Faculty Profiles - TAKEMOTO Mami

Papers - TAKEMOTO Mami

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ADマウスとヒトAD脳における、Aβ沈着を伴ったフィブリノゲンペプチド鎖集積の加速(Acceleration of the accumulation of fibrinogen peptide chains with Aβ deposition in AD mice and human AD brains)

卞之宏, 山下徹, 于海波, 胡欣冉, 卞宇てい, 孫洪銘, 田所功, 武本麻美, 森原隆太, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 22回 221 - 221 2022.6

視線計測計を用いた認知症の早期発見

田所功, 福井裕介, 野村恵美, 涌谷陽介, 高尾芳樹, 東靖人, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 阿部康二, 山下徹

日本抗加齢医学会総会プログラム・抄録集 22回 208 - 208 2022.6

ホヤ由来プラズマローゲンの脳梗塞モデルマウスにおける高酸化ストレス・抗炎症作用の検討

福井裕介, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 山下徹, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 22回 224 - 224 2022.6

虚血性脳卒中モデルマウスにてホタテ由来プラズマローゲンは酸化ストレスと炎症を阻害する(Scallop-derived plasmalogen prevent oxidative stress and inflammation in a mouse model of ischemic stroke)

胡欣冉, 阿部康二, 田馮, 福井裕介, 田所功, 卞之宏, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 山下徹

日本抗加齢医学会総会プログラム・抄録集 22回 252 - 252 2022.6

Clinical and Pathological Benefits of Scallop-Derived Plasmalogen in a Novel Mouse Model of Alzheimer's Disease with Chronic Cerebral Hypoperfusion. International journal

Tian Feng, Xinran Hu, Yusuke Fukui, Zhihong Bian, Yuting Bian, Hongming Sun, Mami Takemoto, Taijun Yunoki, Yumiko Nakano, Ryuta Morihara, Koji Abe, Toru Yamashita

Journal of Alzheimer's disease : JAD 86 ( 4 ) 1973 - 1982 2022.3

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The oral ingestion of scallop-derived plasmalogen (sPlas) significantly improved cognitive function in Alzheimer's disease (AD) patients. OBJECTIVE: However, the effects and mechanisms of sPlas on AD with chronic cerebral hypoperfusion (CCH), a class of mixed dementia contributing to 20-30% among the dementia society, were still elusive. METHODS: In the present study, we applied a novel mouse model of AD with CCH to investigate the potential effects of sPlas on AD with CCH. RESULTS: The present study demonstrated that sPlas significantly recovered cerebral blood flow, improved motor and cognitive deficits, reduced amyloid-β pathology, regulated neuroinflammation, ameliorated neural oxidative stress, and inhibited neuronal loss in AD with CCH mice at 12 M. CONCLUSION: These findings suggest that sPlas possesses clinical and pathological benefits for AD with CCH in the novel model mice. Furthermore, sPlas could have promising prevention and therapeutic effects on patients of AD with CCH.

DOI： 10.3233/JAD-215246

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A case of a heterozygous ABCC6 mutation showing recurrent ischemic strokes and intracranial hemorrhages

Emi Nomura, Yuko Kawahara, Yoshio Omote, Yoshiaki Takahashi, Namiko Matsumoto, Ken Ikegami, Mami Takemoto, Nozomi Hishikawa, Yumiko Nakano, Taijun Yunoki, Ryuta Morihara, Masahiro Uemura, Koji Abe, Toru Yamashita

Neurology and Clinical Neuroscience 10 ( 2 ) 98 - 101 2022.3

Efficacy and safety of spot heating and ultrasound irradiation on in vitro and in vivo thrombolysis models. International journal

Ryuta Morihara, Toru Yamashita, Yosuke Osakada, Tian Feng, Xinran Hu, Yusuke Fukui, Koh Tadokoro, Mami Takemoto, Koji Abe

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 42 ( 7 ) 271678X221079127 - 1334 2022.2

Language：English Publishing type：Research paper (scientific journal)

The feasibility of transcranial sonothrombolysis has been demonstrated, although little is known about the relationships between thermal or mechanical mechanisms and thrombolytic outcomes. Therefore, the present study aims to reveal the effect and safety of temperature and ultrasound through in vitro and in vivo thrombolysis models. Artificial clots in microtubes were heated in a water bath or sonicated by ultrasound irradiation, and then clots weight decrease with rising temperature and sonication time was confirmed. In the in vitro thrombotic occlusion model, based on spot heating, clot volume was reduced and clots moved to the distal side, followed by recanalization of the occlusion. In the in vivo study, the common carotid artery of rats was exposed to a spot heater or to sonication. No brain infarct or brain blood barrier disruption was shown, but endothelial junctional dysintegrity and an inflammatory response in the carotid artery were detected. The present spot heating and ultrasound irradiation models seem to be effective for disintegrating clots in vitro, but the safety of the in vivo model was not fully supported by the data. However, the data indicates that a shorter time exposure could be less invasive than a longer exposure.

DOI： 10.1177/0271678X221079127

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Protective Effect of Rivaroxaban Against Amyloid Pathology and Neuroinflammation Through Inhibiting PAR-1 and PAR-2 in Alzheimer's Disease Mice. International journal

Zhihong Bian, Xia Liu, Tian Feng, Haibo Yu, Xiao Hu, Xinran Hu, Yuting Bian, Hongming Sun, Koh Tadokoro, Mami Takemoto, Taijun Yunoki, Yumiko Nakano, Yusuke Fukui, Ryuta Morihara, Koji Abe, Toru Yamashita

Journal of Alzheimer's disease : JAD 86 ( 1 ) 111 - 123 2022

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Recent studies have revealed that atrial fibrillation (AF) patients have a high risk of developing cognitive impairment, vascular dementia, and Alzheimer's disease (AD). Some reports suggest that the application of oral anticoagulant with an appropriate dose may have a preventive effect on AD. However, which oral anticoagulant drug is more appropriate for preventing AD and the underlying mechanism(s) is still unknown. OBJECTIVE: The aim of the present study was to assess the treatment effect of rivaroxaban administration as well as investigate the roles of PAR-1 and PAR-2 in the AD + CAA mice model. METHODS: In the present study, we compared a traditional oral anticoagulant, warfarin, and a direct oral anticoagulant (DOAC), rivaroxaban, via long-term administration to an AD with cerebral amyloid angiopathy (CAA) mice model. RESULTS: Rivaroxaban treatment attenuated neuroinflammation, blood-brain barrier dysfunction, memory deficits, and amyloid-β deposition through PAR-1/PAR-2 inhibition in the AD + CAA mice model compared with warfarin and no-treatment groups. CONCLUSION: The present study demonstrates that rivaroxaban can attenuate AD progress and can be a potential choice to prevent AD.

DOI： 10.3233/JAD-215318

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Aromatherapy for women migraine patients

Ueno Setsuko, Hishikawa Nozomi, Matsumoto Namiko, Hayashi Saori, Wakutani Yousuke, Tadokoro Koh, Takemoto Mami, Nomura Emi, Sasaki Ryo, Morihara Ryuta, Yamashita Toru, Takao Yoshiki

Japanese Journal of Headache 49 ( 1 ) 215 - 222 2022

Language：Japanese Publisher：The Japanese Headache Society

Chronic headache is a common neurological disease, which sometimes interfere business and life especially in women. In the present study, we newly created a headache diary for catching details of the patients’headache, and conducted an interventional open label cross-over study（each average 28 days）with or without aromatherapy using lavender（n＝12）or geranium（n＝12）．With these aromatic oil therapy, more than 80%of the headache patients（mean age 38.3±12.9 years old, 22 cases＝migraine, 2 cases＝migraine＋tension headache）felt relaxed. Aromatherapy reduced a 4.4%of drug intake on the headache day as compared to the non-aromatherapy period. Aromatherapy shortened the mean sleep-in time from 26.4 to 21.2min. Unfavorable effects on the daily business and house lives decreased in aromatherapy period than non-aroma period from 70.8 to 58.3%．These results suggest a positive effect of the aromatherapy for chronic headache women for giving relaxation and decreasing business stress, and making a short sleep-in．

DOI： 10.50860/jjho.49.1_215

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Chronic Beneficial Effect of Makeup Therapy on Cognitive Function of Dementia and Facial Appearance Analyzed by Artificial Intelligence Software. International journal

Koh Tadokoro, Toru Yamashita, Junko Sato, Yoshio Omote, Mami Takemoto, Ryuta Morihara, Koichiro Nishiura, Tomiko Tani, Koji Abe

Journal of Alzheimer's disease : JAD 85 ( 3 ) 1189 - 1194 2021.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Makeup greatly impacts normal social lives but can also be a non-pharmacological form of therapy for dementia. OBJECTIVE: To evaluate the therapeutic effect of makeup therapy. METHODS: We carried out a prospective interventional study on female nursing home residents with dementia, focusing on the chronic therapeutic effect of makeup therapy. Thirty-four patients who received either only skin care (control group, n = 16) or skin care plus makeup therapy (makeup therapy group, n = 18) once every 2 weeks for 3 months were assessed. RESULTS: Three months of makeup therapy significantly improved the Mini-Mental State Examination (MMSE) score compared with control patients ( *p < 0.05). Artificial intelligence (AI) software revealed that the appearance of age decreased significantly in the makeup group compared with the control, especially among patients without depression ( *p < 0.05). Furthermore, a larger AI happiness score was significantly correlated with a greater improvement of ADL in the makeup therapy group (r = 0.43, *p < 0.05). CONCLUSION: Makeup therapy had a chronic beneficial effect on the cognitive function of female dementia patients, while the chronic effect of makeup therapy on facial appearance was successfully detected by the present AI software.

DOI： 10.3233/JAD-215385

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脳梗塞モデルマウスにおけるホヤ由来プラズマローゲンの神経保護作用の検討

福井裕介, 馮田, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 山下徹, 阿部康二

脳循環代謝 33 ( 1 ) 114 - 114 2021.11

Three cases of GFAP astrocytopathy, one with bilateral ovarian teratoma

Yosuke Osakada, Yoshio Omote, Yuki Taira, Chika Matsuoka, Ken Ikegami, Koh Tadokoro, Emi Nomura, Yuko Kawahara, Kota Sato, Yuka Terasawa, Nozomi Hishikawa, Ryuta Morihara, Mami Takemoto, Akio Kimura, Takayoshi Shimohata, Toru Yamashita, Koji Abe

Neurology and Clinical Neuroscience 10 ( 1 ) 30 - 34 2021.11

外傷と脳循環代謝 in vitro及びin vivo血栓モデルにおける温熱照射と超音波照射の有効性と安全性の検討

森原隆太, 馮田, 小坂田陽介, 山下徹, 胡欣冉, 福井祐介, 田所功, 武本麻美, 阿部康二

脳循環代謝 33 ( 1 ) 49 - 49 2021.11

ALS患者脊髄では低酸素ストレスの増加が起きている

山下徹, 畠山哲宗, 佐藤恒太, 福井裕介, 武本麻美, 太田康之, 西山佳宏, 河井信行, 田宮隆, 阿部康二

神経治療学 38 ( 6 ) S267 - S267 2021.10

幹細胞移植は脳梗塞後の異常蛋白処理機構を変化させる

田所功, 福井裕介, 山下徹, 劉夏, 角田慶一郎, 商敬偉, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 阿部康二

神経治療学 38 ( 6 ) S322 - S322 2021.10

機械的血栓回収による直接的血管損傷とNVU破綻ラットモデルにおける検討

佐々木諒, 山下徹, 福井裕介, 中野由美子, 柚木太淳, 武本麻美, 森原隆太, 阿部康二

神経治療学 38 ( 6 ) S265 - S265 2021.10

Accelerated accumulation of fibrinogen peptide chains with Aβ deposition in Alzheimer's disease (AD) mice and human AD brains. International journal

Zhihong Bian, Toru Yamashita, Xiaowen Shi, Tian Feng, Haibo Yu, Xiao Hu, Xinran Hu, Yuting Bian, Hongming Sun, Koh Tadokoro, Mami Takemoto, Yoshio Omote, Ryuta Morihara, Koji Abe

Brain research 1767 147569 - 147569 2021.9

Language：English Publishing type：Research paper (scientific journal)

Alzheimer's disease (AD) is a common neurodegenerative disease that is characterized by the abnormal accumulation of intracellular and extracellular amyloid-β (Aβ) as well as disruption of the blood brain barrier (BBB). Fibrinogen plays an essential role in regulating thrombosis, wound healing, and other biological functions. In the present study, we investigated the relationship between three polypeptide chains α, β, and γ (FGA, FGB, and FGG) and Aβ deposition in the APP23 plus chronic cerebral hypoperfusion (CCH) mice model as well as the human AD brain. FGA, FGB, and FGG accumulated when Aβ was deposited in neural cells and cerebral vessels. This deposition was significantly higher in AD plus CCH mice models relative to wild-type brains, and in human AD brains compared to control brains. The present study demonstrates that FGA, FGB, and FGG are associated with AD progress, and can thus be potential targets for the diagnosis and therapy of AD.

DOI： 10.1016/j.brainres.2021.147569

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Successful treatment of anti-GAD antibody-associated autoimmune cerebellar ataxia with combined immunotherapies

Yoshio Omote, Chika Matsuoka, Ryo Sasaki, Nozomi Hishikawa, Yuko Kawahara, Emi Nomura, Namiko Matsumoto, Yuki Taira, Mami Takemoto, Ryuta Morihara, Toru Yamashita, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 2021.9

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

Anti-glutamic acid decarboxylase (GAD) antibody (Ab)-associated autoimmune cerebellar ataxia (CA) is a rare neurological disorder, and a standardized therapy has not been established. Here, we report on a 58 year-old man with type 1 diabetes mellitus, who developed progressive CA with high levels of serum and cerebrospinal fluid (CSF) anti-GAD-Ab. He was initially treated with intravenous high-dose methylprednisolone and intravenous immunoglobulin (IVIg), but his CA was gradually worsened. Additional combined immunotherapies with plasma exchange, intravenous cyclophosphamide, and rituximab finally stabilized the progressive CA and suppressed the CSF anti-GAD-Ab index. Our case suggests the effectiveness of combined immunotherapies against progressive CA and the usefulness of the CSF anti-GAD-Ab index as a therapeutic indicator.

DOI： 10.1111/ncn3.12541

Web of Science

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アパシーの成因・治療を考えるアルツハイマー病患者の不安定な精神状態へのより良い処方薬について

武本麻美, 太田康之, 菱川望, 山下徹, 野村恵美, 角田慶一郎, 佐々木諒, 田所功, 松本菜見子, 表芳夫, 阿部康二

老年精神医学雑誌 32 ( 増刊I ) 179 - 179 2021.9

アルツハイマー病患者における主観的・客観的睡眠障害

田所功, 太田康之, 菱川望, 野村恵美, 涌谷陽介, 高尾芳樹, 表芳夫, 武本麻美, 山下徹, 阿部康二

臨床神経学 61 ( Suppl. ) S302 - S302 2021.9

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Papers - TAKEMOTO Mami