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Application of High-Sensitivity UV photoemission Spectroscopy to Examine the Electronic Structure of Thermophilic Rhodopsin 査読

Daisuke Sano, Ichiro Ide, Tomoki Akiyama, Yuya Tanaka, Yuki Sudo, Takeshi Murata, Hisao Ishii

Molecular Crystals and Liquid Crystals 687 ( 1 ) 34 - 39 2019年7月

GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice 査読

Srikanta Chowdhury, Takanori Matsubara, Toh Miyazaki, Daisuke Ono, Noriaki Fukatsu, Manabu Abe, Kenji Sakimura, Yuki Sudo, Akihiro Yamanaka

eLife 8 e44928 2019年6月

掲載種別：研究論文（学術雑誌）出版者・発行元：eLife Sciences Publications, Ltd

Sleep/wakefulness cycle is regulated by coordinated interactions between sleep- and wakefulness-regulating neural circuitry. However, the detailed mechanism is far from understood. Here, we found that glutamic acid decarboxylase 67-positive GABAergic neurons in the ventral tegmental area (VTA_Gad67+) are a key regulator of non-rapid eye movement (NREM) sleep in mice. VTA_Gad67+ project to multiple brain areas implicated in sleep/wakefulness regulation such as the lateral hypothalamus (LH). Chemogenetic activation of VTA_Gad67+ promoted NREM sleep with higher delta power whereas optogenetic inhibition of these induced prompt arousal from NREM sleep, even under highly somnolescent conditions, but not from REM sleep. VTA_Gad67+ showed the highest activity in NREM sleep and the lowest activity in REM sleep. Moreover, VTA_Gad67+ directly innervated and inhibited wake-promoting orexin/hypocretin neurons by releasing GABA. As such, optogenetic activation of VTA_Gad67+ terminals in the LH promoted NREM sleep. Taken together, we revealed that VTA_Gad67+ play an important role in the regulation of NREM sleep.

DOI： 10.7554/elife.44928

PubMed

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その他リンク： https://cdn.elifesciences.org/articles/44928/elife-44928-v2.xml

Photochemical Characterization of a New Heliorhodopsin from the Gram-Negative Eubacterium Bellilinea caldifistulae (BcHeR) and Comparison with Heliorhodopsin-48C12 査読

Atsushi Shibukawa, Keiichi Kojima, Yu Nakajima, Yosuke Nishimura, Susumu Yoshizawa, Yuki Sudo

Biochemistry 58 ( 26 ) 2934 - 2943 2019年5月

Quantitation of the neural silencing activity of anion channelrhodopsins in Caenorhabditis elegans and their applicability for long-term illumination 査読

Taro Yamanashi, Misayo Maki, Keiichi Kojima, Atsushi Shibukawa, Takashi Tsukamoto, Srikanta Chowdhury, Akihiro Yamanaka, Shin Takagi, Yuki Sudo

Scientific Reports 9 ( 1 ) 7863 2019年3月

Retinal–Salinixanthin Interactions in a Thermophilic Rhodopsin 査読

Ramprasad Misra, Tamar Eliash, Yuki Sudo, Mordechai Sheves

The Journal of Physical Chemistry B 123 ( 1 ) 10 - 20 2018年12月

Correction to “High Thermal Stability of Oligomeric Assemblies of Thermophilic Rhodopsin in a Lipid Environment” 査読

Tomomi Shionoya, Misao Mizuno, Takashi Tsukamoto, Kento Ikeda, Hayato Seki, Keiichi Kojima, Mikihiro Shibata, Izuru Kawamura, Yuki Sudo, Yasuhisa Mizutani

The Journal of Physical Chemistry B 122 ( 42 ) 9826 - 9826 2018年10月

Retinal Configuration of ppR Intermediates Revealed by Photoirradiation Solid-State NMR and DFT 査読

Yoshiteru Makino, Izuru Kawamura, Takashi Okitsu, Akimori Wada, Naoki Kamo, Yuki Sudo, Kazuyoshi Ueda, Akira Naito

Biophysical Journal 115 ( 1 ) 72 - 83 2018年7月

High Thermal Stability of Oligomeric Assemblies of Thermophilic Rhodopsin in a Lipid Environment 査読

Tomomi Shionoya, Misao Mizuno, Takashi Tsukamoto, Kento Ikeda, Hayato Seki, Keiichi Kojima, Mikihiro Shibata, Izuru Kawamura, Yuki Sudo, Yasuhisa Mizutani

The Journal of Physical Chemistry B 122 ( 27 ) 6945 - 6953 2018年6月

Production of a Light-Gated Proton Channel by Replacing the Retinal Chromophore with Its Synthetic Vinylene Derivative 査読

Riho Takayama, Akimasa Kaneko, Takashi Okitsu, Satoshi P. Tsunoda, Kazumi Shimono, Misao Mizuno, Keiichi Kojima, Takashi Tsukamoto, Hideki Kandori, Yasuhisa Mizutani, Akimori Wada, Yuki Sudo

The Journal of Physical Chemistry Letters 9 ( 11 ) 2857 - 2862 2018年5月

Presence of a Haloarchaeal Halorhodopsin-Like Cl− Pump in Marine Bacteria 査読

Yu Nakajima, Takashi Tsukamoto, Yohei Kumagai, Yoshitoshi Ogura, Tetsuya Hayashi, Jaeho Song, Takashi Kikukawa, Makoto Demura, Kazuhiro Kogure, Yuki Sudo, Susumu Yoshizawa

Microbes and Environments 33 ( 1 ) 89 - 97 2018年

Spectroscopic characteristics ofRubricoccus marinusxenorhodopsin (RmXeR) and a putative model for its inward H⁺transport mechanism 査読

Saki Inoue, Susumu Yoshizawa, Yu Nakajima, Keiichi Kojima, Takashi Tsukamoto, Takashi Kikukawa, Yuki Sudo

Physical Chemistry Chemical Physics 20 ( 5 ) 3172 - 3183 2018年

担当区分：最終著者,　責任著者掲載種別：研究論文（学術雑誌）出版者・発行元：Royal Society of Chemistry (RSC)

On the basis of functional and spectroscopic characterization, we propose a model for the inward proton transport inRmXeR, a newly discovered microbial rhodopsin.

DOI： 10.1039/c7cp05033j

PubMed

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Mutational analysis of the conserved carboxylates of anion channelrhodopsin-2 (ACR2) expressed in Escherichia coli and their roles in anion transport 査読

Keiichi Kojima, Hiroshi C. Watanabe, Satoko Doi, Natsuki Miyoshi, Misaki Kato, Hiroshi Ishikita, Yuki Sudo

Biophysics and Physicobiology 15 179 - 188 2018年

Few-cycle pulse generation from noncollinear optical parametric amplifier with static dispersion compensation 査読

Shunsuke Adachi, Yuya Watanabe, Yuki Sudo, Toshinori Suzuki

Chemical Physics Letters 683 7 - 11 2017年9月

Comparative evaluation of the stability of seven-transmembrane microbial rhodopsins to various physicochemical stimuli 査読

Naoya Honda, Takashi Tsukamoto, Yuki Sudo

Chemical Physics Letters 682 6 - 14 2017年8月

Hybrid Model Membrane Combining Micropatterned Lipid Bilayer and Hydrophilic Polymer Brush 査読

Toshiki Nishimura, Fuyuko Tamura, Sawako Kobayashi, Yasushi Tanimoto, Fumio Hayashi, Yuki Sudo, Yasuhiko Iwasaki, Kenichi Morigaki

Langmuir 33 ( 23 ) 5752 - 5759 2017年5月

Demonstration of a Light-Driven SO₄^2– Transporter and Its Spectroscopic Characteristics 査読

Akiko Niho, Susumu Yoshizawa, Takashi Tsukamoto, Marie Kurihara, Shinya Tahara, Yu Nakajima, Misao Mizuno, Hikaru Kuramochi, Tahei Tahara, Yasuhisa Mizutani, Yuki Sudo

Journal of the American Chemical Society 139 ( 12 ) 4376 - 4389 2017年3月