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura

Journal of the American Heart Association 12 ( 11 ) e028586 2023年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background Little is known regarding whether arterial stiffness and atherosclerotic burden are each independently associated with brain structural changes. Simultaneous assessments of both arterial stiffness and atherosclerotic burden in associations with brain could provide insights into the mechanisms of brain structural changes. Methods and Results Using data from the SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis), we analyzed data among 686 Japanese men (mean [SD] age, 67.9 [8.4] years; range, 46-83 years) free from history of stroke and myocardial infarction. Brachial-ankle pulse wave velocity and coronary artery calcification on computed tomography scans were measured between March 2010 and August 2014. Brain volumes (total brain volume, gray matter, Alzheimer disease signature and prefrontal) and brain vascular damage (white matter hyperintensities) were quantified using brain magnetic resonance imaging from January 2012 through February 2015. In multivariable adjustment models including mean arterial pressure, when brachial-ankle pulse wave velocity and coronary artery calcification were entered into the same models, the β (95% CI) for Alzheimer disease signature volume for each 1-SD increase in brachial-ankle pulse wave velocity was -0.33 (-0.64 to -0.02), and the unstandardized β (95% CI) for white matter hyperintensities for each 1-unit increase in coronary artery calcification was 0.68 (0.05-1.32). Brachial-ankle pulse wave velocity and coronary artery calcification were not statistically significantly associated with total brain and gray matter volumes. Conclusions Among Japanese men, higher arterial stiffness was associated with lower Alzheimer disease signature volumes, whereas higher atherosclerotic burden was associated with brain vascular damage. Arterial stiffness and atherosclerotic burden may be independently associated with brain structural changes via different pathways.

DOI： 10.1161/JAHA.122.028586

Mendelian Randomization to Evaluate the Causal Effect of Serum Bilirubin on Atrial Fibrillation. 招待査読国際誌

Takashi Hisamatsu

Korean circulation journal 53 ( 7 ) 480 - 482 2023年5月

Non-missense variants of KCNH2 show better outcomes in type 2 long QT syndrome. 査読国際誌

Takanori Aizawa, Yuko Wada, Kanae Hasegawa, Hai Huang, Tomohiko Imamura, Jingshan Gao, Asami Kashiwa, Hirohiko Kohjitani, Megumi Fukuyama, Koichi Kato, Eri Toda Kato, Takashi Hisamatsu, Seiko Ohno, Takeru Makiyama, Takeshi Kimura, Minoru Horie

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 25 ( 4 ) 1491 - 1499 2023年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

AIMS: More than one-third of type 2 long QT syndrome (LQT2) patients carry KCNH2 non-missense variants that can result in haploinsufficiency (HI), leading to mechanistic loss-of-function. However, their clinical phenotypes have not been fully investigated. The remaining two-thirds of patients harbour missense variants, and past studies uncovered that most of these variants cause trafficking deficiency, resulting in different functional changes: either HI or dominant-negative (DN) effects. In this study, we examined the impact of altered molecular mechanisms on clinical outcomes in LQT2 patients. METHODS AND RESULTS: We included 429 LQT2 patients (234 probands) carrying a rare KCNH2 variant from our patient cohort undergoing genetic testing. Non-missense variants showed shorter corrected QT (QTc) and less arrhythmic events (AEs) than missense variants. We found that 40% of missense variants in this study were previously reported as HI or DN. Non-missense and HI-groups had similar phenotypes, while both exhibited shorter QTc and less AEs than the DN-group. Based on previous work, we predicted the functional change of the unreported variants-whether they cause HI or DN via altered functional domains-and stratified them as predicted HI (pHI)- or pDN-group. The pHI-group including non-missense variants exhibited milder phenotypes compared to the pDN-group. Multivariable Cox model showed that the functional change was an independent risk of AEs (P = 0.005). CONCLUSION: Stratification based on molecular biological studies enables us to better predict clinical outcomes in the patients with LQT2.

DOI： 10.1093/europace/euac269

Association between proprotein convertase subtilisin/kexin type 9 (PCSK9) and subclinical cerebrovascular disease in the community. 査読国際誌

Ayako Kunimura, Yuichiro Yano, Takashi Hisamatsu, Sayuki Torii, Keiko Kondo, Aya Kadota, Akira Fujiyoshi, Tomonori Okamura, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

European journal of neurology 30 ( 5 ) 1327 - 1334 2023年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a new target for reducing low-density lipoprotein cholesterol (LDL-C) and incident cardiovascular disease, including stroke. However, the clinical relevance of circulating PCSK9 levels have been poorly elucidated in the general population, particularly in association with subclinical cerebrovascular disease including cerebral small vessel disease (CSVD) and intracranial artery stenosis (ICAS). METHODS: In community-dwelling Japanese men (n = 526) aged 46-82 years without a history of cardiovascular disease, we assessed the associations of serum PCSK9 levels with the prevalence of CSVD and ICAS using magnetic resonance imaging. CSVD included lacunar infarction, deep and subcortical white matter hyperintensity, periventricular hyperintensity, and cerebral microbleeds. RESULTS: The median (interquartile range) age at baseline and serum PCSK9 levels were 69 (63 - 74) years and 240 (205-291) ng/mL, respectively. After adjusting for traditional cardiovascular risk factors including LDL-C, multivariable Poisson regression with robust error variance revealed a significant association between PCSK9 levels (per 1-SD) and ICAS (relative risks 1.18, 95% confidence intervals [CI] 1.02-1.37). Multivariable ordinal logistic regression for ICAS, with stenosis graded as mild (<50%) or moderate-severe (≥50%), revealed a similar association (common odds ratio 1.31, 95% CI 1.04-1.64). However, no significant association was observed between serum PCSK9 levels and CSVD. CONCLUSIONS: Higher circulating PCSK9 levels were independently associated with a ICAS prevalence but not with a CSVD prevalence. The quantification of circulating PCSK9 levels may help to identify individuals at high risk for cerebrovascular disease in the general population.

DOI： 10.1111/ene.15723

Association and dose-response relationship between exposure to alcohol advertising media and current drinking: a nationwide cross-sectional study of Japanese adolescents. 査読

Keita Yoshida, Hideyuki Kanda, Takashi Hisamatsu, Yuki Kuwabara, Aya Kinjo, Hisashi Yoshimoto, Teruna Ito, Hideaki Kasuga, Ruriko Minobe, Hitoshi Maesato, Maki Jike, Yuuki Matsumoto, Yuichiro Otsuka, Osamu Itani, Yoshitaka Kaneita, Susumu Higuchi, Yoneatsu Osaki

Environmental health and preventive medicine 28 58 - 58 2023年

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Underage drinking is a public health concern. However, few studies have examined the association between alcoholic beverage advertising and underage drinking, particularly in countries with low underage drinking rates, such as Japan. Therefore, we aimed to investigate the relationship between exposure to advertising in various media and alcohol drinking among Japanese adolescents. METHODS: We conducted a cross-sectional study involving 15,683 adolescents (51% girls) using data from a nationwide lifestyle survey in 2021 among junior and senior high schools across Japan. Media types were websites, stores, and public transportation. We defined current drinking as alcohol consumption of ≥1 day in the 30 days preceding the survey. Multivariable logistic regression was used to examine the association between exposure to alcohol advertisements and current drinking, adjusting for sex, grades, school area, lifestyle (bedtime and having fun at school), and addictive behaviors (smoking status and parents' alcohol consumption). RESULTS: The prevalence of current drinking was 2.2% (2.3% of boys and 2.0% of girls). Students who were exposed to any alcohol advertising media had higher odds of current drinking compared with those who were not (odds ratio, 1.48; 95% confidence interval [CI], 1.18-1.87). Students who were exposed to web, in-store, and public transportation advertisements had odds ratios of 1.44 (95% CI, 1.14-1.81), 1.62 (1.28-2.05), and 1.45 (1.06-1.98) of current drinking, respectively, compared with those who were not. The association of exposure to alcohol advertising media with the prevalence of current drinking was similar among boys and girls (all p for sex interaction >0.1), except for that of exposure to web advertisements; its association with current drinking was more pronounced in girls (p for sex interaction = 0.046). Exposure to a larger cumulative number of different alcohol advertising media was independently associated with a higher prevalence of current drinking among all students, boys, and girls (p-values for trend <0.001, 0.031, and <0.001, respectively; p for sex interaction = 0.085). CONCLUSIONS: We found an association with a dose-response relationship between exposure to alcohol advertisements and current drinking among adolescents in junior and senior high schools across Japan. Our findings highlight the need for further advertising regulations to prevent underage drinking.

DOI： 10.1265/ehpm.23-00127

Cross-sectional association of equol producing status with aortic calcification in Japanese men aged 40-79 years. 査読国際誌

Xiao Zhang, Akira Fujiyoshi, Aya Kadota, Keiko Kondo, Sayuki Torii, Yukiko Okami, Takashi Hisamatsu, Yuichiro Yano, Emma Barinas-Mitchell, Jared Magnani, Katsuyuki Miura, Hirotsugu Ueshima, Akira Sekikawa

Scientific reports 12 ( 1 ) 20114 - 20114 2022年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Equol is an isoflavone (ISF)-derived metabolite by the gut microbiome in certain individuals termed equol-producers (EP). Equol might be the critical anti-atherogenic component of ISFs. In a population-based study of 979 Japanese men aged 40-79 without cardiovascular (CVD) or chronic kidney disease, we measured the urinary levels of equol and ISFs. Aortic calcification (AC) in the entire aorta was assessed by electron-beam or multi-detector-row computed tomography. Subjects with log10 (urinary equol to daidzein concentration) > - 1.5 were classified as EP. EP was further classified as person with low- and high-equol. We analyzed the association between equol-producing status and AC presence, defined as AC score > 0, by the logistic regressions. We found that EP (50% of the sample) had significantly lower odds of AC presence (odds ratio (OR): 0.62, 95% confidence interval (CI): 0.39, 0.98) compared to non-EP. This association was independent of CVD risk factors. For the dose-response association, compared to non-EP, subjects with low and high levels of equol had ORs of 0.51 (95% CI 0.30, 0.84) and 0.67 (95% CI 0.39, 1.14) after adjusting for major CVD risk factors (p for trend = 0.06). ISFs concentrations were not significantly associated with AC presence (OR: 1.18, 95% CI: 0.82, 1.69). In conclusion, EP had a significantly lower burden of AC than non-EP, while ISFs were not associated with AC presence in Japanese men aged 40-79 years.

DOI： 10.1038/s41598-022-24659-8

Association between serum irisin levels and MRI-measureed cerebral small vessel disease in Japanese men 査読

Moniruzzaman M, Kadota A, Hisamatsu T, Segawa H, Kondo K, Torii S, Miyagawa N, Fujiyoshi A, Yano Y, Watanabe Y, Shiino A, Nozaki A, Ueshima H, Miura K

30 ( 8 ) 1045 - 1056 2022年10月

Relationship between Serum Proprotein Convertase Subtilisin/Kexin Type 9 Concentration and Prevalence of Coronary Artery Calcium in a Community-Based Sample of Japanese Men. 査読

Ayako Kunimura, Katsuyuki Miura, Hiroyoshi Segawa, Sayuki Torii, Keiko Kondo, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Yuichiro Yano, Yoshihisa Nakagawa, Tomonori Okamura, Hirotsugu Ueshima

Journal of atherosclerosis and thrombosis 30 ( 7 ) 767 - 777 2022年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

AIMS: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising new target for reducing low-density lipoprotein cholesterol (LDL-C) and cardiovascular events in high-risk patients. However, the influence of circulating PCSK9 concentration on atherosclerotic plaque formation in the general population remains unknown. We assessed the relationship between serum PCSK9 concentration and coronary artery calcium (CAC) prevalence in the general population. METHODS: Community-dwelling Japanese men (n=622) aged 46-82 years without a history of cardiovascular disease and lipid-lowering medications were included. Serum PCSK9 concentration and CAC score were measured using the Agatston method, and the multivariable analysis was used to assess their association. CAC was defined as an Agatston score of ＞10. We conducted further analysis stratified by age (＜60, 60-69, and ≥ 70 years). RESULTS: The average age, LDL-C, and median serum PCSK9 concentration were 68 years, 122 mg/dL, and 240 ng/mL, respectively. After multivariable adjustment for traditional cardiovascular risk factors, no significant association was observed between serum PCSK9 concentration and CAC prevalence (adjusted relative risk [aRR] 1.05, 95% confidence interval [CI] 0.97-1.13). With age stratification, serum PCSK9 concentration was significantly associated with CAC prevalence in men aged ＜60 years (aRR 1.38, 95% CI 1.01-1.88) but not in men aged 60-69 years (aRR 0.96, 95% CI 0.85-1.10) or ≥ 70 years (aRR 1.08, 95% CI 0.99-1.19). CONCLUSIONS: A higher serum PCSK9 concentration was associated with a higher CAC prevalence in men aged ＜60 years, which was independent of traditional cardiovascular risk factors.

DOI： 10.5551/jat.63549

Effect of Chronic Kidney Disease or Anemia or Both on Cardiovascular Mortality in a 25-Year Follow-Up Study of Japanese General Population (From NIPPON DATA90). 査読国際誌

Kota Kubo, Tomonori Okamura, Daisuke Sugiyama, Takashi Hisamatsu, Aya Hirata, Aya Kadota, Keiko Kondo, Takumi Hirata, Aya Higashiyama, Takehito Hayakawa, Yoshihiro Miyamoto, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima

The American journal of cardiology 184 1 - 6 2022年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

The relation between chronic kidney disease (CKD) and cardiovascular disease (CVD) in the general population is well elucidated. In patients with CKD, anemia is associated with adverse outcomes. However, the effects of CKD and anemia on CVD in the general population remains poorly explored, especially in Asian populations. This study aimed to investigate the effect of CKD and/or anemia on CVD mortality in a long-term cohort study involving Japanese community dwellers. We assessed 7,339 participants (aged ≥30 years) with no CVD history. These participants were divided into 4 categories according to their CKD (estimated glomerular filtration rate <60 or urine protein >1+ by dipstick qualitative test) and/or anemia (hemoglobin: <13 g/100 ml [men], <12 g/100 ml [women]) statuses. For each category, we calculated the hazard ratios (HRs) of CVD mortality by using the Cox proportional hazards model after adjusting for age, body mass index, hypertension, diabetes, dyslipidemia, smoking, and alcohol drinking. Within 25 years of follow-up, 637 participants died because of CVD. The HRs of CVD in patients with CKD only, anemia only, and both were 1.27, 1.59, and 2.60 (95% confidence intervals [CI] 1.06 to 1.53, 1.34 to 1.90, and 1.80 to 3.76) in men and 1.42, 1.08, and 2.00 (95% CI 1.19 to 1.69, 0.99 to 1.18, and 1.54 to 2.60) in women, respectively. In conclusion, CKD with anemia is associated with an increased risk for CVD mortality in a general population in Japan.

DOI： 10.1016/j.amjcard.2022.08.027

Differential Association of Serum n-3 Polyunsaturated Fatty Acids with Various Cerebrovascular Lesions in Japanese Men. 査読国際誌

Keiko Kondo, Hisatomi Arima, Akira Fujiyoshi, Akira Sekikawa, Aya Kadota, Takashi Hisamatsu, Sayuki Torii, Akihiko Shiino, Katsutaro Morino, Naoko Miyagawa, Hiroyoshi Segawa, Yoshiyuki Watanabe, Hiroshi Maegawa, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

Cerebrovascular diseases (Basel, Switzerland) 51 ( 6 ) 1 - 7 2022年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: An association between a high intake of marine-derived n-3 polyunsaturated fatty acids (n-3 PUFAs) with a lower risk of coronary heart disease was previously reported. However, the association between n-3 PUFAs and cerebrovascular lesions remains unclear. We evaluated this association in a general-population-based sample of Japanese men. METHODS: Participants were community-dwelling men (40-79 years old) living in Kusatsu City, Shiga, Japan. Serum concentrations of n-3 PUFAs, defined as the sum of eicosapentaenoic and docosahexaenoic acids, were measured via gas-liquid chromatography between 2006 and 2008. Magnetic resonance imaging was used to assess cerebrovascular lesions (including intracerebral large-artery stenosis, lacunar infarction, and microbleeds) and white matter lesions between 2012 and 2015. Logistic regression adjusting for conventional cardiovascular risk factors was used to estimate the odds ratio of prevalent cerebrovascular lesions per 1 standard deviation higher serum concentration of n-3 PUFAs. RESULTS: Of a total of 739 men, the numbers (crude prevalence in %) of prevalent cerebral large-artery stenoses, lacunar infarctions, microbleeds, and white matter lesions were 222 (30.0), 162 (21.9), 103 (13.9), and 164 (22.2), respectively. A 1 standard deviation higher concentration of n-3 PUFAs (30.5 μmol/L) was independently associated with lower odds of cerebral large-artery stenosis (multivariable-adjusted odds ratio, 0.80; 95% confidential interval, 0.67-0.97). There were no significant associations of n-3 PUFAs with the other types of lesions. CONCLUSIONS: n-3 PUFAs may have protective effects against large-artery stenosis, but not small vessel lesions, in the brain.

DOI： 10.1159/000524243

Home blood pressure variability and target organ damage. 招待査読国際誌

Takashi Hisamatsu, Takayoshi Ohkubo

Hypertension research : official journal of the Japanese Society of Hypertension 45 ( 3 ) 543 - 545 2022年3月

Premature Atrial Contractions and Their Determinants in a General Population of Japanese Men. 査読

Sabrina Ahmed, Takashi Hisamatsu, Aya Kadota, Akira Fujiyoshi, Hiroyoshi Segawa, Sayuki Torii, Naoyuki Takashima, Keiko Kondo, Yoshihisa Nakagawa, Hirotsugu Ueshima, Katsuyuki Miura

Circulation journal : official journal of the Japanese Circulation Society 86 ( 8 ) 1298 - 1306 2022年2月

Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification 査読

Namuun Ganbaatar, Aya Kadota, Takashi Hisamatsu, Shinichi Araki, Shinji Kume, Akira Fujiyoshi, Sayaka Kadowaki, Sayuki Torii, Keiko Kondo, Hiroyoshi Segawa, Ebtehal Salman, Itsuko Miyazawa, Takashi Yamamoto, Yoshihisa Nakagawa, Hiroshi Maegawa, Katsuyuki Miura, Hirotsugu Ueshima

Journal of Atherosclerosis and Thrombosis 29 ( 9 ) 1359 - 1371 2021年10月

Prologue: Special Spotlight Issue on Japan 招待査読国際誌

Yuichiro Yano, Akira Nishiyama, Toshihiko Ishimitsu, Naoki Kashihara, Hiromi Rakugi, Kouichi Tamura, Hiroshi Itoh, Takuya Tsuchihashi, Atsushi Sakima, Hisatomi Arima, Tetsutaro Matayoshi, Yutaka Imai, Katsuyuki Miura, Takashi Hisamatsu, Kei Asayama, Takayoshi Ohkubo, Kouihci Node, Kazuomi Kario

Journal of Human Hypertension 2021年8月

Lipoprotein Particle Profiles Compared With Standard Lipids in the Association With Subclinical Aortic Valve Calcification in Apparently Healthy Japanese Men(和訳中) 査読

Vu Thien, Fujiyoshi Akira, Hisamatsu Takashi, Kadota Aya, Zaid Maryam, Segawa Hiroyoshi, Kondo Keiko, Torii Sayuki, Nakagawa Yoshihisa, Suzuki Tomoaki, Asai Tohru, Miura Katsuyuki, Ueshima Hirotsugu

Circulation Journal 85 ( 7 ) 1076 - 1082 2021年6月

Apolipoprotein A2 Isoforms: New Insight into the Risk of Myocardial Infarction 招待査読

Takashi Hisamatsu

Journal of Atherosclerosis and Thrombosis 28 ( 5 ) 469 - 470 2021年5月

Corrigendum to "A challenge for mutation specific risk stratification in long QT syndrome type 1" [J. Cardiol. 72(1) (2018) 56-65]. 国際誌

Noriaki Yagi, Hideki Itoh, Takashi Hisamatsu, Yukinori Tomita, Hiromi Kimura, Yusuke Fujii, Takeru Makiyama, Minoru Horie, Seiko Ohno

Journal of cardiology 77 ( 3 ) 322 - 326 2021年3月

A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium. 査読

Maryam Zaid, Akira Fujiyoshi, Takashi Hisamatsu, Aya Kadota, Sayaka Kadowaki, Atsushi Satoh, Akira Sekikawa, Emma Barinas-Mitchell, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima

Journal of atherosclerosis and thrombosis 29 ( 2 ) 282 - 295 2021年2月

Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men

Ali Haidar Syaifullah, Akihiko Shiino, Akira Fujiyoshi, Aya Kadota, Keiko Kondo, Takahiro Ito, Hiroyoshi Segawa, Mohammad Moniruzzaman, Takashi Waki, Naoko Miyagawa, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura, Minoru Horie, Yoshihisa Nakagawa, Takashi Yamamoto, Yasutaka Nakano, Emiko Ogawa, Hiroshi Maegawa, Katsutaro Morino, Itsuko Miyazawa, Yoshiyuki Watanabe, Kazuhiko Nozaki, Akira Andoh, Teruhiko Tsuru, Hisakazu Ogita, Naomi Miyamatsu, Yasuyuki Nakamura, Sayuki Torii, Takashi Kadowaki, Sayaka Kadowaki, Sentaro Suzuki, Ayako Kunimura, Aya Higashiyama, Tomonori Okamura, Koichiro Azuma, Tatsuya Sawamura, Michiya Igase, Yasuharu Tabara, Akira Sekikawa, Emma J.M. Barinas-Mitchell, Daniel Edmundowicz, Takayoshi Ohkubo, Atsushi Hozawa, Yoshitaka Murakami, Nagako Okuda, Hisatomi Arima, Atsushi Satoh, Yoshikuni Kita, Takashi Hisamatsu, Masahiko Yanagita, Robert D. Abbott, Seiko Ohno, Naoyuki Takashima, Maryam Zaid, Yoshino Saito

Alcohol 90 57 - 65 2021年2月

Seven-Day Pedometer-Assessed Step Counts and Brain Volume: A Population-Based Observational Study. 査読国際誌

Mohammad Moniruzzaman, Aya Kadota, Akihiko Shiino, Akira Fujiyoshi, Takahiro Ito, Ali Haidar Syaifullah, Naoko Miyagawa, Keiko Kondo, Takashi Hisamatsu, Hiroyoshi Segawa, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura

Journal of physical activity & health 18 ( 2 ) 157 - 164 2021年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Human Kinetics

BACKGROUND: To investigate the association between step counts and brain volumes (BVs)-global and 6 a priori selected cognition-related regions of interest-in Japanese men aged 40-79 years. METHODS: The authors analyzed data from 680 cognitively intact participants of the Shiga Epidemiological Study of Subclinical Atherosclerosis-a population-based observational study. Using multivariable linear regression, the authors assessed cross-sectional associations between 7-day step counts at baseline (2006-2008) and BVs at follow-up (2012-2015) for age-stratified groups (<60 y and ≥60 y). RESULTS: In the older adults ≥60 years, step counts at baseline (per 1000 steps) were associated with total BV at follow-up (β = 1.42, P = .022) while adjusted for potential covariates. Regions of interest-based analyses yielded an association of step counts with both prefrontal cortexes (P < .05) in older adults, while the left entorhinal cortex showed marginally significant association (P = .05). No association was observed with hippocampus, parahippocampal, cingulum, and cerebellum. No association was observed in younger adults (<60 y). CONCLUSIONS: The authors found a positive association between 7-day step counts and BVs, including prefrontal cortexes, and left entorhinal cortex in apparently healthy Japanese men.

DOI： 10.1123/jpah.2019-0659

その他リンク： https://journals.humankinetics.com/downloadpdf/journals/jpah/aop/article-10.1123-jpah.2019-0659/article-10.1123-jpah.2019-0659.xml

Differences between home blood pressure and strictly measured office blood pressure and their determinants in Japanese men. 査読国際誌

Sayaka Kadowaki, Takashi Kadowaki, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Atsushi Satoh, Hisatomi Arima, Sachiko Tanaka, Sayuki Torii, Keiko Kondo, Aya Kadota, Kamal Masaki, Tomonori Okamura, Takayoshi Ohkubo, Katsuyuki Miura, Hirotsugu Ueshima

Hypertension research : official journal of the Japanese Society of Hypertension 44 ( 1 ) 80 - 87 2021年1月

Recent status of self-measured home blood pressure in the Japanese general population: a modern database on self-measured home blood pressure (MDAS). 査読国際誌

Kei Asayama, Yasuharu Tabara, Emi Oishi, Satoko Sakata, Takashi Hisamatsu, Kayo Godai, Mai Kabayama, Yukako Tatsumi, Jun Hata, Masahiro Kikuya, Kei Kamide, Katsuyuki Miura, Toshiharu Ninomiya, Takayoshi Ohkubo

Hypertension research : official journal of the Japanese Society of Hypertension 43 ( 12 ) 1403 - 1412 2020年12月

Relationship Between Step Counts and Cerebral Small Vessel Disease in Japanese Men. 査読国際誌

Mohammad Moniruzzaman, Aya Kadota, Hiroyoshi Segawa, Keiko Kondo, Sayuki Torii, Naoko Miyagawa, Akira Fujiyoshi, Takashi Hisamatsu, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

Stroke 51 ( 12 ) 3584 - 3591 2020年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

BACKGROUND AND PURPOSE: Cerebral small vessel disease (CSVD) is a common subclinical feature of the aging brain. Steps per day may contribute to its prevention. We herein investigated the association between step counts and CSVD in a healthy Japanese male population. METHODS: We analyzed data from 680 men who were free of stroke and participated in this observational study. Seven-day step counts were assessed at baseline (2006-2008) using a pedometer. CSVD was assessed at follow-ups (2012-2015) based on deep and subcortical white matter hyperintensities (WMHs), periventricular hyperintensities, lacunar infarcts, and cerebral microbleeds on magnetic resonance imaging. Using a logistic regression analysis, we computed the adjusted odds ratios, with 95% CIs, of prevalent CSVD according to quartiles of step counts (reference: Q1). We also investigated the association between step counts and WMH volumes using a quantile regression. RESULTS: Steps per day were significantly associated with lower odds ratios, with the lowest at Q3 (8175-10 614 steps/day), of higher (versus low or no burden) deep and subcortical WMHs (odds ratio, 0.52 [95% CI, 0.30-0.89]), periventricular hyperintensities (0.50 [95% CI, 0.29-0.86]), and lacunar infarcts (0.52 [95% CI, 0.30-0.91]) compared with Q1 (≤6060 steps/day) but not cerebral microbleeds. An inverse linear association was observed between step counts and WMH volumes. These associations were independent of age and smoking and drinking status and remained consistent when adjusted for vascular risk factors. CONCLUSIONS: We found a J-shaped relationship between step counts and prevalent CSVD in healthy Japanese men, with the lowest risk being observed among participants with ≈8000 to 10 000 steps/day. Higher steps were also associated with lower WMH volumes.

DOI： 10.1161/STROKEAHA.120.030141

The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men. 査読国際誌

Aya Hirata, Akemi Kakino, Tomonori Okamura, Yoko Usami, Yoshiko Fujita, Aya Kadota, Akira Fujiyoshi, Takashi Hisamatsu, Keiko Kondo, Hiroyoshi Segawa, Tatsuya Sawamura, Katsuyuki Miura, Hirotsugu Ueshima

Atherosclerosis 313 20 - 25 2020年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

BACKGROUND AND AIMS: Dysfunctional high-density lipoprotein (HDL) is a risk factor for cardiovascular disease (CVD) beyond HDL concentrations. Recently, a novel method has been introduced to measure LOX-1 ligand containing apolipoprotein AI (LAA), which is an indicator of various types of modified HDL with binding capacity to LOX-1 and related to impaired anti-atherogenic functions of HDL. This study aimed to examine the relationship between LAA as a novel marker of dysfunctional HDL and coronary artery calcification (CAC). METHODS: We selected 910 community-dwelling Japanese men aged 40-79 years without a history of CVD. The odds ratios per 1SD of LAA for the presence of CAC (Agatston score >10) were estimated using logistic regression model adjusted for confounders, including HDL-C or HDL particle (HDL-P) concentration. In addition, we performed further analysis stratified by age (<65 and ≥ 65 years). RESULTS: The mean age of the participants was 63.6 years, and the median LAA was 187.0 ng/mL. The prevalent CAC was 46.2%. The multivariable adjusted odds ratio (95% confidence interval) per 1SD of LAA for CAC was 1.14 (0.96-1.36) for all participants. After stratification by age, multivariable adjusted odds ratios per 1SD of LAA were 1.34 (1.02-1.76) and 0.97 (0.77-1.23) in men aged <65 and ≥ 65 years, respectively. CONCLUSIONS: The present study showed that LAA was associated with CAC independent of HDL-C or HDL-P in middle-aged Japanese men. This finding suggests that LAA might be an early marker for CVD events. Future longitudinal studies are warranted.

DOI： 10.1016/j.atherosclerosis.2020.09.013

Association between Psychological Factors and Evacuation Status and the Incidence of Cardiovascular Diseases after the Great East Japan Earthquake: A Prospective Study of the Fukushima Health Management Survey 査読

Toshiki Sanoh, Eri Eguchi, Tetsuya Ohira, Fumikazu Hayashi, Masaharu Maeda, Seiji Yasumura, Yuriko Suzuki, Hirooki Yabe, Atsushi Takahashi, Kanae Takase, Mayumi Harigane, Takashi Hisamatsu, Keiki Ogino, Hideyuki Kanda, Kenji Kamiya

International Journal of Environmental Research and Public Health 17 ( 21 ) 7832 - 7832 2020年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Evidence regarding the effect of psychological factors and evacuation on cardiovascular disease occurrence after large-scale disasters is limited. This prospective study followed up a total of 37,810 Japanese men and women aged 30–89 years from the Fukushima Prefecture with no history of stroke or heart disease at baseline (2012), until 2017. This period included 3000 cardiovascular events recorded through questionnaires and death certificates. The participants’ psychological distress, trauma reaction, and evacuation status were defined, and divided into four groups based on combinations of psychological factors and evacuation status. We calculated the hazard ratios and 95% confidence intervals for only psychological, only evacuation, or both of them compared with neither using Cox proportional hazard models. Psychological factors along with evacuation resulted in approximately 5% to 25% higher magnitude of stroke and heart disease risk than psychological factors only among men. Compared to neither, the multivariable hazard ratios of those with both psychological distress and evacuation were 1.75 for stroke and 1.49 for heart disease, and those of both trauma reaction and evacuation were 2.01 and 1.57, respectively, among men. Evacuation combined with psychological factors increased the risk of stroke and heart disease risks especially in men after the Great East Japan Earthquake.

DOI： 10.3390/ijerph17217832

The Association Between Coronary Artery Calcification and Subclinical Cerebrovascular Diseases in Men: An Observational Study. 査読

Md Maruf Haque Khan, Akira Fujiyoshi, Akihiko Shiino, Takashi Hisamatsu, Sayuki Torii, Sentaro Suzuki, Ayako Kunimura, Hiroyoshi Segawa, Aya Kadota, Takayoshi Ohkubo, Kazuhiko Nozaki, Katsuyuki Miura, Hirotsugu Ueshima

Journal of atherosclerosis and thrombosis 27 ( 9 ) 995 - 1009 2020年9月

Cardiac Conduction Disorders as Markers of Cardiac Events in Myotonic Dystrophy Type 1. 査読国際誌

Hideki Itoh, Takashi Hisamatsu, Takuhisa Tamura, Kazuhiko Segawa, Toshiaki Takahashi, Hiroto Takada, Satoshi Kuru, Chizu Wada, Mikiya Suzuki, Shugo Suwazono, Shingo Sasaki, Ken Okumura, Minoru Horie, Masanori P Takahashi, Tsuyoshi Matumura

Journal of the American Heart Association 9 ( 17 ) e015709 2020年9月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

Background Myotonic dystrophy type 1 involves cardiac conduction disorders. Cardiac conduction disease can cause fatal arrhythmias or sudden death in patients with myotonic dystrophy type 1. Methods and Results This study enrolled 506 patients with myotonic dystrophy type 1 (aged ≥15 years; >50 cytosine-thymine-guanine repeats) and was treated in 9 Japanese hospitals for neuromuscular diseases from January 2006 to August 2016. We investigated genetic and clinical backgrounds including health care, activities of daily living, dietary intake, cardiac involvement, and respiratory involvement during follow-up. The cause of death or the occurrence of composite cardiac events (ie, ventricular arrhythmias, advanced atrioventricular blocks, and device implantations) were evaluated as significant outcomes. During a median follow-up period of 87 months (Q1-Q3, 37-138 months), 71 patients expired. In the univariate analysis, pacemaker implantations (hazard ratio [HR], 4.35; 95% CI, 1.22-15.50) were associated with sudden death. In contrast, PQ interval ≥240 ms, QRS duration ≥120 ms, nutrition, or respiratory failure were not associated with the incidence of sudden death. The multivariable analysis revealed that a PQ interval ≥240 ms (HR, 2.79; 95% CI, 1.9-7.19, P<0.05) or QRS duration ≥120 ms (HR, 9.41; 95% CI, 2.62-33.77, P < 0.01) were independent factors associated with a higher occurrence of cardiac events than those observed with a PQ interval <240 ms or QRS duration <120 ms; these cardiac conduction parameters were not related to sudden death. Conclusions Cardiac conduction disorders are independent markers associated with cardiac events. Further investigation on the prediction of occurrence of sudden death is warranted.

DOI： 10.1161/JAHA.119.015709

Smoking habits and progression of coronary and aortic artery calcification: A 5-year follow-up of community-dwelling Japanese men 査読

Tai Pham, Akira Fujiyoshi, Takashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Ayako Kunimura, Sayuki Torii, Hiroyoshi Segawa, Keiko Kondo, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima

International Journal of Cardiology 314 89 - 94 2020年9月

日本人一般男性を対象とした脳MRIを用いた無症候性脳血管疾患と四つの血圧指標との関連性評価(Relationship of Four Blood Pressure Indexes to Subclinical Cerebrovascular Diseases Assessed by Brain MRI in General Japanese Men) 査読

Salman Ebtehal, Kadota Aya, Hisamatsu Takashi, Segawa Hiroyoshi, Torii Sayuki, Fujiyoshi Akira, Kondo Keiko, Arima Hisatomi, Shiino Akihiko, Miura Katsuyuki, Ueshima Hirotsugu

日本循環器学会学術集会抄録集 84回 ( 2 ) OE118 - 3 2020年7月

Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study. 査読

Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Naoko Miyagawa, Yoshino Saito, Itsuko Miyazawa, Akihiko Shiino, Aya Kadota, Sayaka Kadowaki, Takashi Hisamatsu, Sayuki Torii, Naoyuki Takashima, Ikuo Tooyama, Hirotsugu Ueshima

Journal of epidemiology 30 ( 6 ) 244 - 252 2020年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japan Epidemiological Association

BACKGROUND: The association of proteinuria and reduced estimated glomerular filtration rate (eGFR) with cognition needs more clarification. We cross-sectionally examined whether proteinuria and reduced eGFR, even in moderate stages, were independently associated with lower cognition in a community-based sample of elderly men. METHODS: Our cohort initially comprised 1,094 men aged 40-79 years from a random sample from Shiga, Japan in 2006-2008. Of 853 men who returned for the follow-up examination (2009-2014), we analyzed 561 who were ≥65 years, free of stroke, and completed the Cognitive Abilities Screening Instrument (CASI) at follow-up (higher CASI scores [range 0 to 100] indicate better cognition). Proteinuria was assessed via dipstick. eGFR was calculated according to the Chronic Kidney Disease Epidemiology Collaboration Equation. Participants were divided into three groups either by eGFR (≥60, 59-40, and <40 mL/min/1.73 m2) or by proteinuria (no, trace, and positive), considered normal, moderate, and advanced, respectively. Using linear regression, we computed mean CASI score, with simultaneous adjustment for proteinuria and eGFR in addition to other potential confounders. RESULTS: Significant trends of lower cognition were observed across the groups of worse proteinuria and lower eGFR independently: multivariable-adjusted mean CASI scores were 90.1, 89.3, and 88.4 for proteinuria (Ptrend = 0.029), and 90.0, 88.5, and 88.5 for eGFR (Ptrend = 0.015) in mutual-adjustment model. CONCLUSIONS: Proteinuria and reduced eGFR, even in their moderate stages, were independently associated with lower cognition in a community-based sample of elderly men. The results suggest the importance of proteinuria and low eGFR for early detection and prevention of cognitive decline.

DOI： 10.2188/jea.JE20180258

Elevated Fasting Blood Glucose Levels Are Associated With Lower Cognitive Function, With a Threshold in Non-Diabetic Individuals: A Population-Based Study. 査読

Ziyi Liu, Maryam Zaid, Takashi Hisamatsu, Sachiko Tanaka, Akira Fujiyoshi, Naoko Miyagawa, Takahiro Ito, Aya Kadota, Ikuo Tooyama, Katsuyuki Miura, Hirotsugu Ueshima

Journal of epidemiology 30 ( 3 ) 121 - 127 2020年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Cognitive dysfunction has been recognized as a diabetes-related complication. Whether hyperglycemia or elevated fasting glucose are associated with cognitive decline remains controversial. We aimed to investigate the relationship between fasting glucose levels and cognitive function in diabetic and non-diabetic individuals. METHODS: Participants were Japanese diabetic (n = 191) and non-diabetic (n = 616) men, aged 46-81 years, from 2010-2014. Blood samples were taken after a 12 h fast. The Cognitive Ability Screening Instrument (CASI), with a maximum score of 100, was used for cognitive assessment. Cognitive domains of CASI were also investigated. Fractional logit regression with covariate adjustment for potential confounders was used to model cross-sectional relationships between fasting blood glucose and CASI score. RESULTS: For diabetic individuals, CASI score was 0.38 (95% confidence interval: 0.66-0.12) lower per 1 mmol/L higher fasting glucose level. Short-term memory domain also exhibited an inverse association. For non-diabetic individuals, a reverse U-shaped relationship was observed between fasting glucose and cognitive function, identifying a threshold for highest cognitive performance of 91.8 CASI score at 3.97-6.20 mmol/L (71.5-111.6 mg/dL) fasting glucose. Language ability domain displayed a similar relationship with fasting glucose. CONCLUSIONS: Elevated fasting glucose levels in diabetic men were associated with lower cognitive function, in which short-term memory was the main associated domain. Interestingly, in non-diabetic men, we identified a threshold for the inverse relationship of elevated fasting glucose with cognitive function. Contrastingly to diabetic men, language ability was the main associated cognitive domain among non-diabetic men.

DOI： 10.2188/jea.JE20180193

Physical activity levels in American and Japanese men from the ERA-JUMP Study and associations with metabolic syndrome. 査読国際誌

Naoko Sagawa, Bonny Rockette-Wagner, Koichiro Azuma, Hirotsugu Ueshima, Takashi Hisamatsu, Tomoko Takamiya, Aiman El-Saed, Katsuyuki Miura, Andrea Kriska, Akira Sekikawa

Journal of sport and health science 9 ( 2 ) 170 - 178 2020年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

Background: Metabolic syndrome (MetS) is a global health problem. Physical activity (PA) is a known modifiable risk factor for MetS and individual MetS components. However, the role of PA could differ between sub-populations due to differences in the variability of PA and other MetS risk factors. To examine these differences, multi-country studies with standardized outcome measurement methods across cohorts are needed. Methods: Cross-sectional PA levels (total and domain specific) in healthy middle-aged (44-56 years) men in the Risk Factor Assessment among Japanese and U.S. Men in the Post-World War II Birth Cohort (ERA-JUMP) Study (n = 730; American: n = 417; Japanese: n = 313; from population-representative samples in Pittsburgh, Pennsylvania, USA, and Kusatsu, Shiga, Japan) were compared. The relationships between PA levels and MetS (overall and specific components) in/across the American and Japanese sub-cohorts (adjusting for age, smoking, and alcohol consumption) were also assessed using the same instruments (pedometer and validated questionnaire) to measure PA in both cohorts. Results: A total of 510 individuals provided complete data on PA (American: n = 265; Japanese: n = 245). The American cohort had significantly lower mean ± SD steps/day (7878 ± 3399 steps/day) vs. the Japanese cohort (9055 ± 3797 steps/day) (p < 0.001) but had significantly higher self-reported moderate-vigorous leisure PA (American: 15.9 (7.4-30.3) metabolic task equivalent hours per week (MET-h/week) vs. Japanese: 4.0 (0-11.3) MET-h/week, p < 0.0001). In both sub-cohorts, each 1000 steps/day increase was associated with lower odds of having MetS (American: OR = 0.90, 95%CI: 0.83-0.98; Japanese: OR = 0.87, 95%CI: 0.79-0.95) and the individual MetS component of high waist circumference (American: OR = 0.86, 95%CI: 0.79-0.94; Japanese: OR = 0.87, 95%CI: 0.80-0.95). In the American cohort only, higher self-reported leisure PA (Met-h/week) was associated with lower odds of MetS and high waist circumference (OR = 0.98, 95%CI: 0.97-0.99 for MetS and waist circumference, respectively). Conclusion: Higher total step counts/day had an important protective effect on MetS prevalence in both the Japanese and American cohorts, despite differences in PA levels and other MetS risk factors. The effect of steps/day (across all intensity levels) was much greater than domain-specific moderate-vigorous PA captured by questionnaire, suggesting the need for measurement tools that can best capture total movement when examining the effects of PA on MetS development.

DOI： 10.1016/j.jshs.2019.09.007

Liver fat accumulation assessed by computed tomography is an independent risk factor for diabetes mellitus in a population-based study: SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis). 査読

FUSE, Keiko, KADOTA, Aya, KONDO, Keiko, MORINO, Katsutaro, FUJIYOSHI, Akira, HISAMATSU, Takashi, KADOWAKI, Sayaka, MIYAZAWA, Itsuko, UGI, Satoshi, MAEGAWA, Hiroshi, MIURA, Katsuyuki, UESHIMA, Hirotsugu, Shiga, Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group, 布施, 恵子, 門田, 文, 近藤, 慶子, 森野, 勝太郎, 藤吉, 朗, 久松, 隆史, 門脇, 紗也佳, 宮澤, 伊都子, 卯木, 智, 前川, 聡, 三浦, 克之, 上島, 弘嗣

Diabetes research and clinical practice 160 108002 - 108002 2020年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier Scientific Publishers

type:Journal Article
AIMS:Ectopic fat accumulation is related to insulin resistance and diabetes mellitus (DM). However, the effect of fatty liver on DM in non-obese individuals has not been clarified. We investigated whether liver fat accumulation assessed by computed tomography (CT) is associated with the incidence of DM.
METHODS:In a prospective population-based study, 640 Japanese men were followed up for 5 years. The liver to spleen (L/S) ratio of the CT attenuation value was used as the liver fat accumulation index. We calculated the odds ratio (OR) and 95% confidence interval (CI) for the DM incidence of per 1 standard deviation (SD) lower L/S and those of L/S < 1.0 compared with L/S ≥ 1.0, using logistic regression models.
RESULTS:Both per 1 SD lower L/S and L/S < 1.0 were significantly associated with a risk for DM incidence (1 SD lower L/S: OR = 1.57, 95%CI = 1.14-2.16; L/S < 1.0: OR = 2.27, 95%CI = 1.00-5.14). The relationship between L/S and incidence of DM was consistent in the obese and non-obese groups, with thresholds of BMI 25 kg/m2, waist circumference 85 cm, or visceral adipose tissue 100 cm2.
CONCLUSIONS:Liver fat accumulation assessed by CT was associated with the incidence of DM.

DOI： 10.1016/j.diabres.2020.108002

その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H04074/

Anthropometric Obesity Indices were Stronger than CT-Based Indices in Associations with Carotid Intima-Media Thickness in Japanese Men. 査読

Yuyan Liu, Akira Fujiyoshi, Hisatomi Arima, Aya Kadota, Sayaka Kadowaki, Takashi Hisamatsu, Itsuko Miyazawa, Keiko Kondo, Ikuo Tooyama, Katsuyuki Miura, Hirotsugu Ueshima

Journal of atherosclerosis and thrombosis 26 ( 12 ) 1102 - 1114 2019年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

AIM: Computed tomography (CT) can directly provide information on body compositions and distributions, compared to anthropometric indices. It has been shown that various obesity indices are associated with carotid intima-media thickness (IMT). However, whether CT-based obesity indices are stronger than anthropometric indices in association with atherosclerosis remains to be determined in a general population. METHODS: We cross-sectionally assessed carotid IMT using ultrasound in 944 community-dwelling Japanese men free of stroke and myocardial infarction. CT image at the L4-L5 level was obtained to compute areas of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). Anthropometric measures assessed included body mass index (BMI), waist circumference, and waist-to-hip ratio. Using multivariable linear regression, slopes of IMT per 20th to 80th percentile of each index were compared. We also compared the slope of index with simultaneous adjustment for BMI in the same model. RESULTS: Areas of VAT and SAT were positively associated with IMT, but not stronger than those of anthropometric indices in point estimates. Among all obesity indices, BMI was strongest in association with IMT after adjusting for age and lifestyle factors or further adjusting for metabolic factors. In simultaneous adjustment models, BMI, but not CT-based indices, remained significant and showed the strongest association. CONCLUSIONS: In community-dwelling Japanese men, anthropometric obesity indices, BMI in particular, were more strongly associated with carotid atherosclerosis than CT-based obesity indices. The association of general obesity with carotid atherosclerosis was strong and adding CT-based obesity measure did not considerably influence in the association.

DOI： 10.5551/jat.47977

Lipoprotein particles and coronary artery calcium in middle-aged US-White and Japanese men 査読国際誌

Hemant Mahajan, Maryam Zaid, Rachel Mackey, Aya Kadota, Abhishek Vishnu, Akira Fujiyoshi, Ahuja Vasudha, Takashi Hisamatsu, Rhobert Evans, Tomonori Okamura, Katsuyuki Miura, Lewis Kuller, Hirotsugu Ueshima, Akira Sekikawa

Open Heart 6 ( 2 ) e001119 - e001119 2019年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMJ

<sec><title>Objective</title>This cross-sectional study examined whether contrasting distributions of nuclear magnetic resonance (NMR)-measured lipoproteins contribute to differences in the prevalence of subclinical atherosclerosis measured using coronary artery calcium (CAC) between the two groups of middle-aged males: the US-residing Caucasian (US-White) and Japan-residing Japanese (Japanese).

</sec><sec><title>Methods</title>In a population-based study of 570 randomly selected asymptomatic men aged 40–49 years (270 US-White and 300 Japanese), we examined the relationship between race/ethnicity, NMR-measured lipoproteins and CAC (measured by Electron Beam CT and quantified using the Agatston method) using multivariable robust Poisson regression adjusting for traditional and novel risk factors for coronary heart disease (CHD).

</sec><sec><title>Results</title>The US-White compared with the Japanese had significantly different NMR-measured lipoprotein particle distributions. The US-White had a significantly higher prevalence of CAC≥10 (CAC-prevalence) compared with the Japanese adjusting for CHD risk factors (prevalence ratio (PR)=2.10; 95% CI=1.24 to 3.48), and this difference was partially attenuated (~18%) with further adjustment for lipoprotein levels (PR=1.73; 95% CI=1.02 to 3.08). There was no reclassification improvement with further addition of lipoproteins particle concentrations/size to a model that already included traditionally measured lipids (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides), cardiovascular risk factors, and inflammatory markers (net reclassification improvement index=−2% to 3%).

</sec><sec><title>Conclusions</title>Variations in the distribution of NMR-measured lipoprotein particles partially accounted for the difference in the CAC-prevalence between middle-aged US-White and Japanese men.

</sec>

DOI： 10.1136/openhrt-2019-001119

The association of home and accurately measured office blood pressure with coronary artery calcification among general Japanese men. 査読国際誌

Atsushi Satoh, Hisatomi Arima, Atsushi Hozawa, Takayoshi Ohkubo, Takashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Akira Fujiyoshi, Naoko Miyagawa, Maryam Zaid, Sayuki Torii, Tomonori Okamura, Akira Sekikawa, Katsuyuki Miura, Hirotsugu Ueshima

Journal of hypertension 37 ( 8 ) 1676 - 1681 2019年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: We conducted a cross-sectional study to clarify whether home blood pressure (HBP) is more strongly associated with coronary artery calcification (CAC) than accurately measured office blood pressure (OBP) among the general population of Japanese men. METHODS: We analyzed the data of 919 Japanese male participants who were randomly selected from general population (mean age 64.5 years). OBP was measured twice consecutively by a trained nurse using electrical device after 5 min of complete rest alone in a sitting position in a silent room. The participants were asked to measure HBP with an electrical device once in the morning during 7 consecutive days. CAC was assessed using computed tomography. Presence of CAC was defined as Agatston score at least 10. We calculated odds ratios for the presence of CAC per one SD higher OBP and HBP adjusted for age and other cardiovascular risk factors. RESULTS: The mean systolic OBP (SD) and HBP (SD) were 136.8 (19.0) and 137.2 (18.5) mmHg, respectively, without statistical difference between the two (P = 0.595). OBP and HBP were highly correlated (r = 0.74 P < 0.001). CAC was found in 454 (49.4%) participants. Multivariable-adjusted odds ratios [95% confidence interval (CI)] for the presence of CAC were comparable between OBP (1.32, 95% CI: 1.12-1.56) and HBP (1.35, 95% CI: 1.14-1.60) (P heterogeneity = 0.813). CONCLUSION: The strength of association of accurately measured OBP with CAC was comparable with that of HBP among randomly selected male general population aged 40-79 years.

DOI： 10.1097/HJH.0000000000002080

Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical 査読

Kadota A, Miura K, Okamura T, Fujiyoshi A, Ohkubo T, Kadowaki T, Takashima N, Hisamatsu T, Nakamura Y, Kasagi F, Maegawa H, Kashiwagi A, Ueshima H, SESSA Research Group, for the NIPPON DATA, Research Group

Journal of atherosclerosis and thrombosis 26 ( 8 ) 746 - 746 2019年7月

Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). 査読

Masaki Sumi, Takashi Hisamatsu, Akira Fujiyoshi, Aya Kadota, Naoko Miyagawa, Keiko Kondo, Sayaka Kadowaki, Sentaro Suzuki, Sayuki Torii, Maryam Zaid, Atsushi Sato, Hisatomi Arima, Tomohiro Terada, Katsuyuki Miura, Hirotsugu Ueshima

Journal of epidemiology 29 ( 6 ) 205 - 212 2019年6月

記述言語：英語

BACKGROUND: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. METHODS: From 2006-2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: non-drinkers (0 g/week), 0.1-160.9, 161-321.9, 322-482.9, and ≥483 g/week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. RESULTS: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg/m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VAT-to-SAT ratio (all P for trend <0.001), and also with waist circumferences and waist-to-hip ratio (P for trend = 0.042 and 0.007, respectively). These associations remained significant after further adjustment for BMI, whereas alcohol consumption had no significant association with abdominal SAT area. CONCLUSIONS: Higher alcohol consumption was associated with higher VAT area, VAT%, and VAT-to-SAT ratio, independent of confounders, including BMI, in general Japanese men. These results suggest that alcohol consumption may have a potential adverse effect on visceral fat deposition.

DOI： 10.2188/jea.JE20170191

Differences Between Coronary Artery Calcification and Aortic Artery Calcification in Relation to Cardiovascular Disease Risk Factors in Japanese Men 査読

Cecilia Kimani, Aya Kadota, Katsuyuki Miura, Akira Fujiyoshi, Maryam Zaid, Sayaka Kadowaki, Takashi Hisamatsu, Hisatomi Arima, Minoru Horie, Hirotsugu Ueshima

Journal of Atherosclerosis and Thrombosis 26 ( 5 ) 452 - 464 2019年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japan Atherosclerosis Society

AIMS: Calcification in the coronary and aortic arteries has been linked to cardiovascular morbidity and mortality. The pathophysiological influence of aortic artery calcification (AAC) differs from that of coronary artery calcification (CAC). We aimed to compare the relationships between CAC and AAC and cardiovascular disease (CVD) risk factors. METHODS: We examined a random sample of 1035 Japanese men aged 40-79 years. CAC and AAC were measured by computed tomography and scored according to the Agatston method. Using a logistic regression, we calculated the odds ratio (OR) as being in the highest quintile (Q5) of the calcification score compared to the lower quintiles (Q1-Q4) per 1 standard deviation higher CVD risk factor. Models were simultaneously adjusted for age, body mass index (BMI), systolic blood pressure, smoking (pack-year), alcohol intake, hemoglobin A1c, uric acid, estimated glomerular filtration rate (eGFR), serum lipids, and C-reactive protein. Differences in ORs were investigated using a generalized estimating equation. We performed a multiple linear regression using log-transformed CAC and AAC values as dependent variables. RESULTS: CAC and AAC were independently associated with age (OR, 95% CI: 2.30 [1.77-2.98] for CAC and 3.48 [2.57-4.73] for AAC), p for difference ＜0.001), systolic blood pressure (1.29 [1.08-1.53] and 1.28 [1.07-1.54], p for difference=0.270), and smoking (1.22, [1.04-1.43] and 1.34 [1.13-1.58]) p for difference=0.071). Alcohol correlated with AAC only (1.17 [0.97-1.41] for CAC and 1.42 [1.16-1.73] for AAC, p for difference= 0.020). CONCLUSIONS: CAC and AAC were associated with similar CVD risk factors. The strength of association slightly differed between CAC and AAC.

DOI： 10.5551/jat.44784

Change in Pericardial Fat Volume and Cardiovascular Risk Factors in a General Population of Japanese Men 査読

Itsuko Miyazawa, Takayoshi Ohkubo, Sayaka Kadowaki, Akira Fujiyoshi, Takashi Hisamatsu, Aya Kadota, Hisatomi Arima, Matthew Budoff, Kiyoshi Murata, Katsuyuki Miura, Hiroshi Maegawa, Hirotsugu Ueshima

Circulation Journal 82 ( 10 ) 2542 - 2548 2018年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Circulation Society

BACKGROUND: Pericardial fat volume (PFV), defined as the volume of ectopic fat in and around the heart, is associated with the atherosclerotic process in coronary arteries. The magnitude of change in PFV over time and the factors affecting this change in a general population, however, have not been investigated. Methods and Results: Cardiac computed tomography (CT) was carried out at baseline and at follow-up in 623 Japanese men aged 40-79 years without a history of cardiovascular disease who were selected randomly in Kusatsu (Shiga, Japan). PFV was measured on cardiac CT in a qualified laboratory. Age, heart rate, triglycerides, and obesity measurements (weight, body mass index, and waist circumference) were significantly and positively associated with PFV at baseline. Over an average interval of 4.7 years, median PFV increased significantly from 64.1 cm3 (IQR, 47.2-90.0 cm3) to 73.6 cm3 (IQR, 53.3-98.1 cm3; P<0.001). Current smoking and heart rate were significantly and independently associated with changes in PFV (B=3.336, P<0.001 and B=6.409, P=0.003, respectively). CONCLUSIONS: PFV increased significantly over time in a population-based observational study of Japanese men. PFV change was significantly and independently associated with smoking status and heart rate, suggesting that quitting smoking might help reduce PFV, which could be expected to decrease the risk of coronary artery disease.

DOI： 10.1253/circj.cj-18-0153

Comparison of carotid plaque burden among healthy middle-aged men living in the US, Japan, and South Korea 査読

Abhishek Vishnu, Jina Choo, Aya Kadota, Emma J.M. Barinas-Mitchell, Akira Fujiyoshi, Dorothy Leann Long, Takashi Hisamatsu, Vasudha Ahuja, Yasuyuki Nakamura, Rhobert W. Evans, Katsuyuki Miura, Kamal H. Masaki, Chol Shin, Hirotsugu Ueshima, Akira Sekikawa

International Journal of Cardiology 266 245 - 249 2018年9月

Corrigendum to "Lipoprotein-associated phospholipase A2 is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population." [Atherosclerosis 246 (March 2016) 141-147]. 査読国際誌

Ueshima H, Kadowaki T, Hisamatsu T, Fujiyoshi A, Miura K, Ohkubo T, Sekikawa A, Kadota A, Kadowaki S, Nakamura Y, Miyagawa N, Okamura T, Kita Y, Takashima N, Kashiwagi A, Maegawa H, Horie M, Yamamoto T, Kimura T, Kita T, ACCESS, SESSA Research Groups

Atherosclerosis 278 336 - 336 2018年8月

Association of blood levels of marine omega-3 fatty acids with coronary calcification and calcium density in Japanese men. 査読

Takashi Hisamatsu

European journal of clinical nutrition 73 ( 5 ) 783 - 792 2018年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

BACKGROUND/OBJECTIVES:Clinical trials of eicosapentaenoic acid (EPA) among high-risk groups in Japan in which consumption of mairne-omega-3 fatty acids (OM3) is much higher than other countries showed slower progression of coronary atherosclerosis. We aimed to determine the cross-sectional associations of coronary artery calcification (CAC) and calcium density with OM3, EPA, and docosahexaenoic acid (DHA), two principal OM3, in the general population in Japan. SUBJECTS/METHODS:The Shiga Epidemiological Study of Subclinical Atherosclerosis examined a population-based sample of 1074 men aged 40-79 in 2006-08 for computed tomography-measured CAC score (CCS), a well-established biomarker of coronary atherosclerosis, CAC density score (CDS), a potential marker of plaque stabilization, serum levels of OM3, and risk factors. RESULTS:Prevalence of CCS > 0, ≥ 100, and ≥ 300 was 65.8%, 25.9%, and 12.9%, respectively; the mean (SD) OM3, EPA, and DHA were 10.1% (3.2), 3.2% (1.7), and 5.9% (1.6), respectively. Odds ratios (95% CI, p-value) of CCS 0, 100, and 300 in ordinal logistic regression associated with 1 SD increase of OM3, EPA, and DHA were 0.91 (0.81-1.03, p = 0.12), 0.99 (0.88-1.11, p = 0.87) and 0.84 (0.74-0.94, p = < 0.01), respectively. The inverse association of DHA with CCS remained significant in multivariate-adjusted model: odds ratio of 0.87 (0.77-0.99, p = 0.03). Blood levels of OM3, EPA, or DHA did not have any significant associations with CDS. CONCLUSIONS:DHA but not EPA had a significant inverse association with coronary atherosclerosis in the general population with high levels of OM3. Future trials are warranted comparing the effect of high-dose DHA and EPA on atherosclerosis and cardiovascular outcomes.

DOI： 10.1038/s41430-018-0242-7

その他リンク： http://www.nature.com/articles/s41430-018-0242-7

Association of Coronary Artery Calcification with Estimated Coronary Heart Disease Risk from Prediction Models in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). 査読

Akira Fujiyoshi, Hisatomi Arima, Sachiko Tanaka-Mizuno, Takahashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Akira Sekikawa, Takashi Yamamoto, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima

Journal of atherosclerosis and thrombosis 25 ( 6 ) 477 - 489 2018年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

AIM: The clinical significance of coronary artery calcification (CAC) is not fully determined in general East Asian populations where background coronary heart disease (CHD) is less common than in USA/Western countries. We cross-sectionally assessed the association between CAC and estimated CHD risk as well as each major risk factor in general Japanese men. METHODS: Participants were 996 randomly selected Japanese men aged 40-79 y, free of stroke, myocardial infarction, or revascularization. We examined an independent relationship between each risk factor used in prediction models and CAC score ≥100 by logistic regression. We then divided the participants into quintiles of estimated CHD risk per prediction model to calculate odds ratio of having CAC score ≥100. Receiver operating characteristic curve and c-index were used to examine discriminative ability of prevalent CAC for each prediction model. RESULTS: Age, smoking status, and systolic blood pressure were significantly associated with CAC score ≥100 in the multivariable analysis. The odds of having CAC score ≥100 were higher for those in higher quintiles in all prediction models (p-values for trend across quintiles ＜0.0001 for all models). All prediction models showed fair and similar discriminative abilities to detect CAC score ≥100, with similar c-statistics (around 0.70). CONCLUSIONS: In a community-based sample of Japanese men free of CHD and stroke, CAC score ≥100 was significantly associated with higher estimated CHD risk by prediction models. This finding supports the potential utility of CAC as a biomarker for CHD in a general Japanese male population.

DOI： 10.5551/jat.42416

International Comparison of Abdominal Fat Distribution Among Four Populations: The ERA-JUMP Study.

Takashi Hisamatsu

Metabolic syndrome and related disorders 2018年5月

掲載種別：研究論文（学術雑誌）

BACKGROUND:Abdominal fat distribution varies across groups with different races or environments. Whether environmental factors, apart from racial differences, affect abdominal fat distribution is unknown. METHODS:We compared the abdominal fat distribution of four groups; different races with similar environments (Caucasians vs. Japanese Americans), different environments with an identical race (Japanese Americans vs. Japanese), and similar races with similar environments (Japanese vs. Koreans). A population-based sample of 1212 men aged 40-49 were analyzed: 307 Caucasians and 300 Japanese Americans in the United States, 310 Japanese in Japan, and 295 Koreans in Korea. We compared the proportion of visceral adipose tissue area to total abdominal adipose tissue area (VAT%) and other factors that can affect abdominal fat distribution (smoking, alcohol use, physical activity levels, and metabolic factors). RESULTS:VAT% was significantly higher in Japanese and Koreans than in Japanese Americans and Caucasians (50.0, 48.5, 43.2, 41.0%, respectively, P < 0.001). Even after adjustment for possible confounders, the significant VAT% difference remained in comparing groups with identical race but different environments (i.e., Japanese vs. Japanese Americans). In contrast, comparing groups with different races but similar environments (i.e., Caucasians vs. Japanese Americans), VAT% was not significantly different. Comparing groups with similar races and similar environments (i.e., Japanese vs. Koreans), VAT% did not significantly differ. CONCLUSIONS:Environmental differences, apart from racial differences, affect the difference in abdominal fat distribution across different groups in middle-aged men.

DOI： 10.1089/met.2017.0132

Data on alcohol consumption and coronary artery calcification among asymptomatic middle-aged men for the ERA-JUMP study. 査読

Takashi Hisamatsu

Data in brief 17 1091 - 1098 2018年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

Data presented in this article are supplementary data to our primary article 'Association of Alcohol Consumption and Aortic Calcification in Healthy Men Aged 40-49 Years for the ERA JUMP Study' [1]. In this article, we have presented supplementary tables showing the independent association of alcohol consumption with coronary artery calcification using Tobit conditional regression and ordinal logistic regression.

DOI： 10.1016/j.dib.2018.02.032

Reduced Lung Function and Cerebral Small Vessel Disease in Japanese Men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). 査読

Takashi Hisamatsu

Journal of atherosclerosis and thrombosis 25 ( 10 ) 1009 - 1021 2018年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japan Atherosclerosis Society

AIM:We aimed to investigate the association between reduced lung function and cerebral small vessel diseases via cranial magnetic resonance imaging (MRI) in the cross-sectional study of the general Japanese population. METHODS:We recruited participants aged ≥40 years from the general population of a single city in Japan. We clarified the comorbidities and treatments, smoking habits, second-hand smoke exposure, current alcohol consumption, education level, exercise habits, and occupation. The pulmonary function test was performed to assess the forced expiratory volume in 1 second (FEV1) % predicted and forced vital capacity (FVC) % predicted values. Cranial MRI was performed to evaluate the white matter lesions (WMLs) and lacunar infarcts. We examined the association of the WMLs and lacunar infarcts with a 1-standard deviation (SD) lower in the FEV1 % predicted and FVC % predicted, on the basis of the smoking status. RESULTS:A total of 473 men were examined. The association of WMLs and lacunar infarcts with the spirometry-based indices were significant only in never smokers. The association between lung function impairment and cerebral small vessel disease did not change after further adjusting for second-hand smoke exposure. CONCLUSION:In a community-based sample of Japanese men, we found an association between reduced lung function and WMLs and lacunar infarcts in never smokers.

DOI： 10.5551/jat.42127

Self-reported Sleep Duration and Subclinical Atherosclerosis in a General Population of Japanese Men 査読

Suzuki Sentaro, Arima Hisatomi, Miyazaki Soichiro, Fujiyoshi Akira, Kadota Aya, Takashima Naoyuki, Hisamatsu Takashi, Kadowaki Sayaka, Zaid Maryam, Torii Sayuki, Horie Minoru, Murata Kiyoshi, Miura Katsuyuki, Ueshima Hirotsugu, the SESSA Research Group

ＪｏｕｒｎａｌｏｆＡｔｈｅｒｏｓｃｌｅｒｏｓｉｓａｎｄＴｈｒｏｍｂｏｓｉｓ 25 ( 2 ) 186 - 198 2018年2月

Association of alcohol consumption and aortic calcification in healthy men aged 40–49 years for the ERA JUMP Study 査読

Hemant Mahajan, Jina Choo, Kamal Masaki, Akira Fujiyoshi, Jingchuan Guo, Takashi Hisamatsu, Rhobert Evans, Siyi Shangguan, Bradley Willcox, Tomonori Okamura, Abhishek Vishnu, Emma Barinas-Mitchell, Vasudha Ahuja, Katsuyuki Miura, Lewis Kuller, Chol Shin, Hirotsugu Ueshima, Akira Sekikawa

Atherosclerosis 268 84 - 91 2018年1月

Significant inverse association of equol-producer status with coronary artery calcification but not dietary isoflavones in healthy Japanese men 査読

Vasudha Ahuja, Katsuyuki Miura, Abhishek Vishnu, Akira Fujiyoshi, Rhobert Evans, Maryam Zaid, Naoko Miyagawa, Takashi Hisamatsu, Aya Kadota, Tomonori Okamura, Hirotsugu Ueshima, Akira Sekikawa

BRITISH JOURNAL OF NUTRITION 117 ( 2 ) 260 - 266 2017年1月

The role of initial and longitudinal change in blood pressure on progression of arterial stiffness among multiethnic middle-aged men 査読

Jingchuan Guo, Akira Fujiyoshi, Kamal Masaki, Abhisek Vishnu, Aya Kadota, Emma J. M. Barinas-Mitchell, Takashi Hisamatsu, Vasudha Ahuja, Naoyuki Takashima, Rhobert W. Evans, Bradley J. Willcox, Katsuyuki Miura, Beatriz Rodriguez, Hirotsugu Ueshima, Lewis H. Kuller, Akira Sekikawa

JOURNAL OF HYPERTENSION 35 ( 1 ) 111 - 117 2017年1月

Lifetime cigarette smoking is associated with abdominal obesity in a community-based sample of Japanese men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). 査読国際誌

Akira Fujiyoshi, Katsuyuki Miura, Sayaka Kadowaki, Koichiro Azuma, Sachiko Tanaka, Takashi Hisamatsu, Hisatomi Arima, Aya Kadota, Naoko Miyagawa, Naoyuki Takashima, Takayoshi Ohkubo, Yoshino Saitoh, Sayuki Torii, Itsuko Miyazawa, Hiroshi Maegawa, Kiyoshi Murata, Hirotsugu Ueshima

Preventive medicine reports 4 225 - 32 2016年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Studies from Western countries suggest that smokers tend to display greater abdominal obesity than non-smokers, despite showing lower weight. Whether this holds true in a leaner population requires clarification. Using indices of abdominal obesity including visceral adipose tissue, we examined whether lifetime cigarette smoking is associated with unfavorable fat distribution among Japanese men. From 2006 to 2008, we conducted a cross-sectional investigation of a community-based sample of Japanese men at 40-64 years old, free of cardiovascular diseases and cancer. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography. We divided participants into four groups: never-smokers; and tertiles of pack-years of smoking among ever-smokers. Using multivariable linear regression, we calculated adjusted means of obesity indices (VAT, SAT, VAT-SAT ratio [VSR], and waist-hip ratio [WHR]) for each group, and mean differences between consecutive groups. We analyzed 513 men (median age, 58.2 years; current smokers, 40.1%). Two-thirds showed body mass index (BMI) < 25 kg/m(2) (median, 23.5 kg/m(2)). Overall, greater lifetime smoking group was associated with greater WHR and VSR. On average, one higher smoking group was associated with 0.005 higher WHR (95% CI, 0.001-0.008; P = 0.005) and 0.041 greater VSR (95% CI, 0.009-0.073; P = 0.012) after adjustment for potential confounders, including BMI. In this sample of relatively lean Japanese men, greater lifetime smoking was associated with a metabolically more adverse fat distribution. Although smoking is commonly associated with lower BMI, minimizing the amount of lifetime smoking should be advocated.

DOI： 10.1016/j.pmedr.2016.06.013

Mendelian randomization analysis in three Japanese populations supports a causal role of alcohol consumption in lowering low-density lipid cholesterol levels and particle numbers 査読

Yasuharu Tabara, Hirotsugu Ueshima, Naoyuki Takashima, Takashi Hisamatsu, Akira Fujiyoshi, Maryam Zaid, Masaki Sumi, Katsuhiko Kohara, Tetsuro Miki, Katsuyuki Miura

ATHEROSCLEROSIS 254 242 - 248 2016年11月

Early repolarization and risk of arrhythmia events in long QT syndrome 査読

Kanae Hasegawa, Hiroshi Watanabe, Takashi Hisamatsu, Seiko Ohno, Hideki Itoh, Takashi Ashihara, Hideki Hayashi, Takeru Makiyama, Tohru Minamino, Minoru Horie

INTERNATIONAL JOURNAL OF CARDIOLOGY 223 540 - 542 2016年11月

Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification 査読

Maryam Zaid, Katsuyuki Miura, Akira Fujiyoshi, Robert D. Abbott, Takashi Hisamatsu, Aya Kadota, Hisatomi Arima, Sayaka Kadowaki, Sayuki Torii, Naoko Miyagawa, Sentaro Suzuki, Naoyuki Takashima, Takayoshi Ohkubo, Akira Sekikawa, Hiroshi Maegawa, Minoru Horie, Yasuyuki Nakamura, Tomonori Okamura, Hirotsugu Ueshima

JOURNAL OF CLINICAL LIPIDOLOGY 10 ( 5 ) 1195 - 1202 2016年10月

Lipoprotein-associated phospholipase A(2) is related to risk of subclinical atherosclerosis but is not supported by Mendelian randomization analysis in a general Japanese population 査読

Hirotsugu Ueshima, Takashi Kadowaki, Takashi Hisamatsu, Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Akira Sekikawa, Aya Kadota, Sayaka Kadowaki, Yasuyuki Nakamura, Naoko Miyagawa, Tomonori Okamura, Yoshikuni Kita, Naoyuki Takashima, Atsunori Kashiwagi, Hiroshi Maegawa, Minoru Horie, Takashi Yamamoto, Takeshi Kimura, Toru Kita

ATHEROSCLEROSIS 246 141 - 147 2016年3月

Pediatric Cohort With Long QT Syndrome-KCNH2 Mutation Carriers Present Late Onset But Severe Symptoms - 査読

Junichi Ozawa, Seiko Ohno, Takashi Hisamatsu, Hideki Itoh, Takeru Makiyama, Hiroshi Suzuki, Akihiko Saitoh, Minoru Horie

CIRCULATION JOURNAL 80 ( 3 ) 696 - 702 2016年3月

Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemia LOX-1 ligand and IMT in Japanese 査読

Tomonori Okamura, Katsuyuki Miura, Tatsuya Sawamura, Aya Kadota, Takashi Hisamatsu, Akira Fujiyoshi, Naomi Miyamatsu, Naoyuki Takashima, Naoko Miyagawa, Takashi Kadowaki, Takayoshi Ohkubo, Yoshitaka Murakami, Yasuyuki Nakamura, Hirotsugu Ueshima

JOURNAL OF CLINICAL LIPIDOLOGY 10 ( 1 ) 172 - 180 2016年2月

High Frequency of Early Repolarization and Brugada-Type Electrocardiograms in Hypercalcemia 査読

Keiko Sonoda, Hiroshi Watanabe, Takashi Hisamatsu, Takashi Ashihara, Seiko Ohno, Hideki Hayashi, Minoru Horie, Tohru Minamino

ANNALS OF NONINVASIVE ELECTROCARDIOLOGY 21 ( 1 ) 30 - 40 2016年1月

Association between pulse wave velocity and coronary artery calcification in Japanese men the shiga epidemiological study of subclinical atherosclerosis (SESSA 査読

Sayuki Torii, Hisatomi Arima, Takayoshi Ohkubo, Akira Fujiyoshi, Aya Kadota, Naoyuki Takashima, Sayaka Kadowaki, Takashi Hisamatsu, Yoshino Saito, Naoko Miyagawa, Maryam Zaid, Yoshitaka Murakami, Robert D. Abbott, Minoru Horie, Katsuyuki Miura, SESSA Research Group, Hirotsugu Ueshima

Journal of Atherosclerosis and Thrombosis 22 ( 12 ) 1266 - 1277 2015年12月

Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men 査読

Abhishek Vishnu, Jina Choo, Bradley Wilcox, Takashi Hisamatsu, Emma J. M. Barinas-Mitchell, Akira Fujiyoshi, Rachel H. Mackey, Aya Kadota, Vasudha Ahuja, Takashi Kadowaki, Daniel Edmundowicz, Katsuyuki Miura, Beatriz L. Rodriguez, Lewis H. Kuller, Chol Shin, Kamal Masaki, Hirotsugu Ueshima, Akira Sekikawa

INTERNATIONAL JOURNAL OF CARDIOLOGY 189 67 - 72 2015年6月

High-density lipoprotein particle concentration and subclinical atherosclerosis of the carotid arteries in Japanese men 査読

Maryam Zaid, SESSA Research group, Akira Fujiyoshi, Katsuyuki Miura, Robert D. Abbott, Tomonori Okamura, Naoyuki Takashima, Sayuki Torii, Yoshino Saito, Takashi Hisamatsu, Naoko Miyagawa, Takayoshi Ohkubo, Aya Kadota, Akira Sekikawa, Hiroshi Maegawa, Yasuyuki Nakamura, Kenichi Mitsunami, Hirotsugu Ueshima, Minoru Horie, Yasutaka Nakano, Takashi Yamamoto, Emiko Ogawa, Itsuko Miyazawa, Kiyoshi Murata, Kazuhiko Nozaki, Akihiko Shiino, Isao Araki, Teruhiko Tsuru, Ikuo Toyama, Hisakazu Ogita, Souichi Kurita, Toshinaga Maeda, Naomi Miyamatsu, Toru Kita, Takeshi Kimura, Yoshihiko Nishio, Emma Barinas-Mitchell, Daniel Edmundowicz, Atsushi Hozawa, Nagako Okuda, Aya Higashiyama, Shinya Nagasawa, Yoshikuni Kita, Takashi Kadowaki, Sayaka Kadowaki, Yoshitaka Murakami, Seiko Ohno

Atherosclerosis 239 ( 2 ) 444 - 450 2015年4月

Ectopic cardiovascular fat in middle-aged men: effects of race/ethnicity, overall and central adiposity. The ERA JUMP study 査読

S. R. El Khoudary, C. Shin, K. Masaki, K. Miura, M. Budoff, D. Edmundowicz, S. Kadowaki, E. Barinas-Mitchell, A. El-Saed, A. Fujiyoshi, R. W. Evans, T. Hisamatsu, T. Ohkubo, B. J. Willcox, L. H. Kuller, H. Ueshima, A. Sekikawa

INTERNATIONAL JOURNAL OF OBESITY 39 ( 3 ) 488 - 494 2015年3月

Comparison of HOMA-IR, HOMA-β%, and disposition index between U.S. Caucasian men and Japanese men in Japan: the ERA JUMP study 査読

Ahuja V, Kadowaki T, Evans RW, Kadota A, Okamura T, El Khoudary SR, Fujiyoshi A, Barinas-Mitchell E, Hisamatsu T, Vishnu A, Miura K, Maegawa H, El-Saed A, Kashiwagi A, Kuller LH, Ueshima H, Sekikawa A, for the ERA JUMP, Study Group

Diabetologia 58 ( 2 ) 265 - 271 2015年2月

Associations between Inflammatory Markers and Subclinical Atherosclerosis in Middle-aged White, Japanese-American and Japanese Men: The ERA-JUMP Study 査読

Shin-ya Nagasawa, Takayoshi Ohkubo, Kamal Masaki, Emma Barinas-Mitchell, Katsuyuki Miura, Todd B. Seto, Aiman El-Saed, Takashi Kadowaki, Bradley J. Willcox, Daniel Edmundowicz, Aya Kadota, Rhobert W. Evans, Sayaka Kadowaki, Akira Fujiyoshi, Takashi Hisamatsu, Marianne H. Bertolet, Tomonori Okamura, Yasuyuki Nakamura, Lewis H. Kuller, Hirotsugu Ueshima, Akira Sekikawa

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 22 ( 6 ) 590 - 598 2015年

Long-term outcomes associated with prolonged PR interval in the general Japanese population 査読

Takashi Hisamatsu, NIPPON DATA80 Research Group, Katsuyuki Miura, Akira Fujiyoshi, Tomonori Okamura, Takayoshi Ohkubo, Shin-Ya Nagasawa, Minoru Horie, Akira Okayama, Hirotsugu Ueshima, Shigeyuki Saitoh, Kiyomi Sakata, Atsushi Hozawa, Takehito Hayakawa, Yosikazu Nakamura, Yasuhiro Matsumura, Nobuo Nishi, Nagako Okuda, Fumiyoshi Kasagi, Toru Izumi, Toshiyuki Ojima, Koji Tamakoshi, Hideaki Nakagawa, Yoshitaka Murakami, Yoshikuni Kita, Naomi Miyamatsu, Yasuyuki Nakamura, Katsushi Yoshita, Aya Kadota, Yoshihiro Miyamoto, Kazunori Kodama, Yutaka Kiyohara

International Journal of Cardiology 184 ( 1 ) 291 - 293 2015年

Cross-Sectional Comparison of Coronary Artery Calcium Scores Between Caucasian Men in the United States and Japanese Men in Japan The Multi-Ethnic Study of Atherosclerosis and the Shiga Epidemiological Study of Subclinical Atherosclerosis 査読

Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Kadowaki, Sayaka Kadowaki, Maryam Zaid, Takashi Hisamatsu, Akira Sekikawa, Matthew J. Budoff, Kiang Liu, Hirotsugu Ueshima

AMERICAN JOURNAL OF EPIDEMIOLOGY 180 ( 6 ) 590 - 598 2014年9月

Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: A 24-year follow-up of NIPPON DATA80 査読

Naoko Miyagawa, Katsuyuki Miura, Nagako Okuda, Takashi Kadowaki, Naoyuki Takashima, Shin-ya Nagasawa, Yasuyuki Nakamura, Yasuhiro Matsumura, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Katsushi Yoshita, Akira Sekikawa, Takayoshi Ohkubo, Robert D. Abbott, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

ATHEROSCLEROSIS 232 ( 2 ) 384 - 389 2014年2月

Carotid intima-media thickness and plaque in apparently healthy Japanese individuals with an estimated 10-year absolute risk of CAD death according to the Japan Atherosclerosis Society (JAS) guidelines 2012: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA).

Takashi Hisamatsu

Journal of atherosclerosis and thrombosis 2013年7月

掲載種別：研究論文（学術雑誌）

AIM:To examine whether subclinical atherosclerosis of the carotid arteries is concordant with the categories in the 2012 atherosclerosis prevention guidelines proposed by the Japan Atherosclerosis Society (JAS guidelines 2012), which adopted the estimated 10-year absolute risk of coronary artery disease (CAD) death in the NIPPON DATA80 Risk Assessment Chart. METHODS:Between 2006 and 2008, 868 Japanese men 40 to 74 years of age without a history of cardiovascular disease were randomly selected from Kusatsu City, Japan. The intima media thickness (IMT) and plaque number from the common to internal carotid arteries were investigated using ultrasonography. The absolute risk of CAD death was estimated based on the individual risk factor data, and the mean IMT and plaque number in Categories Ⅰ, Ⅱ and Ⅲ of the guidelines were examined. RESULTS:The estimated 10-year absolute risk of CAD was directly related to the IMT (mean IMT (mean ± SD) (mm) for a 10-year absolute risk of ≥ 2.0% and ≥ 5.0%: 0.88 ± 0.18 and 0.95 ± 0.19, respectively) and the plaque number. These results are compatible with the categories described by the guidelines (mean IMT (mean ± SD) (mm) for Categories Ⅰ, Ⅱ, and Ⅲ: 0.70 ± 0.11, 0.81 ± 0.16 and 0.88 ± 0.18, respectively; mean plaque number: 0.9, 2.1 and 3, respectively). These findings were similar for Category Ⅲ participants with or without DM and CKD. CONCLUSIONS:Subclinical atherosclerosis of the carotid arteries is concordant with the 10-year absolute risk of CAD and the categories in the JAS guidelines 2012.

DOI： 10.5551/jat.17244

Is more aggressive prevention of coronary artery disease required for patients with early repolarization syndrome?--Reply.

Takashi Hisamatsu

Circulation journal : official journal of the Japanese Circulation Society 77 ( 6 ) 1643 - 1643 2013年3月

Long-chain n-3 Polyunsaturated Fatty Acids Intake and Cardiovascular Disease Mortality Risk in a General Japanese Population: NIPPON DATA80 査読

Naoko Miyagawa, Katsuyuki Miura, Nagako Okuda, Takashi Kadowaki, Naoyuki Takashima, Shin-ya Nagasawa, Yasuyuki Nakamura, Yasuhiro Matsumura, Atsushi Hozawa, Akira Fujiyoshi, Takashi Hisamatsu, Katsushi Yoshita, Takayoshi Ohkubo, Tomonori Okamura, Akira Okayama, Hirotsugu Ueshima

STROKE 44 ( 2 ) 2013年2月

Association between J-point elevation and death from coronary artery disease--15-year follow up of the NIPPON DATA90.

Takashi Hisamatsu

Circulation journal : official journal of the Japanese Circulation Society 2013年1月

掲載種別：研究論文（学術雑誌）

BACKGROUND:An early repolarization pattern, characterized by an elevation of the QRS-ST junction (J-point) on 12-lead electrocardiography (ECG) is associated with cardiac and sudden death. However, little is known about the prognostic significance of J-point elevation for various disease-specific cardiovascular outcomes, including coronary artery disease (CAD). METHODS AND RESULTS:To investigate the association between the presence of J-point elevation≥0.1 mV and various disease-specific cardiovascular outcomes, we conducted a 15-year prospective study in a representative general Japanese population of 7,630 individuals (41% men, mean age 52.4 years) who participated in the National Survey of Circulatory Disorders. Cox models were used to estimate the hazard ratios (HRs) adjusted for possible confounding factors. J-point elevation was present in 264 individuals (3.5%) and was associated with an increased risk of cardiac death (adjusted HR, 2.54; 95% confidence interval [CI] 1.40-4.58; P=0.002) and death from CAD (adjusted HR, 4.66; 95% CI 2.30-9.46; P<0.001). In a subgroup analysis by age, the association between J-point elevation and cardiovascular outcomes was more remarkable in middle-aged (<60 years) than in older individuals (≥60 years) (all P for interaction<0.05). CONCLUSIONS:J-point elevation on standard 12-lead ECG was an independent predictor of cardiac death and death from CAD in a representative sample of the general Japanese population, particularly among the middle-aged.

DOI： 10.1253/circj.cj-12-1273

Is More Aggressive Prevention of Coronary Artery Disease Required for Patients With Early Repolarization Syndrome? (Letter) 査読

Hisamatsu T, Ohkubo T, Miura K, Horie M, Ueshima H

Circ J 77 ( 6 ) 1643 2013年

Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical 査読

Kadota A, Miura K, Okamura T, Fujiyoshi A, Ohkubo T, Kadowaki T, Takashima N, Hisamatsu T, Nakamura Y, Kasagi F, Maegawa H, Kashiwagi A, Ueshima H

J Atheroscler Thromb.? 20 ( 10 ) 755 - 766 2013年

Long-term risk of BP values above normal for cardiovascular mortality: a 24-year observation of Japanese aged 30 to 92 years 査読国際誌

Takashima N, Ohkubo T, Miura K, Okamura T, Murakami Y, Fujiyoshi A, Nagasawa SY, Kadota A, Kita Y, Miyagawa N, Hisamatsu T, Hayakawa T, Okayama A, Ueshima H

J Hypertens 30 ( 12 ) 2209 - 2306 2012年

ループス腎炎に対する免疫抑制剤加療中に出現した尿蛋白量の減少にACE阻害薬(イミダプリル)が奏効した一例査読

下垣保恵, 筒井崇, 大平直人, 久松隆史, 田中雅博, 望月裕司, 豊田嘉清, 中井直治, 竹内孝男, 郡山健治, 河野厚

臨床リウマチ 22 ( 4 ) 389 - 393 2010年

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