Faculty Profiles - NAKAMURA Yoshimasa

MISC - NAKAMURA Yoshimasa

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3週間前に摂取した野菜の履歴が血中に(バイオミディア)

中村宜督

生物工学会誌 : seibutsu-kogaku kaishi 89 ( 4 ) 206 - 206 2011

キウイ幼果抽出物は脂肪細胞分化と脂肪細胞へのグルコース取り込みを促進する

齋藤武, 阿部大吾, 久保康隆, 中村宜督

近畿中国四国農業研究成果情報(CD-ROM) 2010 2011

女子高生が測定した調理における抗酸化活性の変化

山田直史, 中村宜督

日本調理科学会大会研究発表要旨集 2011 34 2011

IQGAP(1) Compartmentalizes ROS-ependent VEGF Receptor 2 Activation and Signaling Linked to Endothelial Proliferation and Angiogenesis

Masooma Razvi, Nihal Kaplan, Cristiana Caliceti, Yoshimasa Nakamura, Norifumi Urao, Ronald D. McKinney, Tohru Fukai, Masuko Ushio-Fukai

CIRCULATION 122 ( 21 ) 2010.11

ROS-dependent Cysteine Sulfenic Acid Formation of IQGAP1 and ERK1/2 in VEGF-induced Endothelial Cell Proliferation and Migration

Nihal Kaplan, Norifumi Urao, Masooma Razvi, Yoshimasa Nakamura, Leslie B. Poole, Tohru Fukai, Masuko Ushio-Fukai

CIRCULATION 120 ( 18 ) S1085 - S1085 2009.11

食品に含まれる生体防御活性化物質

中村宜督

ニューフードインダストリー 51 ( 9 ) 29 - 39 2009.9

Detection of Cysteine Sulfenic Acid Formation: Role In Reactive Oxygen Species-dependent VEGF signaling Linked to Endothelial Migration

Yoshimasa Nakamura, Nihal Kaplan, Leslie B. Poole, Tohru Fukai, Masuko Ushio-Fukai

CIRCULATION 118 ( 18 ) S273 - S273 2008.10

イリノイ大学シカゴ校での留学生活 : 血管新生のレドックス制御機構に関する研究

中村宜督

化学と生物 46 ( 9 ) 653 - 659 2008.9

Language：Japanese Publisher：Japan Society for Bioscience, Biotechnology, and Agrochemistry

筆者は，2006年10月から2008年3月までの約1年半の間，アメリカ・シカゴのイリノイ大学シカゴ校薬理学科にて，特別訪問研究員として研究活動を行なった．ここでは，Dr. Masuko Ushio-Fukai 研究室おける血管新生と活性酸素依存的シグナル伝達調節に関する研究と，シカゴでの留学生活を紹介したい．

DOI： 10.1271/kagakutoseibutsu.46.653

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Alpha-tocopherol induces procaspase-3 expression mediated by the transcriptional factor Sp1 Reviewed

Miyoshi Noriyuki, Nakamura Yoshimasa, Ohshima Hiroshi

FASEB JOURNAL 22 2008.4

Molecular targets for cancer chemoprevention by dietary isothiocyanate

中村宜督

Foods & food ingredients journal of Japan 213 ( 10 ) 910 - 915 2008

Regulation of cell-cell adhesion and ROS-dependent VEGF signaling by protein tyrosine phosphatase 1B in endothelial cells

Yoshimasa Nakamura, Nkolay A. Patrushev, Norifumi Urao, Hyoe Inomata, Ha Won Kim, Tohru Fukai, Masuko Ushio-Fukai

CIRCULATION 116 ( 16 ) 25 - 25 2007.10

Oxidative stress and cell signal

中村宜督

Food style 21 11 ( 10 ) 47 - 49 2007.10

Molecular mechanism underlying the relationship between cell cycle arrest and apoptosis induced by benzyl isothiocyanate Reviewed

Miyoshi Noriyuki, Nakamura Yoshimasa, Ohshima Hiroshi

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 127 145 - 146 2007

研究紹介イソチオシアネートによるがんの化学予防の可能性

中村宜督

岡山大学農学部学術報告 95 87 - 91 2006.2

基礎研究からの未来予想図サプリメントはこれからどうなるか? (特集サプリメントとどうつき合うか)

中村宜督

栄養と料理 71 ( 12 ) 82 - 86 2005.12

イソチオシアネートの細胞死誘導に関与する内因性因子

中村宜督, 渡辺悦子, 三好規之, 内田浩二, 大沢俊彦

日本農芸化学会大会講演要旨集 2005 106 2005.3

Galanals A & B, cytotoxic constituents isolated from Zingiber mioga Roscoe, interfere with the respiratory chain of liver mitchondra Reviewed

K Kawai, Y Ozawa, Y Nakamura

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 125 86 - 87 2005

Cancer chemoprevention by isothiocyanates : Cancerous cell-specific control of cell proliferation and its molecular mechanism(Symposium : The 15th JEMS Annual Symposium"Strategy for Cancer Prevention by Foods : The Mechanisms of Antimutagenic and Anticarc

Nakamura Yoshimasa

Environmental Mutagen Research 26 ( 3 ) 253 - 258 2004.12

Language：Japanese Publisher：The Environmental Mutagen Society of Japan

An important group of compounds that have a chemopreventive property is organosulfur compounds such as isothiocyanates. In the present study, we clarified the molecular mechanism underlying the relationship between benzyl isothiocyanate (BITC)-induced cell cycle arrest and apoptosis. The exposure of the cultured cells to BITC resulted in the inhibition of the G_2/M progression that coincided with apoptosis induction. An experiment using phase-specific synchronized cells demonstrated that the G_2/M phase-arrested cells are more sensitive to undergoing apoptotic stimulation by BITC than the cells in other phases. We identified phosphorylated Bcl-2 as a key molecule linking the p38 MAPK-dependent cell cycle arrest with JNK activation by BITC. We also found that BITC induced a cytotoxic effect more preferentially in the proliferating normal human colon epithelial cells than the quiescent cells. Moreover, down-regulation of p53 resulted in the enhancement of susceptibility to undergoing apoptotic stimulation by BITC. These findings suggested that p53 might play a negative regulating role in BITC-induced apoptosis. In conclusion, the results from this study provided biological evidence that BITC has a potential to induce apoptosis selectively in p53-mutated proliferating pre-cancerous cells.

DOI： 10.3123/jems.26.253

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ベンジルイソチオシアネートによる細胞周期特異的なアポトーシス誘導機構

中村宜督, 三好規之, 内田浩二, 大沢俊彦

日本癌学会総会記事 63rd 521 2004.8

野菜による解毒酵素誘導と生体内での抗酸化機能の向上 (特集野菜と健康)

中村宜督

食の科学 ( 317 ) 17 - 24 2004.7

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