研究者詳細 - 清田　洋正

論文 - 清田　洋正

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清田洋正

香料 272 ( 272 ) 21 - 28 2016年

Recearch Advances on Biological Activities of Tanshinone IIA- a Mini Review

Yan Zhong, Man-Li Zhang, Jin-Sheng Qi, Qing-Wen Shi, Hiromasa Kiyota

Mini-Reviews in Organic Chemistry 13 ( 4 ) 305 - 311 2016年

Synthesis of the Spiroacetal Fragments of Spifofungins A and B, Antibiotics Isolated from Streptomyces violaceusniger Tü 4113

Hiroyuki Sakauchi, Emi Higashi, Yuko Shimizu, Mikiko Kojima, Yuko Asamitsu, Shigefumi Kuwahara, Minoru Izumi, Hiromasa Kiyota

Heterocyclic Communications 21 ( 6 ) 337 - 343 2015年12月

Two New Taxane-glycosides from the Needles of Taxus canadensis

Nan Li, JIn Wang, Hui-Min Yan, Man-Li Zhang, Qing-Wen Shi, Francoise Sauriol, Hiromasa Kiyota, Mei Dong

Zeitschrift f?r Narurforshung, B 70 ( 11 ) 829 - 835 2015年11月

New Limonoids from the Seeds of Xylocarpus granatum

Yi-Bing Wu, Dan Liu, Pei-Yu Liu, Xue-Mei Yang, Man Liao, Nan-Nan Lu, Francoise Sauriol, Yu-Cheng Gu, Qing-Wen Shi, Hiromasa Kiyota, Mei Dong

Helvetica Chimica Acta 98 ( 5 ) 691 - 698 2015年5月

Synthetic Studies of Enacyloxins: a Series of Antibiotics Isolated from Frateuria sp. W-315: C1'-C8' and C9'-C15' Fragments

Aki Saito, Wataru Igarashi, Hiroyuki Furukawa, Teiko Yamada, Shigefumi Kuwahara, Hiromasa Kiyota*

Natural Product Communications 10 ( 4 ) 645 - 648 2015年4月

Hydrolysis of octachlorodipropyl ether photolysis in aqueous solution

Yan-Hong Shi, Min Liao, Hiromasa Kiyota, Ri-Mao Hua, Xiang-Wei Wu, Jun Tang, Hai-Qun Cao

Fresenius Environmental Bulletin 24 ( 8 ) 2534 - 2539 2015年

Kinetics of octachlorodipropyl ether photolysis in aqueous solution

Yan-Hong Shi, Min Liao, Hiromasa Kiyota, Hai-Qun Cao, Ri-Mao Hua, Feng Tang, Yong-De Yue

Journal of Pesticide Science 40 ( 2 ) 49 - 54 2015年

12T061C, a New Julichrome Family Radical Scavenger from Streptomyces species

Toshikazu Komoda, Naoko, Saeki, Yoshitaka Koseki, Hiromasa Kiyota

Heterocyclic Communications 20 ( 5 ) 271 - 274 2014年10月

Novel phosphorylation of aldrin-trans-diol by dieldrin-degrading fungus Mucor racemosus strain DDF

Ken-ichi Yamazaki, Kazuhiro Takagi, Ryota Kataoka, Masaaki Kotake, Teiko Yamada, Hiromasa Kiyota

INTERNATIONAL BIODETERIORATION & BIODEGRADATION 92 36 - 40 2014年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCI LTD

Dieldrin is one of the most persistent organic pollutants, and its oxidative degradation pathways by aerobic microorganisms to 6,7-trans-dihydroxydihydroaldrin (otherwise known as aldrin-trans-diol) and 9-hydroxydieldrin are well documented. The dieldrin-degrading fungus, Mucor racemosus strain DDF, can decrease dieldrin levels with simultaneous production of a small amount of aldrin-trans-diol. A reduction in the levels of aldrin-trans-diol by strain DDF has also been observed. Based on these results, it has been suggested that strain DDF transforms dieldrin to more polar compounds via aldrin-trans-diol. We have conducted a study to identify the metabolites arising from aldrin-trans-diol. The results showed that strain DDF gave reduced levels of aldrin-trans-diol and also produced unknown metabolites. Ultra performance liquid chromatography-electrospray ionization-mass spectroscopy (UPLC-ESI-MS) analysis indicated the metabolites to be either sulfated- or phosphorylated- derivatives of aldrin-trans-diol, but with the metabolites retaining six chlorine atoms. Therefore, the candidate derivatives were synthesized and the retention times of the natural metabolite and the synthetic phosphate were compared. As a result of a co-injection experiment, the metabolites were determined to be aldrin-trans-diol exo- and endo-phosphates. These results were also supported by high-resolution-fast atom bombardment-mass spectrometry (HR-FAB-MS) of the natural metabolite (Delta = 0.63 ppm). Phosphorylation of aldrin-transdiol is the first reported example of phosphate conjugation in microorganisms. (C) 2014 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.ibiod.2014.04.005

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Xylomexicanin E-H, New Limonoids from Xylocarpus granatum

Yi-Bing Wu, Xia Qing, Chang-Hong Huo, Hui-Min Yan, Qing-Wen Shi, Francoise Sauriol, Yu-Cheng Gu, Hiromasa Kiyota

Tetrahedron 70 ( 30 ) 4557 - 4562 2014年7月

Synthesis of o-Formyl-m-hydroxycinnamic Acid, the Most Oxidized Salicylaldehyde-type Phytotoxin Isolated from Rice Blast Fungus, Magnaporthe grisea, from 5-(2,2-Dimethyl-4H-1,3-benzdioxin)methanol

Akihito Saito, Konosuke Hiramatsu, Hai-Qun Cao, Yuta Nagashima, Koji Tanaka, Ayaka Sasaki, Teiko Yamada, Shigefumi Kuwahara, Manabu Nukina, Hiromasa Kiyota

Heterocyclic Communications 20 ( 3 ) 185 - 188 2014年6月

Facile Synthesis of the Cyclohexane Fragment of Enacyloxins, a Series of Antibiotics Isolated from Frateruria sp. W-315

Aki Saito, Wataru Igarashi, Hiroyuki Furukawa, Teiko Yamada, Shigefumi Kuwahara, Hiromasa Kiyota

Bioscience, Biotechnology, and Biochemistry 78 ( 5 ) 766 - 769 2014年5月

Structural Modification of Isoalantolactone and Biological Activity Against the Hepatoma Cell Line

Rui-Xia Guo, Li-Geng Li, Man-Li Zhang, Fran腔ise Sauriol, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota

Heterocyclic Communications 20 ( 2 ) 117 - 121 2014年4月

Chemical Constituents of Plants from the Genus Neolitsea

Qia Qing, Ting Zhao, Rui-Xia Guo, Yi-Bing Wu, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota

Heterocyclic Communications 20 ( 2 ) 61 - 75 2014年4月

A New Eudesmane Sesquiterpene from Dichrocephala integrifolia 査読

Fang Qin, Yi-Bing Wu, Rui-xia Guo, Mei Dong, Francoise Sauriol, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota

NATURAL PRODUCT COMMUNICATIONS 9 ( 2 ) 149 - 150 2014年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NATURAL PRODUCTS INC

A new sesquiterpene, eudesm-11-ene-4 alpha,7 beta,9 beta-triol, was isolated from the EtOH extract of aerial parts of Dichrocephala integrifolia. Its structure was determined on the basis of spectral analysis of ID and 2D NMR data.

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A New Taxane with a 4beta,20-Epoxy Ring from the Rooted Cuttings of Taxus canadensis

Geng-Dong Yao, Hong-Feng Zhang, Yun Huang, Francoise Sauriol, Qing-Wen Shi, Hiromasa Kiyota, Yu-Cheng Gu

Chemistry of Natural Compounds 49 ( 5 ) 861 - 863 2013年11月

Arteminal, a New Eudesmane Sesquiterpenolide Isolated from Artemisia frigida

Cun-Fang Li, Man-Li Zhang, Yu-Fang Wang, Mei Dong, Fran?oise Sauriol, Chang-Hong Huo, Qing-Wen Shi, Teiko Yamada, Hiromasa Kiyota*, Yu-Cheng Gu, Bin Cong

Chemistry of Natural Compounds 49 ( 5 ) 872 - 874 2013年11月

Functional and Structural Analysis of Influenza Virus Neuraminidase N3 Offers Further Insight into the Mechanisms of Oseltamivir Resistance

Qing Li, Jianxun Qi, Yan Wu, Hiromasa Kiyota, Kosuke Tanaka, Yoshitomo Suhara, Hiroshi Ohrui, Yasuo Suzuki, Christopher J. Vavricka, George F. Gao

JOURNAL OF VIROLOGY 87 ( 18 ) 10016 - 10024 2013年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AMER SOC MICROBIOLOGY

The influenza virus neuraminidase H274Y substitution is a highly prevalent amino acid substitution associated with resistance to the most heavily used influenza drug, oseltamivir. Previous structural studies suggest that the group specific 252 residue ( Y252 in group 1 and T252 in group 2) might be a key factor underlying H274Y resistance. However, H274Y has only been reported in N1 subtypes, which indicates that there must be additional key residues that determine H274Y resistance. Furthermore, we found that members of NA serotype N3 also possess Y252, raising the key question as to whether or not H274Y resistance may also be possible for some group 2 NAs. Here, we demonstrate that the H274Y substitution results in mild oseltamivir resistance for N3. Comparative structural analysis of N3, N1, and their 274Y variants indicates that the interaction of residue 296 ( H in N1 and nonaromatic for other serotypes) with conserved W295 is another important determinant of oseltamivir resistance.

DOI： 10.1128/JVI.01129-13

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11-Hydroxyisocom-2-en-5-one, a new sesquiterpenoid from Echinops spinosissimus

Zhi-Yu Ni, Yuta Nagashima, Man-Li Zhang, Yu-Fang Wang, Mei Dong, Fran?oise Sauriol, Chang-Hong Huo, Qing-Wen Shi, Yu-Cheng Gu, Hiromasa Kiyota*

Chemistry of Natural Compounds 49 ( 4 ) 632 - 634 2013年9月

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