論文 - 加来田 博貴
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Structural basis for the full and partial agonist activities of retinoid X receptor α ligands with an iso-butoxy and an isopropyl group. 国際誌
Daisuke Imai, Nobutaka Numoto, Hiroaki Tokiwa, Hiroki Kakuta, Nobutoshi Ito
Biochemical and biophysical research communications 734 150617 - 150617 2024年11月
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Simple Fluorescence Labeling Method Enables Detection of Intracellular Distribution and Expression Level of Retinoid X Receptors 査読
Yukina Tanaka, Michiko Fujihara, Yuta Takamura, Mayu Kawasaki, Shogo Nakano, Makoto Makishima, Hiroki Kakuta
ACS Medicinal Chemistry Letters 2024年5月
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Direct evaluation of polarity of the ligand binding pocket in retinoid X receptor using a fluorescent solvatochromic agonist. 査読 国際誌
Kizuku Miura, Michiko Fujihara, Masaki Watanabe, Yuta Takamura, Mayu Kawasaki, Shogo Nakano, Hiroki Kakuta
Bioorganic & medicinal chemistry letters 96 129536 - 129536 2023年10月
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Ligand Screening System for the RXRα Heterodimer Using the Fluorescence RXR Agonist CU-6PMN 査読
Mayu Kawasaki, Tomoharu Motoyama, Shoya Yamada, Masaki Watanabe, Michiko Fujihara, Akira Kambe, Shogo Nakano, Hiroki Kakuta, Sohei Ito
ACS Medicinal Chemistry Letters 14 ( 3 ) 291 - 296 2023年2月
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Structural characterization of 1,3-bis-tert-butyl monocyclic benzene derivatives with agonistic activity towards retinoid X receptor alpha. 査読 国際誌
Susumu Kodama, Shuzo Matsumoto, Yuta Takamura, Michiko Fujihara, Masaki Watanabe, Atsushi Ono, Hiroki Kakuta
Toxicology letters 373 76 - 83 2022年11月
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Analysis of absorption-enhancing mechanisms for combinatorial use of spermine with sodium taurocholate in Caco-2 cells. 査読 国際誌
Masato Maruyama, Yohei Nishida, Hironori Tanaka, Takako Minami, Ken-Ichi Ogawara, Masateru Miyake, Yuta Takamura, Hiroki Kakuta, Kazutaka Higaki
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 180 332 - 343 2022年11月
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Teratogenicity and Fetal-Transfer Assessment of the Retinoid X Receptor Agonist Bexarotene. 査読 国際誌
Yuta Takamura, Izumi Kato, Manami Fujita-Takahashi, Midori Azuma-Nishii, Masaki Watanabe, Rui Nozaki, Masaru Akehi, Takanori Sasaki, Hiroyuki Hirano, Hiroki Kakuta
ACS pharmacology & translational science 5 ( 9 ) 811 - 818 2022年9月
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Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors In Vivo. 査読 国際誌
Negar Khazan, Kyu Kwang Kim, Jeanne N Hansen, Niloy A Singh, Taylor Moore, Cameron W A Snyder, Ravina Pandita, Myla Strawderman, Michiko Fujihara, Yuta Takamura, Ye Jian, Nicholas Battaglia, Naohiro Yano, Yuki Teramoto, Leggy A Arnold, Russell Hopson, Keshav Kishor, Sneha Nayak, Debasmita Ojha, Ashoke Sharon, John M Ashton, Jian Wang, Michael T Milano, Hiroshi Miyamoto, David C Linehan, Scott A Gerber, Nada Kawar, Ajay P Singh, Erdem D Tabdanov, Nikolay V Dokholyan, Hiroki Kakuta, Peter W Jurutka, Nina F Schor, Rachael B Rowswell-Turner, Rakesh K Singh, Richard G Moore
Journal of Medicinal Chemistry 65 ( 8 ) 6039 - 6055 2022年4月
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Masaki Watanabe, Mariko Nakamura-Nakayama, Michiko Fujihara, Mayu Kawasaki, Shogo Nakano, Hiroki Kakuta
ACS Medicinal Chemistry Letters 13 ( 2 ) 211 - 217 2022年1月
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Ryohtaroh Matsumoto, Daisuke Takahashi, Masaki Watanabe, Shunsuke Nakatani, Yuta Takamura, Yuji Kurosaki, Hiroki Kakuta, Koji Hase
Frontiers in Pharmacology 12 715752 2021年8月
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Maho Takioku, Yuta Takamura, Michiko Fujihara, Masaki Watanabe, Shoya Yamada, Mayu Kawasaki, Sohei Ito, Shogo Nakano, Hiroki Kakuta
ACS Medicinal Chemistry Letters 2021年6月
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In Vivo Receptor Visualization and Evaluation of Receptor Occupancy with Positron Emission Tomography 招待 査読
Yuta Takamura, Hiroki Kakuta
Journal of Medicinal Chemistry 64 ( 9 ) 5226 - 5251 2021年5月
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Masaki Watanabe, Michiko Fujihara, Tomoharu Motoyama, Mayu Kawasaki, Shoya Yamada, Yuta Takamura, Sohei Ito, Makoto Makishima, Shogo Nakano, Hiroki Kakuta
Journal of Medicinal Chemistry 64 ( 1 ) 430 - 439 2021年1月
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Fluorescence properties of retinoid X receptor antagonist NEt-SB 査読
Shoya Yamada, Yuta Takamura, Michiko Fujihara, Mayu Kawasaki, Sohei Ito, Shogo Nakano, Hiroki Kakuta
Bioorganic & Medicinal Chemistry Letters 31 127666 - 127666 2021年1月
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A Retinoid X Receptor Agonist Directed to the Large Intestine Ameliorates T-Cell-Mediated Colitis in Mice. 査読 国際誌
Ryohtaroh Matsumoto, Daisuke Takahashi, Masaki Watanabe, Shunsuke Nakatani, Yuta Takamura, Yuji Kurosaki, Hiroki Kakuta, Koji Hase
Frontiers in pharmacology 12 715752 - 715752 2021年
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Hiroki Kakuta
Journal of Medicinal Chemistry 64 ( 1 ) 861 - 870 2020年12月
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Hend M Nawara, SAID M AFIFY, Ghmkin Hassan, Maram H. Zahra, Marwa Atallah, Hager Mansour, Hagar A. Abu Quora, Md Jahangir Alam, Amira Osman, Hiroki Kakuta, Hiroki Hamada, Akimasa Seno, Masaharu Seno
Cancers 12 ( 6 ) 1360 - 1360 2020年5月
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Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice 査読 国際誌
Ikuo Kimura, Junki Miyamoto, Ryuji Ohue-Kitano, Keita Watanabe, Takahiro Yamada, Masayoshi Onuki, Ryo Aoki, Yosuke Isobe, Daiji Kashihara, Daisuke Inoue, Akihiko Inaba, Yuta Takamura, Satsuki Taira, Shunsuke Kumaki, Masaki Watanabe, Masato Ito, Fumiyuki Nakagawa, Junichiro Irie, Hiroki Kakuta, Masakazu Shinohara, Ken Iwatsuki, Gozoh Tsujimoto, Hiroaki Ohno, Makoto Arita, Hiroshi Itoh, Koji Hase
Science 367 ( 6481 ) 2020年2月
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Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets 査読 国際誌
Noriko Itaba, Yohei Kono, Kaori Watanabe, Tsuyoshi Yokobata, Hiroyuki Oka, Mitsuhiko Osaki, Hiroki Kakuta, Minoru Morimoto, Goshi Shiota
Scientific Reports 9 ( 1 ) 6841 - 6841 2019年12月
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Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening. 査読 国際誌
Shoya Yamada, Mayu Kawasaki, Michiko Fujihara, Masaki Watanabe, Yuta Takamura, Maho Takioku, Hiromi Nishioka, Yasuo Takeuchi, Makoto Makishima, Tomoharu Motoyama, Sohei Ito, Hiroaki Tokiwa, Shogo Nakano, Hiroki Kakuta
Journal of Medicinal Chemistry 62 ( 19 ) 8809 - 8818 2019年10月
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3H-Imidazo[4,5-b]pyridine-6-carboxylic acid derivatives as rexinoids with reduced teratogenicity 査読 国際誌
Yuta Takamura, Manami Takahashi, Midori Nishii, Osamu Shibahara, Masaki Watanabe, Michiko Fujihara, Hiroki Kakuta
Bioorganic & Medicinal Chemistry Letters 29 ( 15 ) 1891 - 1894 2019年8月
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Correction to Synthesis of 11C-Labeled RXR Partial Agonist 1-[(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic Acid (CBt-PMN) by Direct [11C]Carbon Dioxide Fixation via Organolithiation of Tri 査読
Shibahara O, Watanabe M, Takamura Y, Yamada S, Akehi M, Sasaki T, Akahoshi A, Hanada T, Hirano H, Nakatani S, Nishioka H, Takeuchi Y, Kakuta H
Journal of Medicinal Chemistry 62 ( 9 ) 4780 - 4781 2019年5月
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Fluorine-18 (18F)-labeled retinoid x receptor (RXR) partial agonist whose tissue transferability is affected by other RXR ligands. 査読 国際誌
Takamura Y, Shibahara O, Watanabe M, Fujihara M, Yamada S, Akehi M, Sasaki T, Hirano H, Kakuta H
Bioorganic & medicinal chemistry 27 ( 14 ) 3128 - 3134 2019年5月
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A partial agonist for retinoid X receptor mitigates experimental colitis. 査読 国際誌
Masayoshi Onuki, Masaki Watanabe, Narumi Ishihara, Koichiro Suzuki, Kei Takizawa, Masato Hirota, Takahiro Yamada, Aiko Egawa, Osamu Shibahara, Midori Nishii, Michiko Fujihara, Makoto Makishima, Daisuke Takahashi, Yukihiro Furusawa, Hiroki Kakuta, Koji Hase
International immunology 31 ( 4 ) 251 - 262 2019年3月
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変形性関節症:from bench to bedside 関節軟骨のバイオイメージング
大橋 俊孝, 加来田 博貴, 大野 充昭, 西田 圭一郎
日本整形外科学会雑誌 93 ( 2 ) S331 - S331 2019年3月
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A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation. 査読 国際誌
Daisuke Morichika, Nobuaki Miyahara, Utako Fujii, Akihiko Taniguchi, Naohiro Oda, Satoru Senoo, Mikio Kataoka, Mitsune Tanimoto, Hiroki Kakuta, Katsuyuki Kiura, Yoshinobu Maeda, Arihiko Kanehiro
Respiratory research 20 ( 1 ) 2 - 2 2019年1月
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Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα). 査読 国際誌
Miyashita Y, Numoto N, Arulmozhiraja S, Nakano S, Matsuo N, Shimizu K, Shibahara O, Fujihara M, Kakuta H, Ito S, Ikura T, Ito N, Tokiwa H
FEBS letters 593 ( 2 ) 242 - 250 2019年1月
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Problems with laboratory notebooks in academia and how to resolve them
Kakuta, H.
Yakugaku Zasshi 139 ( 6 ) 2019年
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Kakuta, H., Sudo, H.
Yakugaku Zasshi 139 ( 6 ) 2019年
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Retinoid X Receptor Antagonists
Masaki Watanabe, Hiroki Kakuta
International Journal of Molecular Sciences 19 ( 8 ) 2354 - 2354 2018年8月
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Retinoid X Receptor Antagonists
Hiroki Kakuta
International Journal of Molecular Sciences 2018年8月
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Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer 査読 国際誌
Rayna Rosati, Lisa Polin, Charles Ducker, Jing Li, Xun Bao, Dakshnamurthy Selvakumar, Seongho Kim, Besa Xhabija, Martha Larsen, Thomas McFall, Yanfang Huang, Benjamin L Kidder, Andrew Fribley, Janice Saxton, Hiroki Kakuta, Peter Shaw, Manohar Ratnam
Clinical cancer research : an official journal of the American Association for Cancer Research 24 ( 24 ) 6509 - 6522 2018年
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Retinoid X receptor antagonists
Watanabe, M., Kakuta, H.
International Journal of Molecular Sciences 19 ( 8 ) 2018年
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Retinoid X Receptor Antagonists
Hiroki Kakuta
International journal of molecular sciences 2018年
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Synthesis of 11C-Labeled RXR Partial Agonist 1-[(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic Acid (CBt-PMN) by Direct [11C]Carbon Dioxide Fixation via Organolithiation of Trialkyltin Precursor and PET Imagin・・・ 査読 国際誌
Osamu Shibahara, Masaki Watanabe, Shoya Yamada, Masaru Akehi, Takanori Sasaki, Akiya Akahoshi, Takahisa Hanada, Hiroyuki Hirano, Shunsuke Nakatani, Hiromi Nishioka, Yasuo Takeuchi, Hiroki Kakuta
Journal of Medicinal Chemistry 60 ( 16 ) 7139 - 7145 2017年8月
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Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma. 査読 国際誌
Utako Fujii, Nobuaki Miyahara, Akihiko Taniguchi, Naohiro Oda, Daisuke Morichika, Etsuko Murakami, Hikari Nakayama, Koichi Waseda, Mikio Kataoka, Hiroki Kakuta, Mitsune Tanimoto, Arihiko Kanehiro
Respiratory research 18 ( 1 ) 23 - 23 2017年1月
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Effect Of A Retinoid X Receptor Partial Agonist On The Development Of Emphysema And Airway Inflammation In A Murine Model Of Emphysema 査読
D. Morichika, A. Kanehiro, H. Kakuta, A. Taniguchi, U. Fujii, N. Oda, N. Miyahara, K. Kiura, M. Tanimoto
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 195 2017年
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Retinoid X Receptor Ligands with Anti-Type 2 Diabetic Activity
Hiroki Kakuta
Current topics in medicinal chemistry 2017年
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Treatment With Novel Retinoid X Receptor Partial Agonist Attenuates Eosinophilic Airway Inflammation And Airway Hyperresponsiveness 査読
U. Fujii, A. Kanehiro, N. Miyahara, N. Oda, D. Morichika, A. Taniguchi, G. Ikeda, H. Nakayama, K. Waseda, E. Murakami, H. Kakuta, M. Kataoka, K. Kiura, M. Tanimoto
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 193 2016年
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Retinoid x receptor ligands with anti-type 2 diabetic activity
Morishita, K.-I., Kakuta, H.
Current Topics in Medicinal Chemistry 16 ( 30 ) 2016年
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RXR Partial Agonist Produced by Side Chain Repositioning of Alkoxy RXR Full Agonist Retains Antitype 2 Diabetes Activity without the Adverse Effects 査読
Kohei Kawata, Ken-ichi Morishita, Mariko Nakayama, Shoya Yamada, Toshiki Kobayashi, Yuki Furusawa, Sakae Arimoto-Kobayashi, Toshitaka Oohashi, Makoto Makishima, Hirotaka Naitou, Erika Ishitsubo, Hiroaki Tokiwa, Akihiro Tai, Hiroki Kakuta
JOURNAL OF MEDICINAL CHEMISTRY 58 ( 2 ) 912 - 926 2015年1月
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Toshiki Kobayashi, Yuki Furusawa, Shoya Yamada, Masaru Akehi, Fumiaki Takenaka, Takanori Sasaki, Akiya Akahoshi, Takahisa Hanada, Eiji Matsuura, Hiroyuki Hirano, Akihiro Tai, Hiroki Kakuta
ACS medicinal chemistry letters 6 ( 3 ) 334 - 338 2015年
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Involvement of glucocorticoid receptor activation on anti-inflammatory effect induced by peroxisome proliferator-activated receptor γ agonist in mice. 査読 国際誌
Yamamoto A, Kakuta H, Sugimoto Y
International immunopharmacology 22 ( 1 ) 204 - 8 2014年
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Interspecies comparison of hepatic metabolism of six newly synthesized retinoid X receptor agonistic compounds possessing a 6-[N-ethyl-N-(alkoxyisopropylphenyl)amino]nicotinic acid skeleton in rat and human liver microsomes 査読
Yoshiki Murakami, Yasumasa Shimizu, Akemi Ogasawara, Satoshi Ueshima, Mariko Nakayama, Kohei Kawata, Hiroki Kakuta, Tetsuya Aiba
Drug development and industrial pharmacy 40 ( 8 ) 1065 - 1071 2014年
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In vitro anti-proliferative and anti-angiogenic activities of thalidomide dithiocarbamate analogs 査読
Bishoy Y A El-Aarag, Tomonari Kasai, Magdy A H Zahran, Nadia I Zakhary, Tsukasa Shigehiro, Sreeja C Sekhar, Hussein S Agwa, Akifumi Mizutani, Hiroshi Murakami, Hiroki Kakuta, Masaharu Seno
International immunopharmacology 21 ( 2 ) 283 - 292 2014年
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Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency 査読
Fuminori Ohsawa, Shoya Yamada, Nobumasa Yakushiji, Ryosuke Shinozaki, Mariko Nakayama, Kohei Kawata, Manabu Hagaya, Toshiki Kobayashi, Kazutaka Kohara, Yuuki Furusawa, Chisa Fujiwara, Yui Ohta, Makoto Makishima, Hirotaka Naitou, Akihiro Tai, Yutaka Yoshikawa, Hiroyuki Yasui, Hiroki Kakuta
Journal of medicinal chemistry 56 ( 5 ) 1865 - 1877 2013年
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Hiroki Kakuta, Nobumasa Yakushiji, Ryosuke Shinozaki, Fuminori Ohsawa, Shoya Yamada, Yui Ohta, Kohei Kawata, Mariko Nakayama, Manabu Hagaya, Chisa Fujiwara, Makoto Makishima, Shigeyuki Uno, Akihiro Tai, Ami Maehara, Masaru Nakayama, Toshitaka Oohashi, Hiroyuki Yasui, Yutaka Yoshikawa
ACS medicinal chemistry letters 3 ( 5 ) 427 - 432 2012年
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Suzuki M, Takeuchi M, Tsuji-Takayama K, Harashima A, Otani T, Toraya T, Kakuta H, Yamasaki F, Nakamura S, Kibata M
Results in immunology 2 158 - 165 2012年
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Feasibility of structural modification of retinoid X receptor agonists to separate blood glucose-lowering action from adverse effects: studies in KKA(y) type 2 diabetes model mice 査読
Hiroki Kakuta, Fuminori Ohsawa, Shoya Yamada, Makoto Makishima, Akihiro Tai, Hiroyuki Yasui, Yutaka Yoshikawa
Biological & pharmaceutical bulletin 35 ( 4 ) 629 - 633 2012年
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Yamamoto A, Kakuta H, Miyachi H, Sugimoto Y
PPAR research 2011 840194 2011年
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An arylidene-thiazolidinedione derivative, GPU-4, without PPARγ activation, reduces retinal neovascularization. 査読
Nakamura S, Hayashi K, Takizawa H, Murase T, Tsuruma K, Shimazawa M, Kakuta H, Nagasawa H, Hara H
Current neurovascular research 8 ( 1 ) 25 - 34 2011年
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Design and synthesis of novel cyclooxygenase-1 inhibitors as analgesics: 5-amino-2-ethoxy-N-(substituted-phenyl)benzamides 査読
Ryosuke Fukai, Xiaoxia Zheng, Kazunori Motoshima, Akihiro Tai, Futoshi Yazama, Hiroki Kakuta
ChemMedChem 6 ( 3 ) 550 - 560 2011年
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Pharmacokinetic properties of newly synthesized retinoid X receptor agonists possessing a 6-[N-ethyl-N-(3-alkoxy-4-isopropylphenyl)amino]nicotinic acid skeleton in rats 査読
Akemi Ogasawara, Yoshiki Murakami, Nobumasa Yakushiji, Fuminori Ohsawa, Jun-Ichi Kusaba, Tetsuya Aiba, Yuji Kurosaki, Hiroki Kakuta
Drug development and industrial pharmacy 37 ( 9 ) 1060 - 1067 2011年
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Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity 査読
Takashi Okitsu, Kana Sato, Kinya Iwatsuka, Natsumi Sawada, Kimie Nakagawa, Toshio Okano, Shoya Yamada, Hiroki Kakuta, Akimori Wada
Bioorganic & medicinal chemistry 19 ( 9 ) 2939 - 2949 2011年
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Mariko Nakayama, Shoya Yamada, Fuminori Ohsawa, Yui Ohta, Kohei Kawata, Makoto Makishima, Hiroki Kakuta
ACS medicinal chemistry letters 2 ( 12 ) 896 - 900 2011年
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Kakuta, H, Azumaya, I, Masu, H, Matsumura, M, Yamaguchi, K, Kagechika, H, Tanatani, A
Tetrahedron 66 ( 42 ) 8254 - 8260 2010年10月
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Fluorescent retinoid X receptor ligands for fluorescence polarization assay 査読
Yamada S, Ohsawa F, Fujii S, Shinozaki R, Makishima M, Naitou H, Enomoto S, Tai A, Kakuta H.
Bioorganic & medicinal chemistry letters 20 ( 17 ) 5143 - 5146 2010年
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Fuminori Ohsawa, Ken-Ichi Morishita, Shoya Yamada, Makoto Makishima, Hiroki Kakuta
ACS medicinal chemistry letters 1 ( 9 ) 521 - 525 2010年
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Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor 査読
Hiroki Kakuta, Ryosuke Fukai, Zheng Xiaoxia, Fuminori Ohsawa, Takeshi Bamba, Kazumasa Hirata, Akihiro Tai
Bioorganic & medicinal chemistry letters 20 ( 6 ) 1840 - 1843 2010年
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Effect of 5-aminosalicylate on allergic rhinitis model in mice 査読
Shoji Kuyama, Atsuki Yamamoto, Mayu Sugiyama, Hiroki Kakuta, Yukio Sugimoto
International immunopharmacology 10 ( 6 ) 713 - 716 2010年
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Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation 査読
Shuji Fujii, Fuminori Ohsawa, Shoya Yamada, Ryosuke Shinozaki, Ryosuke Fukai, Makoto Makishima, Shuichi Enomoto, Akihiro Tai, Hiroki Kakuta
Bioorganic & medicinal chemistry letters 20 ( 17 ) 5139 - 5142 2010年
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Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity 査読
Ken-ichi Morishita, Nobumasa Yakushiji, Fuminori Ohsawa, Kayo Takamatsu, Nobuyasu Matsuura, Makoto Makishima, Masatoshi Kawahata, Kentaro Yamaguchi, Akihiro Tai, Kenji Sasaki, Hiroki Kakuta
Bioorganic & medicinal chemistry letters 19 ( 3 ) 1001 - 1003 2009年
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Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation 査読
Xiaoxia Zheng, Hiroyuki Oda, Shun Harada, Yukio Sugimoto, Akihiro Tai, Kenji Sasaki, Hiroki Kakuta
Journal of pharmaceutical sciences 97 ( 12 ) 5446 - 5452 2008年
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Design and synthesis of benzenesulfonanilides active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus 査読
Kensuke Namba, Xiaoxia Zheng, Kazunori Motoshima, Hidetomo Kobayashi, Akihiro Tai, Eizo Takahashi, Kenji Sasaki, Keinosuke Okamoto, Hiroki Kakuta
Bioorganic & medicinal chemistry 16 ( 11 ) 6131 - 6144 2008年
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Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype-preference: RXRα-preferential agonist possessing a sulfonamide moiety 査読
Kayo Takamatsu, Atsushi Takano, Nobumasa Yakushiji, Ken-ichi Morishita, Nobuyasu Matsuura, Makoto Makishima, Hamed Ismail Ali, Eiichi Akaho, Akihiro Tai, Kenji Sasaki, Hiroki Kakuta
ChemMedChem 3 ( 3 ) 454 - 460 2008年
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Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor 査読
Hiroki Kakuta, Xiaoxia Zheng, Hiroyuki Oda, Shun Harada, Yukio Sugimoto, Kenji Sasaki, Akihiro Tai
Journal of medicinal chemistry 51 ( 8 ) 2400 - 2411 2008年
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The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety, NEt-3IP (RXRalpha/beta-dual agonist) 査読
Kayo Takamatsu, Atsushi Takano, Nobumasa Yakushiji, Kazunori Morohashi, Ken-ichi Morishita, Nobuyasu Matsuura, Makoto Makishima, Akihiro Tai, Kenji Sasaki, Hiroki Kakuta
ChemMedChem 3 ( 5 ) 780 - 787 2008年
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Pyridinium cationic-dimer antimalarials, unlike chloroquine, act selectively between the schizont stage and the ring stage of Plasmodium falciparum 査読
Mai Yoshikawa, Kazunori Motoshima, Kanji Fujimoto, Akihiro Tai, Hiroki Kakuta, Kenji Sasaki
Bioorganic & medicinal chemistry 16 ( 11 ) 6027 - 6033 2008年
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Necessity is the mother of invention: an ingenious method for leukocyte-targeted delivery of siRNA in stabilized nanoparticles demonstrates a role of cyclin D1 in inflammation
Hiroki Kakuta
ChemMedChem 2008年
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Kakuta, H.
ChemMedChem 3 ( 7 ) 2008年
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Analgesic agents without gastric damage: Design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors (vol 15, pg 1014, 2007) 査読
Xiaoxia Zheng, Hiroyuki Oda, Kayo Takamatsu, Yukio Sugimoto, Akihiro Tai, Eiichi Akaho, Hamed Ismail Ali, Toshiyuki Oshiki, Hiroki Kakuta, Kenji Sasaki
BIOORGANIC & MEDICINAL CHEMISTRY 15 ( 9 ) 3299 - 3300 2007年5月
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Antimalarial cation-dimers synthesized in two steps from an inexpensive starting material, isonicotinic acid 査読
Kazunori Motoshima, Yoshiko Hiwasa, Mai Yoshikawa, Kanji Fujimoto, Akihiro Tai, Hiroki Kakuta, Kenji Sasaki
ChemMedChem 2 ( 10 ) 1527 - 1532 2007年
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Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors 査読
Xiaoxia Zheng, Hiroyuki Oda, Kayo Takamatsu, Yukio Sugimoto, Akihiro Tai, Eiichi Akaho, Hamed Ismail Ali, Toshiyuki Oshiki, Hiroki Kakuta, Kenji Sasaki
Bioorganic & medicinal chemistry 15 ( 2 ) 1014 - 1021 2007年
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Antimalarial effect of bis-pyridinium salts, N,N'-hexamethylenebis(4-carbamoyl-1-alkylpyridinium bromide) 査読
Kanji Fujimoto, Daiki Morisaki, Munehiro Yoshida, Tetsuto Namba, Kim Hye-Sook, Yusuke Wataya, Hiroki Kourai, Hiroki Kakuta, Kenji Sasaki
Bioorganic & medicinal chemistry letters 16 ( 10 ) 2758 - 2760 2006年
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Membrane permeabilization by non-steroidal anti-inflammatory drugs 査読
Tomisato W, Tanaka K, Katsu T, Kakuta H, Sasaki K, Tsutsumi S, Hoshino T, Aburaya M, Li D, Tsuchiya T, Suzuki K, Yokomizo K, Mizushima T.
Biochemical and biophysical research communications 323 ( 3 ) 1032 - 1039 2004年
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Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton 査読
Hiroki Kakuta, Aya Tanatani, Kazuo Nagasawa, Yuichi Hashimoto
Chemical & pharmaceutical bulletin 51 ( 11 ) 1273 - 1282 2003年
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Cyclooxygenase inhibitors derived from thalidomide 査読
Mamiko Suizu, Yohei Muroya, Hiroki Kakuta, Hiroyuki Kagechika, Aya Tanatani, Kazuo Nagasawa, Yuichi Hashimoto
Chemical & pharmaceutical bulletin 51 ( 9 ) 1098 - 1102 2003年
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Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells 査読
Hiroki Kakuta, Yukiko Koiso, Kazuo Nagasawa, Yuichi Hashimoto
Bioorganic & medicinal chemistry letters 13 ( 1 ) 83 - 86 2003年
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Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: Identification of the target molecule and a structure-activity relationship study 査読
M Komoda, H Kakuta, H Takahashi, Y Fujimoto, S Kadoya, F Kato, Y Hashimoto
BIOORGANIC & MEDICINAL CHEMISTRY 9 ( 1 ) 121 - 131 2001年1月
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Novel Specific Puromycin-sensitive Aminopeptidase Inhibitors: 3-(2,6-Diethylphenyl)-2,4(1H,3H)quinazolinedione and N-(2,6-Diethylphenyl)-2-amino-4H-3,1-benzoxazin-4-one 査読
Hiroki Kakuta, Yukiko Koiso, Hiroyasu Takahashi, Kazuo Nagasawa, and Yuichi Hashimoto
HETEROCYCLES 55 ( 8 ) 1433 - 1438 2001年
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Aromatic layered guanidines bind sequence-specifically to DNA minor groove with precise fit 査読
Ryuuta Fukutomi, Aya Tanatani, Hiroki Kakuta, Nobuo Tomioka, Akiko Itai, Yuichi Hashimoto, Koichi Shudo, Hiroyuki Kagechika
Tetrahedron Letters 39 ( 36 ) 6475 - 6478 1998年9月