論文 - 加来田　博貴

Aromatic layered guanidines bind sequence-specifically to DNA minor groove with precise fit 査読

Ryuuta Fukutomi, Aya Tanatani, Hiroki Kakuta, Nobuo Tomioka, Akiko Itai, Yuichi Hashimoto, Koichi Shudo, Hiroyuki Kagechika

Tetrahedron Letters   39 ( 36 )   6475 - 6478   1998年9月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier Ltd  

Tetraguanidines (1 and 2) with an aromatic multilayered structure exhibit potent binding to a specific site of DNAS with binding constants of the order of 107 M-1 as deduced from Scatchard analysis of ultrafiltration data and simulation of CD titration curves. NMR spectra of the complexes indicated that 1 and 2 bind DNAs sequence-specifically at the minor groove, as predicted by computational docking studies.

DOI： 10.1016/s0040-4039(98)01378-1

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