研究者詳細 - 高木　章乃夫

MISC - 高木　章乃夫

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糖尿病性腎症に合併したANCA関連急速進行性糸球体腎炎の1例

中司敦子, 佐藤千景, 岩田康義, 高木章乃夫, 福島正樹, 津嘉山朝達, 西崎哲一

腎と透析 2002年

【肝炎 EBMに基づく最新の知見と最新の治療】ウイルス肝炎における肝線維化とその臨床的意義

高木章乃夫, 医歯総合研究, 消化器肝臓感染症内科, 白鳥康史

Medical Practice 19,6,973-975 2002年

ANCA関連腎炎の治療と予後に関する検討

中司敦子, 高木章乃夫, 岩田康義, 福島正樹

倉敷中央病院年報 2002年

アンギオテンシン変換酵素阻害剤(ACE-I)投与中に発生した急性腎不全症例の検討

高木章乃夫, 岩田康義, 佐藤千景, 江口潤, 中司敦子, 福島正樹

ICUとCCU 2002年

Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C

Akinobu Takaki, Manfred Wiese, Geert Maertens, Erik Depla, Ulrike Seifert, Anke Liebetrau, Jeffery L. Miller, Michael P. Manns, Barbara Rehermann

Nature Medicine 6 ( 5 ) 578 - 582 2000年5月

記述言語：英語

As acute hepatitis C virus (HCV) infection is clinically inapparent in most cases, the immunologic correlates of recovery are not well defined. The cellular immune response is thought to contribute to the elimination of HCV- infected cells and a strong HCV-specific T-helper-cell (Th) response is associated with recovery from acute hepatitis C (ref. 2). However, diagnosis of resolved hepatitis C is based at present on the detection of HCV-specific antibodies and the absence of detectable HCV RNA, and detailed comparison of the humoral and cellular immune response has been hampered by the fact that patient cohorts as well as HCV strains are usually heterogeneous and that clinical data from acute-phase and long-term follow-up after infection generally are not available. We studied a cohort of women accidentally exposed to the same HCV strain of known sequence and found that circulating HCV-specific antibodies were undetectable in many patients 18-20 years after recovery, whereas HCV-specific helper and cytotoxic T-cell responses with an interferon (IFN)-γ-producing (Tc1) phenotype persisted. The data indicate these HCV-specific CD4+ and CD8+ T cells are biomarkers for a prior HCV exposure and recovery. Because of undetectable antibodies against HCV, the incidence of self-limited HCV infections and recovery may be underestimated in the general population.

DOI： 10.1038/75063

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Increase in CD95 (Fas/APO-1)-positive CD4+ and CD8+ T cells in peripheral blood derived from patients with autoimmune hepatitis or chronic hepatitis C with autoimmune phenomena

Shin Ogawa, Kohsaku Sakaguchi, Akinobu Takaki, Kunihiro Shiraga, Tomoyuki Sawayama, Hirokazu Mouri, Manabi Miyashita, Norio Koide, Takao Tsuji

Journal of Gastroenterology and Hepatology (Australia) 15 ( 1 ) 69 - 75 2000年

記述言語：英語出版者・発行元：Blackwell Publishing

Background: The expressions of CD95 (Fas/APO-1) and Bcl-2 are determinants of apoptosis in normal lymphocytes, and abnormalities in their expressions might contribute to the induction of autoimmunity. In this study, we examined the expressions of CD95 and Bcl-2 on freshly isolated T and B cells from patients with autoimmune hepatitis (AIH) or chronic hepatitis C associated with autoimmune phenomena (CH-C(AI)). Methods: The CD95 and Bcl-2 expressions within CD4+ T, CD8+ T, and CD19+ B cell subsets were analysed by two-colour flow cytometry. Results: The surface expression of CD95 was significantly high in both the CD4+ T and CD8+ T cell subsets derived from the patients with AIH and those with CH-C(AI), compared with expression in patients with CH-C and normal subjects. The increase in CD95 expression was associated with the phenotypic conversion of naive CD45RO- to primed CD45RO+ CD4+T cells. Bcl-2 was detected in the vast majority of peripheral T and B cells. There was no significant difference in the percentage of Bcl2- positive cells in the CD4+T cell, CD8+T cell and CD19+ B cell subsets among the patient groups and normal subjects. Conclusions: These results indicate that an increase in CD4+T cells expressing CD45RO and CD95 marks an important subset of AIH and CH-C(AI) patients. These expanded CD95+ CD45RO+ primed T cells most likely reflect a continuous antigen-specific or non- specific activation oft lymphocytes, and/or the persistent presence of activated lymphocytes as a consequence of abnormalities in the peripheral deletion of activated lymphocytes. These persistently activated lymphocytes might play a role in the induction of autoimmunity in AIH and CH-C(AI). (C) 2000 Blackwell Science Asia Pty Ltd.

DOI： 10.1046/j.1440-1746.2000.02044.x

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Specificities and Clinical Significance of Anti-Cytoskeleton Antibodies in Anti-Smooth Muscle Antibody-Positive Patients with Chronic Liver Disease C

Takaki Akinobu, Sakaguchi Kohsaku, Ogawa Shin, Kawamoto Hirofumi, Tsuji Takao

Acta Medica Okayama 48(3), 143-149 ( 3 ) 143 - 149 1994年6月

記述言語：英語出版者・発行元：Okayama University Medical School

We investigated the specificities and characteristics of anti-cytoskeleton antibodies in 13 anti-smooth muscle antibody (ASMA)-positive patients with chronic liver disease C (CLD-C), and compared them with those in 7 ASMA-positive patients with autoimmune hepatitis (AIH), and 6 ASMA-positive patients with chronic liver disease B (CLD-B). Anti-microfilaments (anti-MF) were found not only in 6/7 AIH patients (85.7%), but also in 8/13 CLD-C patients (61.5%) with a relatively high incidence, when compared with 1/6 CLD-B patients (16.7%), while, there was no significant difference in the incidence of anti-intermediate filaments (anti-IMF), especially anti-IMF IgM, among these patient groups. Among the patients with CLD-C, the mean levels of serum gammaglobulin and IgG in the anti-MF-positive patients were 2.46 +/- 1.03 g/dl and 3277 +/- 1089 mg/dl, respectively, which were higher than those in the anti-MF-negative patients (1.60 +/- 0.53 g/dl, 2245 +/- 610 mg/dl) and those in the patients with CLD-B (1.60 +/- 0.57 g/dl, 2192 +/- 339 mg/dl). Furthermore, 4 of the 8 anti-MF-positive patients with CLD-C satisfied the serological criteria for the diagnosis of AIH. These findings suggest that autoimmune mechanisms might be involved in the pathogenesis of anti-MF-positive CLD-C, and that anti-MF might be used as a marker.

DOI： 10.18926/AMO/31129

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Autoimmune responses as assessed by hepergammaglobulinemia and the presence of autoantibodies in patients with chronic hepatitis C

Kawamoto Hirofumi, Sakaguchi Kohsaku, Takaki Akinobu, Ogawa Shin, Tsuji Takao

Acta Medica Okayama 75(5), 305-310 ( 5 ) 305 - 310 1993年10月

記述言語：英語出版者・発行元：Okayama University Medical School

We investigated autoimmunity, as assessed by hypergammaglobulinemia and the presence of autoantibodies including anti-nuclear antibodies (ANA) and anti-liver membrane antibodies (LMA), in 149 patients with chronic hepatitis C, 55 patients with chronic hepatitis B and 11 patients with autoimmune hepatitis. There was no significant difference in the incidence of these autoantibodies between chronic hepatitis C and chronic hepatitis B. Nine patients with chronic hepatitis C satisfied the serological criteria of autoimmune hepatitis (ANA positive and gammaglobulin or serum IgG greater than 2500 mg/dl), but none of the patients with chronic hepatitis B met the criteria. This suggests that autoimmunity is greater in chronic hepatitis C than in chronic hepatitis B. Of the 9 patients with chronic hepatitis C, all 4 patients tested for human leukocyte antigen (HLA) phenotype had HLA-DR4, which is known to be associated with autoimmune hepatitis in Japanese patients. We believe that hepatitis C virus (HCV) infection enhances the initiation and perpetuation of autoimmunity in susceptible individuals.

DOI： 10.18926/AMO/31582

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Autoimmune responses as assessed by hypergammaglobulinemia and the presence of autoantibodies in patients with chronic hepatitis C.

Kawamoto Hirofumi, Sakaguchi Kohsaku, Takaki Akinobu, Ogawa Shin, Tsuji Takao

Acta Medica Okayama 75(5), 305-310 ( 5 ) 305 - 310 1993年10月

記述言語：英語出版者・発行元：Okayama University Medical School

DOI： 10.18926/AMO/31582

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CiNii Books

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