Faculty Profiles - TAKEMOTO Mami

Papers - TAKEMOTO Mami

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Different Characteristics of Anterior and Posterior Branch Atheromatous Diseases with or without Early Neurologic Deterioration Reviewed

Yoshiaki Takahashi, Toru Yamashita, Ryuta Morihara, Yumiko Nakano, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Yasuhiro Manabe, Koji Abe

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 26 ( 6 ) 1314 - 1320 2017.6

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER

Background: Among several types of ischemic stroke (IS), branch atheromatous disease (BAD) is known to be the leading cause of disability. Methods: A total of 1919 patients with acute IS were retrospectively analyzed, and BAD patients were classified into anterior or posterior BAD, depending on the responsible vascular territories. These patients were further subcategorized with or without early neurologic deterioration (END or no-END). Results: Of all IS patients, 14.3% had BAD, and 202 patients (73.7%) were further classified as anterior BAD and 72 patients (26.3%) as posterior BAD. The prevalence of diabetes mellitus and END was significantly higher in posterior than in anterior BAD (44.4% vs 26.4%, P <.01; 18.1% vs 5.4%, P <.01, respectively). Posterior BAD showed a higher proportion of female patients and an older age (69.2% vs 39.0%, P <.05; 79.1 +/- 7.7 vs 70.5 +/- 10.7, P <.01, respectively) in END than in no-END. The modified Rankin Scale was worse in posterior BAD at 90 days (2.5 +/- 1.6, P <.01) than in anterior BAD (1.6 +/- 1.4). Conclusions: Our present study shows that posterior BAD is a worse clinical outcome than anterior BAD, with more vascular risk factors. Older female patients with posterior BAD showed a higher risk of END, leading to a worse clinical outcome.

DOI： 10.1016/j.jstrokecerebrovasdis.2017.02.001

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Factors related to continuous and discontinuous attendance at memory clinics Reviewed

N. Hishikawa *,Y. Fukui ,Y. Nakano ,R. Morihara ,M. Takemoto *,K. Sato *,T. Yamashita *,Y. Ohta *,K. Abe *

European Journal of Neurology 24 ( 5 ) 673 - 679 2017.5

Familial amyotrophic lateral sclerosis of the G37V-superoxide dismutase 1 mutation with a slow disease progression

Koh Tadokoro, Yasuyuki Ohta, Yoshiaki Takahashi, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Koji Abe

NEUROLOGY AND CLINICAL NEUROSCIENCE 5 ( 3 ) 96 - 98 2017.5

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

The majority of amyotrophic lateral sclerosis patients have the sporadic form, but 5-10% of those have familial amyotrophic lateral sclerosis. A total of 15-20% of familial amyotrophic lateral sclerosis patients have genetic mutations in the superoxide dismutase 1 gene. In 2012, Kobayashi et al. reported the first case of a familial amyotrophic lateral sclerosis patient carrying a G37V superoxide dismutase 1 mutation, who showed rapid progression and died within 1.2 years of onset from respiratory failure. In contrast, here we report the second case of familial amyotrophic lateral sclerosis carrying the G37V superoxide dismutase 1 mutation, showing a very slow progression, and his father and aunt also had longer disease durations from 4 to 6 years. Further clinical and biological studies will clarify the detailed pathological role of the G37V superoxide dismutase 1 mutation for amyotrophic lateral sclerosis.

DOI： 10.1111/ncn3.12123

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Ataxic form of autosomal recessive PEX10-related peroxisome biogenesis disorders with a novel compound heterozygous gene mutation and characteristic clinical phenotype Reviewed

Toru Yamashita, Jun Mitsui, Nobuyuki Shimozawa, Shigeo Takashima, Hiroshi Umemura, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Takashi Matsukawa, Hiroyuki Ishiura, Jun Yoshimura, Koichiro Doi, Shinichi Morishita, Shoji Tsuji, Koji Abe

JOURNAL OF THE NEUROLOGICAL SCIENCES 375 424 - 429 2017.4

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

Peroxisome biogenesis factor 10 (PEX10) is involved in the import of peroxisomal matrix proteins, and the mutation of this gene causes 3 subtypes of peroxisome biogenesis disorders, namely Zellweger syndrome (severe), neonatal adrenoleukodystrophy (moderate) and an ataxic form (mild). Here, we report 3 siblings of the ataxic form with cerebellar ataxia, mild mental retardation, and 3 additional characteristic features: mydriasis, hyperreflexia and involuntary head movement. All 3 siblings are compound heterozygous for a previously reported mutation, c.2T>C (p.M1T), and a novel mutation, c920G>A, causing a missense change (p.C307Y) located in the RING finger domain of PEX10. The present cases suggest that these PEX10 mutations involve not only cerebellar but also more multiple nervous systems including pupillary autonomic, pyramidal and extrapyramidal systems. (C) 2017 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jns.2017.02.058

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Potential multisystem degeneration in Asidan patients Reviewed

Yasuyuki Ohta, Toru Yamashita, Nozomi Hishikawa, Kota Sato, Kosuke Matsuzono, Keiichiro Tsunoda, Noriko Hatanaka, Mami Takemoto, Toshihiko Takemi, Kazuhiro Takamatsu, Koji Abe

JOURNAL OF THE NEUROLOGICAL SCIENCES 373 216 - 222 2017.2

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

Objective: To evaluate a potential multisystem involvement of neurodegeneration in Asidan, in addition to cerebellar ataxia and signs of motor neuron disease.Methods: We compared the new Asidan patients and those identified in previous studies with Parkinson's disease (PD, n = 21), and progressive supranuclear palsy (PSP, n = 13) patients using I-123-2 beta-Carbomethoxy-3 beta-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (I-123-FP-CIT) dopamine transporter single photon emission computed tomography (DAT-SPECT) and I-123-metaiodobenzylguanidine (MIBG) myocardial scintigraphy (Asidan, DAT: n = 10; MIBG: n = 15).Results: Both the PD and PSP groups served as positive controls for DAT decline. The PD and PSP groups served as a positive and negative control, respectively, of MIBG decline in the early phase H/M ratio. Of the Asidan patients, 60.0% showed DAT decline without evident parkinsonian features and 6.7% showed impaired MIBG in only the delayed phase H/M ratio. Combined with a normal range of the early phase H/M ratio, this phenotype was newly named Declined DAT Without Evident Parkinsonism (DWEP).Interpretation: The results of present study including DWEP suggest a wider spectrum of neurodegeneration for extrapyramidal and autonomic systems in Asidan patients than expected, involving cerebellar, motor system and cognitive functioning. (C) 2017 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jns.2017.01.003

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Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) with Limbic Encephalitis Reviewed

Yasuyuki Ohta, Emi Nomura, Keiichiro Tsunoda, Toru Yamashita, Yoshiaki Takahashi, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Koji Abe

INTERNAL MEDICINE 56 ( 18 ) 2513 - 2518 2017

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC INTERNAL MEDICINE

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids ( CLIPPERS) is an inflammatory central nervous system disorder that mainly involves in the brainstem, basal ganglia and cerebellum. We herein report the case of a patient with CLIPPERS, which was diagnosed based on the clinical and radiological features. After initially responded to steroid treatment, the patient developed limbic encephalitis. The patient presented with memory disturbance, a delirious state and emotional incontinence. A cerebrospinal fluid study revealed interleukin-6 elevation and enhanced bilateral hippocampal lesions were observed on MRI. The patient was successfully treated with methylprednisolone pulse therapy. This is the first case of CLIPPERS with limbic encephalitis involving the bilateral hippocampus.

DOI： 10.2169/internalmedicine.8533-16

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Emergency caesarean section saved both an anti-musk antibody-positive myasthenia gravis mother with pregnancy-induced hypertension and her premature baby

Yoshiaki Takahashi, Toru Yamashita, Ryuta Morihara, Yumiko Nakano, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Kei Hayata, Hisashi Masuyama, Tomoka Okamura, Yosuke Washio, Koji Abe

Internal Medicine 56 ( 24 ) 3361 - 3364 2017

Publishing type：Research paper (scientific journal)

© 2017 The Japanese Society of Internal Medicine. We herein report the case of a 46-year-old pregnant woman with anti-muscle specific kinase (MuSK) antibody-positive myasthenia gravis (MG) who showed pregnancy-induced hypertension and developed respiratory failure at 30 weeks and 5 days of pregnancy, and who underwent an emergency caesarean section (CS). Her MG symptoms gradually improved in the subsequent weeks. The premature baby with positive MuSK antibodies was successfully delivered, but the male baby required temporary artificial ventilation. However, his condition also gradually improved over time. The present case suggests that an emergency CS could rescue both the mother, who was in critical condition, and the prematurely born baby, even when suffering from acute respiratory insufficiency.

DOI： 10.2169/internalmedicine.8636-16

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アルツハイマー病患者におけるガランタミンの長期的効果について

中野由美子, 山下徹, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 阿部康二

Anti-aging Science 8 ( 1 ) 69 - 69 2016.12

脳血管性認知症モデルラットにおけるテルミサルタンの治療効果

山下徹, 菱川望, 佐藤恒太, 武本麻美, 太田康之, 阿部康二

Anti-aging Science 8 ( 1 ) 72 - 72 2016.12

難病患者就労に対する山陽神経難病ネットワークの役割

太田康之, 山下徹, 菱川望, 佐藤恒太, 武本麻美, 阿部康二, 三宅進, 重實比呂子, 三村あゆみ, 三垣亮輔, 竹内秀将, 岩藤弘子, 薮田智子, 斎藤文恵, 鈴木美穂, 竹内ひかり

日本難病医療ネットワーク学会機関誌 4 ( 1 ) 61 - 61 2016.11

ラット一過性脳虚血モデルにおけるTDP43とFUS/TLSの発現亢進による神経細胞保護効果について

中野由美子, Sun Miao, 山下徹, 森原隆太, 武本麻美, 佐藤恒太, 菱川望, 太田康之, 阿部康二

脳循環代謝 28 ( 1 ) 232 - 232 2016.11

多発脳神経麻痺が急速に進行した腎癌の頭蓋底転移の1剖検例

武本麻美, 河原由子, 佐藤恒太, 佐藤康晴, 太田康之, 菱川望, 山下徹, 阿部康二

日本老年医学会雑誌 53 ( 4 ) 461 - 461 2016.10

Asidan(ALS/SCA crossroad mutation)はSWEDDsと正反対所見DWEPを呈する

阿部康二, 太田康之, 山下徹, 菱川望, 佐藤恒太, 武本麻美

パーキンソン病・運動障害疾患コングレスプログラム・抄録集 10回 84 - 84 2016.10

PDDとDLB患者の認知機能・情動機能・日常生活活動強度の比較

武本麻美, 菱川望, 太田康之, 山下徹, 佐藤恒太, 幡中典子

パーキンソン病・運動障害疾患コングレスプログラム・抄録集 10回 88 - 88 2016.10

Temporal Profiles of Stress Protein Inductions after Focal Transient Ischemia in Mice Brain Reviewed

Qian Li, Yumiko Nakano, Jingwei Shang, Yasuyuki Ohta, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Koji Abe

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 25 ( 10 ) 2344 - 2351 2016.10

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER

Background: Stress proteins have been found to play important protective roles against ischemic brain injury under hypoxic, oxidative, heat shock, and proteasome stresses. Methods: In the present study, we investigated the temporal profiles of the major stress proteins including hypoxia-inducible factor-1 alpha (HIF-1 alpha), glutathione (GSH), heat shock protein 72 (HSP72), constitutive heat shock cognate protein 73 (HSC73), and ubiquitin after 45 minutes of transient middle cerebral artery occlusion (tMCAO) in the mice brain up to 7 days after reperfusion. Results: Immunohistochemical analyses of HIF-1 alpha, GSH, HSP72, and ubiquitin showed little immunoreactivity of neural cells in sham control brain, whereas HSC73 showed a constitutive immunoreactivity. After tMCAO, HSC73 showed the fastest increase at 12 hours in the peri-ischemic area, followed by HIF-1 alpha with a peak at 24 hours, GSH, HSP72, and ubiquitin with a peak at 72 hours. All these stress proteins returned toward the baseline levels until 7 days. In the ischemic core, these stress proteins showed a similar change with less reaction compared to the peri-ischemic area. Conclusions: These data showed temporal expressions of HIF-1 alpha, GSH, HSP72, HSC73, and ubiquitin in the mice brain after tMCAO, which might provide a better understanding of neuroprotective mechanisms and novel targets for therapeutic intervention of brain ischemic disease. (C) 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.

DOI： 10.1016/j.jstrokecerebrovasdis.2016.05.031

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Differences between the behavioral and psychological symptoms of Alzheimer's disease and Parkinson's disease Reviewed

Ryo Tokuchi, Nozomi Hishikawa, Kota Sato, Noriko Hatanaka, Yusuke Fukui, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

JOURNAL OF THE NEUROLOGICAL SCIENCES 369 278 - 282 2016.10

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

Aim: We compared the behavioral and psychological symptoms of Alzheimer's disease (AD) and Parkinson's disease (PD) in order to determine the characteristic features of each disorder.Methods: For this retrospective cohort study, we compared the behavioral and psychological symptoms of 288 AD patients and 189 PD patients (mean age, 74.6 +/- 5.9 and 73.0 +/- 8.7 years respectively). Symptoms were evaluated using the geriatric depression scale (GDS), apathy scale (AS), and Abe's behavioral and psychological symptoms of dementia score (ABS).Results: AD patients had higher AS and ABS scores than PD patients. A gender-dependent comparison showed that ABS scores were worse in female AD patients than in female PD patients (p=0.001). A subscale analysis of ABS scores revealed that male AD patients were only significantly different from male PD patients in I item, whereas female AD patients were significantly different from female PD patients in 4 items. Among patients with mild cognitive decline, no differences in affective scores were observed. Alternatively, among patients with moderate cognitive decline, affective scores on all 3 scales were worse in PD patients than in AD patients.Conclusions: The present age-and gender-matched retrospective analysis identified greater behavioral and psychological disease severity in female AD patients relative to female PD patients, and greater affective severity in PD patients versus AD patients with a similar degree of cognitive decline. (C) 2016 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jns.2016.08.053

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Comparative Gait Analysis in Progressive Supranuclear Palsy and Parkinson's Disease Reviewed

Noriko Hatanaka, Kota Sato, Nozomi Hishikawa, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

European Neurology 75 ( 5-6 ) 282 - 289 2016.7

Language：English Publishing type：Research paper (scientific journal)

© 2016 S. Karger AG, Basel. Background: Although changes to gait are an important clinical feature of progressive supranuclear palsy (PSP), systematic analyses have not been well examined, especially in comparison to Parkinson's disease (PD). Methods: The characteristics of gait in 20 PSP patients (14 males and 6 females) were evaluated in comparison to 124 PD patients (64 males and 60 females) and 24 controls, that is, healthy age-matched adults (5 males and 19 females). Gait in patients was recorded in a 10-m walking test at a self-selected speed. During this time, patients felt most comfortable while wearing a new portable triaxial accelerometer rhythmogram device. Gait variables among the 3 groups were compared. Results: Both PSP and PD patients shared the following similar hypokinetic gait characteristics: decreased velocity, step length, cadence and mean acceleration. Step time and variability in step time were mutually related. However, among the 3 groups, PSP patients showed characteristically low vertical displacement and a higher acceleration than PD patients at the same cadence. Conclusion: Although PSP and PD patients showed similar hypokinetic gait, a reduced vertical displacement characterized walking in PSP patients, differing substantially from the characteristics of walking displayed by PD patients.

DOI： 10.1159/000445111

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脳血管性認知症モデルラットにおけるテルミサルタンの治療効果

山下徹, 菱川望, 佐藤恒太, 武本麻美, 太田康之, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 16回 191 - 191 2016.6

Age-dependent cognitive and affective differences in Alzheimer's and Parkinson's diseases in relation to MRI findings Reviewed

Ryo Tokuchi, Nozomi Hishikawa, Kota Sato, Noriko Hatanaka, Yusuke Fukui, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

JOURNAL OF THE NEUROLOGICAL SCIENCES 365 3 - 8 2016.6

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

Objective: To compare age-dependent changes in cognitive and affective functions related to white matter changes between patients with Alzheimer's disease (AD) and Parkinson's disease (PD).Methods: We retrospectively compared age-dependent cognitive and affective functions in 216 AD patients, 153 PD patients, and 103 healthy controls with cerebral white matter lesions (WMLs), periventricular hyperintensity (PVH), deep white matter hyperintensity (DWMH), micro-bleeds (MBs), and lacunar infarcts (LIs).Results: The average mini-mental state examination (MMSE) scores were 19.6 +/- 6.1 and 26.8 +/- 3.6 in AD and PD patients, respectively. Significant decreases were found in the MMSE score, Hasegawa's dementia scale-revised (HDS-R) score, frontal assessment battery score, and Abe's BPSD score (ABS) among the age-dependent AD subgroups and in the MMSE, HDS-R, Montreal cognitive assessment, geriatric depression scale, and ABS scores among the age-dependent PD subgroups; they were worse in AD patients. White matter changes were observed in > 88% and > 72% of patients with AD and PD, respectively. An age-dependent direct comparison of AD and PD showed significant differences in the PVH and DWMH grades, and numbers of MBs and LIs.Conclusion: WML-related cognitive and affective functions worsen with age in AD and PD patients; however, the abnormalities were more frequent and stronger in AD patients. (C) 2016 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jns.2016.03.031

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New susceptible variant of COQ2 gene in Japanese patients with sporadic multiple system atrophy

Zhuoran Sun, Yasuyuki Ohta, Toru Yamashita, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Koji Abe

Neurology: Genetics 2 ( 2 ) 2016.4

Publishing type：Research paper (scientific journal)

© 2016 American Academy of Neurology. Objective: The aim of this study was to analyze the association between the variations of coenzyme Q2 4-hydroxybenzoate polyprenyltransferase gene (COQ2) and Japanese patients with multiple system atrophy (MSA). Methods: We investigated the genetic variations in exons 1, 2, 6, and 7 of the COQ2 gene in 133 Japanese patients with MSA and 200 controls and analyzed the association between the variations and MSA. Results: Six DNA variations (G21S, L25V, V66L, P157S, V393A, and X422K) were found in the 133 patients with MSA, and G21S and X422K were new variations that had never been reported. V66L was a common variation that was found in all 133 patients with MSA. G21S, P157S, V393A, and X422K did not show gene frequency differences between patients with MSA and controls. On the other hand, L25V was newly proven to be the only risk factor of sporadic MSA with predominant olivopontocerebellar ataxia. Conclusions: The present study suggests L25V variant of COQ2 gene as a genetic risk factor in Japanese patients with MSA with cerebellar ataxia.

DOI： 10.1212/NXG.0000000000000054

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Papers - TAKEMOTO Mami