研究者詳細 - 清田　洋正

論文 - 清田　洋正

分割表示 235 件中 101 - 120 件目／全件表示 >>

Identification of the Mesorhizobium loti gene responsible for glycerophosphorylation of periplasmic cyclic beta-1,2-glucans 査読

Yasuyuki Kawaharada, Hiromasa Kiyota, Shima Eda, Kiwamu Minamisawa, Hisayuki Mitsui*

FEMS Microb. Lett. 302 ( 2 ) 131 - 137 2010年1月

Sencodary Metabolites of Plants from the Genus Saussurea: Chemistry and Biological Activity

Yu-Fang Wang, Zhi-Yu NI, Mei Dong, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota*

Chemistry and Biodiversity 7 ( 11 ) 2623 - 2659 2010年

Synthesis of Pteroenone and its Diastereomers, a Defensive Metabolite of the Abducted Antarctic Pteropod Clione antarctica

Hiroki Asao, Yoko Nakamura,Yukito Furuya, Shigefumi Kuwahara, Bill J. Baker, Hiromasa Kiyota*

Helvetica Chimica Acta 93 ( 10 ) 1933 - 1944 2010年

Anti-nitric oxide production activity of isothiocyanates correlates with their polar surface area rather than their lipophilicity

Toshiro Noshita, Yumi Kidachi, Hirokazu Funayama, Hiromasa Kiyota, Hideaki Yamaguchi, Kazuo Ryoyama

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 44 ( 12 ) 4931 - 4936 2009年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

There is increasing demand for novel anti-inflammatory drugs with different mechanisms of action. We synthesized a series of isothiocyanates 2b-h based on 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) found in the pungent spice Wasabia japonica. Inhibitory activities against in-vitro growth of tumor cells and production of nitric oxide (NO) using the mouse macrophage-like cell line J774.1 were noted. All isothiocyanates were optimized by Hartree-Fock/3-21G model, and the log P values and the polar surface area (PSA) values were calculated. Substitution of the methylsulfinyl group (CH(3)S(=O)-R) in 6-MITC with a formyl (CHO-R), a methylsulfanyl (CH(2)S-R) or a methyl (CH(3)-R) group reduced the activities of the parent isothiocyanate. Substitution with a formyl group resulted in lower lipophilicity (log P value) whereas substitution with a methylsulfanyl or methyl group resulted in a lower PSA value. The inhibitory activity of isothiocyanates showed better correlation with their PSA values rather than their partition coefficient (log P) values. Isothiocyanates with higher PSA values and some degree of log P value may have potent biological activity. (C) 2009 Elsevier Masson SAS. All rights reserved.

DOI： 10.1016/j.ejmech.2009.08.005

Web of Science

researchmap

P-17 プロシアニジン,メチル化カテキン類縁体,レスベラトロールの合成研究(ポスター発表の部)

飯島崇士, 毛利圭宏, 提箸正義, 山田大士, 服部恭尚, 濱渦康範, 加茂綱嗣, 廣田満, 清田洋正, 真壁秀文

天然有機化合物討論会講演要旨集 ( 51 ) 289 - 294 2009年9月

記述言語：日本語出版者・発行元：天然有機化合物討論会

1. Synthesis of procyanidin B1-B4(1-4). Stereoselective synthesis of catechin and epocatechin under intermolecular condensation of equimolar amount of catechin derivatives catalyzed by Yb(OTf)_3. The coupled products were successfully converted to procyanidin B1 (1), B2 (2), B3 (3), and B4 (4), respectively. 2. synthetic of (-)-epicatechin 3-(3"-O-methylgallate) (13) and (+)-catechin 3-(3"-O-methylgallate) (14) A concise synthesis of (-)-epicatechin 3-(3"-O-methylgallate)(13, ECG3"Me), which is a minor constituent of tea, and (+)-catechin 3-(3"-O-methylgallate)(14, CG3"Me) via condensation of equimolar amount of catechin and gallate derivatives has been achieved. The anti-inflammatory effect of the synthetic compounds on TPA-induced inflammation of mouse ears was examined. Compounds 13 and 14 suppressed the TPA-induced inflammation of mouse ears by 50% and 43%, respectively, at a dose of 200μg. 3. Short step synthesis of resveratrol derivative. An efficient synthesis of trimethoxylated resveratrol (20) is presented using advanced Heck reaction promoted by Pd(dba)_2 in the presence of P(t-Bu)_3.

DOI： 10.24496/tennenyuki.51.0_289

CiNii Article

CiNii Books

researchmap

First synthesis and absolute configuration of (–)-pyriculariol, a phytotoxin isolated from rice blast fungus, Magnaporthe grisea. Use of microwave irradiation to control Stille coupling reaction products

Ayaka Sasaki, Koji Tanaka, Yuuki Sato, Shigefumi Kuwahara, Hiromasa Kiyota

Tetrahedron Letters 50 ( 32 ) 4637 - 4638 2009年8月

Synthesis and plant growth inhibitory activity of both enantiomers of pyricuol, a phytotoxin isolated from rice blast disease fungus Magnaporthe grisea

Koji Tanaka, Yoko Nakamura, Ayaka Sasaki, Rumi Ueda, Yuji Suzuki, Shigefumi Kuwahara, Hiromasa Kiyota

TETRAHEDRON 65 ( 31 ) 6115 - 6122 2009年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

Both enantiomers and racemate of pyricuol, a phytotoxin isolated from the rice blast disease fungus, Magnaporthe grisea, have been synthesized by using Stille coupling and [2,3]-Wittig rearrangement reactions as the key steps. Both enantiomers induced dark necrotic lesions on rice leaves almost equally, but did not affect the growth of rice second leaf sheath and the germination of lettuce. Only natural enantiomer promoted the root growth of rice and lettuce. (C) 2009 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tet.2009.05.052

Web of Science

researchmap

Gene expression profiles in differentiating leukemia cells induced by methyl jasmonate are similar to those of cytokinins and methyl jasmonate analogs induce the differentiation of human leukemia cells in primary culture

H. Tsumura, M. Akimoto, H. Kiyota, Y. Ishii, H. Ishikura, Y. Honma

LEUKEMIA 23 ( 4 ) 753 - 760 2009年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NATURE PUBLISHING GROUP

Jasmonates are potent lipid regulators in plants that play pivotal roles in their biological activities. Methyl jasmonate (MJ) is very effective at inducing the myelomonocytic differentiation of human myeloid leukemia HL-60 cells. We examined the gene expression profiles associated with exposure to MJ using cDNA microarrays, and compared the results with those obtained with other inducers of differentiation, such as all-trans retinoic acid (ATRA), 1 alpha,25-dihydroxyvitamin D(3) (VD(3)), isopentenyladenine (IPA) and cotylenin A (CN-A). Many genes were upregulated, and only a small fraction was downregulated, upon exposure to the inducers. MJ, IPA and CN-A, but not ATRA or VD3, immediately induced the expression of mRNA for the calcium-binding protein S100P. The gene expression profile induced by MJ resembled that induced by IPA, suggesting that these inducers share many common signal transduction systems for inducing the differentiation of leukemia cells. Methyl 4,5-didehydrojasmonate was about 30 times more potent than MJ and the natural form of the stereoisomer was more effective than the unnatural isomer. It significantly stimulated both the functional and morphological differentiation of leukemia cells that had been freshly isolated from patients with hematological malignancies. Jasmonate derivatives may be promising therapeutic agents for differentiation therapy of leukemia.

DOI： 10.1038/leu.2008.347

Web of Science

researchmap

New Cytotoxic Phenolic Derivatives from Matured Fruits of Magnolia denudata

Toshiro Noshita, Hiromasa Kiyota, Yumi Kidachi, Kazuo Ryoyama, Shinji Funayama, Ken Hanada, Tetsuya Murayama

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 73 ( 3 ) 726 - 728 2009年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：TAYLOR & FRANCIS LTD

Magnolia species are widely cultivated in Japan as garden plants, and have been found to contain various compounds, including alkaloids, terpenoids, lignans, and neolignans. The constituents of the mature fruits of M. denudata were investigated, and two new phenolic derivatives, named denudalide and denudaquinol, were isolated and characterized, together with a known neolignan compound (denudatin A). Denudalide and denudaquinol showed cytotoxicity against the SFME and r/mHM-SFME-1 cell lines.

DOI： 10.1271/bbb.80597

Web of Science

researchmap

Taxusecone, a Novel Taxane with an Unprecedented 11,12-Secotaxane Skeleton, from Taxus cuspidata Needles

Shu-Hong Yu, Zhi-Yu Ni, Jing Zhang, Mei Dong, Francoise Sauriol, Chang-Hong Huo, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota, Bin Cong

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 73 ( 3 ) 756 - 758 2009年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：TAYLOR & FRANCIS LTD

Taxusecone, 2 alpha,7 beta,9 alpha,10 beta-tetraacetoxy-5 alpha,12-dihydroxy-11,12-secotax-4(20)-ene-11,13-dione (1), a novel taxane with an unprecedented skeleton, was isolated from the needles of Taxus cuspidata.

DOI： 10.1271/bbb.80698

Web of Science

researchmap

Xylomexicanins A and B, New Δ14,15-Mexicanolides from the Seeds of the Chinese Mangrove Xylocarpus granatum

Li-Ru Shen, Mei Dong, Dong Guo, Bao-Wei Yin, Man-Li Zhang, Qing-Wen Shi, Chang-Hong Huo, Hiromasa Kiyota, Nobuo Suzuki, Bin Cong

Zeitshrift fuer Naturforschung, C 64 ( 1-2 ) 37 - 42 2009年1月

Two New 11(15→1)Abeotaxanes with a 2,20-Epoxy Ring from the Needles of Taxus canadensis

Man-Li Zhang, Jing Zhang, Mei Dong, Shu-Hua Feng, Chang-Hong Huo, Françoise Sauriol, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota, Bin Cong

Zeitshrift fuer Naturforschung, C 64 ( 1-2 ) 43 - 48 2009年1月

The Daphyniphyllum Alkaloids

Xiao-Hui Su, Su-Zhen Gong, Qing-Wen Shi, Hiromasa Kiyota*

Current Organic Chemistry 13 ( 6 ) 646 - 682 2009年

Chemical and Pharmacological Studies of the Plants from Genus Celastrus

Xiao-Hui Su, Man-Li Zhang, Wen-Hong Zhan, Chang-Hong Huo, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota

Chemistry and Biodiversity 6 ( 2 ) 146 - 161 2009年

Synthesis and Anti-inflammatory Activity of (–)-Epicatechin-3-(3-O-methylgallate) and (+)-Catechin-3-(3-O-methylgallate)

Takashi Iijima, Yoshihiro Mohri, Yasunao Hattori, Atsushi Kashima, Tsunashi Kamo, Mitsuru Hirota, Hiromasa Kiyota, Hidefumi Makabe

Chemistry and Biodiversity 6 ( 4 ) 520 - 526 2009年

Enzymatic Resolution of (±)-2-Exo-7-syn-7-(1-propynyl)norbornan-2-ol, a Key Synthetic Intermediate for Jasmonoids

Hiromasa Kiyota, Daisuke Nakashima, Shigefumi Kuwahara, Takayuki Oritani

Zeitshrift fuer Naturforschung, B 63 ( 12 ) 1441 - 1442 2008年12月

Synthesis and Anti-Angiogenic Activity of Cortistatin Analogs

Yuuki Sato, Hiroshi Kamiyama, Takeo Usui, Tamio Saito, Hiroyuki Osada, Shigefumi Kuwahara, Hiromasa Kiyota

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 72 ( 11 ) 2992 - 2997 2008年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：TAYLOR & FRANCIS LTD

Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.

DOI： 10.1271/bbb.80562

Web of Science

researchmap

Taxpropellane, a Novel Taxane with an Unprecedented Polycyclic Skeleton from the Needles of Taxus canadensis

Man-Li Zhang, Mei Dong, Chang-Hong Huo, Li-Geng Li, Fran?oise Sauriol, Qing-Wen Shi, Yu-Cheng, Gu, Hidefumi Makabe, Hiromasa Kiyota*

European Journal of Organic Chemistry ( 32 ) 5414 - 5417 2008年11月

Chemical and Pharmacological Research of the Plants in Genus Euphorbia

Qing-Wen Shi, Xiao-Hui Su, Hiromasa Kiyota*

Chemical Reviews 108 ( 10 ) 4295 - 4327 2008年10月

Synthesis of the L-Acid (C1-C18) Fragment of Pamamycin-593 and De-N-methylpamamycin-579

Ayako Miura, Shin-ya Takigawa, Yukito Furuya, Yusuke Yokoo, Shigefumi Kuwahara, Hiromasa Kiyota

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY ( 29 ) 4955 - 4962 2008年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-V C H VERLAG GMBH

The L-acid (C1-C18) fragment of pamamycin-593 and de-N-methylpamamycin-579, strong aerial mycelium-inducers of Streptomyces alboniger, was synthesized using a cis-selecfive iodoetherification and a nucleophilic addition of a cerium acetylide to an aldehyde as the key steps. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

DOI： 10.1002/ejoc.200800600

Web of Science

researchmap

　前のページ - 次のページ　

<清田 洋正>

論文 - 清田 洋正

<清田　洋正>

論文 - 清田　洋正