研究者詳細 - 光井　崇

論文 - 光井　崇

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Comparison of Kidney Function between Gestational Hypertension and Preeclampsia 査読

Etsuko Nobumoto, Hisashi Masuyama, Jota Maki, Takeshi Eguchi, Shoko Tamada, Takashi Mitsui, Eriko Eto, Kei Hayata, Yuji Hiramatsu

ACTA MEDICA OKAYAMA 71 ( 2 ) 161 - 169 2017年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

Although gestational hypertension (GH) is thought to be different from preeclampsia (PE), in Japan GH and PE are usually treated as the same disease (i.e., pregnancy-induced hypertension). Here we sought to determine whether there are any differences in fetal growth and maternal kidney function between pregnancies with PE and those with GH. We retrospectively analyzed 61 GH patients and 60 PE patients with singleton pregnancies who delivered at Okayama University Hospital (2008-2015). We compared maternal and perinatal outcomes and maternal kidney function parameters between the GH and PE pregnancies. The mean values of maternal age (p=0.01), gestational age at delivery (p<0.0001), placental weight (p=0.002), birth weight and height (p<0.0001, p=0.0001), and head circumference standard deviation score (p=0.007) of newborns of the GH group were significantly higher than those of the PE group. The duration until termination of PE or GH was not significantly correlated with kidney function. The birth weight percentile was significantly correlated with kidney function in PE but not GH. However, GH patients with poor kidney function and small-for-gestational age infants showed perinatal outcomes similar to those of the PE group. Monitoring kidney function is thus important for determining the severity of PE and GH.

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Successful pregnancy located in a uterine cesarean scar: A case report. 査読国際誌

Shoko Tamada, Hisashi Masuyama, Jota Maki, Takeshi Eguchi, Takashi Mitsui, Eriko Eto, Kei Hayata, Yuji Hiramatsu

Case reports in women's health 14 8 - 10 2017年4月

記述言語：英語

Cesarean scar pregnancy (CSP) is a rare form of ectopic pregnancy. Because CSP carries a high risk of uterine rupture and life-threatening bleeding, the pregnancy should be terminated upon confirmation of diagnosis. There have been few reports of CSP with successful delivery. We present a case of CSP under expectant management, with delivery via planned cesarean section at 35 weeks of gestation. This report suggests that successful pregnancy outcome can be achieved in some women with uterine cesarean scar, but further analysis and additional studies are required in order to describe the optimal protocol of expectant management in CSP.

DOI： 10.1016/j.crwh.2017.03.003

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口唇裂をきっかけに出生前診断された分葉型全前脳胞症の一例

玉田祥子, 岡本和浩, 牧尉太, 江口武志, 光井崇, 衛藤英理子, 早田桂, 増山寿, 平松祐司

超音波医学 44 ( Suppl. ) S577 - S577 2017年4月

Beckwith-Wiedemann症候群を合併した間葉性異形成胎盤の一例

衛藤英理子, 岡本和浩, 谷和祐, 牧尉太, 江口武志, 玉田祥子, 光井崇, 早田桂, 増山寿, 平松祐司

超音波医学 44 ( Suppl. ) S677 - S677 2017年4月

左心低形成症候群における胎児心臓超音波所見と新生児経過の比較新生児仮死との関連について査読

江口武志, 牧尉太, 岡本和浩, 玉田祥子, 光井崇, 衛藤英理子, 早田桂, 増山寿, 平松祐司

日本産科婦人科学会雑誌 69 ( 2 ) 1011 - 1011 2017年2月

当院における超緊急帝王切開術シミュレーションの成果とその後の変化査読

玉田祥子, 岡本和浩, 牧尉太, 江口武志, 光井崇, 衛藤英理子, 早田桂, 増山寿, 平松祐司

日本産科婦人科学会雑誌 69 ( 2 ) 966 - 966 2017年2月

安静時代謝量の変化からみた糖代謝異常妊婦の至適エネルギー量

衛藤英理子, 岡本和浩, 牧尉太, 江口武志, 玉田祥子, 光井崇, 早田桂, 増山寿, 平松祐司

日本産科婦人科学会雑誌 69 ( 2 ) 914 - 914 2017年2月

機械弁による心臓弁置換術後の妊娠管理経験、症例報告

岡本和浩, 増山寿, 柏原麻子, 牧尉太, 江口武志, 玉田祥子, 光井崇, 衛藤英理子, 早田桂, 平松祐司

日本産科婦人科学会雑誌 69 ( 2 ) 881 - 881 2017年2月

妊娠により急性増悪した常染色体優性多発性嚢胞腎合併妊娠の1例

杉井裕和, 牧尉太, 岡本和浩, 江口武志, 玉田祥子, 光井崇, 衛藤英理子, 早田桂, 増山寿, 平松祐司

日本産科婦人科学会雑誌 69 ( 2 ) 894 - 894 2017年2月

漿液性網膜剥離を発症した重症妊娠高血圧症候群の一例

三島桜子, 早田桂, 岡本和浩, 牧尉太, 玉田祥子, 江口武志, 光井崇, 衛藤英理子, 増山寿, 平松祐司

日本産科婦人科学会雑誌 69 ( 2 ) 995 - 995 2017年2月

Differences in uterine artery blood flow and fetal growth between the early and late onset of pregnancy-induced hypertension 査読

Takashi Mitsui, Hisashi Masuyama, Jota Maki, Shoko Tamada, Yumika Hirano, Eriko Eto, Etsuko Nobumoto, Kei Hayata, Yuji Hiramatsu

JOURNAL OF MEDICAL ULTRASONICS 43 ( 4 ) 509 - 517 2016年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER JAPAN KK

We continuously measured bilateral uterine artery (UA) blood flow and compared differences in UA blood flow to investigate the differences in pathophysiology between early- and late-onset pregnancy-induced hypertension (PIH) and the usefulness of continuous monitoring of UA blood flow for the prediction of early-onset PIH.
The subjects were 76 PIH patients. The mean pulsatility index of bilateral UA (UAPI), an early diastolic notch in the velocity waveform, and regression curves were retrospectively examined and compared between early- and late-onset groups and the groups with and without fetal growth restriction (FGR).
Regression curves of the UAPI in the early-onset group persisted at +2.0 standard deviations or more from the second to third trimester, while the UAPI in the late-onset group stayed within the normal range. A significantly higher mean UAPI with a high frequency of an early diastolic notch was observed in the early-onset group compared with the late-onset group in all pregnancy trimesters. There was a significant difference in UA resistance between the mild and severe groups and between the FGR and non-FGR groups, but to a small extent compared with the onset period.
There was a difference in pathophysiology between early- and late-onset PIH. Continuous monitoring of UA blood flow might be useful for the prediction of early-onset PIH if high UA resistance has been observed.

DOI： 10.1007/s10396-016-0729-6

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Sex differences in early growth during the first three years of life in offspring from mothers with pregnancy-induced hypertension 査読

Takashi Mitsui, Hisashi Masuyama, Takeshi Eguchi, Shoko Tamada, Eriko Eto, Kei Hayata, Yuji Hiramatsu

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH 6 ( 4 ) 361 - 366 2016年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCI LTD

Objectives: Newborns born to mothers with pregnancy-induced hypertension (PIH) are thought to be at high risk for lifestyle-related diseases, such as obesity and hypertension, in adulthood.
Study design: A longitudinal study of 78 pregnant women with PIH and their newborns, who visited Okayama University Hospital from 2009 to 2013.
Main outcome measures: We investigated the change in growth of offspring born to mothers with PIH and compared it with the standard growth curve in Japanese to examine whether there was rapid catch-up growth during the first 3 years of life.
Results: Subjects were 78 pregnant women with PIH and their offspring, who visited Okayama University Hospital from 2009 to 2013. Valid responses were obtained from 29 of 78 (37.1%) women. Body weight and length at birth were at the third percentile or less in females, and at the 10th percentile or less, in males. When body weight and length were compared at 6 months, 18 months, and 3 years old between male and female toddlers, male toddlers slowly caught up until 3 years old, but female toddlers rapidly caught up in the first 6 months. Furthermore, in newborns with fetal growth restriction caused by the intrauterine environment of PIH, differences in physical development between male and female toddlers were more remarkable.
Conclusions: There is a significant sex difference in catch-up growth during the first 3 years, which might be involved in lifestyle-related diseases in adulthood, suggesting continuous follow-up is necessary, especially for female offspring. (C) 2016 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

DOI： 10.1016/j.preghy.2016.08.238

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糖代謝異常妊婦のエネルギー変化から食事指導を考える査読

衛藤英理子, 岡本和浩, 柏原麻子, 牧尉太, 江口武志, 玉田祥子, 光井崇, 早田桂, 増山寿, 平松祐司

糖尿病と妊娠 16 ( 3 ) S - 67 2016年10月

妊娠中の75gOGTTから産後早期の境界型糖尿病発症を予測できるか?

田村奈悠, 衛藤英理子, 岡本和浩, 柏原麻子, 牧尉太, 江口武志, 玉田祥子, 光井崇, 早田桂, 増山寿, 平松祐司

糖尿病と妊娠 16 ( 3 ) S - 67 2016年10月

安心・安全な周産期医療のシステム県下統一に向かって OKAYAMA母体搬送・産後出血チェックシートの導入

牧尉太, 岡本和浩, 柏原麻子, 玉田祥子, 江口武志, 光井崇, 衛藤英理子, 早田桂, 増山寿, 平松祐司

現代産婦人科 65 ( Suppl. ) S59 - S59 2016年9月

出生後早期に気道確保を必要とした上顎体、舌奇形腫、舌裂を合併した唇顎口蓋裂の一例

江口武志, 牧尉太, 谷和祐, 岡本和浩, 玉田祥子, 光井崇, 衛藤英理子, 早田桂, 増山寿, 鷲尾洋介, 吉本順子, 飯田征二, 平松祐司

現代産婦人科 65 ( Suppl. ) S46 - S46 2016年9月

Dimethylesculetin ameliorates maternal glucose intolerance and fetal overgrowth in high-fat diet-fed pregnant mice via constitutive androstane receptor 査読

Hisashi Masuyama, Takashi Mitsui, Jota Maki, Kazumasa Tani, Keiichiro Nakamura, Yuji Hiramatsu

MOLECULAR AND CELLULAR BIOCHEMISTRY 419 ( 1-2 ) 185 - 192 2016年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

The constitutive androstane receptor (CAR) has been reported to decrease insulin resistance along with obesity. 6,7-dimethylesculetin (DE) is an active component of Yin Zhi Huang which is a traditional Asian medicine used to treat neonatal jaundice via CAR. In this study, we examined whether DE could affect the expression of gluconeogenic and lipogenic genes via human CAR pathway using human HepG2 cells in vitro. We also studied whether DE treatment during pregnancy could prevent maternal hypertension, glucose intolerance and hyperlipidemia, and fetal overgrowth in high-fat diet (HFD)-induced obese pregnant mice. Dimethylesculetin suppressed the mRNA expression of gluconeogenic genes, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase, and lipogenic genes, sterol regulatory element-binding protein 1 and stearoyl-CoA desaturase 1, and enhanced CAR-mediated transcription. Blocking the CAR-mediated pathway abolished the effect of DE in vitro. DE treatment during pregnancy could prevent maternal hypertension, glucose intolerance and hyperlipidemia, and fetal overgrowth in HFD-induced obese pregnant mice in vivo. Our data indicate that DE might be a potential therapeutic agent for obese pregnant patients with insulin resistance through CAR to prevent the perinatal outcomes such as preeclampsia, gestational diabetes, and macrosomia. Further analysis of possible complications and side effects using animal models is required.

DOI： 10.1007/s11010-016-2772-4

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The effects of paternal high-fat diet exposure on offspring metabolism with epigenetic changes in the mouse adiponectin and leptin gene promoters 査読

Hisashi Masuyama, Takashi Mitsui, Takeshi Eguchi, Shoko Tamada, Yuji Hiramatsu

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 311 ( 1 ) E236 - E245 2016年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AMER PHYSIOLOGICAL SOC

Recent studies have demonstrated that epigenetic changes resulting from malnutrition might play important roles in transgenerational links with metabolic diseases. Previously, we observed that exposure to a high-fat diet (HFD) in utero caused a metabolic syndrome-like phenomenon through epigenetic modifications of the adiponectin and leptin genes that persisted for multiple generations. Recent etiological studies indicated that paternal BMI had effects on offspring BMI that were independent of but additive to maternal BMI effects. Thus, we examined whether paternal HFD-induced obesity affected the metabolic status of offspring through epigenetic changes in the adiponectin and leptin genes. Additionally, we investigated whether a normal diet during subsequent generations abolished the epigenetic changes associated with paternal HFD exposure before conception. We observed the effects of paternal HFD exposure before conception over multiple generations on offspring metabolic traits, including weight and fat gain, glucose intolerance, hypertriglyceridemia, abnormal adipocytokine levels, hypertension, and adiponectin and leptin gene expression and epigenetic changes. Normal diet consumption by male offspring during the subsequent generation following paternal HFD exposure diminished whereas consumption for two generations completely abolished the effect of paternal HFD exposure on metabolic traits and adipocytokine promoter epigenetic changes in the offspring. The effects of paternal HFD exposure on offspring were relatively weaker than those following HFD exposure in utero. However, paternal HFD exposure had an additive metabolic effect for two generations, suggesting that both paternal and maternal nutrition might affect offspring metabolism through epigenetic modifications of adipocytokine genes for multiple generations.

DOI： 10.1152/ajpendo.00095.2016

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妊娠高血圧症候群における発症週数や胎児発育による子宮動脈血流の相違

光井崇, 増山寿, 岡本和浩, 柏原麻子, 牧尉太, 江口武志, 玉田祥子, 平野友美加, 衛藤英理子, 延本悦子, 早田桂, 平松祐司

日本周産期・新生児医学会雑誌 52 ( 2 ) 671 - 671 2016年6月

糖代謝異常妊婦の安静時代謝量

衛藤英理子, 岡本和浩, 柏原麻子, 牧尉太, 江口武志, 玉田祥子, 光井崇, 平野友美加, 早田桂, 増山寿, 平松祐司

日本周産期・新生児医学会雑誌 52 ( 2 ) 574 - 574 2016年6月

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