Faculty Profiles - TAKEMOTO Mami

Papers - TAKEMOTO Mami

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Comparative Gait Analysis in Progressive Supranuclear Palsy and Parkinson's Disease

Noriko Hatanaka, Kota Sato, Nozomi Hishikawa, Mami Takemoto, Yasuyuki Ohta, Toru Yamashita, Koji Abe

EUROPEAN NEUROLOGY 75 ( 5-6 ) 282 - 289 2016

Language：English Publishing type：Research paper (scientific journal) Publisher：KARGER

Background: Although changes to gait are an important clinical feature of progressive supranuclear palsy (PSP), systematic analyses have not been well examined, especially in comparison to Parkinson's disease (PD). Methods: The characteristics of gait in 20 PSP patients (14 males and 6 females) were evaluated in comparison to 124 PD patients (64 males and 60 females) and 24 controls, that is, healthy age-matched adults (5 males and 19 females). Gait in patients was recorded in a 10-m walking test at a self-selected speed. During this time, patients felt most comfortable while wearing a new portable triaxial accelerometer rhythmogram device. Gait variables among the 3 groups were compared. Results: Both PSP and PD patients shared the following similar hypokinetic gait characteristics: decreased velocity, step length, cadence and mean acceleration. Step time and variability in step time were mutually related. However, among the 3 groups, PSP patients showed characteristically low vertical displacement and a higher acceleration than PD patients at the same cadence. Conclusion: Although PSP and PD patients showed similar hypokinetic gait, a reduced vertical displacement characterized walking in PSP patients, differing substantially from the characteristics of walking displayed by PD patients. (C) 2016 S. Karger AG, Basel

DOI： 10.1159/000445111

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Different Clinical and Neuroimaging Characteristics in Early Stage Parkinson's Disease with Dementia and Dementia with Lewy Bodies Reviewed

Mami Takemoto, Kota Sato, Noriko Hatanaka, Toru Yamashita, Yasuyuki Ohta, Nozomi Hishikawa, Koji Abe

JOURNAL OF ALZHEIMERS DISEASE 52 ( 1 ) 205 - 211 2016

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：IOS PRESS

Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) both commonly exhibit brain Lewy body pathology and similar end-stage symptoms, but early symptoms differ. To clarify these differences, we compared the demographic characteristics, symptoms, cognitive and affective functioning, activities of daily life, and neuroimaging results between PDD (n = 52) and DLB (n = 46) patients. In measures of cognitive functioning, PDD patients had worse Hasegawa dementia scale-revised (HDS-R) scores (11.2 +/- 4.8) and better frontal assessment battery (FAB) scores (11.3 +/- 4.1) compared with DLB (17.0 +/- 6.4, p = 0.013 and 8.6 +/- 4.7, p = 0.039, respectively). DLB patients performed worse than PDD patients in "orientation to place" tasks. In affective functions, DLB patients had worse GDS (7.6 +/- 3.4) and ABS (9.9 +/- 5.3) scores than PDD patients (5.1 +/- 4.1 and 4.8 +/- 3.0, respectively). Tc-99m-ECD images showed greater CBF in the whole cingulate gyrus and a lower CBF in the precuneus area in DLB than in PDD. These results suggest that PDD patients' lower average scores for "repetition" (MMSE), "recent memory" (HDS-R), and "lexical fluency" (FAB) were related to lower CBF in the cingulate gyrus than in DLB. Furthermore, DLB patients' poorer average subscale scores of " orientation to place" (MMSE) and "similarities", "conflicting instructions", and "go-no go" (FAB) tasks may be related to the lower CBF in the precuneus area in DLB than PDD.

DOI： 10.3233/JAD-150952

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多発性硬化症および視神経脊髄炎におけるタッチパネル式認知機能検査の有用性

太田康之, 河原由子, 薮田智子, 竹内ひかり, 佐藤恒太, 武本麻美, 菱川望, 山下徹, 阿部康二

日本難病医療ネットワーク学会機関誌 3 ( 1 ) 55 - 55 2015.11

脳卒中慢性期患者では再発よりも認知症移行(direct conversion)が高い

中野由美子, 出口健太郎, 山下徹, 武本麻美, 佐藤恒太, 菱川望, 太田康之, 高尾芳樹, 東靖人, 阿部康二

脳循環代謝 27 ( 1 ) 149 - 149 2015.10

進行性核上性麻痺・パーキンソン病患者における歩行の比較

幡中典子, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 山下徹, 阿部康二

パーキンソン病・運動障害疾患コングレスプログラム・抄録集 9回 81 - 81 2015.10

テルミサルタン長期投与がラット梗塞後脳に及ぼすメタボリックシンドローム関連因子発現の検討

出口健太郎, ざい蘊, 佐藤恒太, 武本麻美, 菱川望, 太田康之, 山下徹, 阿部康二

脳循環代謝 27 ( 1 ) 195 - 195 2015.10

多発性硬化症および視神経脊髄炎におけるタッチパネル式認知機能検査の検討

太田康之, 河原由子, 佐藤恒太, 武本麻美, 菱川望, 山下徹, 阿部康二

Dementia Japan 29 ( 3 ) 404 - 404 2015.9

PDDとDLBの認知機能、情動機能の比較検討

武本麻美, 菱川望, 太田康之, 山下徹, 佐藤恒太, 幡中典子, 阿部康二

日本神経心理学会総会プログラム・予稿集 39回 204 - 204 2015.8

MCIの予後と関連因子の検討

徳地亮, 菱川望, 佐藤恒太, 幡中典子, 武本麻美, 福井裕介, 太田康之, 山下徹, 阿部康二

日本抗加齢医学会総会プログラム・抄録集 15回 190 - 190 2015.5

タッチパネル式コンピュータを活用した脳梗塞既往患者の認知機能と画像所見の関連の検討

出口健太郎, 河野祥一郎, 柚木太淳, 松薗構佑, 中野由美子, 角田慶一郎, 河原由子, 幡中典子, 武本麻美, 太田康之, 菱川望, 山下徹, 阿部康二

脳循環代謝 26 ( 1 ) 168 - 168 2014.11

側頭葉内側萎縮と大脳白質病変の併存がアルツハイマー病患者の認知機能と情動機能に及ぼす影響

徳地亮, 菱川望, 佐藤恒太, 幡中典子, 武本麻美, 福井裕介, 太田康之, 出口健太郎, 山下徹, 阿部康二

脳循環代謝 26 ( 1 ) 214 - 214 2014.11

Myocardial microvascular perfusion after transfusion of liposome-encapsulated hemoglobin evaluated in cross-circulated rat hearts using tracer digital radiography

Takahisa Asano, Takeshi Matsumoto, Hiroyuki Tachibana, Mami Takemoto, Fumihiko Kajiya

Journal of Artificial Organs 7 ( 3 ) 145 - 148 2004.9

Language：English Publishing type：Research paper (scientific journal)

The effect of hemodilution with Neo Red Cell (NRC, liposome-encapsulated hemoglobin) on myocardial perfusion was evaluated in cross-circulated rat hearts under 300-bpm pacing and 100-mmHg perfusion pressure. In NRC-transfused hearts (n = 5), NRC volume fraction and hematocrit were 9% ± 3% and 22% ± 4%, respectively
the latter decreased from 43% ± 3% before NRC transfusion. Coronary perfusion rate and left ventricular isovolemic developed pressure increased after NRC transfusion to 4.6 ± 1.0 ml/min/g and 127 ± 32 mmHg from basal values of 2.5 ± 0.3 ml/min/g and 115 ± 28 mmHg, respectively. In contrast, the flow increase during reperfusion following 30-s flow cessation decreased from 74% ± 24% to 64% ± 24%. The arteriovenous difference in O2 saturation was slightly higher after NRC transfusion. Within-layer regional flow distributions from subepicardium to subendocardium assessed by tracer digital radiography (100-μm resolution) showed that coefficients of variation of flows in 400 X 400-μm regions were 0.41 ± 0.10 in NRC-transfused hearts and 0.54 ± 0.11 in nontransfused hearts (n = 5)
i.e., the myocardial flow distribution was more uniform in NRC-transfused hearts. These results suggest that NRC is superior to erythrocytes in terms of the homogenization of O 2 delivery, indicating its potential therapeutic value in myocardial microcirculatory failure.

DOI： 10.1007/s10047-004-0260-1

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Pattern differences between distributions of microregional myocardial flows in crystalloid- and blood-perfused rat hearts

Takeshi Matsumoto, Hiroyuki Tachibana, Takahisa Asano, Mami Takemoto, Yasuo Ogasawara, Keiji Umetani, Fumihiko Kajiya

American Journal of Physiology - Heart and Circulatory Physiology 286 ( 4 ) H1331 - H1338 2004

Language：English Publishing type：Research paper (scientific journal)

Regional myocardial flow distributions in Langendorff rat hearts under Tyrode and blood perfusion were assessed by tracer digital radiography (100-μm resolution). Flow distributions during baseline and maximal hyperemia following a 60-s flow cessation were evaluated by the coefficient of variation of regional flows (CV
related to global flow heterogeneity) and the correlation between adjacent regional flows (CA
inversely related to local flow randomness). These values were obtained for the original images (64 2 pixels) and for coarse-grained images (322, 16 2, and 82 blocks of nearby pixels). At a given point in time during baseline, both CV and CA were higher in blood (n = 7) than in Tyrode perfusion (n = 7) over all pixel aggregates (P &lt
0.05, two-way ANOVA). During the maximal hyperemia, CV and CA were still significantly higher in blood (n = 7) than in Tyrode perfusion (n = 7)
however, these values decreased substantially in blood perfusion and the CV and CA differences became smaller than those at baseline accordingly. During basal blood perfusion, the 60-s average flow distribution (n = 7) showed a smaller CV and CA than those at a given point in time (P &lt
0.05, two-way ANOVA). Coronary flow reserve was significantly higher in blood than in Tyrode perfusion. In conclusion, the flow heterogeneity and the local flow similarity are both higher in blood than in Tyrode perfusion, probably due to the different degree of coronary tone preservation and the presence or absence of blood corpuscles. Under blood perfusion, temporal flow fluctuations over 60-s order are largely involved in shaping microregional flow distributions.

DOI： 10.1152/ajpheart.00120.2003

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