研究者詳細 - 武本　麻美

論文 - 武本　麻美

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A case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex presenting as progressive parkinsonism with corresponding tau imaging.

Ohta Y, Shimada H, Ikegami K, Tsunoda K, Hishikawa N, Yamashita T, Takemoto M, Omote Y, Tagai K, Matsuoka K, Higuchi M, Abe K

Neurol Clin Neurosci. 9 ( 1 ) 124 - 126 2021年1月

Retinal Amyloid Imaging for Screening Alzheimer's Disease. 国際誌

Koh Tadokoro, Toru Yamashita, Shuhei Kimura, Emi Nomura, Yasuyuki Ohta, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Ryuta Morihara, Yuki Morizane, Koji Abe

Journal of Alzheimer's disease : JAD 83 ( 2 ) 927 - 934 2021年

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Cost-effective and noninvasive methods for in vivo imaging of amyloid deposition are needed to screen Alzheimer's disease (AD). Although retinal amyloid is a possible diagnostic marker of AD, there are very few studies on in vivo retinal amyloid imaging. OBJECTIVE: To examine the usefulness of in vivo imaging of retinal amyloid in AD patients. METHODS: To examine amyloid deposition, 30 Japanese subjects (10 normal control (NC), 7 with mild cognitive impairment (MCI), and 13 with AD) underwent a complete ophthalmic examination, including fundus imaging by scanning laser ophthalmoscopy before and after oral curcumin intake. RESULTS: Retinal amyloid deposition was greater in AD than in NC subjects (*p < 0.05) while MCI showed a slight but insignificant increase of retinal amyloid deposition relative to NC subjects. Retinal amyloid deposition was correlated with whole gray matter atrophy (r = 0.51, *p < 0.05) but not with the cognitive score of the Mini-Mental State Examination, nor with medial temporal lobe atrophy. CONCLUSION: The present noninvasive in vivo detection of retinal amyloid deposition is useful for screening AD patients.

DOI： 10.3233/JAD-210327

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Immediate Beneficial Effect of Makeup Therapy on Behavioral and Psychological Symptoms of Dementia and Facial Appearance Analyzed by Artificial Intelligence Software. 国際誌

Koh Tadokoro, Toru Yamashita, Satoko Kawano, Junko Sato, Yoshio Omote, Mami Takemoto, Ryuta Morihara, Koichiro Nishiura, Natsuki Sagawa, Tomiko Tani, Koji Abe

Journal of Alzheimer's disease : JAD 83 ( 1 ) 57 - 63 2021年

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Possible benefits of makeup therapy, in terms of immediate and late effects on cognitive and affective functions, have not been fully proved for dementia patients. OBJECTIVE: To evaluate the immediate effect of makeup therapy on dementia patients. METHODS: Female nursing home residents with dementia received either only skin care treatment (control group, n = 17) or skin care plus makeup therapy treatment (makeup therapy group, n = 19). Cognitive, affective, and activity of daily living (ADL) scores were evaluated before and just after treatments. Apparent age and emotion were also evaluated with artificial intelligence (AI) software. RESULTS: Makeup therapy significantly improved Abe's behavioral and psychological symptoms of dementia (BPSD) score (ABS, *p < 0.05). AI software judged that makeup therapy significantly made the apparent age younger (*p < 0.05). In particular, patients with moderate ADL scores had a significantly higher happiness score in makeup therapy (*p < 0.05), with a modest correlation to the Mini-Mental State Examination (MMSE, r = 0.42, *p < 0.05). The severe baseline MMSE group reported a greater feeling of satisfaction following makeup therapy (*p < 0.05). CONCLUSION: The present makeup therapy is a promising non-pharmacological approach to immediately alleviate BPSD in female dementia patients, and the present AI software quickly and quantitatively evaluated the beneficial effects of makeup therapy on facial appearance.

DOI： 10.3233/JAD-210284

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Cerebral Microbleeds in Patients with Parkinson's Disease and Dementia with Lewy Bodies: Comparison Using Magnetic Resonance Imaging and 99 mTc-ECD SPECT Subtraction Imaging. 国際誌

Mami Takemoto, Toru Yamashita, Yasuyuki Ohta, Koh Tadokoro, Yoshio Omote, Ryuta Morihara, Koji Abe

Journal of Alzheimer's disease : JAD 80 ( 1 ) 331 - 335 2021年

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Cerebral microbleeds (CMBs) in patients with Parkinson's disease (PD) or dementia with Lewy bodies (DLB) have not been adequately studied. OBJECTIVE: This study aims to find a difference in the total number, prevalence, and common locations of CMBs between PD and DLB and evaluate 99 mTc-ECD SPECT subtraction images of these two diseases. METHODS: We examined 112 patients with PD (53 males and 59 females; age: 77.4±3.6 years) and 28 age-matched patients with DLB (15 males and 13 females; age: 77.1±6.7 years) using brain magnetic resonance imaging (MRI) and 99 mTc-ECD SPECT subtraction imaging. RESULTS: The total number of CMBs was higher in patients with DLB (41.2%) than in those with PD (11.5%), and the prevalence was significantly higher in the former (0.7±1.1) than the latter (0.2±0.5, p < 0.05). The odds ratio was 5.4 (95% confidence interval [CI]: 1.7-17.4). Furthermore, CMBs were commonly located in the basal ganglia of patients with PD (6 out of 87 patients) but in the occipital lobe of patients with DLB (8 out of 17 patients). 99 mTc-ECD SPECT subtraction imaging indicated lower cerebral blood flow in the posterior cingulate gyrus among the patients with CMB-positive DLB than among those with CMB-positive PD; additionally, the cerebral blood flow was lower in the bilateral basal ganglia and midbrain among patients with CMB-positive DLB compared to those with CMB-negative DLB. CONCLUSION: A reduction in occipital glucose metabolism may be related to CMBs in the occipital lobe of patients with DLB.

DOI： 10.3233/JAD-201495

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A case of tocilizumab-induced leukoencephalopathy with a reversible clinical course.

Sasaki R, Hishikawa N, Nomura E, Omote Y, Takemoto M, Yamashita T, Hatanaka N, Higashi Y, Abe K

Intern Med 59 ( 22 ) 2927 - 2930 2020年11月

Repeat sizes of NOP56 gene in a Japanese Asidan (SCA36) family with clinical anticipation. 国際誌

Ohta Y, Ikegami K, Sato K, Hishikawa N, Omote Y, Takemoto M, Yamashita T, Abe K

J Neurol Sci 418 117150 - 117150 2020年11月

ALS患者脊髄における低酸素ストレスを可視化する

山下徹, 畠山哲宗, 佐藤恒太, 福井裕介, 菱川望, 武本麻美, 太田康之, 西山佳宏, 河井信行, 田宮隆, 阿部康二

脳循環代謝 32 ( 1 ) 102 - 102 2020年11月

認知機能正常者ならびに軽度認知障害における認知症周辺症状の出現

角田慶一郎, 山下徹, 小坂田陽介, 佐々木諒, 田所功, 松本菜見子, 野村恵美, 森原隆太, 中野由美子, 高橋義秋, 幡中典子, 商敬偉, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 阿部康二

臨床神経学 60 ( Suppl. ) S445 - S445 2020年11月

アルツハイマー病患者の臨床的進行予測因子についての検討

菱川望, 表芳夫, 武本麻美, 太田康之, 山下徹, 阿部康二

臨床神経学 60 ( Suppl. ) S424 - S424 2020年11月

PDDとDLBの認知機能と情動機能、脳血流画像の比較検討

武本麻美, 田所功, 表芳夫, 菱川望, 太田康之, 山下徹, 阿部康二

臨床神経学 60 ( Suppl. ) S408 - S408 2020年11月

幹細胞移植による虚血脳のタンパク分解分子機構への影響

田所功, 福井裕介, 山下徹, 劉夏, 角田慶一郎, 商敬偉, 表芳夫, 武本麻美, 菱川望, 太田康之, 阿部康二

脳循環代謝 32 ( 1 ) 124 - 124 2020年11月

同種骨髄移植が有用であった大脳型に進展した副腎白質ジストロフィーの1例

表芳夫, 佐藤恒太, 浦田知宏, 藤井伸治, 下澤伸行, 山下徹, 武本麻美, 菱川望, 太田康之, 阿部康二

臨床神経学 60 ( Suppl. ) S416 - S416 2020年11月

Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis. 国際誌

Yamashita T, Kushida Y, Wakao S, Tadokoro K, Nomura E, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Dezawa M, Abe K

Scientific Reports 10 ( 1 ) 17102 - 17102 2020年10月

Direct arterial damage and neurovascular unit disruption by mechanical thrombectomy in a rat stroke model.

Sasaki R, Yamashita T, Tadokoro K, Matsumoto N, Nomura E, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K

J Neurosci Res 98 ( 10 ) 2018 - 2026 2020年10月

脳梗塞後に神経細胞を新たに生み出し再生を目指す脳内グリア細胞から神経細胞を誘導する新技術の確立

山下徹, 商敬偉, 中野由美子, 森原隆太, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 阿部康二

神経治療学 37 ( 6 ) S253 - S253 2020年10月

幹細胞移植による虚血脳のタンパク分解分子機構への影響

田所功, 福井裕介, 山下徹, 劉夏, 角田慶一郎, 商敬偉, 表芳夫, 武本麻美, 菱川望, 太田康之, 阿部康二

神経治療学 37 ( 6 ) S253 - S253 2020年10月

実は見逃されている血管性認知症の危険因子

山下徹, 野崎洋明, 涌谷陽介, 田所功, 野村恵美, 菱川望, 武本麻美, 太田康之, 小野寺理, 阿部康二

Dementia Japan 34 ( 4 ) 493 - 493 2020年10月

アルツハイマー病患者の主観的・客観的睡眠障害

田所功, 太田康之, 菱川望, 野村恵美, 涌谷陽介, 高尾芳樹, 表芳夫, 武本麻美, 山下徹, 阿部康二

Dementia Japan 34 ( 4 ) 477 - 477 2020年10月

Clinical anticipation of disease onset in a Japanese Asidan (SCA36) family. 国際誌

Ohta Y, Ikegami K, Sato K, Hishikawa N, Omote Y, Takemoto M, Yamashita T, Abe K

J Neurol Sci 416 ( 15 ) 117043 - 117043 2020年9月

A Case of Triple Seronegative Myasthenia Gravis with Graves’ Disease Ameliorated after the Removal of Enlarged Thymus with elevated uptake in fluorine‐18 fluorodeoxyglucose positron emission tomography.

Matsumoto N, Omote Y, Nakano Y, Takemoto M, Hishikawa N, Sato K, Ohta Y, Yamashita T, Toji T, Abe K

Neurol Clin Neurosci 8 ( 5 ) 313 - 316 2020年9月

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