研究者詳細 - 武本　麻美

論文 - 武本　麻美

分割表示 253 件中 61 - 80 件目／全件表示 >>

アルツハイマー病患者の不安定な精神状態へのより良い処方薬についての研究

武本麻美, 太田康之, 山下徹, 野村恵美, 表芳夫, 田所功, 佐々木諒, 松本菜見子, 角田慶一郎, 阿部康二

臨床神経学 61 ( Suppl. ) S300 - S300 2021年9月

Early detection of cognitive decline in mild cognitive impairment and Alzheimer's disease with a novel eye tracking test. 国際誌

Koh Tadokoro, Toru Yamashita, Yusuke Fukui, Emi Nomura, Yasuyuki Ohta, Setsuko Ueno, Saya Nishina, Keiichiro Tsunoda, Yosuke Wakutani, Yoshiki Takao, Takahiro Miyoshi, Yasuto Higashi, Yosuke Osakada, Ryo Sasaki, Namiko Matsumoto, Yuko Kawahara, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Ryuta Morihara, Koji Abe

Journal of the neurological sciences 427 117529 - 117529 2021年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Due to an increasing number of dementia patients, the development of a rapid and sensitive method for cognitive assessment is awaited. Here, we examined the usefulness of a novel and short (3 min) eye tracking device to evaluate the cognitive function of normal control (NC, n = 52), mild cognitive impairment (MCI, n = 52), and Alzheimer's disease (AD, n = 70) subjects. Eye tracking total score declined significantly in MCI (**p < 0.01 vs NC) and AD (**p < 0.01 vs NC, ##p < 0.01 vs MCI), and correlated well with the mini-mental state examination (MMSE) score (r = 0.57, *p < 0.05). Furthermore, the eye tracking test, especially memory and deductive reasoning tasks, effectively discriminated NC, MCI and AD. The present novel eye tracking test clearly discriminated cognitive functions among NC, MCI, and AD subjects, thereby providing an advantage for the early detection of MCI and AD in screening.

DOI： 10.1016/j.jns.2021.117529

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A case of rheumatoid meningoencephalitis induced by pembrolizumab

Chika Matsuoka, Yoshio Omote, Yuko Kawahara, Ryo Sasaki, Namiko Matsumoto, Ko Tadokoro, Yuki Taira, Mami Takemoto, Ryuta Morihara, Toru Yamashita, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 2021年8月

Switching the Proteolytic System from the Ubiquitin-Proteasome System to Autophagy in the Spinal Cord of an Amyotrophic Lateral Sclerosis Mouse Model. 国際誌

Koh Tadokoro, Toru Yamashita, Jingwei Shang, Yasuyuki Ohta, Emi Nomura, Ryuta Morihara, Yoshio Omote, Mami Takemoto, Koji Abe

Neuroscience 466 47 - 57 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

The degradation of damaged proteins takes place via two major proteolytic pathways: the ubiquitin-proteasome system (UPS) and autophagy. However, since it is unclear how these two proteolytic pathways contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS), we investigated the switching mechanism from UPS to autophagy by pharmacologically modifying these pathways by treating the spinal cords of female ALS mouse model bearing G93A human SOD1 (G93A mice) with MG132 or 3-methyladenine (3MA). G93A mice exhibited a progressive increase in the amount of ubiquitin and p62 aggregates, BAG3 expression, and LC3-II/LC3-I ratio in both astroglia and motor neurons. Treatment with MG132 or 3MA significantly increased the clinical hanging wire score and exacerbated α-motor neuron loss at 18 weeks in G93A mice, and increased the amount of ubiquitin, p62 aggregates, and BAG3 expression. This study's results demonstrate that the molecular switch from UPS to autophagy occurred not only in motor neurons but also in astroglia at the end stage (18 weeks) when the autophagic flux was impaired in G93A mice. This finding suggests that the defense system was disrupted against aggregate-prone protein production in ALS.

DOI： 10.1016/j.neuroscience.2021.04.034

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A Unique Case of Encephalopathy with an Elevated IgG-4 and Extremely High Interleukin-6 Level and Delayed Myelodysplastic Syndrome.

Namiko Matsumoto, Nozomi Hishikawa, Ken Ikegami, Kota Sato, Yoshio Omote, Mami Takemoto, Toru Yamashita, Kohei Taniguchi, Koji Abe

Internal medicine (Tokyo, Japan) 60 ( 13 ) 2125 - 2128 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

We herein report a 75-year-old man who developed disturbed consciousness with polynuclear cell dominant pleocytosis and low glucose and extremely high interleukin (IL)-6 levels in his cerebrospinal fluid. The biopsy specimen from his right supraclavicular lymph node showed the infiltration of inflammatory cells positive for IgG, IgG4 and IL-6. Prednisolone and azathioprine administered under suspicion of IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD) successfully remitted the symptoms. However, he developed myelodysplastic syndrome (MDS) and died 18 months later. The extremely high IL-6 may have been related to the rare neurological manifestations and development of MDS in the present case.

DOI： 10.2169/internalmedicine.6098-20

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The first case of chronic inflammatory demyelinating polyneuropathy after transsexualism and continuous testosterone administration

Yuki Taira, Yoshio Omote, Yuko Kawahara, Emi Nomura, Ryo Sasaki, Namiko Matsumoto, Chika Matsuoka, Mami Takemoto, Ryuta Morihara, Nozomi Hishikawa, Toru Yamashita, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 9 ( 4 ) 346 - 348 2021年7月

AIを用いたパーキンソン病患者の見た目年齢・感情の評価

田所功, 山下徹, 福井裕介, 武本麻美, 佐々木諒, 松本菜見子, 野村恵美, 森原隆太, 表芳夫, 阿部康二

パーキンソン病・運動障害疾患コングレスプログラム・抄録集 15回 81 - 81 2021年7月

Author Correction: Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis. 国際誌

Toru Yamashita, Yoshihiro Kushida, Shohei Wakao, Koh Tadokoro, Emi Nomura, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Mari Dezawa, Koji Abe

Scientific reports 11 ( 1 ) 12828 - 12828 2021年6月

Hypoxic stress visualized in the cervical spinal cord of ALS patients. 国際誌

Yamashita T, Hatakeyama T, Sato K, Fukui Y, Hishikawa N, Takemoto M, Ohta Y, Nishiyama Y, Kawai N, Tamiya T, Abe K

Neurol Res 43 ( 6 ) 429 - 433 2021年6月

ALS患者における低酸素ストレスを可視化する

山下徹, 畠山哲宗, 佐藤恒太, 福井裕介, 菱川望, 武本麻美, 太田康之, 西山佳宏, 河井信行, 田宮隆, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 21回 214 - 214 2021年6月

化粧美容セラピーの認知・情動機能改善効果

田所功, 川野公子, 佐藤順子, 谷都美子, 表芳夫, 武本麻美, 森原隆太, 山下徹, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 21回 211 - 211 2021年6月

AIを用いたパーキンソン病の顔についての解析

田所功, 山下徹, 福井裕介, 武本麻美, 佐々木諒, 松本菜見子, 野村恵美, 表芳夫, 森原隆太, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 21回 222 - 222 2021年6月

AIによる新しい脳機能・認知症診断 AIなどの新たな技術を活用した認知症診療

田所功, 佐々木諒, 松本菜見子, 福井裕介, 表芳夫, 武本麻美, 森原隆太, 山下徹, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 21回 155 - 155 2021年6月

ALS患者における低酸素ストレスを可視化する

山下徹, 畠山哲宗, 佐藤恒太, 福井裕介, 菱川望, 武本麻美, 太田康之, 西山佳宏, 河井信行, 田宮隆, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 21回 214 - 214 2021年6月

Neuroprotective effect of CuATSM in mice stroke model by ameliorating oxidative stress. 国際誌

Shi X, Ohta Y, Nakano Y, Liu X, Tadokoro K, Feng T, Nomura E, Tsunoda K, Sasaki R, Matsumoto N, Osakada Y, Bian Y, Bian Z, Omote Y, Takemoto M, Hishikawa N, Yamashita T, Abe K

Neuroscience Res 166 55 - 61 2021年5月

Positive baseline behavioral and psychological symptoms of dementia predict a subsequent cognitive impairment in cognitively normal population

Keiichiro Tsunoda, Toru Yamashita, Yosuke Osakada, Ryo Sasaki, Koh Tadokoro, Namiko Matsumoto, Emi Nomura, Noriko Hatanaka, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 9 ( 3 ) 218 - 222 2021年5月

4-Hydroxyl-2-Nonenal Localized Expression Pattern in Retrieved Clots is Associated with Large Artery Atherosclerosis in Stroke Patients. 国際誌

Yosuke Osakada, Toru Yamashita, Ryuta Morihara, Namiko Matsumoto, Ryo Sasaki, Koh Tadokoro, Emi Nomura, Yuko Kawahara, Yoshio Omote, Nozomi Hishikawa, Mami Takemoto, Yasuyuki Ohta, Yasuki Suruga, Takayuki Nagase, Yuji Takasugi, Satoshi Inoue, Kyoichi Watanabe, Kentaro Deguchi, Koji Tokunaga, Susumu Sasada, Kazuki Kobayashi, Ryosuke Maeoka, Kenji Fukutome, Kenkichi Takahashi, Hiroyuki Ohnishi, Yoshihiro Kuga, Hideyuki Ohnishi, Koji Abe

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 30 ( 3 ) 105583 - 105583 2021年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: The relationship between stroke etiology and clot pathology remains controversial. MATERIALS AND METHODS: We performed histological analysis of clots retrieved from 52 acute ischemic stroke patients using hematoxylin and eosin staining and immunohistochemistry (CD42b and oxidative/hypoxic stress markers). The correlations between clot composition and the stroke etiological group (i.e., cardioembolic, cryptogenic, or large artery atherosclerosis) were assessed. RESULTS: Of the 52 clots analyzed, there were no significant differences in histopathologic composition (e.g., white blood cells, red blood cells, fibrin, and platelets) between the 3 etiological groups (P = .92). By contrast, all large artery atherosclerosis clots showed a localized pattern with the oxidative stress marker 4-hydroxyl-2-nonenal (P < .01). From all 52 clots, 4-hydroxyl-2-nonenal expression patterns were localized in 28.8% of clots, diffuse in 57.7% of clots, and no signal in 13.5% of clots. CONCLUSIONS: A localized pattern of 4-hydroxyl-2-nonenal staining may be a novel and effective marker for large artery atherosclerosis (sensitivity 100%, specificity 82%).

DOI： 10.1016/j.jstrokecerebrovasdis.2020.105583

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A new telestroke network system in northern area of Okayama prefecture

Ryo Sasaki, Toru Yamashita, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Taijun Yunoki, Kazuki Kobayashi, Takashi Sawata, Yuki Sato, Junichi Kubota, Masayuki Mizobuchi, Takashi Hayashi, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 9 ( 2 ) 166 - 170 2021年3月

The Oldest Japanese Case of Combined Central and Peripheral Demyelination, which Developed Nine Years After the First Instance of Optic Neuritis.

Nomura E, Kawahara Y, Omote Y, Tadokoro K, Takemoto M, Hishikawa N, Yamashita T, Ogata H, and Abe K

Intern Med 60 ( 2 ) 305 - 308 2021年1月

A case of autoimmune GFAP astrocytopathy with profound weight loss and increased uptake in the spinal cord on 18F‐FDG PET.

Osakada Y, Omote Y, Ikegami K, Tadokoro K, Sato k, Hishikawa N, Takemoto M, Ohta Y, Yamashita T, Kimura A, Abe K

Neurology Clinical Neurosci 9 ( 1 ) 95 - 97 2021年1月

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論文 - 武本　麻美