研究者詳細 - 武本　麻美

論文 - 武本　麻美

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ATXN2遺伝子のCAGリピートをホモ接合性に有し同胞と臨床病型が異なりパーキンソニズムと痙性を呈した症例

小坂田陽介, 松岡千加, 中田有美, 佐々木諒, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 山下徹, 石浦浩之

臨床神経学 64 ( 10 ) 755 - 755 2024年10月

当院における2家系のSCAR8の検討

柚木太淳, 松岡千加, 小坂田陽介, 中野由美子, 武本麻美, 森原隆太, 山下徹, 石浦浩之

臨床神経学 64 ( 10 ) 751 - 751 2024年10月

レカネマブ治療に伴うAPOE遺伝子型検査の実際

森原隆太, 小坂田陽介, 池上憲, 平祐貴, 石田将大, 樹下明典, 柚木太淳, 武本麻美, 野村恵美, 河野智仁, 松岡千加, 山下徹, 加藤芙美乃, 深野智華, 平沢晃, 石浦浩之

Dementia Japan 38 ( 4 ) 681 - 681 2024年10月

髄液中抗MOG抗体を指標にIVIGによる維持療法を行った再発性MOGADの一例

池上憲, 佐々木諒, 石田将大, 樹下明典, 平祐貴, 小坂田陽介, 武本麻美, 森原隆太, 柚木太淳, 山下徹, 石浦浩之

神経免疫学 29 ( 1 ) 262 - 262 2024年10月

Suppression of PTBP1 in hippocampal astrocytes promotes neurogenesis and ameliorates recognition memory in mice with cerebral ischemia. 国際誌

Yusuke Fukui, Ryuta Morihara, Xinran Hu, Yumiko Nakano, Taijun Yunoki, Mami Takemoto, Koji Abe, Toru Yamashita

Scientific reports 14 ( 1 ) 20521 - 20521 2024年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

The therapeutic potential of suppressing polypyrimidine tract-binding protein 1 (Ptbp1) messenger RNA by viral transduction in a post-stroke dementia mouse model has not yet been examined. In this study, 3 days after cerebral ischemia, we injected a viral vector cocktail containing adeno-associated virus (AAV)-pGFAP-mCherry and AAV-pGFAP-CasRx (control vector) or a cocktail of AAV-pGFAP-mCherry and AAV-pGFAP-CasRx-SgRNA-(Ptbp1) (1:5, 1.0 × 1011 viral genomes) into post-stroke mice via the tail vein. We observed new mCherry/NeuN double-positive neuron-like cells in the hippocampus 56 days after cerebral ischemia. A portion of mCherry/GFAP double-positive astrocyte-like glia could have been converted into new mCherry/NeuN double-positive neuron-like cells with morphological changes. The new neuronal cells integrated into the dentate gyrus and recognition memory was significantly ameliorated. These results demonstrated that the in vivo conversion of hippocampal astrocyte-like glia into functional new neurons by the suppression of Ptbp1 might be a therapeutic strategy for post-stroke dementia.

DOI： 10.1038/s41598-024-71212-w

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Protective effect of scallop-derived plasmalogen against vascular dysfunction, via the pSTAT3/PIM1/NFATc1 axis, in a novel mouse model of Alzheimer's disease with cerebral hypoperfusion. 国際誌

Yun Zhai, Ryuta Morihara, Tian Feng, Xinran Hu, Yusuke Fukui, Zhihong Bian, Yuting Bian, Haibo Yu, Hongming Sun, Mami Takemoto, Yumiko Nakano, Taijun Yunoki, Ying Tang, Hiroyuki Ishiura, Toru Yamashita

Brain research 1828 148790 - 148790 2024年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

A strong relationship between Alzheimer's disease (AD) and vascular dysfunction has been the focus of increasing attention in aging societies. In the present study, we examined the long-term effect of scallop-derived plasmalogen (sPlas) on vascular remodeling-related proteins in the brain of an AD with cerebral hypoperfusion (HP) mouse model. We demonstrated, for the first time, that cerebral HP activated the axis of the receptor for advanced glycation endproducts (RAGE)/phosphorylated signal transducer and activator of transcription 3 (pSTAT3)/provirus integration site for Moloney murine leukemia virus 1 (PIM1)/nuclear factor of activated T cells 1 (NFATc1), accounting for such cerebral vascular remodeling. Moreover, we also found that cerebral HP accelerated pSTAT3-mediated astrogliosis and activation of the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome, probably leading to cognitive decline. On the other hand, sPlas treatment attenuated the activation of the pSTAT3/PIM1/NFATc1 axis independent of RAGE and significantly suppressed NLRP3 inflammasome activation, demonstrating the beneficial effect on AD.

DOI： 10.1016/j.brainres.2024.148790

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A Unique Case of Sarcoid-associated Myelopathy Accompanied by Lung Cancer.

Koh Tadokoro, Yumi Nakada, Ryo Sasaki, Yumiko Nakano, Taijun Yunoki, Kotaro Shin, Masataka Taoka, Kiichiro Ninomiya, Emi Nomura, Mami Takemoto, Ryuta Morihara, Toru Yamashita

Internal medicine (Tokyo, Japan) 62 ( 23 ) 3531 - 3535 2023年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

The differential diagnosis of myelopathy in patients with malignancies may be challenging, as a spinal biopsy is not always applicable. A 66-year-old woman who had shown transient double vision and nausea developed spasticity and impaired deep sensation in both feet. Magnetic resonance imaging showed abnormal gadolinium enhancement of the brainstem, spinal meninges, and nerve root. Cerebrospinal fluid (CSF) revealed mild pleocytosis and elevated protein and decreased glucose levels, although CSF cytology was normal. Lung carcinoma was simultaneously detected, and noncaseating granuloma was detected from the hilar and axillary lymph nodes, so she was diagnosed with sarcoid-associated myelopathy. Her symptoms were kept stable by intravenous methylprednisolone, oral prednisolone, and methotrexate. This is the first case of sarcoid-associated myelopathy accompanied by lung cancer, suggesting the importance of clinical course, repetitive CSF cytology, and a biopsy of the lymph nodes to distinguish sarcoid-associated myelopathy from meningeal metastasis in patients with malignancies.

DOI： 10.2169/internalmedicine.0943-22

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視線計測計を用いた認知機能検査の有用性

田所功, 福井裕介, 野村恵美, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 阿部康二, 山下徹

日本老年医学会雑誌 60 ( 4 ) 476 - 477 2023年10月

神経疾患患者における遠隔診療のニーズ調査

佐々木諒, 田所功, 福井裕介, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 山下徹

臨床神経学 63 ( Suppl. ) S261 - S261 2023年9月

Foix-Chavany-Marie症候群を呈した持続性部分てんかんの一例

佐々木諒, 柚木太淳, 中田有美, 松岡千加, 田所功, 中野由美子, 武本麻美, 森原隆太, 山下徹, 石浦浩之

臨床神経学 63 ( 9 ) 620 - 620 2023年9月

脊髄性筋萎縮症患者7名に対するリスジプラムの治療効果

山下徹, 柚木太淳, 中田有美, 松岡千加, 佐々木涼, 田所功, 中野由美子, 武本麻美, 森原隆太, 石浦浩之

臨床神経学 63 ( Suppl. ) S215 - S215 2023年9月

エフガルチギモドへのスイッチを行った抗アセチルコリン受容体抗体・抗横紋筋抗体陽性の全身型重症筋無力症の一例

中野由美子, 佐々木諒, 中田有美, 松岡千加, 小坂田陽介, 田所功, 野村恵美, 柚木太淳, 武本麻美, 森原隆太, 山下徹, 石浦浩之

臨床神経学 63 ( 9 ) 621 - 621 2023年9月

エフガルチギモドへのスイッチを行った抗アセチルコリン受容体抗体・抗横紋筋抗体陽性の全身型重症筋無力症の一例

中野由美子, 佐々木諒, 中田有美, 松岡千加, 小坂田陽介, 田所功, 野村恵美, 柚木太淳, 武本麻美, 森原隆太, 山下徹, 石浦浩之

臨床神経学 63 ( 9 ) 621 - 621 2023年9月

脊髄性筋萎縮症患者7名に対するリスジプラムの治療効果

山下徹, 柚木太淳, 中田有美, 松岡千加, 佐々木涼, 田所功, 中野由美子, 武本麻美, 森原隆太, 石浦浩之

臨床神経学 63 ( Suppl. ) S215 - S215 2023年9月

神経疾患患者における遠隔診療のニーズ調査

佐々木諒, 田所功, 福井裕介, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 山下徹

臨床神経学 63 ( Suppl. ) S261 - S261 2023年9月

Foix-Chavany-Marie症候群を呈した持続性部分てんかんの一例

佐々木諒, 柚木太淳, 中田有美, 松岡千加, 田所功, 中野由美子, 武本麻美, 森原隆太, 山下徹, 石浦浩之

臨床神経学 63 ( 9 ) 620 - 620 2023年9月

ADSSL1遺伝子変異を認め心不全を発症したが早期介入にて改善しえたネマリンミオパチーの一例

柚木太淳, 中野由美子, 野村恵美, 中田有美, 佐々木諒, 田所功, 武本麻美, 森原隆太, 山下徹, 斎藤良彦, 西野一三

臨床神経学 63 ( 5 ) 322 - 322 2023年5月

ADSSL1遺伝子変異を認め心不全を発症したが早期介入にて改善しえたネマリンミオパチーの一例

柚木太淳, 中野由美子, 野村恵美, 中田有美, 佐々木諒, 田所功, 武本麻美, 森原隆太, 山下徹, 斎藤良彦, 西野一三

臨床神経学 63 ( 5 ) 322 - 322 2023年5月

Neuroprotective effects of carnosine in a mice stroke model concerning oxidative stress and inflammatory response. 国際誌

Xinran Hu, Yusuke Fukui, Tian Feng, Zhihong Bian, Haibo Yu, Ryuta Morihara, Xiao Hu, Yuting Bian, Hongming Sun, Mami Takemoto, Yumiko Nakano, Taijun Yunoki, Koji Abe, Toru Yamashita

Journal of the neurological sciences 447 120608 - 120608 2023年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Carnosine (β-alanyl-L-histidine) is a natural dipeptide with multiple neuroprotective properties. Previous studies have advertised that carnosine scavenges free radicals and displays anti-inflammatory activity. However, the underlying mechanism and the efficacies of its pleiotropic effect on prevention remained obscure. In this study, we aimed to investigate the anti-oxidative, anti-inflammative, and anti-pyroptotic effects of carnosine in the transient middle cerebral artery occlusion (tMCAO) mouse model. After a daily pre-treatment of saline or carnosine (1000 mg / kg / day) for 14 days, mice (n = 24) were subjected to tMCAO for 60 min and continuously treated with saline or carnosine for additional 1 and 5 days after reperfusion. The administration of carnosine significantly decreased infarct volume 5 days after the tMCAO (*p < 0.05) and effectively suppressed the expression of 4-HNE, 8-OHdG, Nitrotyrosine 5 days, and RAGE 5 days after tMCAO. Moreover, the expression of IL-1β was also significantly suppressed 5 days after tMCAO. Our present findings demonstrated that carnosine effectively relieves oxidative stress caused by ischemic stroke and significantly attenuates neuroinflammatory responses related to IL-1β, suggesting that carnosine can be a promising therapeutic strategy for ischemic stroke.

DOI： 10.1016/j.jns.2023.120608

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A young female case of asymptomatic immune-mediated necrotizing myopathy: a potential diagnostic option of antibody testing for rhabdomyolysis. 国際誌

Ryo Sasaki, Taijun Yunoki, Yumiko Nakano, Yusuke Fukui, Mami Takemoto, Ryuta Morihara, Eri Katsuyama, Ichizo Nishino, Toru Yamashita

Neuromuscular disorders : NMD 33 ( 2 ) 183 - 186 2023年2月

記述言語：英語

Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) immune-mediated necrotizing myopathy (IMNM) is a neuromuscular disorder that presents muscle weakness in proximal extremities and/or the trunk with an elevation of creatine kinase (CK). Young and asymptomatic anti-HMGCR IMNM patients are very rare and a treatment regimen has not been established. The present case, a 17-year-old woman without any muscular symptoms, only showed hyperCKemia that was detected by chance. After close examinations, including a muscle biopsy and antibody search, she was diagnosed as anti-HMGCR IMNM, and initial treatment with methotrexate and continuous intravenous immunoglobulin seemed to be effective. The present case is the unusually young asymptomatic case of anti-HMGCR IMNM. The diagnosis was successfully made, leading to the early introduction of a treatment. Given the course of this case, we believe that the preceding antibody testing is one of the diagnostic option for rhabdomyolysis.

DOI： 10.1016/j.nmd.2022.12.012

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Human Cord Blood-Endothelial Progenitor Cells Alleviate Intimal Hyperplasia of Arterial Damage in a Rat Stroke Model. 国際誌

Hongming Sun, Ryuta Morihara, Tian Feng, Zhihong Bian, Haibo Yu, Xiao Hu, Xinran Hu, Yuting Bian, Ryo Sasaki, Yusuke Fukui, Mami Takemoto, Taijun Yunoki, Yumiko Nakano, Koji Abe, Toru Yamashita

Cell transplantation 32 9636897231193069 - 9636897231193069 2023年

記述言語：英語掲載種別：研究論文（学術雑誌）

Human cord blood-endothelial progenitor cells (hCB-EPCs) isolated from the human umbilical cord can be used to repair damaged arteries. In this study, we used an animal model with pathological changes that mimics artery wall damage caused by stent retrievers in humans. We injected hCB-EPCs to investigate their effect on endothelial hyperplasia and dysfunction during intimal repair. Four groups were established based on the length of reperfusion (3 and 28 days), as well as the presence or absence of hCB-EPC therapy. Damage to the internal carotid artery was evaluated by hematoxylin-eosin and immunohistochemical staining. Stroke volume was not significantly different between non-EPC and EPC groups although EPC treatment alleviated intimal hyperplasia 28 days after intimal damage. Vascular endothelial growth factor (VEGF) and eNOS expression were significantly higher in the EPC-treated group than in the non-EPC group 3 days after intimal damage. In addition, MMP9 and 4HNE expression in the EPC-treated group was significantly lower than in the non-EPC group. Ultimately, this study found that venous transplantation of hCB-EPCs could inhibit neointimal hyperplasia, alleviate endothelial dysfunction, suppress intimal inflammation, and reduce oxidative stress during healing of intimal damage.

DOI： 10.1177/09636897231193069

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Tocovid Attenuated Oxidative Stress and Cognitive Decline by Inhibiting Amyloid-β-Induced NOX2 Activation in Alzheimer's Disease Mice. 国際誌

Zhihong Bian, Haibo Yu, Xinran Hu, Yuting Bian, Hongming Sun, Koh Tadokoro, Mami Takemoto, Taijun Yunoki, Yumiko Nakano, Yusuke Fukui, Ryuta Morihara, Koji Abe, Toru Yamashita

Journal of Alzheimer's disease : JAD 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: NADPH oxidase 2 (NOX2) is an important source of reactive oxygen species (ROS). Activated NOX2 may contribute to Alzheimer's disease (AD). Our previous studies showed that a novel vitamin E mixture, Tocovid, had potential neuroprotective effects in a stroke mice model and an AD cell model. OBJECTIVE: The aim of this study was two-fold: to assess whether long-term Tocovid treatment can regulate NOX2, and the therapeutic effects of long-term administration of Tocovid to an AD mice model. METHODS: Therapeutic effects of long-term administration of Tocovid (200 mg/kg /day) on an Aβ-overexpressed transgenic AD mice model (APP23, n = 8) was investigated. The therapeutic effect of Tocovid in 16-month-old mice compared with the no-treatment APP23 group (n = 9) was assessed. RESULTS: Tocovid treatment strongly improved motor and memory deficits of APP23 mice by attenuating NOX2 expression, oxidative stress, neuroinflammation, neurovascular unit dysfunction, synaptic alteration, and Aβ deposition after 16 months. CONCLUSION: These findings suggest that NOX2 is a potential target in AD pathology. Long-term administration of Tocovid may be a promising candidate for AD treatment.

DOI： 10.3233/JAD-220761

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Actual Telemedicine Needs of Japanese Patients with Neurological Disorders in the COVID-19 Pandemic.

Ryo Sasaki, Taijun Yunoki, Yumiko Nakano, Yusuke Fukui, Mami Takemoto, Ryuta Morihara, Koji Abe, Toru Yamashita

Internal medicine (Tokyo, Japan) 62 ( 3 ) 365 - 371 2022年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Objective During the coronavirus disease 2019 (COVID-19) pandemic, many social activities have moved online using applications for digital devices (e.g. computers, smartphones). We investigated the needs of telemedicine and trends in medical status and social care situations of Japanese patients with neurological disorders in order to estimate their affinity for an online telemedicine application. Methods We designed an original questionnaire for the present study that asked participants what problems they had with hospital visits, how the COVID-19 pandemic had affected their lives, and whether or not they would like to receive telemedicine. Patients The present study included volunteer caregivers, participants with Parkinson's disease (PD), epilepsy, stroke, dementia, immune-mediated neurological disease (IMMD), spinocerebellar degeneration (SCD), amyotrophic lateral sclerosis (ALS), headache, myopathy, and other neurological diseases from Okayama University Hospital. Results A total of 29.6% of patients wanted to use telemedicine. Patients with headaches (60.0%) and epilepsy (38.1%) were more likely to want to use telemedicine than patients with PD (17.8%) or stroke (19.0%). Almost 90% of patients had access to a digital device, and there was no association between favoring telemedicine, ownership of a digital device, hospital visiting time, or waiting time at the hospital, although age was associated with motivation to telemedicine use (52.6 vs. 62.2 years old, p <0.001*). Conclusion We can contribute to the management of the COVID-19 pandemic and the medical economy by promoting telemedicine, especially for young patients with headaches or epilepsy.

DOI： 10.2169/internalmedicine.9702-22

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Novel <scp> ABCD1 </scp> mutation detected in a symptomatic female carrier of adrenoleukodystrophy

Yumiko Nakano, Yuki Taira, Ryo Sasaki, Koh Tadokoro, Taijun Yunoki, Emi Nomura, Yusuke Fukui, Mami Takemoto, Ryuta Morihara, Nobuyuki Shimozawa, Toru Yamashita

Neurology and Clinical Neuroscience 2022年10月

Anti-oxidative and the anti-inflammatory response of carnosine in a mice stroke model(和訳中)

胡欣冉, 阿部康二, 福井裕介, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 山下徹

脳循環代謝 34 ( 1 ) 153 - 153 2022年10月

視線計測計を用いた認知機能障害の早期スクリーニング

福井裕介, 田所功, 野村恵美, 涌谷陽介, 高尾芳樹, 東靖人, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 阿部康二, 山下徹

脳循環代謝 34 ( 1 ) 150 - 150 2022年10月

Efficiency of Plasmalogen in a Mouse Model of Alzheimer's Disease with Cerebral Hypoperfusion(和訳中)

Zhai Yun, Feng Tian, 胡欣冉, 福井裕介, 卞之宏, Bian Yuting, 孫洪銘, 武本麻美, 柚木太淳, 中野由美子, 森原隆太, 阿部康二, 山下徹

脳循環代謝 34 ( 1 ) 160 - 160 2022年10月

Rivaroxaban attenuated amyloid pathology and neuroinflammation by inhibiting PAR-1/PAR-2 in AD mice(和訳中)

Bian Zhihong, Liu Xia, Yu Haibo, Hu Xinran, Bian Yuting, Sun Hongming, 田所功, 武本麻美, 柚木太淳, 中野由美子, 福井裕介, 森原隆太, 阿部康二, 山下徹

脳循環代謝 34 ( 1 ) 158 - 158 2022年10月

腺性自己免疫症候群3型に抗MOG抗体関連急性脊髄炎を合併した一例

柚木太淳, 中野由美子, 中田有美, 佐々木諒, 田所功, 武本麻美, 森原隆太, 山下徹

臨床神経学 62 ( 10 ) 824 - 824 2022年10月

髄液検体から診断に至った再発性の抗MOG抗体関連疾患の2症例

中野由美子, 佐々木諒, 中田有美, 田所功, 柚木太淳, 野村恵美, 武本麻美, 森原隆太, 山下徹

臨床神経学 62 ( 10 ) 824 - 824 2022年10月

腺性自己免疫症候群3型に抗MOG抗体関連急性脊髄炎を合併した一例

柚木太淳, 中野由美子, 中田有美, 佐々木諒, 田所功, 武本麻美, 森原隆太, 山下徹

臨床神経学 62 ( 10 ) 824 - 824 2022年10月

視線計測計Gazefinderを用いた認知症診断の可能性

田所功, 福井裕介, 野村恵美, 涌谷陽介, 高尾芳樹, 東靖人, 小坂田陽介, 松本菜見子, 佐々木諒, 武本麻美, 菱川望, 森原隆太, 阿部康二, 山下徹

臨床神経学 62 ( Suppl. ) S323 - S323 2022年10月

髄液検体から診断に至った再発性の抗MOG抗体関連疾患の2症例

中野由美子, 佐々木諒, 中田有美, 田所功, 柚木太淳, 野村恵美, 武本麻美, 森原隆太, 山下徹

臨床神経学 62 ( 10 ) 824 - 824 2022年10月

視線計測計を用いた認知機能障害の早期スクリーニング

福井裕介, 田所功, 野村恵美, 涌谷陽介, 高尾芳樹, 東靖人, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 阿部康二, 山下徹

脳循環代謝 34 ( 1 ) 150 - 150 2022年10月

脳梗塞モデルマウスにおけるカルノシンの抗酸化作用と抗炎症作用(Anti-oxidative and the anti-inflammatory response of carnosine in a mice stroke model)

胡欣冉, 阿部康二, 福井裕介, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 山下徹

脳循環代謝 34 ( 1 ) 153 - 153 2022年10月

RivaroxabanはADマウスのPAR-1/PAR-2阻害によりアミロイド病態と神経炎症を抑制する(Rivaroxaban attenuated amyloid pathology and neuroinflammation by inhibiting PAR-1/PAR-2 in AD mice)

Bian Zhihong, Liu Xia, Yu Haibo, Hu Xinran, Bian Yuting, Sun Hongming, 田所功, 武本麻美, 柚木太淳, 中野由美子, 福井裕介, 森原隆太, 阿部康二, 山下徹

脳循環代謝 34 ( 1 ) 158 - 158 2022年10月

脳低灌流を伴うアルツハイマー病モデルマウスにおけるプラズマローゲンの有効性(Efficiency of Plasmalogen in a Mouse Model of Alzheimer's Disease with Cerebral Hypoperfusion)

Zhai Yun, Feng Tian, 胡欣冉, 福井裕介, 卞之宏, Bian Yuting, 孫洪銘, 武本麻美, 柚木太淳, 中野由美子, 森原隆太, 阿部康二, 山下徹

脳循環代謝 34 ( 1 ) 160 - 160 2022年10月

Japanese case of Charcot-Marie-Tooth disease type 2Z with severe retinitis pigmentosa

Emi Nomura, Koh Tadokoro, Ryo Sasaki, Yumi Nakata, Yumiko Nakano, Taijun Yunoki, Mami Takemoto, Ryuta Morihara, Masahiro Ando, Hiroshi Takashima, Toru Yamashita

NEUROLOGY AND CLINICAL NEUROSCIENCE 10 ( 5 ) 266 - 268 2022年9月

A case of successful renal transplantation of Charcot-Marie-Tooth disease associated with FSGS due to mutation of the INF2 gene

Chika Matsuoka, Yuki Taira, Ryo Sasaki, Namiko Matsumoto, Koh Tadokoro, Emi Nomura, Yuko Kawahara, Mami Takemoto, Ryuta Morihara, Akihiro Hashiguchi, Hiroshi Takashima, Hidemi Takeuchi, Motoo Araki, Koji Abe, Toru Yamashita

Neurology and Clinical Neuroscience 10 ( 5 ) 252 - 254 2022年9月

A Japanese case of successful surgical resection of cerebral cavernous malformations with a CCM2 mutation

Emi Nomura, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yumiko Nakano, Taijun Yunoki, Ryuta Morihara, Tatsuya Sasaki, Hiroyuki Akagawa, Koji Abe, Toru Yamashita

NEUROLOGY AND CLINICAL NEUROSCIENCE 2022年6月

ADマウスとヒトAD脳における、Aβ沈着を伴ったフィブリノゲンペプチド鎖集積の加速(Acceleration of the accumulation of fibrinogen peptide chains with Aβ deposition in AD mice and human AD brains)

卞之宏, 山下徹, 于海波, 胡欣冉, 卞宇てい, 孫洪銘, 田所功, 武本麻美, 森原隆太, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 22回 221 - 221 2022年6月

視線計測計を用いた認知症の早期発見

田所功, 福井裕介, 野村恵美, 涌谷陽介, 高尾芳樹, 東靖人, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 阿部康二, 山下徹

日本抗加齢医学会総会プログラム・抄録集 22回 208 - 208 2022年6月

ホヤ由来プラズマローゲンの脳梗塞モデルマウスにおける高酸化ストレス・抗炎症作用の検討

福井裕介, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 山下徹, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 22回 224 - 224 2022年6月

虚血性脳卒中モデルマウスにてホタテ由来プラズマローゲンは酸化ストレスと炎症を阻害する(Scallop-derived plasmalogen prevent oxidative stress and inflammation in a mouse model of ischemic stroke)

胡欣冉, 阿部康二, 田馮, 福井裕介, 田所功, 卞之宏, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 山下徹

日本抗加齢医学会総会プログラム・抄録集 22回 252 - 252 2022年6月

Clinical and Pathological Benefits of Scallop-Derived Plasmalogen in a Novel Mouse Model of Alzheimer's Disease with Chronic Cerebral Hypoperfusion. 国際誌

Tian Feng, Xinran Hu, Yusuke Fukui, Zhihong Bian, Yuting Bian, Hongming Sun, Mami Takemoto, Taijun Yunoki, Yumiko Nakano, Ryuta Morihara, Koji Abe, Toru Yamashita

Journal of Alzheimer's disease : JAD 86 ( 4 ) 1973 - 1982 2022年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The oral ingestion of scallop-derived plasmalogen (sPlas) significantly improved cognitive function in Alzheimer's disease (AD) patients. OBJECTIVE: However, the effects and mechanisms of sPlas on AD with chronic cerebral hypoperfusion (CCH), a class of mixed dementia contributing to 20-30% among the dementia society, were still elusive. METHODS: In the present study, we applied a novel mouse model of AD with CCH to investigate the potential effects of sPlas on AD with CCH. RESULTS: The present study demonstrated that sPlas significantly recovered cerebral blood flow, improved motor and cognitive deficits, reduced amyloid-β pathology, regulated neuroinflammation, ameliorated neural oxidative stress, and inhibited neuronal loss in AD with CCH mice at 12 M. CONCLUSION: These findings suggest that sPlas possesses clinical and pathological benefits for AD with CCH in the novel model mice. Furthermore, sPlas could have promising prevention and therapeutic effects on patients of AD with CCH.

DOI： 10.3233/JAD-215246

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A case of a heterozygous ABCC6 mutation showing recurrent ischemic strokes and intracranial hemorrhages

Emi Nomura, Yuko Kawahara, Yoshio Omote, Yoshiaki Takahashi, Namiko Matsumoto, Ken Ikegami, Mami Takemoto, Nozomi Hishikawa, Yumiko Nakano, Taijun Yunoki, Ryuta Morihara, Masahiro Uemura, Koji Abe, Toru Yamashita

Neurology and Clinical Neuroscience 10 ( 2 ) 98 - 101 2022年3月

Efficacy and safety of spot heating and ultrasound irradiation on in vitro and in vivo thrombolysis models. 国際誌

Ryuta Morihara, Toru Yamashita, Yosuke Osakada, Tian Feng, Xinran Hu, Yusuke Fukui, Koh Tadokoro, Mami Takemoto, Koji Abe

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 42 ( 7 ) 271678X221079127 - 1334 2022年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

The feasibility of transcranial sonothrombolysis has been demonstrated, although little is known about the relationships between thermal or mechanical mechanisms and thrombolytic outcomes. Therefore, the present study aims to reveal the effect and safety of temperature and ultrasound through in vitro and in vivo thrombolysis models. Artificial clots in microtubes were heated in a water bath or sonicated by ultrasound irradiation, and then clots weight decrease with rising temperature and sonication time was confirmed. In the in vitro thrombotic occlusion model, based on spot heating, clot volume was reduced and clots moved to the distal side, followed by recanalization of the occlusion. In the in vivo study, the common carotid artery of rats was exposed to a spot heater or to sonication. No brain infarct or brain blood barrier disruption was shown, but endothelial junctional dysintegrity and an inflammatory response in the carotid artery were detected. The present spot heating and ultrasound irradiation models seem to be effective for disintegrating clots in vitro, but the safety of the in vivo model was not fully supported by the data. However, the data indicates that a shorter time exposure could be less invasive than a longer exposure.

DOI： 10.1177/0271678X221079127

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Protective Effect of Rivaroxaban Against Amyloid Pathology and Neuroinflammation Through Inhibiting PAR-1 and PAR-2 in Alzheimer's Disease Mice. 国際誌

Zhihong Bian, Xia Liu, Tian Feng, Haibo Yu, Xiao Hu, Xinran Hu, Yuting Bian, Hongming Sun, Koh Tadokoro, Mami Takemoto, Taijun Yunoki, Yumiko Nakano, Yusuke Fukui, Ryuta Morihara, Koji Abe, Toru Yamashita

Journal of Alzheimer's disease : JAD 86 ( 1 ) 111 - 123 2022年

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Recent studies have revealed that atrial fibrillation (AF) patients have a high risk of developing cognitive impairment, vascular dementia, and Alzheimer's disease (AD). Some reports suggest that the application of oral anticoagulant with an appropriate dose may have a preventive effect on AD. However, which oral anticoagulant drug is more appropriate for preventing AD and the underlying mechanism(s) is still unknown. OBJECTIVE: The aim of the present study was to assess the treatment effect of rivaroxaban administration as well as investigate the roles of PAR-1 and PAR-2 in the AD + CAA mice model. METHODS: In the present study, we compared a traditional oral anticoagulant, warfarin, and a direct oral anticoagulant (DOAC), rivaroxaban, via long-term administration to an AD with cerebral amyloid angiopathy (CAA) mice model. RESULTS: Rivaroxaban treatment attenuated neuroinflammation, blood-brain barrier dysfunction, memory deficits, and amyloid-β deposition through PAR-1/PAR-2 inhibition in the AD + CAA mice model compared with warfarin and no-treatment groups. CONCLUSION: The present study demonstrates that rivaroxaban can attenuate AD progress and can be a potential choice to prevent AD.

DOI： 10.3233/JAD-215318

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女性頭痛患者に対するアロマテラピーの有効性に関する研究

上野節子, 菱川望, 松本菜見子, 林紗織, 涌谷陽介, 田所功, 武本麻美, 野村恵美, 佐々木諒, 森原隆太, 山下徹, 高尾芳樹

日本頭痛学会誌 49 ( 1 ) 215 - 222 2022年

記述言語：日本語出版者・発行元：一般社団法人日本頭痛学会

女性頭痛患者に対するアロマテラピーの臨床的効果について，オープンラベル・クロスオーバー法を行った．対象は片頭痛患者24例で2例は緊張型頭痛を伴っていた．平均年齢は38.3±12.9歳であった．アロマテラピーに用いる精油は，ラベンダーかゼラニウムを自由選択させた．結果，アロマテラピーは月平均頭痛回数を減少させる傾向を示し，急性期頭痛治療薬の使用率を4.4%減少させ，仕事・家事に影響を与えた人数が減少した．月経関連期間における頭痛も日数・回数・程度ともに軽減傾向を示し，睡眠では入眠時間を約5分間短縮するなど不眠スコアの軽減もみられた．アロマテラピーは頭痛の非薬物療法として有効である可能性が示唆された．

DOI： 10.50860/jjho.49.1_215

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Chronic Beneficial Effect of Makeup Therapy on Cognitive Function of Dementia and Facial Appearance Analyzed by Artificial Intelligence Software. 国際誌

Koh Tadokoro, Toru Yamashita, Junko Sato, Yoshio Omote, Mami Takemoto, Ryuta Morihara, Koichiro Nishiura, Tomiko Tani, Koji Abe

Journal of Alzheimer's disease : JAD 85 ( 3 ) 1189 - 1194 2021年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Makeup greatly impacts normal social lives but can also be a non-pharmacological form of therapy for dementia. OBJECTIVE: To evaluate the therapeutic effect of makeup therapy. METHODS: We carried out a prospective interventional study on female nursing home residents with dementia, focusing on the chronic therapeutic effect of makeup therapy. Thirty-four patients who received either only skin care (control group, n = 16) or skin care plus makeup therapy (makeup therapy group, n = 18) once every 2 weeks for 3 months were assessed. RESULTS: Three months of makeup therapy significantly improved the Mini-Mental State Examination (MMSE) score compared with control patients ( *p < 0.05). Artificial intelligence (AI) software revealed that the appearance of age decreased significantly in the makeup group compared with the control, especially among patients without depression ( *p < 0.05). Furthermore, a larger AI happiness score was significantly correlated with a greater improvement of ADL in the makeup therapy group (r = 0.43, *p < 0.05). CONCLUSION: Makeup therapy had a chronic beneficial effect on the cognitive function of female dementia patients, while the chronic effect of makeup therapy on facial appearance was successfully detected by the present AI software.

DOI： 10.3233/JAD-215385

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脳梗塞モデルマウスにおけるホヤ由来プラズマローゲンの神経保護作用の検討

福井裕介, 馮田, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 山下徹, 阿部康二

脳循環代謝 33 ( 1 ) 114 - 114 2021年11月

Three cases of GFAP astrocytopathy, one with bilateral ovarian teratoma

Yosuke Osakada, Yoshio Omote, Yuki Taira, Chika Matsuoka, Ken Ikegami, Koh Tadokoro, Emi Nomura, Yuko Kawahara, Kota Sato, Yuka Terasawa, Nozomi Hishikawa, Ryuta Morihara, Mami Takemoto, Akio Kimura, Takayoshi Shimohata, Toru Yamashita, Koji Abe

Neurology and Clinical Neuroscience 10 ( 1 ) 30 - 34 2021年11月

外傷と脳循環代謝 in vitro及びin vivo血栓モデルにおける温熱照射と超音波照射の有効性と安全性の検討

森原隆太, 馮田, 小坂田陽介, 山下徹, 胡欣冉, 福井祐介, 田所功, 武本麻美, 阿部康二

脳循環代謝 33 ( 1 ) 49 - 49 2021年11月

ALS患者脊髄では低酸素ストレスの増加が起きている

山下徹, 畠山哲宗, 佐藤恒太, 福井裕介, 武本麻美, 太田康之, 西山佳宏, 河井信行, 田宮隆, 阿部康二

神経治療学 38 ( 6 ) S267 - S267 2021年10月

幹細胞移植は脳梗塞後の異常蛋白処理機構を変化させる

田所功, 福井裕介, 山下徹, 劉夏, 角田慶一郎, 商敬偉, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 阿部康二

神経治療学 38 ( 6 ) S322 - S322 2021年10月

機械的血栓回収による直接的血管損傷とNVU破綻ラットモデルにおける検討

佐々木諒, 山下徹, 福井裕介, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 阿部康二

神経治療学 38 ( 6 ) S265 - S265 2021年10月

Accelerated accumulation of fibrinogen peptide chains with Aβ deposition in Alzheimer's disease (AD) mice and human AD brains. 国際誌

Zhihong Bian, Toru Yamashita, Xiaowen Shi, Tian Feng, Haibo Yu, Xiao Hu, Xinran Hu, Yuting Bian, Hongming Sun, Koh Tadokoro, Mami Takemoto, Yoshio Omote, Ryuta Morihara, Koji Abe

Brain research 1767 147569 - 147569 2021年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

Alzheimer's disease (AD) is a common neurodegenerative disease that is characterized by the abnormal accumulation of intracellular and extracellular amyloid-β (Aβ) as well as disruption of the blood brain barrier (BBB). Fibrinogen plays an essential role in regulating thrombosis, wound healing, and other biological functions. In the present study, we investigated the relationship between three polypeptide chains α, β, and γ (FGA, FGB, and FGG) and Aβ deposition in the APP23 plus chronic cerebral hypoperfusion (CCH) mice model as well as the human AD brain. FGA, FGB, and FGG accumulated when Aβ was deposited in neural cells and cerebral vessels. This deposition was significantly higher in AD plus CCH mice models relative to wild-type brains, and in human AD brains compared to control brains. The present study demonstrates that FGA, FGB, and FGG are associated with AD progress, and can thus be potential targets for the diagnosis and therapy of AD.

DOI： 10.1016/j.brainres.2021.147569

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Successful treatment of anti-GAD antibody-associated autoimmune cerebellar ataxia with combined immunotherapies

Yoshio Omote, Chika Matsuoka, Ryo Sasaki, Nozomi Hishikawa, Yuko Kawahara, Emi Nomura, Namiko Matsumoto, Yuki Taira, Mami Takemoto, Ryuta Morihara, Toru Yamashita, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 2021年9月

アパシーの成因・治療を考えるアルツハイマー病患者の不安定な精神状態へのより良い処方薬について

武本麻美, 太田康之, 菱川望, 山下徹, 野村恵美, 角田慶一郎, 佐々木諒, 田所功, 松本菜見子, 表芳夫, 阿部康二

老年精神医学雑誌 32 ( 増刊I ) 179 - 179 2021年9月

アルツハイマー病患者における主観的・客観的睡眠障害

田所功, 太田康之, 菱川望, 野村恵美, 涌谷陽介, 高尾芳樹, 表芳夫, 武本麻美, 山下徹, 阿部康二

臨床神経学 61 ( Suppl. ) S302 - S302 2021年9月

アルツハイマー病患者の不安定な精神状態へのより良い処方薬についての研究

武本麻美, 太田康之, 山下徹, 野村恵美, 表芳夫, 田所功, 佐々木諒, 松本菜見子, 角田慶一郎, 阿部康二

臨床神経学 61 ( Suppl. ) S300 - S300 2021年9月

Early detection of cognitive decline in mild cognitive impairment and Alzheimer's disease with a novel eye tracking test. 国際誌

Koh Tadokoro, Toru Yamashita, Yusuke Fukui, Emi Nomura, Yasuyuki Ohta, Setsuko Ueno, Saya Nishina, Keiichiro Tsunoda, Yosuke Wakutani, Yoshiki Takao, Takahiro Miyoshi, Yasuto Higashi, Yosuke Osakada, Ryo Sasaki, Namiko Matsumoto, Yuko Kawahara, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Ryuta Morihara, Koji Abe

Journal of the neurological sciences 427 117529 - 117529 2021年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Due to an increasing number of dementia patients, the development of a rapid and sensitive method for cognitive assessment is awaited. Here, we examined the usefulness of a novel and short (3 min) eye tracking device to evaluate the cognitive function of normal control (NC, n = 52), mild cognitive impairment (MCI, n = 52), and Alzheimer's disease (AD, n = 70) subjects. Eye tracking total score declined significantly in MCI (**p < 0.01 vs NC) and AD (**p < 0.01 vs NC, ##p < 0.01 vs MCI), and correlated well with the mini-mental state examination (MMSE) score (r = 0.57, *p < 0.05). Furthermore, the eye tracking test, especially memory and deductive reasoning tasks, effectively discriminated NC, MCI and AD. The present novel eye tracking test clearly discriminated cognitive functions among NC, MCI, and AD subjects, thereby providing an advantage for the early detection of MCI and AD in screening.

DOI： 10.1016/j.jns.2021.117529

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A case of rheumatoid meningoencephalitis induced by pembrolizumab

Chika Matsuoka, Yoshio Omote, Yuko Kawahara, Ryo Sasaki, Namiko Matsumoto, Ko Tadokoro, Yuki Taira, Mami Takemoto, Ryuta Morihara, Toru Yamashita, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 2021年8月

Switching the Proteolytic System from the Ubiquitin-Proteasome System to Autophagy in the Spinal Cord of an Amyotrophic Lateral Sclerosis Mouse Model. 国際誌

Koh Tadokoro, Toru Yamashita, Jingwei Shang, Yasuyuki Ohta, Emi Nomura, Ryuta Morihara, Yoshio Omote, Mami Takemoto, Koji Abe

Neuroscience 466 47 - 57 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

The degradation of damaged proteins takes place via two major proteolytic pathways: the ubiquitin-proteasome system (UPS) and autophagy. However, since it is unclear how these two proteolytic pathways contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS), we investigated the switching mechanism from UPS to autophagy by pharmacologically modifying these pathways by treating the spinal cords of female ALS mouse model bearing G93A human SOD1 (G93A mice) with MG132 or 3-methyladenine (3MA). G93A mice exhibited a progressive increase in the amount of ubiquitin and p62 aggregates, BAG3 expression, and LC3-II/LC3-I ratio in both astroglia and motor neurons. Treatment with MG132 or 3MA significantly increased the clinical hanging wire score and exacerbated α-motor neuron loss at 18 weeks in G93A mice, and increased the amount of ubiquitin, p62 aggregates, and BAG3 expression. This study's results demonstrate that the molecular switch from UPS to autophagy occurred not only in motor neurons but also in astroglia at the end stage (18 weeks) when the autophagic flux was impaired in G93A mice. This finding suggests that the defense system was disrupted against aggregate-prone protein production in ALS.

DOI： 10.1016/j.neuroscience.2021.04.034

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A Unique Case of Encephalopathy with an Elevated IgG-4 and Extremely High Interleukin-6 Level and Delayed Myelodysplastic Syndrome.

Namiko Matsumoto, Nozomi Hishikawa, Ken Ikegami, Kota Sato, Yoshio Omote, Mami Takemoto, Toru Yamashita, Kohei Taniguchi, Koji Abe

Internal medicine (Tokyo, Japan) 60 ( 13 ) 2125 - 2128 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

We herein report a 75-year-old man who developed disturbed consciousness with polynuclear cell dominant pleocytosis and low glucose and extremely high interleukin (IL)-6 levels in his cerebrospinal fluid. The biopsy specimen from his right supraclavicular lymph node showed the infiltration of inflammatory cells positive for IgG, IgG4 and IL-6. Prednisolone and azathioprine administered under suspicion of IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD) successfully remitted the symptoms. However, he developed myelodysplastic syndrome (MDS) and died 18 months later. The extremely high IL-6 may have been related to the rare neurological manifestations and development of MDS in the present case.

DOI： 10.2169/internalmedicine.6098-20

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The first case of chronic inflammatory demyelinating polyneuropathy after transsexualism and continuous testosterone administration

Yuki Taira, Yoshio Omote, Yuko Kawahara, Emi Nomura, Ryo Sasaki, Namiko Matsumoto, Chika Matsuoka, Mami Takemoto, Ryuta Morihara, Nozomi Hishikawa, Toru Yamashita, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 9 ( 4 ) 346 - 348 2021年7月

AIを用いたパーキンソン病患者の見た目年齢・感情の評価

田所功, 山下徹, 福井裕介, 武本麻美, 佐々木諒, 松本菜見子, 野村恵美, 森原隆太, 表芳夫, 阿部康二

パーキンソン病・運動障害疾患コングレスプログラム・抄録集 15回 81 - 81 2021年7月

Author Correction: Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis. 国際誌

Toru Yamashita, Yoshihiro Kushida, Shohei Wakao, Koh Tadokoro, Emi Nomura, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Mari Dezawa, Koji Abe

Scientific reports 11 ( 1 ) 12828 - 12828 2021年6月

Hypoxic stress visualized in the cervical spinal cord of ALS patients. 国際誌

Yamashita T, Hatakeyama T, Sato K, Fukui Y, Hishikawa N, Takemoto M, Ohta Y, Nishiyama Y, Kawai N, Tamiya T, Abe K

Neurol Res 43 ( 6 ) 429 - 433 2021年6月

ALS患者における低酸素ストレスを可視化する

山下徹, 畠山哲宗, 佐藤恒太, 福井裕介, 菱川望, 武本麻美, 太田康之, 西山佳宏, 河井信行, 田宮隆, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 21回 214 - 214 2021年6月

化粧美容セラピーの認知・情動機能改善効果

田所功, 川野公子, 佐藤順子, 谷都美子, 表芳夫, 武本麻美, 森原隆太, 山下徹, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 21回 211 - 211 2021年6月

AIを用いたパーキンソン病の顔についての解析

田所功, 山下徹, 福井裕介, 武本麻美, 佐々木諒, 松本菜見子, 野村恵美, 表芳夫, 森原隆太, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 21回 222 - 222 2021年6月

AIによる新しい脳機能・認知症診断 AIなどの新たな技術を活用した認知症診療

田所功, 佐々木諒, 松本菜見子, 福井裕介, 表芳夫, 武本麻美, 森原隆太, 山下徹, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 21回 155 - 155 2021年6月

ALS患者における低酸素ストレスを可視化する

山下徹, 畠山哲宗, 佐藤恒太, 福井裕介, 菱川望, 武本麻美, 太田康之, 西山佳宏, 河井信行, 田宮隆, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 21回 214 - 214 2021年6月

Neuroprotective effect of CuATSM in mice stroke model by ameliorating oxidative stress. 国際誌

Shi X, Ohta Y, Nakano Y, Liu X, Tadokoro K, Feng T, Nomura E, Tsunoda K, Sasaki R, Matsumoto N, Osakada Y, Bian Y, Bian Z, Omote Y, Takemoto M, Hishikawa N, Yamashita T, Abe K

Neuroscience Res 166 55 - 61 2021年5月

Positive baseline behavioral and psychological symptoms of dementia predict a subsequent cognitive impairment in cognitively normal population

Keiichiro Tsunoda, Toru Yamashita, Yosuke Osakada, Ryo Sasaki, Koh Tadokoro, Namiko Matsumoto, Emi Nomura, Noriko Hatanaka, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 9 ( 3 ) 218 - 222 2021年5月

4-Hydroxyl-2-Nonenal Localized Expression Pattern in Retrieved Clots is Associated with Large Artery Atherosclerosis in Stroke Patients. 国際誌

Yosuke Osakada, Toru Yamashita, Ryuta Morihara, Namiko Matsumoto, Ryo Sasaki, Koh Tadokoro, Emi Nomura, Yuko Kawahara, Yoshio Omote, Nozomi Hishikawa, Mami Takemoto, Yasuyuki Ohta, Yasuki Suruga, Takayuki Nagase, Yuji Takasugi, Satoshi Inoue, Kyoichi Watanabe, Kentaro Deguchi, Koji Tokunaga, Susumu Sasada, Kazuki Kobayashi, Ryosuke Maeoka, Kenji Fukutome, Kenkichi Takahashi, Hiroyuki Ohnishi, Yoshihiro Kuga, Hideyuki Ohnishi, Koji Abe

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 30 ( 3 ) 105583 - 105583 2021年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: The relationship between stroke etiology and clot pathology remains controversial. MATERIALS AND METHODS: We performed histological analysis of clots retrieved from 52 acute ischemic stroke patients using hematoxylin and eosin staining and immunohistochemistry (CD42b and oxidative/hypoxic stress markers). The correlations between clot composition and the stroke etiological group (i.e., cardioembolic, cryptogenic, or large artery atherosclerosis) were assessed. RESULTS: Of the 52 clots analyzed, there were no significant differences in histopathologic composition (e.g., white blood cells, red blood cells, fibrin, and platelets) between the 3 etiological groups (P = .92). By contrast, all large artery atherosclerosis clots showed a localized pattern with the oxidative stress marker 4-hydroxyl-2-nonenal (P < .01). From all 52 clots, 4-hydroxyl-2-nonenal expression patterns were localized in 28.8% of clots, diffuse in 57.7% of clots, and no signal in 13.5% of clots. CONCLUSIONS: A localized pattern of 4-hydroxyl-2-nonenal staining may be a novel and effective marker for large artery atherosclerosis (sensitivity 100%, specificity 82%).

DOI： 10.1016/j.jstrokecerebrovasdis.2020.105583

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A new telestroke network system in northern area of Okayama prefecture

Ryo Sasaki, Toru Yamashita, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Taijun Yunoki, Kazuki Kobayashi, Takashi Sawata, Yuki Sato, Junichi Kubota, Masayuki Mizobuchi, Takashi Hayashi, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 9 ( 2 ) 166 - 170 2021年3月

The Oldest Japanese Case of Combined Central and Peripheral Demyelination, which Developed Nine Years After the First Instance of Optic Neuritis.

Nomura E, Kawahara Y, Omote Y, Tadokoro K, Takemoto M, Hishikawa N, Yamashita T, Ogata H, and Abe K

Intern Med 60 ( 2 ) 305 - 308 2021年1月

A case of autoimmune GFAP astrocytopathy with profound weight loss and increased uptake in the spinal cord on 18F‐FDG PET.

Osakada Y, Omote Y, Ikegami K, Tadokoro K, Sato k, Hishikawa N, Takemoto M, Ohta Y, Yamashita T, Kimura A, Abe K

Neurology Clinical Neurosci 9 ( 1 ) 95 - 97 2021年1月

A case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex presenting as progressive parkinsonism with corresponding tau imaging.

Ohta Y, Shimada H, Ikegami K, Tsunoda K, Hishikawa N, Yamashita T, Takemoto M, Omote Y, Tagai K, Matsuoka K, Higuchi M, Abe K

Neurol Clin Neurosci. 9 ( 1 ) 124 - 126 2021年1月

Retinal Amyloid Imaging for Screening Alzheimer's Disease. 国際誌

Koh Tadokoro, Toru Yamashita, Shuhei Kimura, Emi Nomura, Yasuyuki Ohta, Yoshio Omote, Mami Takemoto, Nozomi Hishikawa, Ryuta Morihara, Yuki Morizane, Koji Abe

Journal of Alzheimer's disease : JAD 83 ( 2 ) 927 - 934 2021年

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Cost-effective and noninvasive methods for in vivo imaging of amyloid deposition are needed to screen Alzheimer's disease (AD). Although retinal amyloid is a possible diagnostic marker of AD, there are very few studies on in vivo retinal amyloid imaging. OBJECTIVE: To examine the usefulness of in vivo imaging of retinal amyloid in AD patients. METHODS: To examine amyloid deposition, 30 Japanese subjects (10 normal control (NC), 7 with mild cognitive impairment (MCI), and 13 with AD) underwent a complete ophthalmic examination, including fundus imaging by scanning laser ophthalmoscopy before and after oral curcumin intake. RESULTS: Retinal amyloid deposition was greater in AD than in NC subjects (*p < 0.05) while MCI showed a slight but insignificant increase of retinal amyloid deposition relative to NC subjects. Retinal amyloid deposition was correlated with whole gray matter atrophy (r = 0.51, *p < 0.05) but not with the cognitive score of the Mini-Mental State Examination, nor with medial temporal lobe atrophy. CONCLUSION: The present noninvasive in vivo detection of retinal amyloid deposition is useful for screening AD patients.

DOI： 10.3233/JAD-210327

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Immediate Beneficial Effect of Makeup Therapy on Behavioral and Psychological Symptoms of Dementia and Facial Appearance Analyzed by Artificial Intelligence Software. 国際誌

Koh Tadokoro, Toru Yamashita, Satoko Kawano, Junko Sato, Yoshio Omote, Mami Takemoto, Ryuta Morihara, Koichiro Nishiura, Natsuki Sagawa, Tomiko Tani, Koji Abe

Journal of Alzheimer's disease : JAD 83 ( 1 ) 57 - 63 2021年

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Possible benefits of makeup therapy, in terms of immediate and late effects on cognitive and affective functions, have not been fully proved for dementia patients. OBJECTIVE: To evaluate the immediate effect of makeup therapy on dementia patients. METHODS: Female nursing home residents with dementia received either only skin care treatment (control group, n = 17) or skin care plus makeup therapy treatment (makeup therapy group, n = 19). Cognitive, affective, and activity of daily living (ADL) scores were evaluated before and just after treatments. Apparent age and emotion were also evaluated with artificial intelligence (AI) software. RESULTS: Makeup therapy significantly improved Abe's behavioral and psychological symptoms of dementia (BPSD) score (ABS, *p < 0.05). AI software judged that makeup therapy significantly made the apparent age younger (*p < 0.05). In particular, patients with moderate ADL scores had a significantly higher happiness score in makeup therapy (*p < 0.05), with a modest correlation to the Mini-Mental State Examination (MMSE, r = 0.42, *p < 0.05). The severe baseline MMSE group reported a greater feeling of satisfaction following makeup therapy (*p < 0.05). CONCLUSION: The present makeup therapy is a promising non-pharmacological approach to immediately alleviate BPSD in female dementia patients, and the present AI software quickly and quantitatively evaluated the beneficial effects of makeup therapy on facial appearance.

DOI： 10.3233/JAD-210284

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Cerebral Microbleeds in Patients with Parkinson's Disease and Dementia with Lewy Bodies: Comparison Using Magnetic Resonance Imaging and 99 mTc-ECD SPECT Subtraction Imaging. 国際誌

Mami Takemoto, Toru Yamashita, Yasuyuki Ohta, Koh Tadokoro, Yoshio Omote, Ryuta Morihara, Koji Abe

Journal of Alzheimer's disease : JAD 80 ( 1 ) 331 - 335 2021年

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Cerebral microbleeds (CMBs) in patients with Parkinson's disease (PD) or dementia with Lewy bodies (DLB) have not been adequately studied. OBJECTIVE: This study aims to find a difference in the total number, prevalence, and common locations of CMBs between PD and DLB and evaluate 99 mTc-ECD SPECT subtraction images of these two diseases. METHODS: We examined 112 patients with PD (53 males and 59 females; age: 77.4±3.6 years) and 28 age-matched patients with DLB (15 males and 13 females; age: 77.1±6.7 years) using brain magnetic resonance imaging (MRI) and 99 mTc-ECD SPECT subtraction imaging. RESULTS: The total number of CMBs was higher in patients with DLB (41.2%) than in those with PD (11.5%), and the prevalence was significantly higher in the former (0.7±1.1) than the latter (0.2±0.5, p < 0.05). The odds ratio was 5.4 (95% confidence interval [CI]: 1.7-17.4). Furthermore, CMBs were commonly located in the basal ganglia of patients with PD (6 out of 87 patients) but in the occipital lobe of patients with DLB (8 out of 17 patients). 99 mTc-ECD SPECT subtraction imaging indicated lower cerebral blood flow in the posterior cingulate gyrus among the patients with CMB-positive DLB than among those with CMB-positive PD; additionally, the cerebral blood flow was lower in the bilateral basal ganglia and midbrain among patients with CMB-positive DLB compared to those with CMB-negative DLB. CONCLUSION: A reduction in occipital glucose metabolism may be related to CMBs in the occipital lobe of patients with DLB.

DOI： 10.3233/JAD-201495

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A case of tocilizumab-induced leukoencephalopathy with a reversible clinical course.

Sasaki R, Hishikawa N, Nomura E, Omote Y, Takemoto M, Yamashita T, Hatanaka N, Higashi Y, Abe K

Intern Med 59 ( 22 ) 2927 - 2930 2020年11月

Repeat sizes of NOP56 gene in a Japanese Asidan (SCA36) family with clinical anticipation. 国際誌

Ohta Y, Ikegami K, Sato K, Hishikawa N, Omote Y, Takemoto M, Yamashita T, Abe K

J Neurol Sci 418 117150 - 117150 2020年11月

ALS患者脊髄における低酸素ストレスを可視化する

山下徹, 畠山哲宗, 佐藤恒太, 福井裕介, 菱川望, 武本麻美, 太田康之, 西山佳宏, 河井信行, 田宮隆, 阿部康二

脳循環代謝 32 ( 1 ) 102 - 102 2020年11月

認知機能正常者ならびに軽度認知障害における認知症周辺症状の出現

角田慶一郎, 山下徹, 小坂田陽介, 佐々木諒, 田所功, 松本菜見子, 野村恵美, 森原隆太, 中野由美子, 高橋義秋, 幡中典子, 商敬偉, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 阿部康二

臨床神経学 60 ( Suppl. ) S445 - S445 2020年11月

アルツハイマー病患者の臨床的進行予測因子についての検討

菱川望, 表芳夫, 武本麻美, 太田康之, 山下徹, 阿部康二

臨床神経学 60 ( Suppl. ) S424 - S424 2020年11月

PDDとDLBの認知機能と情動機能、脳血流画像の比較検討

武本麻美, 田所功, 表芳夫, 菱川望, 太田康之, 山下徹, 阿部康二

臨床神経学 60 ( Suppl. ) S408 - S408 2020年11月

幹細胞移植による虚血脳のタンパク分解分子機構への影響

田所功, 福井裕介, 山下徹, 劉夏, 角田慶一郎, 商敬偉, 表芳夫, 武本麻美, 菱川望, 太田康之, 阿部康二

脳循環代謝 32 ( 1 ) 124 - 124 2020年11月

同種骨髄移植が有用であった大脳型に進展した副腎白質ジストロフィーの1例

表芳夫, 佐藤恒太, 浦田知宏, 藤井伸治, 下澤伸行, 山下徹, 武本麻美, 菱川望, 太田康之, 阿部康二

臨床神経学 60 ( Suppl. ) S416 - S416 2020年11月

Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis. 国際誌

Yamashita T, Kushida Y, Wakao S, Tadokoro K, Nomura E, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Dezawa M, Abe K

Scientific Reports 10 ( 1 ) 17102 - 17102 2020年10月

Direct arterial damage and neurovascular unit disruption by mechanical thrombectomy in a rat stroke model.

Sasaki R, Yamashita T, Tadokoro K, Matsumoto N, Nomura E, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K

J Neurosci Res 98 ( 10 ) 2018 - 2026 2020年10月

脳梗塞後に神経細胞を新たに生み出し再生を目指す脳内グリア細胞から神経細胞を誘導する新技術の確立

山下徹, 商敬偉, 中野由美子, 森原隆太, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 阿部康二

神経治療学 37 ( 6 ) S253 - S253 2020年10月

幹細胞移植による虚血脳のタンパク分解分子機構への影響

田所功, 福井裕介, 山下徹, 劉夏, 角田慶一郎, 商敬偉, 表芳夫, 武本麻美, 菱川望, 太田康之, 阿部康二

神経治療学 37 ( 6 ) S253 - S253 2020年10月

実は見逃されている血管性認知症の危険因子

山下徹, 野崎洋明, 涌谷陽介, 田所功, 野村恵美, 菱川望, 武本麻美, 太田康之, 小野寺理, 阿部康二

Dementia Japan 34 ( 4 ) 493 - 493 2020年10月

アルツハイマー病患者の主観的・客観的睡眠障害

田所功, 太田康之, 菱川望, 野村恵美, 涌谷陽介, 高尾芳樹, 表芳夫, 武本麻美, 山下徹, 阿部康二

Dementia Japan 34 ( 4 ) 477 - 477 2020年10月

Clinical anticipation of disease onset in a Japanese Asidan (SCA36) family. 国際誌

Ohta Y, Ikegami K, Sato K, Hishikawa N, Omote Y, Takemoto M, Yamashita T, Abe K

J Neurol Sci 416 ( 15 ) 117043 - 117043 2020年9月

A Case of Triple Seronegative Myasthenia Gravis with Graves’ Disease Ameliorated after the Removal of Enlarged Thymus with elevated uptake in fluorine‐18 fluorodeoxyglucose positron emission tomography.

Matsumoto N, Omote Y, Nakano Y, Takemoto M, Hishikawa N, Sato K, Ohta Y, Yamashita T, Toji T, Abe K

Neurol Clin Neurosci 8 ( 5 ) 313 - 316 2020年9月

Dynamic changes and mislocalizations of neurodegenerative disease-related proteins in mice stroke model.

Liu X, Yamashita T, Shi X, Bian Y, Bian Z, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K

Brain Res 1742 ( 1 ) 146862 2020年9月

A unique leukoencephalopathy accompanied by palmoplantar pustulosis with identical pathological feature of helper T cell accumulation.

Sasaki R, Omote Y, Tadokoro K, Matsumoto N, Nomura E, Takemoto M, Hishikawa N, Yamashita T, Ohta Y, and Abe K

Neurology Asia 25 ( 3 ) 415 - 418 2020年9月

脳卒中マウスモデルにおけるTocotrienol製剤前投与の治療効果

山下徹, 商敬偉, 馮田, 武本麻美, 菱川望, 太田康之, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 20回 224 - 224 2020年9月

Improvement of a decreased anti-oxidative activity by edaravone in amyotrophic lateral sclerosis patients.

Ohta Y, Yamashita T, Nomura E, Hishikawa N, Ekegami K, Osakada Y, Matsumoto N, Kawahara Y, Yunoki T, Takahashi Y, Takamiya M, Tadokoro K, Sasaki R, Nakano Y, Tsunoda K, Sato K, Omote Y, Takemoto M, Abe K

J Neurol Sci 415 ( 15 ) 116906 2020年8月

Antioxidative effects of a novel dietary supplement Neumentix in a mouse stroke model. 国際誌

Taira Y, Yamashita T, Bian Y, Shang J, Matsumoto N, Sasaki R, Tadokoro K, Nomura E, Tsunoda K, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K

J Stroke Cerebrovasc Dis 29 ( 8 ) 104818 - 104818 2020年8月

PDDとDLBの認知機能と情動機能、脳血流画像の比較

武本麻美, 田所功, 表芳夫, 菱川望, 太田康之, 山下徹, 阿部康二

日本老年医学会雑誌 57 ( Suppl. ) 111 - 112 2020年7月

Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice.

Matsumoto N, Yamashita T, Shang J, Feng T, Osakada Y, Sasaki R, Tadokoro K, Nomura E, Tsunoda K, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K

Brain Research 1739 ( 15 ) 146831 2020年7月

Adult‐onset frequent non‐convulsive status epilepticus in a patient with ring chromosome 20 syndrome.

Liu X, Omote Y, Ikegami K, Tadokoro K, Takemoto M, Hishikawa N, Yamashita T, Ohta Y, Abe K

Neurol Clin Neurosci 8 ( 4 ) 202 - 204 2020年7月

Familial dropped head syndrome with extremity muscle weakness.

Tsunoda K, Hishikawa N, Omote Y, Ikegami K, Nakano Y, Sato K, Takemoto M, Ohta Y, Yamashita T, Abe K

Neurol Clin Neurosci 8 ( 4 ) 189 - 191 2020年7月

抗酸化サプリメントTwendee Xの軽度認知障害に対する効果についての検討

松本菜見子, 田所功, 森原隆太, 太田康之, 菱川望, 川野公子, 武本麻美, 山下徹, 犬房春彦, 阿部康二

日本老年医学会雑誌 57 ( Suppl. ) 113 - 113 2020年7月

PDDとDLBの認知機能と情動機能、脳血流画像の比較

武本麻美, 田所功, 表芳夫, 菱川望, 太田康之, 山下徹, 阿部康二

日本老年医学会雑誌 57 ( Suppl. ) 111 - 112 2020年7月

"もの忘れ外来"通院患者の通院脱落に関わる因子

菱川望, 表芳夫, 武本麻美, 太田康之, 山下徹, 阿部康二

日本老年医学会雑誌 57 ( Suppl. ) 112 - 112 2020年7月

Bone Marrow Stromal Cell Transplantation Drives Molecular Switch from Autophagy to the Ubiquitin-Proteasome System in Ischemic Stroke Mice.

Tadokoro K, Fukui Y, Yamashita T, Liu X, Tsunoda K, Shang J, Morihara R, Nakano Y, Feng T, Sasaki R, Matsumoto N, Nomura E, Shi X, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K

J Stroke Cerebrovasc Dis 29 ( 5 ) 104743 2020年5月

Diabetic painful truncal neuropathy with hypohidrosis and facial palsy.

Tsunoda K, Omote Y, Hishikawa N, Ikegami K, Nakano Y, Sato K, Takemoto M, Ohta Y, Yamashita T, Deguchi K, Abe K

Neurol Clin Neurosci 8 ( 3 ) 155 - 157 2020年5月

A spontaneous recovery of anti‐galactocerebroside antibody‐associated encephalitis without evidence of Mycoplasma infection.

Tadokoro K, Omote Y, Osakada Y, Ikegami K, Sato K, Takemoto M, Hishikawa N, Ohta Y, Yamashita T, Abe K

Neurol Clin Neurosci 8 ( 3 ) 164 - 166 2020年5月

Discrepancy of subjective and objective sleep problems in Alzheimer’s disease and mild cognitive impairment detected by a home-based sleep analysis.

Tadokoro K, Ohta Y, Hishikawa N, Nomura E, Wakutani Y, Takao Y, Omote Y, Takemoto M, Yamashita T, Abe K

J Clin Neurosci 74 76 - 80 2020年4月

A unique case of myasthenia gravis mimicking Garcin’s syndrome.

Tadokoro K, Hishikawa N, Ikegami K, Nomura E, Kawahara Y, Omote Y, Takemoto M, Yamashita T, Abe K

Neurol Clin Neurosci 1 - 4 2020年4月

Delayed Serial Microvascular Injury and Cognitive Decline After Whole Brain Irradiation.

Osakada Y, Yamashita T, Ikegami K, Kawahara Y, Omote Y, Hishikawa N, Takemoto M, Ohta Y, Abe K

Japanese Society of Vascular Cognitive Impairment 6 23 - 26 2020年4月

A juvenile case of idiopathic hypertrophic pachymeningitis involved cavernous sinus and proximal trigeminal nerve.

Bian Z, Omote Y, Tadokoro K, Ikegami K, Osakada Y, Takemoto M, Hishikawa N, Yamashita T, Ohta Y, Abe K

J Clin Neurosci 8 ( 2 ) 82 - 85 2020年3月

A unique case with positive anti-myelin oligodendrocyte glycoprotein antibody presenting multiple brain lesions

Namiko Matsumoto, Kota Sato, Nozomi Hishikawa, Yuko Kawahara, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Kentaro Fujii, Kazuhiko Kurozumi, Isao Date, Toshiyuki Takahashi, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 8 ( 2 ) 92 - 95 2020年3月

LGI1 antibody‐associated limbic encephalitis started from unilateral basal ganglia to medial temporal lobe and insula.

Liu X, Omote Y, Osakada Y, Tadokoro k, Takemoto M, Hishikawa N, Yamashita T, Ohta Y, Abe K

Neurol Clin Neurosci. (2019) Epub ahead of print 8 ( 2 ) 68 - 71 2020年3月

Different clinical and neuroimaging features of Japanese dementia siblings with a new N-terminal mutation (Val225Ala) of APP gene

Yasuyuki Ohta, Nozomi Hishikawa, Ken Ikegami, Kota Sato, Yosuke Osakada, Mami Takemoto, Toru Yamashita, Yoshio Omote, Takeshi Ikeuchi, Koji Abe

JOURNAL OF CLINICAL NEUROSCIENCE 72 482 - 484 2020年2月

Molecular switching from ubiquitin-proteasome to autophagy pathways in mice stroke model.

Liu X, Yamashita T, Shang J, Shi X, Morihara R, Huang Y, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

Journal of Cerebral Blood Flow & Metabolism 40 ( 1 ) 214 - 224 2020年1月

A dramatic increase in serum CK levels after switching from oral to intravenous administration of LEV.

Takemoto M, Sato K, Hishikawa N, Yamashita T, Ohta Y, Shang J, Abe K

Neurol Clin Neurosci 8 ( 1 ) 39 - 41 2020年1月

A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology

Koji Abe, Jingwei Shang, Xiaowen Shi, Toru Yamashita, Nozomi Hishikawa, Mami Takemoto, Ryuta Morihara, Yumiko Nakano, Yasuyuki Ohta, Kentaro Deguchi, Masaki Ikeda, Yoshio Ikeda, Koichi Okamoto, Mikio Shoji, Masamitsu Takatama, Motohisa Kojo, Takeshi Kuroda, Kenjiro Ono, Noriyuki Kimura, Etsuro Matsubara, Yosuke Osakada, Yosuke Wakutani, Yoshiki Takao, Yasuto Higashi, Kyoichi Asada, Takehito Senga, Lyang Ja Lee, Kenji Tanaka

Journal of Alzheimer's Disease 73 ( 1 ) 217 - 227 2020年

A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology.

Abe K, Shang J, Shi X, Yamashita T, Hishikawa N, Takemoto M, Morihara R, Nakano Y, Ohta Y, Deguchi K, Ikeda M, Ikeda Y, Okamoto K, Shoji M, Takatama M, Kojo M, Kuroda T, Ono K, Kimura N, Matsubara E, Osakada Y, Wakutani Y, Takao Y, Higashi Y, Asada K, Senga T, Lee LJ, Tanaka K

J Alzheimers Dis 73 ( 1 ) 217 - 227 2020年

A Polyphenolic Complex Attenuates Inflammatory Response and Blood-Brain Barrier Disruption. 国際誌

Bian Y, Yamashita T, Taira Y, Shang J, Tsunoda K, Feng T, Sasaki R, Liu X, Shi X, Tadokoro K, Nomura M, Matsumoto N, Osakada Y, Omote Y, Takemoto M, Hishikawa N, Ohta Y, Abe K

Curr Neurovasc Res 17 ( 3 ) 286 - 293 2020年

The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP) 国際誌

Takemoto M, Ohta Y, Hishikawa N, Yamashita T, Nomura E, Tsunoda K, Sasaki R, Tadokoro K, Matsumoto N, Omote Y, Abe K

J Alzheimers Dis 76 ( 2 ) 769 - 772 2020年

Early Emergence of Neuropsychiatric Symptoms in Cognitively Normal Subjects and Mild Cognitive Impairment.

Tsunoda K, Yamashita T, Osakada Y, Sasaki R, Tadokoro K, Matsumoto N, Nomura E, Morihara R, Nakano Y, Takahashi Y, Hatanaka N, Shang J, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

J Alzheimers Dis. 73 ( 1 ) 209 - 215 2020年

Female dominant association of sarcopenia and physical frailty in mild cognitive impairment and Alzheimer's disease.

Ohta Y, Nomura E, Hatanaka N, Osakada Y, Matsumoto N, Sasaki R, Tsunoda K, Takemoto M, Tadokoro K, Hishikawa N, Wakutani Y, Yamashita T, Sato K, Omote Y, Abe K

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 70 96 - 101 2019年12月

Intracranial invasive fungal aneurysm due to Aspergillus sinusitis successflly treated by voriconazle plus interal carotid artery ligation therapy in an aged woman.

Takemoto M, Ohta Y, Tadokoro K, Sasaki R, Takahashi Y, Sato K, Yamashita T, Hishikawa N, Sang JW, Hiramatsu M, Sugiu K, Hishikawa T, Date I, Abe K

Neurology Asia 24 ( 4 ) 363 - 367 2019年12月

Yoga-plus exercise mix promotes cognitive, affective, and physical functions in elderly people.

Hishikawa N, Takahashi Y, Fukui Y, Tokuchi R, Furusawa J, Takemoto M, Sato K, Yamashita T, Ohta Y, Abe K

Neurological research 41 ( 11 ) 1001 - 1007 2019年11月

Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction.

Sasaki R, Ohta Y, Sato K, Tadokoro K, Takahashi Y, Shang J, Takemoto M, Hishikawa N, Yamashita T, Ishiura H, Tsuji S, Abe K

Internal medicine (Tokyo, Japan) 58 ( 21 ) 3163 - 3165 2019年11月

時間で追う脳虚血の病態と治療:(2)亜急性期虚血脳内グリア細胞から神経細胞を誘導するダイレクトリプログラミング法の確立

山下徹, 商敬偉, 中野由美子, 森原隆太, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 阿部康二

脳循環代謝 31 ( 1 ) 65 - 65 2019年11月

パーキンソン病とレビー小体型認知症の検査所見やmicrobleeds出現頻度の違いについて

武本麻美, 佐藤恒太, 太田康之, 山下徹, 菱川望, 阿部康二

臨床神経学 59 ( Suppl. ) S266 - S266 2019年11月

Chronic cerebral hypoperfusion alters amyloid-β transport related proteins in the cortical blood vessels of Alzheimer's disease model mouse.

Shang J, Yamashita T, Tian F, Li X, Liu X, Shi X, Nakano Y, Tsunoda K, Nomura E, Sasaki R, Tadokoro K, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

Brain research 1723 146379 - 146379 2019年11月

A unique stroke case with contralateral sulcal hyperintensity on fluid-attenuated inversion recovery image changed to linear serpiginous structures

Osakada Y, Takahashi Y, Sato K, Shang J, Takemoto M, Hishikawa N, Ohta Y, Yamashita T, Abe K

Neurol Clin Neurosci 7 ( 6 ) 351 - 353 2019年11月

Yoga-plus exercise mix promotes cognitive, affective, and physical functions in elderly people

Nozomi Hishikawa, Yoriko Takahashi, Yusuke Fukui, Ryo Tokuchi, Junichi Furusawa, Mami Takemoto, Kota Sato, Toru Yamashita, Yasuyuki Ohta, Koji Abe

NEUROLOGICAL RESEARCH 41 ( 11 ) 1001 - 1007 2019年11月

A Japanese patient with a VCP mutation c.290G > A (p.G97E) presenting a rapid progressive respiratory failure 査読

Emi Nomura, Yasuyuki Ohta, Kota Sato, Yuko Kawahara, Mami Takemoto, Yoshiaki Takahashi, Namiko Matsumoto, Taijun Yunoki, Toru Yamashita, Nozomi Hishikawa, Ichizo Nishino, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 7 ( 6 ) 361 - 364 2019年11月

見逃したくない治療可能な小脳性運動失調症 PEX10変異による小脳失調症

山下徹, 三井純, 下澤伸行, 高島茂雄, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 松川敬志, 石浦浩之, 吉村淳, 土井晃一郎, 森下真一, 辻省次, 阿部康二

臨床神経学 59 ( Suppl. ) S45 - S45 2019年11月

パーキンソン病とレビー小体型認知症の検査所見やmicrobleeds出現頻度の違いについて

武本麻美, 佐藤恒太, 太田康之, 山下徹, 菱川望, 阿部康二

臨床神経学 59 ( Suppl. ) S266 - S266 2019年11月

筋萎縮性側索硬化症患者の前頭葉機能の特徴

太田康之, 山下徹, 菱川望, 佐藤恒太, 武本麻美, 表芳夫, 阿部康二

Dementia Japan 33 ( 4 ) 529 - 529 2019年10月

アルツハイマー病の進行に関する臨床的予測因子(Clinical predictors of Alzheimer's disease progression)

菱川望, 表芳夫, 武本麻美, 太田康之, 山下徹, 阿部康二

Dementia Japan 33 ( 4 ) 523 - 523 2019年10月

多発性の大脳・脳幹病変を認め、診断及び治療に苦慮した抗MOG抗体関連症候群の1例

松本菜見子, 佐藤恒太, 河原由子, 武本麻美, 菱川望, 表芳夫, 商敬偉, 太田康之, 山下徹, 藤井謙太郎, 黒住和彦, 伊達勲, 阿部康二

神経治療学 36 ( 6 ) S251 - S251 2019年10月

Sleep problems in subacute myelo-optico neuropathy (SMON)

Nozomi Hishikawa, Mami Takemoto, Kota Sato, Toru Yamashita, Yasuyuki Ohta, Kenichi Sakai, Koji Abe

JOURNAL OF CLINICAL NEUROSCIENCE 68 128 - 133 2019年10月

Sleep problems in subacute myelo-optico neuropathy (SMON)

Nozomi Hishikawa, Mami Takemoto, Kota Sato, Toru Yamashita, Yasuyuki Ohta, Kenichi Sakai, Koji Abe

Journal of Clinical Neuroscience 68 128 - 133 2019年10月

Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion.

Liu X, Yamashita T, Shang J, Shi X, Morihara R, Huang Y, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 28 ( 10 ) 104310 - 104310 2019年10月

胃瘻造設後に高浸透圧高血糖症候群を発症した進行性核上性麻痺の1例

田所功, 佐藤恒太, 森原隆太, 商敬偉, 武本麻美, 表芳夫, 太田康之, 山下徹, 菱川望, 阿部康二

神経治療学 36 ( 6 ) S269 - S269 2019年10月

Chronic Cerebral Hypoperfusion Activates the Coagulation and Complement Cascades in Alzheimer's Disease Mice.

Shi X, Ohta Y, Liu X, Shang J, Morihara R, Nakano Y, Feng T, Huang Y, Sato K, Takemoto M, Hishikawa N, Yamashita T, Abe K

Neuroscience 416 126 - 136 2019年9月

Late presented congenital myasthenic syndrome with novel compound heterozygous CHRNE mutations mimicking seronegative myasthenia gravis.

Nakano Y, Tsunoda K, Yamashita T, Mitsui J, Sato K, Takemoto M, Hishikawa N, Ohta Y, Toda T, Tsuji S, Abe K

Neuro Clin Neurosci 7 ( 5 ) 288 - 290 2019年9月

Imaging Hypoxic Stress and the Treatment of Amyotrophic Lateral Sclerosis with Dimethyloxalylglycine in a Mice Model.

Nomura E, Ohta Y, Tadokoro K, Shang J, Feng T, Liu X, Shi X, Matsumoto N, Sasaki R, Tsunoda K, Sato K, Takemoto M, Hishikawa N, Yamashita T, Kuchimaru T, Kizaka-Kondoh S, Abe K

Neuroscience 415 31 - 43 2019年9月

A Japanese patient with a VCP mutation c.290G > A (p.G97E) presenting a rapid progressive respiratory failure.

Nomura E, Ohta Y, Sato K, Kawahara Y, Takemoto M, Takahashi Y, Matsumoto N, Yunoki T, Yamashita T, Hishikawa N, Nishino I, Abe K

Neuro Clin Neurosci 7 ( 6 ) 361 - 364 2019年8月

A Unique Recurrent Stroke Case due to Bilateral Vertebral Artery Dissection with Familial Hirschsprung Disease

Kota Sato, Ryo Sasaki, Yasuyuki Ohta, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Koji Abe

Journal of Stroke and Cerebrovascular Diseases 28 ( 8 ) e113 - e115 2019年8月

Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion.

Liu X, Yamashita T, Shang J, Shi X, Morihara R, Huang Y, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 28 ( 7 ) 1993 - 2002 2019年7月

In vivo direct reprogramming of glial linage to mature neurons after cerebral ischemia.

Yamashita T, Shang J, Nakano Y, Morihara R, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

Scientific reports 9 ( 1 ) 10956 - 10956 2019年7月

A pneumococcal meningoencephalitis with a small spleen.

Tsunoda K, Sato K, Takahashi Y, Tadokoro K, Sasaki R, Nomura E, Takemoto M, Hishikawa N, Ohta Y, Abe K

Neurol Clin Neurosci 7 ( 4 ) 215 - 217 2019年7月

Acceleration of NLRP3 inflammasome by chronic cerebral hypoperfusion in Alzheimer's disease model mouse.

Shang J, Yamashita T, Zhai Y, Nakano Y, Morihara R, Li X, Tian F, Liu X, Huang Y, Shi X, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

Neuroscience research 143 61 - 70 2019年6月

Enhanced oxidative stress and the treatment by edaravone in mice model of amyotrophic lateral sclerosis.

Ohta Y, Nomura E, Shang J, Feng T, Huang Y, Liu X, Shi X, Nakano Y, Hishikawa N, Sato K, Takemoto M, Yamashita T, Abe K

Journal of neuroscience research 97 ( 5 ) 607 - 619 2019年5月

Very rare solitary primary peripheral nerne onset cytotoxic molecule - positive peripheral T- cell lymphoma(PTCL).

Matsumoto N, Sato K, Takahashi Y, Kawahara Y, Yunoki T, Shang J-W, Takemoto M, Hishikawa N, Ohta Y, Yamashita T, Sakamoto M, Kondou E, Shibata R, Yoshino T, Ozaki T, Abe K

Neurology and Clinical Neuroscience 7 ( 3 ) 146 - 149 2019年5月

Multi‐modal combination therapy rescued a frequent ischemic stroke patient due to giant cell arteritis. 査読

Takahashi Y, Sato K, Matsumoto N, Kawahara Y, Yunoki T, Shang J, Takemoto M, Hishikawa N, Ohta Y, Yamashita T, Abe K

Neurol Clin Neurosci 7 ( 3 ) 132 - 135 2019年5月

Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G>A Plus c.3139-1G>C.

Matsumoto N, Ohta Y, Deguchi K, Kishida M, Sato K, Shang J, Takemoto M, Hishikawa N, Yamashita T, Watanabe A, Yokote K, Takemoto M, Oshima J, Abe K

Internal medicine (Tokyo, Japan) 58 ( 7 ) 1033 - 1036 2019年4月

A Japanese family of autosomal dominant cerebral small vessel disease with heterozygous HTRA1 mutation showing dementia, gait disturbance and subarachnoid hemorrhage.

Yamashita T, Nozaki H, Wakutani Y, Tadokoro K, Nomura E, Takahashi Y, Sato K, Hishikawa N, Takemoto M, Shang J, Ohta Y, Onodera O, Abe K

Vas-Cog Journal 5 20 - 26 2019年4月

Improving Anxiety in Subacute Myelo-optico-neuropathy (SMON) after an Automated Telephone Call Service.

Ohta Y, Hishikawa N, Sato K, Takemoto M, Yamashita T, Doutare S, Abe K

Internal medicine (Tokyo, Japan) 58 ( 8 ) 1081 - 1085 2019年

Asymmetrical and Isolated Hypoglossal Nerve Palsy Accompanied by a New Subset of Anti-ganglioside Antibodies in a Patient with Diffuse Large B Cell Lymphoma.

Ohta Y, Kawahara Y, Tadokoro K, Sato K, Sasaki R, Takahashi Y, Takemoto M, Hishikawa N, Yamashita T, Asano T, Inomata T, Abe K

Internal medicine (Tokyo, Japan) 58 ( 2 ) 283 - 286 2019年

A Rare Case of Klinefelter Syndrome Accompanied by Spastic Paraplegia and Peripheral Neuropathy.

Sasaki R, Ohta Y, Takahashi Y, Tsunoda K, Tadokoro K, Sato K, Shang J, Takemoto M, Hishikawa N, Yamashita T, Abe K

Internal medicine (Tokyo, Japan) 58 ( 3 ) 437 - 440 2019年

Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study.

Nomura E, Nakano Y, Takahashi Y, Takemoto M, Yamashita T, Ueno S, Wakutani Y, Takao Y, Morimoto N, Kutoku Y, Sunada Y, Taomoto K, Manabe Y, Deguchi K, Higashi Y, Inufusa H, You F, Yoshikawa T, von Greiffenclau MM, Abe K

J Alzheimers Dis 71 ( 3 ) 1063 - 1069 2019年

Acute Anti-Inflammatory Markers ITIH4 and AHSG in Mice Brain of a Novel Alzheimer's Disease Model.

Shi X, Ohta Y, Liu X, Shang J, Morihara R, Nakano Y, Feng T, Huang Y, Sato K, Takemoto M, Hishikawa N, Yamashita T, Abe K

Journal of Alzheimer's disease : JAD 68 ( 4 ) 1667 - 1675 2019年

一般住民健診における不眠症と認知・情動機能障害の特徴

菱川望, 福井裕介, 武本麻美, 商敬偉, 佐藤恒太, 太田康之, 山下徹, 阿部康二

臨床神経学 58 ( Suppl. ) S299 - S299 2018年12月

Neuroprotective effects of SMTP-44D in mice stroke model in relation to neurovascular unit and trophic coupling.

Shi X, Ohta Y, Shang J, Morihara R, Nakano Y, Fukui Y, Liu X, Feng T, Huang Y, Sato K, Takemoto M, Hishikawa N, Yamashita T, Suzuki E, Hasumi K, Abe K

J Neurosci Res 96 ( 12 ) 1887 - 1899 2018年12月

Different clinicopathological features between Japanese siblings with facioscapulohumeral muscular dystrophy 2 with a novel nonsense SMCHD1 mutation (Arg552?).

Ohta Y, Tadokoro K, Sasaki R, Takahashi Y, Sato K, Takemoto M, Hishikawa N, Shang J, Yamashita T, Takehisa Y, Nishino I, Abe K

J Clin Neurosci 58 215 - 217 2018年12月

Cervical compressive myelopathy caused by malfunction of a programmable cerebrospinal fluid shunt valve. 査読

Sato K, Yamashita T, Tsunoda K, Takemoto M, Hishikawa N, Shang J, Ohta Y, Kuwahara K, Yasuhara T, Date I, Abe K

Interdiscip Neurosurg 14 183 - 185 2018年12月

Reduction of Ischemia Reperfusion-Related Brain Hemorrhage by Stachybotrys Microspora Triprenyl Phenol-7 in Mice With Antioxidant Effects

Yong Huang, Yasuyuki Ohta, Jingwei Shang, Xianghong Li, Xia Liu, Xiaowen Shi, Tian Feng, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Eriko Suzuki, Keiji Hasumi, Koji Abe

Journal of Stroke and Cerebrovascular Diseases 27 ( 12 ) 3521 - 3528 2018年12月

Reduction of Ischemia Reperfusion-Related Brain Hemorrhage by Stachybotrys Microspora Triprenyl Phenol-7 in Mice With Antioxidant Effects.

Huang Y, Ohta Y, Shang J, Li X, Liu X, Shi X, Feng T, Yamashita T, Sato K, Takemoto M, Hishikawa N, Suzuki E, Hasumi K, Abe K

J Stroke Cerebrovasc Dis 27 ( 12 ) 3521 - 3528 2018年12月

コリンエステラーゼ阻害剤変更によるアルツハイマー病患者への影響

太田康之, 菱川望, 山下徹, 佐藤恒太, 武本麻美, 阿部康二

神経治療学 35 ( 6 ) S238 - S238 2018年11月

A case of aspergillotic orbital apex syndrome diagnosed by an additional intraorbital biopsy after nasal endoscopy. 査読

Matsumoto N, Sato K, Tadokoro K, Takahashi Y, Yunoki T, Takemoto M, Hishikawa N, Ohta Y, Yamashita T, Fujii K, Ichikawa T, Date I, Abe K

Neurol Clin Neurosci 6 ( 6 ) 188 - 190 2018年11月

Antineuroinflammatory Effect of SMTP-7 in Ischemic Mice.

Huang Y, Ohta Y, Shang J, Morihara R, Nakano Y, Fukui Y, Liu X, Shi X, Feng T, Yamashita T, Sato K, Takemoto M, Hishikawa N, Suzuki E, Hasumi K, Abe K

J Stroke Cerebrovasc Dis 27 ( 11 ) 3084 - 3094 2018年11月

Antineuroinflammatory Effect of SMTP-7 in Ischemic Mice

Yong Huang, Yasuyuki Ohta, Jingwei Shang, Ryuta Morihara, Yumiko Nakano, Yusuke Fukui, Xia Liu, Xiaowen Shi, Tian Feng, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Eriko Suzuki, Keiji Hasumi, Koji Abe

Journal of Stroke and Cerebrovascular Diseases 27 ( 11 ) 3084 - 3094 2018年11月

胃瘻造設後に高浸透圧高血糖症候群をきたした進行性核上性麻痺の一例

田所功, 佐藤恒太, 森原隆太, 佐々木諒, 高橋義秋, 商敬偉, 武本麻美, 菱川望, 太田康之, 山下徹, 阿部康二

日本難病医療ネットワーク学会機関誌 6 ( 1 ) 81 - 81 2018年11月

マウス脳梗塞モデルにおける新規抗酸化サプリメントTwendeeXの脳保護効果

中野由美子, 草木桃子, 太田康之, 山下徹, 犬房春彦, 森原隆太, 商敬偉, 佐藤恒太, 武本麻美, 菱川望, 阿部康二

脳循環代謝 30 ( 1 ) 140 - 140 2018年10月

Affective improvement of neurological disease patients and caregivers using an automated telephone call service

Yasuyuki Ohta, Toru Yamashita, Nozomi Hishikawa, Kota Sato, Noriko Hatanaka, Mami Takemoto, Shinji Doutare, Koji Abe

JOURNAL OF CLINICAL NEUROSCIENCE 56 74 - 78 2018年10月

コリンエステラーゼ阻害剤変更によるアルツハイマー病患者への治療効果

太田康之, 菱川望, 山下徹, 佐藤恒太, 武本麻美, 阿部康二

Dementia Japan 32 ( 3 ) 473 - 473 2018年9月

Rare valiant vertical one-and-a-half syndrome without ipsilateral upward gaze palsy in a patient with thalamomesencephalic stroke.

Sato K, Takahashi Y, Matsumoto N, Yunoki T, Takemoto M, Hishikawa N, Ohta Y, Yamashita T, Abe K

Neurol Clin Neurosci 6 ( 5 ) 133 - 135 2018年9月

Vogt?Koyanagi?Harada case accompanied by polyneuropathy. 査読

Tsunoda K, Ohta Y, Tadokoro K, Sasaki R, Takahashi Y, Sato K, Nomura E, Takemoto M, Hishikawa N, Yamashita T, Kajita A, Abe K

Neurol Clin Neurosci 6 ( 5 ) 138 - 140 2018年9月

Therapeutic Effects of Pretreatment with Tocovid on Oxidative Stress in Postischemic Mice Brain.

Shang J, Yan H, Jiao Y, Ohta Y, Liu X, Li X, Morihara R, Nakano Y, Fukui Y, Shi X, Huang Y, Feng T, Takemoto M, Sato K, Hishikawa N, Yamashita T, Abe K

J Stroke Cerebrovasc Dis 27 ( 8 ) 2096 - 2105 2018年8月

Detecting spinal spinal pyramidal tract of amyotrophic lateral sclerosis patients with diffusion tensor tractography

Yusuke Fukui, Nozomi Hishikawa, Kota Sato, Yumiko Nakano, Ryuta Morihara, Jingwei Shang, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

NEUROSCIENCE RESEARCH 133 58 - 63 2018年8月

Detecting spinal pyramidal tract of amyotrophic lateral sclerosis patients with diffusion tensor tractography 査読

Yusuke Fukui,Nozomi Hishikawa*,Kota Sato*,Yumiko Nakano,Ryuta Morihara,Jingwei Shang*,Mami Takemoto*,Yasuyuki Ohta*,Toru Yamashita*,Koji Abe*

Neuroscience Research 133 58 - 63 2018年8月

Neuroprotective Effects of Tocovid Pretreatment in a Mouse Stroke Model.

Jiao Y, Shang J, Ohta Y, Yan H, Liu X, Li X, Morihara R, Nakano Y, Fukui Y, Shi X, Huang Y, Feng T, Takemoto M, Sato K, Hishikawa N, Yamashita T, Abe K

J Stroke Cerebrovasc Dis 27 ( 8 ) 2166 - 2174 2018年8月

A unique telephone support system for dementia patients and their caregivers managed in Japan (Okayama Dementia Call Center, ODCC). 査読

Nakano Y, Hishikawa N, Sakamoto K, Myoraku Y, Ozaki Y, Takemoto M, Sato K, Yamashita T, Ohta Y, Abe K

Neurol Clin Neurosci 6 ( 4 ) 100 - 103 2018年7月

Fulminant Guillain-Barre syndrome with Takotsubo cardiomyopathy: Report of an autopsied case. 査読

Takemoto M, Yamashita T, Ohta Y, Hishikawa N, Sato K, Tsunoda K, Shang J, Deguchi K, Tanaka T, Nishimura H, Furutani M, Abe K

Neurol Clin Neurosci 6 ( 4 ) 117 - 119 2018年7月

Clinical predictors of Alzheimer's disease progression.

Hishikawa N, Fukui Y, Takemoto M, Sato K, Shang J, Yamashita T, Ohta Y, Abe K

Geriatr Gerontol Int 18 ( 6 ) 929 - 936 2018年6月

Clinical predictors of Alzheimer's disease progression

Nozomi Hishikawa, Yusuke Fukui, Mami Takemoto, Kota Sato, Jingwei Shang, Toru Yamashita, Yasuyuki Ohta, Koji Abe

Geriatrics and Gerontology International 18 ( 6 ) 929 - 936 2018年6月

A case of bilateral internal carotid artery dissection in young adult with cranial nerve IX and X palsies. 査読

Sasaki R, Yamashita T, Takahashi Y, Shang J, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

Neurol Clin Neurosci 6 ( 3 ) 80 - 82 2018年5月

Case of acromegalic myopathy and arthropathy long after trans‐sphenoidal surgery. 査読

Sasaki R, Yamashita T, Takahashi Y, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K

Neurol Clin Neurosci 6 ( 3 ) 77 - 79 2018年5月

Case of congenital fibrosis of the extraocular muscles type 1 with progressive cerebellar ataxia

Toru Yamashita, Yoshiaki Takahashi, Keiichiro Tsunoda, Emi Nomura, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 6 ( 2 ) 48 - 50 2018年3月

Emergency ventricular drainage plus systemic antibiotics saved an elderly patient with intraventricular rupture as a result of a pituitary abscess

Yoshiaki Takahashi, Toru Yamashita, Ryuta Morihara, Yumiko Nakano, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 6 ( 1 ) 13 - 15 2018年1月

A Japanese Encephalitis Patient Presenting with Parkinsonism with Corresponding Laterality of Magnetic Resonance and Dopamine Transporter Imaging Findings.

Tadokoro K, Ohta Y, Sato K, Maeki T, Sasaki R, Takahashi Y, Shang J, Takemoto M, Hishikawa N, Yamashita T, Lim CK, Tajima S, Abe K

Intern Med 57 ( 15 ) 2243 - 2246 2018年

Neurolymphomatosis in the Cauda Equina Diagnosed by an Open Biopsy.

Sasaki R, Ohta Y, Yamada Y, Tadokoro K, Takahashi Y, Sato K, Shang J, Takemoto M, Hishikawa N, Yamashita T, Yasuhara T, Date I, Ikegawa S, Fujii N, Abe K

Intern Med 57 ( 23 ) 3463 - 3465 2018年

A unique case of hemi-tongue pseudohypertrophy, necrotizing myopathy, and erythema nodosum.

Sato K, Takahashi Y, Yamashita T, Takemoto M, Hishikawa N, Jinwei S, Ohta Y, Abe K

Neurol Int 10 ( 4 ) 95 - 96 2018年

A Unique Case with Oral Dyskinesia, Chorea, Ataxia, and Mild Cognitive Impairment with Caudate Atrophy and Characteristic Brain Calcifications

Nozomi Flishikawa, Yusuke Fukui, Kota Sato, Mami Takemoto, Tom Yamashita, Yasuyuki Ohta, Koji Abe

INTERNAL MEDICINE 57 ( 16 ) 2399 - 2402 2018年

A Unique Case with Oral Dyskinesia, Chorea, Ataxia, and Mild Cognitive Impairment with Caudate Atrophy and Characteristic Brain Calcifications.

Hishikawa N, Fukui Y, Sato K, Takemoto M, Yamashita T, Ohta Y, Abe K

Intern Med 57 ( 16 ) 2399 - 2402 2018年

PDDとDLBの認知機能、情動機能、脳血流分布の比較検討

武本麻美, 菱川望, 太田康之, 山下徹, 佐藤恒太, 幡中典子, 阿部康二

Anti-aging Science 9 ( 2 ) 109 - 109 2017年12月

メタボリック症候群を伴うアルツハイマー病の特徴

菱川望, 福井裕介, 武本麻美, 佐藤恒太, 太田康之, 山下徹, 阿部康二

Anti-aging Science 9 ( 2 ) 111 - 111 2017年12月

大脳白質病変を伴うアルツハイマー病患者における抗認知症薬の臨床的効果

福井裕介, 菱川望, 佐藤恒太, 中野由美子, 森原隆太, 武本麻美, 商敬偉, 太田康之, 山下徹, 阿部康二

Anti-aging Science 9 ( 2 ) 110 - 110 2017年12月

A migration case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex with the shortest stay in the endemic area and the longest incubation to develop the disease 査読

Keiichiro Tsunoda,Toru Yamashita*,Hitoshi Shimada,Emi Nomura,Yoshiaki Takahashi,Jingwei Shang*,Kota Sato*,Mami Takemoto*,Nozomi Hishikawa*,Yasuyuki Ohta*,Makoto Higuchi,Tetsuya Suhara,Yasumasa Kokubo,Shigeki Kuzuhara,Koji Abe*

Journal of Clinical Neuroscience 46 64 - 67 2017年12月

Serious hyponatremia induced by a combination of angiotensin II receptor blocker and thiazide caused deterioration of cognitive functions and psychological symptoms in an elderly Alzheimer's disease patient

Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Toru Yamashita, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 5 ( 6 ) 192 - 194 2017年11月

Japanese sibling cases of multiple sclerosis presenting with different clinical phenotypes

Kota Sato, Yasuyuki Ohta, Toru Yamashita, Keiichiro Tsunoda, Kentaro Deguchi, Mami Takemoto, Nozomi Hishikawa, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 5 ( 6 ) 186 - 188 2017年11月

Type 2 Alexander disease with a novel glial fibrillary acidic protein gene mutation and its unique clinical features

Yuko Kawahara, Toru Yamashita, Yasuyuki Ohta, Kota Sato, Emi Nomura, Mami Takemoto, Nozomi Hishikawa, Jingwei Shang, Tomokatsu Yoshida, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 5 ( 6 ) 183 - 185 2017年11月

Therapeutic effects of drug switching between acetylcholinesterase inhibitors in patients with Alzheimer's disease 査読

Yasuyuki Ohta*,Mohamed Darwish,Nozomi Hishikawa*,Toru Yamashita*,Kota Sato*,Mami Takemoto*,Koji Abe*

Geriatrics and Gerontology International 17 ( 11 ) 1843 - 1848 2017年11月

緊急脳室ドレナージと全身抗生剤で救命しえた下垂体部膿瘍から脳室穿破を来した一例

高橋義秋, 山下徹, 森原隆太, 中野由美子, 商敬偉, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 阿部康二

日本頭痛学会誌 44 ( 2 ) 386 - 386 2017年11月

拍動性頭痛を伴う繰り返すTIA症状で再発性の内頸動脈攣縮が疑われた一例

中野由美子, 佐藤恒太, 高橋義秋, 武本麻美, 菱川望, 山下徹, 太田康之, 阿部康二

日本頭痛学会誌 44 ( 2 ) 374 - 374 2017年11月

緊急脳室ドレナージと全身抗生剤で救命しえた下垂体部膿瘍から脳室穿破を来した一例

高橋義秋, 山下徹, 森原隆太, 中野由美子, 商敬偉, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 阿部康二

日本頭痛学会誌 44 ( 2 ) 386 - 386 2017年11月

緊急脳室ドレナージと全身抗生剤投与にて救命しえた下垂体部膿瘍から脳室穿破に伸展した一例

高橋義秋, 山下徹, 佐々木諒, 田所功, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 阿部康二

臨床神経学 57 ( 10 ) 651 - 651 2017年10月

Behavioral and affective features of amyotrophic lateral sclerosis patients 査読

Yasuyuki Ohta*,Kota Sato*,Mami Takemoto*,Yoshiaki Takahashi,Ryuta Morihara,Yumiko Nakano,Keiichiro Tsunoda,Emi Nomura,Nozomi Hishikawa*,Toru Yamashita*,Koji Abe*

Journal of the Neurological Sciences, World neurology, Journal of the neurological sciences 381 119 - 125 2017年10月

新しいSCA/ALS crossroad mutation AsidanのDWEP現象

太田康之, 山下徹, 佐藤恒太, 幡中典子, 角田慶一郎, 武本麻美, 菱川望, 阿部康二

日本難病医療ネットワーク学会機関誌 5 ( 1 ) 59 - 59 2017年9月

Non-ketotic hyperosmolar coma after percutaneous endoscopic gastrostomy in an advanced stage of progressive supranuclear palsy

Koh Tadokoro, Kota Sato, Ryuta Morihara, Jingwei Shang, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Nozomi Hishikawa, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 5 ( 5 ) 162 - 164 2017年9月

Occult chronic progressive cervical and thoracic myelopathy without evident magnetic resonance imaging lesion

Emi Nomura, Toru Yamashita, Yoshiaki Takahashi, Keiichiro Tsunoda, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Hiroki Ueno, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 5 ( 5 ) 155 - 158 2017年9月

Case of myasthenia gravis and Lambert-Eaton myasthenic syndrome overlap syndrome accompanied by autoimmune encephalitis and cerebellar ataxia with multiple neuronal antibodies

Yumiko Nakano, Emi Nomura, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 5 ( 5 ) 152 - 154 2017年9月

Dissociated recovery between dementia and parkinsonism by transvenous embolization of recurrent dural arteriovenous fistula

Yumiko Nakano, Emi Nomura, Masafumi Hiramatsu, Mami Takemoto, Kota Sato, Nozomi Hishikawa, Toru Yamashita, Yasuyuki Ohta, Kenji Sugiu, Isao Date, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 5 ( 5 ) 159 - 161 2017年9月

認知症の早期診断に有用な新しい簡易BPSDスコア(阿部式BPSDスコア=ABS)

阿部康二, 菱川望, 森原隆太, 中野由美子, 佐藤恒太, 武本麻美, 商敬偉, 山下徹

日本早期認知症学会誌 10 ( 3 ) 61 - 61 2017年8月

Neuroprotective Effects of a Novel Antioxidant Mixture Twendee X in Mouse Stroke Model 査読

Momoko Kusaki,Yasuyuki Ohta*,Haruhiko Inufusa,Toru Yamashita*,Ryuta Morihara,Yumiko Nakano,Xia Liu,Jingwei Shang*,Feng Tian,Yusuke Fukui,Kota Sato*,Mami Takemoto*,Nozomi Hishikawa*,Koji Abe*

Journal of Stroke and Cerebrovascular Diseases 26 ( 6 ) 1191 - 1196 2017年6月

Different Characteristics of Anterior and Posterior Branch Atheromatous Diseases with or without Early Neurologic Deterioration 査読

Yoshiaki Takahashi,Toru Yamashita*,Ryuta Morihara,Yumiko Nakano,Kota Sato*,Mami Takemoto*,Nozomi Hishikawa*,Yasuyuki Ohta*,Yasuhiro Manabe,Koji Abe*

Journal of Stroke and Cerebrovascular Diseases 26 ( 6 ) 1314 - 1320 2017年6月

Factors related to continuous and discontinuous attendance at memory clinics 査読

N. Hishikawa *,Y. Fukui ,Y. Nakano ,R. Morihara ,M. Takemoto *,K. Sato *,T. Yamashita *,Y. Ohta *,K. Abe *

European Journal of Neurology 24 ( 5 ) 673 - 679 2017年5月

Familial amyotrophic lateral sclerosis of the G37V-superoxide dismutase 1 mutation with a slow disease progression

Koh Tadokoro, Yasuyuki Ohta, Yoshiaki Takahashi, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 5 ( 3 ) 96 - 98 2017年5月

Ataxic form of autosomal recessive PEX10-related peroxisome biogenesis disorders with a novel compound heterozygous gene mutation and characteristic clinical phenotype 査読

Toru Yamashita*,Jun Mitsui,Nobuyuki Shimozawa,Shigeo Takashima,Hiroshi Umemura*,Kota Sato*,Mami Takemoto*,Nozomi Hishikawa*,Yasuyuki Ohta*,Takashi Matsukawa,Hiroyuki Ishiura,Jun Yoshimura,Koichiro Doi,Shinichi Morishita,Shoji Tsuji,Koji Abe*

Journal of the Neurological Sciences, World neurology, Journal of the neurological sciences 375 424 - 429 2017年4月

Potential multisystem degeneration in Asidan patients 査読

Yasuyuki Ohta*,Toru Yamashita*,Nozomi Hishikawa*,Kota Sato*,Kosuke Matsuzono,Keiichiro Tsunoda,Noriko Hatanaka,Mami Takemoto*,Toshihiko Takemi,Kazuhiro Takamatsu,Koji Abe*

Journal of the Neurological Sciences, World neurology, Journal of the neurological sciences 373 216 - 222 2017年2月

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) with limbic encephalitis 査読

Yasuyuki Ohta*,Emi Nomura,Keiichiro Tsunoda,Toru Yamashita*,Yoshiaki Takahashi,Kota Sato*,Mami Takemoto*,Nozomi Hishikawa*,Koji Abe*

Internal Medicine, Japanese Journal of Medicine, Internal medicine (Tokyo, Japan) 56 ( 18 ) 2513 - 2518 2017年

Emergency caesarean section saved both an anti-musk antibody-positive myasthenia gravis mother with pregnancy-induced hypertension and her premature baby

Yoshiaki Takahashi, Toru Yamashita, Ryuta Morihara, Yumiko Nakano, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Kei Hayata, Hisashi Masuyama, Tomoka Okamura, Yosuke Washio, Koji Abe

Internal Medicine 56 ( 24 ) 3361 - 3364 2017年

脳血管性認知症モデルラットにおけるテルミサルタンの治療効果

山下徹, 菱川望, 佐藤恒太, 武本麻美, 太田康之, 阿部康二

Anti-aging Science 8 ( 1 ) 72 - 72 2016年12月

アルツハイマー病患者におけるガランタミンの長期的効果について

中野由美子, 山下徹, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 阿部康二

Anti-aging Science 8 ( 1 ) 69 - 69 2016年12月

難病患者就労に対する山陽神経難病ネットワークの役割

太田康之, 山下徹, 菱川望, 佐藤恒太, 武本麻美, 阿部康二, 三宅進, 重實比呂子, 三村あゆみ, 三垣亮輔, 竹内秀将, 岩藤弘子, 薮田智子, 斎藤文恵, 鈴木美穂, 竹内ひかり

日本難病医療ネットワーク学会機関誌 4 ( 1 ) 61 - 61 2016年11月

ラット一過性脳虚血モデルにおけるTDP43とFUS/TLSの発現亢進による神経細胞保護効果について

中野由美子, Sun Miao, 山下徹, 森原隆太, 武本麻美, 佐藤恒太, 菱川望, 太田康之, 阿部康二

脳循環代謝 28 ( 1 ) 232 - 232 2016年11月

多発脳神経麻痺が急速に進行した腎癌の頭蓋底転移の1剖検例

武本麻美, 河原由子, 佐藤恒太, 佐藤康晴, 太田康之, 菱川望, 山下徹, 阿部康二

日本老年医学会雑誌 53 ( 4 ) 461 - 461 2016年10月

Asidan(ALS/SCA crossroad mutation)はSWEDDsと正反対所見DWEPを呈する

阿部康二, 太田康之, 山下徹, 菱川望, 佐藤恒太, 武本麻美

パーキンソン病・運動障害疾患コングレスプログラム・抄録集 10回 84 - 84 2016年10月

PDDとDLB患者の認知機能・情動機能・日常生活活動強度の比較

武本麻美, 菱川望, 太田康之, 山下徹, 佐藤恒太, 幡中典子

パーキンソン病・運動障害疾患コングレスプログラム・抄録集 10回 88 - 88 2016年10月

Temporal Profiles of Stress Protein Inductions after Focal Transient Ischemia in Mice Brain 査読

Qian Li,Yumiko Nakano,Jingwei Shang,Yasuyuki Ohta*,Kota Sato*,Mami Takemoto*,Nozomi Hishikawa*,Toru Yamashita*,Koji Abe*

Journal of Stroke and Cerebrovascular Diseases 25 ( 10 ) 2344 - 2351 2016年10月

Differences between the behavioral and psychological symptoms of Alzheimer's disease and Parkinson's disease 査読

Ryo Tokuchi,Nozomi Hishikawa*,Kota Sato*,Noriko Hatanaka,Yusuke Fukui,Mami Takemoto*,Yasuyuki Ohta*,Toru Yamashita*,Koji Abe*

Journal of the Neurological Sciences, World neurology 369 278 - 282 2016年10月

Comparative Gait Analysis in Progressive Supranuclear Palsy and Parkinson's Disease 査読

Noriko Hatanaka,Kota Sato*,Nozomi Hishikawa*,Mami Takemoto*,Yasuyuki Ohta*,Toru Yamashita*,Koji Abe*

European Neurology 75 ( 5-6 ) 282 - 289 2016年7月

脳血管性認知症モデルラットにおけるテルミサルタンの治療効果

山下徹, 菱川望, 佐藤恒太, 武本麻美, 太田康之, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 16回 191 - 191 2016年6月

Age-dependent cognitive and affective differences in Alzheimer's and Parkinson's diseases in relation to MRI findings 査読

Ryo Tokuchi,Nozomi Hishikawa*,Kota Sato*,Noriko Hatanaka,Yusuke Fukui,Mami Takemoto*,Yasuyuki Ohta*,Toru Yamashita*,Koji Abe*

Journal of the Neurological Sciences, World neurology 365 3 - 8 2016年6月

New susceptible variant of COQ2 gene in Japanese patients with sporadic multiple system atrophy

Zhuoran Sun, Yasuyuki Ohta, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Koji Abe

Neurology: Genetics 2 ( 2 ) 2016年4月

Comparative Gait Analysis in Progressive Supranuclear Palsy and Parkinson's Disease

Noriko Hatanaka, Kota Sato, Nozomi Hishikawa, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

EUROPEAN NEUROLOGY 75 ( 5-6 ) 282 - 289 2016年

Different Clinical and Neuroimaging Characteristics in Early Stage Parkinson's Disease with Dementia and Dementia with Lewy Bodies 査読

Mami Takemoto*,Kota Sato*,Noriko Hatanaka,Toru Yamashita*,Yasuyuki Ohta*,Nozomi Hishikawa*,Koji Abe*

Journal of Alzheimer's Disease 52 ( 1 ) 205 - 211 2016年

多発性硬化症および視神経脊髄炎におけるタッチパネル式認知機能検査の有用性

太田康之, 河原由子, 薮田智子, 竹内ひかり, 佐藤恒太, 武本麻美, 菱川望, 山下徹, 阿部康二

日本難病医療ネットワーク学会機関誌 3 ( 1 ) 55 - 55 2015年11月

脳卒中慢性期患者では再発よりも認知症移行(direct conversion)が高い

中野由美子, 出口健太郎, 山下徹, 武本麻美, 佐藤恒太, 菱川望, 太田康之, 高尾芳樹, 東靖人, 阿部康二

脳循環代謝 27 ( 1 ) 149 - 149 2015年10月

進行性核上性麻痺・パーキンソン病患者における歩行の比較

幡中典子, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 山下徹, 阿部康二

パーキンソン病・運動障害疾患コングレスプログラム・抄録集 9回 81 - 81 2015年10月

テルミサルタン長期投与がラット梗塞後脳に及ぼすメタボリックシンドローム関連因子発現の検討

出口健太郎, ざい蘊, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 山下徹, 阿部康二

脳循環代謝 27 ( 1 ) 195 - 195 2015年10月

多発性硬化症および視神経脊髄炎におけるタッチパネル式認知機能検査の検討

太田康之, 河原由子, 佐藤恒太, 武本麻美, 菱川望, 山下徹, 阿部康二

Dementia Japan 29 ( 3 ) 404 - 404 2015年9月

PDDとDLBの認知機能、情動機能の比較検討

武本麻美, 菱川望, 太田康之, 山下徹, 佐藤恒太, 幡中典子, 阿部康二

日本神経心理学会総会プログラム・予稿集 39回 204 - 204 2015年8月

MCIの予後と関連因子の検討

徳地亮, 菱川望, 佐藤恒太, 幡中典子, 武本麻美, 福井裕介, 太田康之, 山下徹, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 15回 190 - 190 2015年5月

タッチパネル式コンピュータを活用した脳梗塞既往患者の認知機能と画像所見の関連の検討

出口健太郎, 河野祥一郎, 柚木太淳, 松薗構佑, 中野由美子, 角田慶一郎, 河原由子, 幡中典子, 武本麻美, 太田康之, 菱川望, 山下徹, 阿部康二

脳循環代謝 26 ( 1 ) 168 - 168 2014年11月

側頭葉内側萎縮と大脳白質病変の併存がアルツハイマー病患者の認知機能と情動機能に及ぼす影響

徳地亮, 菱川望, 佐藤恒太, 幡中典子, 武本麻美, 福井裕介, 太田康之, 出口健太郎, 山下徹, 阿部康二

脳循環代謝 26 ( 1 ) 214 - 214 2014年11月

Myocardial microvascular perfusion after transfusion of liposome-encapsulated hemoglobin evaluated in cross-circulated rat hearts using tracer digital radiography

Takahisa Asano, Takeshi Matsumoto, Hiroyuki Tachibana, Mami Takemoto, Fumihiko Kajiya

Journal of Artificial Organs 7 ( 3 ) 145 - 148 2004年9月

Pattern differences between distributions of microregional myocardial flows in crystalloid- and blood-perfused rat hearts

Takeshi Matsumoto, Hiroyuki Tachibana, Takahisa Asano, Mami Takemoto, Yasuo Ogasawara, Keiji Umetani, Fumihiko Kajiya

American Journal of Physiology - Heart and Circulatory Physiology 286 ( 4 ) H1331 - H1338 2004年

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