論文 - 座間味　義人

Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives 査読

Kohji Matsumoto, Tominari Choshi, Mai Hourai, Yoshito Zamami, Kenji Sasaki, Takumi Abe, Minoru Ishikura, Noriyuki Hatae, Tatsunori Iwamura, Shigeo Tohyama, Junko Nobuhiro, Satoshi Hibino

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   22 ( 14 )   4762 - 4764   2012年7月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.bmcl.2012.05.064

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Neurogenic Vascular Responses in Male Mouse Mesenteric Vascular Beds 査読

Hiroki Fujiwara, Narumi Hashikawa-Hobara, Yoshihiro Wake, Shingo Takatori, Mitsuhiro Goda, Hiroshi Higuchi, Yoshito Zamami, Panot Tangsucharit, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES   119 ( 3 )   260 - 270   2012年7月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1254/jphs.12014FP

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The Mechanism of Calcitonin Gene-Related Peptide-Containing Nerve Innervation 査読

Narumi Hashikawa-Hobara, Naoya Hashikawa, Yoshito Zamami, Shingo Takatori, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES   119 ( 2 )   117 - 121   2012年6月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1254/jphs.12R02CP

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Involvement of perivascular nerves and transient receptor potential vanilloid 1 (TRPV1) in vascular responses to histamine in rat mesenteric resistance arteries 査読

Honghua Jin, Pengyuan Sun, Shingo Takatori, Toshihiro Koyama, Yoshito Zamami, Panot Tangsucharit, Yoshihisa Kitamura, Hiromu Kawasaki

EUROPEAN JOURNAL OF PHARMACOLOGY   680 ( 1-3 )   73 - 80   2012年4月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.ejphar.2012.01.018

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Candesartan Cilexetil Improves Angiotensin II Type 2 Receptor-Mediated Neurite Outgrowth via the PI3K-Akt Pathway in Fructose-Induced Insulin-Resistant Rats 査読

Narumi Hashikawa-Hobara, Naoya Hashikawa, Yusuke Inoue, Hitomi Sanda, Yoshito Zamami, Shingo Takatori, Hiromu Kawasaki

DIABETES   61 ( 4 )   925 - 932   2012年4月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.2337/db11-1468

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Anandamide Induces Endothelium-Dependent Vasoconstriction and CGRPergic Nerve-Mediated Vasodilatation in the Rat Mesenteric Vascular Bed 査読

Chihiro Tamaki, Hideki Nawa, Shingo Takatori, Sakiko Oda, Toshiaki Sendo, Yoshito Zamami, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES   118 ( 4 )   496 - 505   2012年4月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1254/jphs.11236FP

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Adrenergic Stimulation-Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries 査読

Yuto Haruki, Shingo Takatori, Sayo Hattori, Yoshito Zamami, Toshihiro Koyama, Panot Tangsucharit, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES   118 ( 4 )   537 - 542   2012年4月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1254/jphs.12012SC

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Quinolone analogs 11: Synthesis of novel 4-quinolone-3-carbohydrazide derivatives with antimalarial activity 査読

Yoshihisa Kurasawa, Kiminari Yoshida, Naoki Yamazaki, Eisuke Kaji, Kenji Sasaki, Yoshito Zamami, Yasuhiro Sakai, Takatoshi Fujii, Hideyuki Ito

JOURNAL OF HETEROCYCLIC CHEMISTRY   49 ( 2 )   288 - 292   2012年3月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/jhet.774

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Endothelium-Derived Relaxing Factor Mediated Vasodilation in Mouse Mesenteric Vascular Beds 査読

Hiroki Fujiwara, Yoshihiro Wake, Narumi Hashikawa-Hobara, Kento Makino, Shingo Takatori, Yoshito Zamami, Yoshihisa Kitamura, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES   118 ( 3 )   373 - 381   2012年3月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1254/jphs.11197FP

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Long-term treatment with losartan augments vasodilator CGRPergic nerve activity in Spontaneously Hypertensive Rats 査読

Yoshito Zamami, Shingo Takatori, Narumi Hashikawa, Hiroko Ishikawa, Kenji Sasaki, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES   118   198P - 198P   2012年

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記述言語：英語  

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Hyperinsulinemia induces hypertension associated with neurogenic vascular dysfunction resulting from abnormal perivascular innervations in rat mesenteric resistance arteries 査読

Yoshito Zamami, Shingo Takatori, Narumi Hobara, Nana Yabumae, Panot Tangsucharit, Xin Jin, Naoya Hashikawa, Yoshihisa Kitamura, Kenji Sasaki, Hiromu Kawasaki

HYPERTENSION RESEARCH   34 ( 11 )   1190 - 1196   2011年11月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/hr.2011.97

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The Akt-Nitric Oxide-cGMP Pathway Contributes to Nerve Growth Factor-Mediated Neurite Outgrowth in Apolipoprotein E Knockout Mice 査読

Narumi Hashikawa-Hobara, Naoya Hashikawa, Chikao Yutani, Yoshito Zamami, Xin Jin, Shingo Takatori, Mitsunobu Mio, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS   338 ( 2 )   694 - 700   2011年8月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1124/jpet.111.181487

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New Molecular Mechanisms for Cardiovascular Disease: Contribution of Endothelium-Derived Hyperpolarizing Factor in the Regulation of Vasoconstriction in Peripheral Resistance Arteries 査読

Xin Jin, Yukiko Satoh-Otonashi, Yoshito Zamami, Shingo Takatori, Narumi Hashikawa-Hobara, Yoshihisa Kitamura, Hiromu Kawasaki

JOURNAL OF PHARMACOLOGICAL SCIENCES   116 ( 4 )   332 - 336   2011年8月

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記述言語：英語  

DOI： 10.1254/jphs.10R30FM

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Quercetin Diacylglycoside Analogues Showing Dual Inhibition of DNA Gyrase and Topoisomerase IV as Novel Antibacterial Agents 査読

Abugafar M. L. Hossion, Yoshito Zamami, Rafiya K. Kandahary, Tomofusa Tsuchiya, Wakano Ogawa, Akimasa Iwado, Kenji Sasaki

JOURNAL OF MEDICINAL CHEMISTRY   54 ( 11 )   3686 - 3703   2011年6月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1021/jm200010x

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Histamine H-3 receptor-mediated modulation of perivascular nerve transmission in rat mesenteric arteries 査読

Pengyuan Sun, Shingo Takatori, Xin Jin, Toshihiro Koyama, Panot Tangsucharit, Simin Li, Yoshito Zamami, Yoshihisa Kitamura, Hiromu Kawasaki

EUROPEAN JOURNAL OF PHARMACOLOGY   655 ( 1-3 )   67 - 73   2011年3月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.ejphar.2011.01.020

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Paracrine control of mesenteric perivascular axo-axonal interaction. 査読

H Kawasaki, S Takatori, 座間味 義人, T Koyama, M Goda, K Hirai, P Tangsucharit, X Jin, N Hobara, Y Kitamura

Acta Physiologica   Vol.203 ( No.1 )   3 - 11   2010年11月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Immunohistochemical study of rat mesenteric arteries showed dense innervation of adrenergic nerves, calcitonin gene-related peptide (CGRP)-containing nerves (CGRPergic nerves), nitric oxide-containing nerves (nitrergic nerves). Double-immunostaining revealed that most CGRPergic or nitrergic nerves were in close contact with adrenergic nerves. CGRPergic and transient receptor potential vanilloid-1 (TRPV1)-immunopositive nerves appeared in the same neurone. In rat perfused mesenteric vascular beds without endothelium and with active tone, perfusion of nicotine, or bolus injection of capsaicin and acetylcholine and periarterial nerve stimulation (PNS) lowered pH levels of out flowed perfusate concomitant with vasodilation. Cold-storage denervation of preparations abolished pH lowering induced by nicotine and PNS. Guanethidine inhibited PNS- and nicotine-, but not acetylcholine- and capsaicin-, induced pH lowering. Pharmacological analysis showed that protons were released not only from adrenergic nerves but also from CGRPergic nerves. A study using a fluorescent pH indicator demonstrated that nicotine, acetylcholine and capsaicin applied outside small mesenteric artery lowered perivascular pH levels, which were not observed in Ca(2+) free medium. Exogenously injected hydrochloric acid in denuded preparations induced pH lowering and vasodilation, which was inhibited by denervation, TRPV1 antagonists and capsaicin without affecting pH lowering. These results suggest that excitement of adrenergic nerves releases protons to activate TRPV1 in CGRPergic nerves and thereby induce vasodilation. It is also suggested that CGRPergic nerves release protons with exocytosis to facilitate neurotransmission via a positive feedback mechanism.

DOI： 10.1111/j.1748-1716.2010.02197.x

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Role of Angiontensin Receptors on Remodeling Perivascular Nerves 査読

Narumi Hobara, Mitsuhiro Goda, Naoya Hashikawa, Xin Jin, Yoshito Zamami, Shingo Takatori, Hiromu Kawasaki

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   130 ( 11 )   1421 - 1425   2010年11月

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記述言語：日本語  

DOI： 10.1248/yakushi.130.1421

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Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents 査読

Abugafar M. L. Hossion, Nao Otsuka, Rafiya K. Kandahary, Tomofusa Tsuchiya, Wakano Ogawa, Akimasa Iwado, Yoshito Zamami, Kenji Sasaki

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS   20 ( 17 )   5349 - 5352   2010年9月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.bmcl.2010.02.060

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Altered function of nitrergic nerves inhibiting sympathetic neurotransmission in mesenteric vascular beds of renovascular hypertensive rats 査読

Toshihiro Koyama, Yukako Hatanaka, Xin Jin, Ayako Yokomizo, Hidetoshi Fujiwara, Mitsuhiro Goda, Narumi Hobara, Yoshito Zamami, Yoshihisa Kitamura, Hiromu Kawasaki

HYPERTENSION RESEARCH   33 ( 5 )   485 - 491   2010年5月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/hr.2010.48

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Ameliorative effect of Eucommia ulmoides Oliv. leaves extract (ELE) on insulin resistance and abnormal perivascular innervation in fructose-drinking rats 査読

Xin Jin, Keisuke Amitani, Yoshito Zamami, Shingo Takatori, Narumi Hobara, Naomi Kawamura, Tetsuya Hirata, Atsunori Wada, Yoshihisa Kitamura, Hiromu Kawasaki

JOURNAL OF ETHNOPHARMACOLOGY   128 ( 3 )   672 - 678   2010年4月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.jep.2010.02.019

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