Faculty Profiles - TOYOOKA Shinichi

Papers - TOYOOKA Shinichi

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EGFR変異とUracil-Tegafurによる肺腺癌術後補助療法の関連性についての検討

末久弘, 豊岡伸一, 堀田勝幸, 内田亜希子, 宗淳一, 藤原義朗, 松尾恵太郎, 大内田守, 高田穣, 木浦勝行, 伊達洋至

岡山医学会雑誌 120 ( 3 ) 265 - 269 2008.12

Language：Japanese Publisher：岡山医学会

完全切除された肺腺癌患者に補助療法としてUracil-Tegafur(UFT)を投与した場合における、EGFR変異の予後判定因子としての可能性を検討した。また、in vitro系のEGFR遺伝子導入細胞株における5-FUの効果も検討した。UFT投与群68例、手術のみの経過観察群119例であった。EGFR変異は187例中79例に認め、49例がエクソン19欠失変異、30例がエクソン21点突然変異であった。女性、非喫煙者に有意に変異が多かった。単変量解析では、UFT投与群が経過観察群よりも、EGFR変異群が野生群よりも予後がよい傾向であった。多変量解析では、術後補助療法が独立して有意に予後を延長していた。EGFR変異群では術後補助療法による予後延長の効果は認めなかった。EGFR変異型細胞株は5-FU低感受性を有することが示唆された。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2008&ichushi_jid=J00175&link_issn=&doc_id=20081205250002&doc_link_id=10.4044%2Fjoma.120.265&url=https%3A%2F%2Fdoi.org%2F10.4044%2Fjoma.120.265&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Age-related methylation in normal colon mucosa differs between the proximal and distal colon in patients who underwent colonoscopy Reviewed

Joichiro Horii, Sakiko Hiraoka, Jun Kato, Keita Harada, Kenji Kuwaki, Hideyuki Fujita, Shinichi Toyooka, Kazuhide Yamamoto

CLINICAL BIOCHEMISTRY 41 ( 18 ) 1440 - 1448 2008.12

Language：English Publishing type：Research paper (scientific journal) Publisher：PERGAMON-ELSEVIER SCIENCE LTD

Objectives: To examine the difference in the methylation status ill normal colon mucosa between the proximal and distal colon. in relation to the correlation between the methylation status of normal mucosa and characteristics of neoplasia.
Design and methods: Paired biopsy specimens of normal mucosa from the proximal and distal colon of 82 patients who underwent colonoscopy were obtained. The methylation status of the promoter region of estrogen receptor 1 (ESR1) and myogenic differentiation 1 (MYOD1) was examined.
Results: Normal mucosa was more highly methylated ill the distal than in the proximal colon in both ESR1 and MYOD1 loci (p<0.0001 and p = 0.0009, respectively). Advanced characteristics of polyps in the distal colon were frequently observed in patients with lower methylation of ESR1 in the distal colon normal mucosa.
Conclusions: Methylation levels in normal mucosa differ between the proximal and distal colon, and lower methylation of ESR1 in the distal colon normal mucosa may correlate with advanced features of neoplasia in the distal colon. (c) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

DOI： 10.1016/j.clinbiochem.2008.08.089

Web of Science

PubMed

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The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas. Reviewed

Kimura K, Toyooka S, Tsukuda K, Yamamoto H, Suehisa H, Soh J, Otani H, Kubo T, Aoe K, Fujimoto N, Kishimoto T, Sano Y, Pass HI, Date H

Oncology reports 20 ( 5 ) 1265 - 1268 2008.11

Genetic predictors of MEK dependence in non-small cell lung cancer. Reviewed International journal

Pratilas CA, Hanrahan AJ, Halilovic E, Persaud Y, Soh J, Chitale D, Shigematsu H, Yamamoto H, Sawai A, Janakiraman M, Taylor BS, Pao W, Toyooka S, Ladanyi M, Gazdar A, Rosen N, Solit DB

Cancer research 68 ( 22 ) 9375 - 9383 2008.11

Language：English Publishing type：Research paper (scientific journal)

Hyperactivated extracellular signal-regulated kinase (ERK) signaling is common in human cancer and is often the result of activating mutations in BRAF, RAS, and upstream receptor tyrosine kinases. To characterize the mitogen-activated protein kinase/ERK kinase (MEK)/ERK dependence of lung cancers harboring BRAF kinase domain mutations, we screened a large panel of human lung cancer cell lines (n = 87) and tumors (n = 916) for BRAF mutations. We found that non-small cell lung cancers (NSCLC) cells with both V600E and non-V600E BRAF mutations were selectively sensitive to MEK inhibition compared with those harboring mutations in epidermal growth factor receptor (EGFR), KRAS, or ALK and ROS kinase fusions. Supporting its classification as a "driver" mutation in the cells in which it is expressed, MEK inhibition in (V600E)BRAF NSCLC cells led to substantial induction of apoptosis, comparable with that seen with EGFR kinase inhibition in EGFR mutant NSCLC models. Despite high basal ERK phosphorylation, EGFR mutant cells were uniformly resistant to MEK inhibition. Conversely, BRAF mutant cell lines were resistant to EGFR inhibition. These data, together with the nonoverlapping pattern of EGFR and BRAF mutations in human lung cancer, suggest that these lesions define distinct clinical entities whose treatment should be guided by prospective real-time genotyping. To facilitate such an effort, we developed a mass spectrometry-based genotyping method for the detection of hotspot mutations in BRAF, KRAS, and EGFR. Using this assay, we confirmed that BRAF mutations can be identified in a minority of NSCLC tumors and that patients whose tumors harbor BRAF mutations have a distinct clinical profile compared with those whose tumors harbor kinase domain mutations in EGFR.

DOI： 10.1158/0008-5472.CAN-08-2223

PubMed

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Frequent p16 inactivation by homozygous deletion or methylation is associated with a poor prognosis in Japanese patients with pleural mesothelioma. Reviewed

Kobayashi N, Toyooka S, Yanai H, Soh J, Fujimoto N, Yamamoto H, Ichihara S, Kimura K, Ichimura K, Sano Y, Kishimoto T, Date H

Lung cancer (Amsterdam, Netherlands) 62 ( 1 ) 120 - 125 2008.10

EGFR遺伝子異常を伴う肺癌細胞株におけるTAE226の抗腫瘍効果

大谷弘樹, 豊岡伸一, 渡辺信之, 治田賢, 高岡宗徳, 久保孝文, 山本寛斉, 山根正修, 大藤剛宏, 大橋圭明, 荻野敦子, 木浦勝行, 猶本良夫, 佐野由文

日本癌治療学会誌 43 ( 2 ) 798 - 798 2008.10

高齢者肺癌に対する新たな治療戦略高齢者肺癌に対する新たな治療戦略としてのラジオ波焼灼術(RFA)

佐野由文, 山根正修, 豊岡伸一, 大藤剛宏, 岡崎幹生, 金澤右

日本癌治療学会誌 43 ( 2 ) 293 - 293 2008.10

ゲフィチニブ未使用肺癌におけるMET遺伝子増幅について

久保孝文, 山本寛斉, 宗淳一, 藤井徹也, 大内田守, 瀧川奈義夫, 木浦勝行, 清水憲二, 伊達洋至, 豊岡伸一

肺癌 48 ( 5 ) 508 - 508 2008.10

日本人胸膜中皮腫におけるP16遺伝子異常の意義遺伝子診断・治療の可能性

小林成行, 豊岡伸一, 柳井広之, 宗淳一, 藤本伸一, 市原周治, 木村賢太郎, 市村浩一, 佐野由文, 岸本卓巳, 伊達洋至

日本癌治療学会誌 43 ( 2 ) 640 - 640 2008.10

肺癌におけるPIK3CA遺伝子異常と機能解析

山本寛斉, 重松久之, 野村将春, ロックウッド・ウィリアム, 佐藤光夫, 奥村直樹, 宗淳一, 鈴木実, ウィストゥバ・イグナシオ, フォン・クワン, リー・ヒュエイ, 豊岡伸一, 伊達洋至, ラム・ワン, ミンナ・ジョン, ガズダー・アディ

日本癌治療学会誌 43 ( 2 ) 797 - 797 2008.10

【肺癌のUp-To-Date】肺癌手術の実際

山根正修, 岡崎幹生, 枝園和彦, 大藤剛宏, 佐野由文, 豊岡伸一

THE LUNG-perspectives 16 ( 4 ) 469 - 473 2008.10

Language：Japanese Publisher：(株)メディカルレビュー社

肺癌、特に早期の非小細胞肺癌に対する治療において外科的切除は重要な位置を占める。医学の進歩により胸腔鏡を用いた手術、また、非浸潤肺癌に対する積極的縮小手術、術前導入療法、術後補助療法の付加など手術を取り巻く環境も次第に変化している。本稿では岡山大学で行っている肺癌手術を中心とした肺癌への取り組みについて述べる。(著者抄録)

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術前治療後肺切除時の有茎大網被覆術に伴う消化器合併症の検討

枝園和彦, 豊岡伸一, 岡崎幹生, 山根正修, 羽藤慎二, 伊野英男, 大藤剛宏, 内藤稔, 土井原博義, 佐野由文

日本臨床外科学会雑誌 69 ( 増刊 ) 663 - 663 2008.10

原発性肺癌に対するCTガイド下肺生検の功罪

佐野由文, 岡崎幹生, 山根正修, 豊岡伸一, 大藤剛宏

日本臨床外科学会雑誌 69 ( 増刊 ) 664 - 664 2008.10

移植後のPrimary graft failureをいかに克服するか? marginal donorからDCDまで海外の肺移植におけるDCDの現状と対策

大藤剛宏, 山根正修, 吉田修, 大谷真二, 柿下大一, 堀志郎, 脇直久, 山本澄治, 犬飼倫子, 森田麻由美, 横山千恵, 岡崎恵, 角南直美, 岡崎幹生, 豊岡伸一, 佐野由文

移植 43 ( 総会臨時 ) 170 - 170 2008.9

ゲフィチニブ未使用肺癌におけるMET遺伝子増幅について(METGene Amplification in Lung Cancers Untreated With Gefitinib)

久保孝文, 山本寛斉, 宗淳一, 大内田守, 瀧川奈義夫, 木浦勝行, 清水憲二, 伊達洋至, 豊岡伸一

日本癌学会総会記事 67回 275 - 275 2008.9

Native lung-sparing lobar transplantation for pulmonary emphysema. Reviewed

Yamane M, Okutani D, Sugimoto S, Toyooka S, Aoe M, Okazaki M, Sano Y, Date H

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 27 ( 9 ) 1046 - 1049 2008.9

The allelic distribution of a single nucleotide polymorphism in the PDCD5 gene locus of Japanese non-small cell lung cancer patients. Reviewed

Nanba K, Toyooka S, Soh J, Tsukuda K, Yamamoto H, Sakai A, Ouchida M, Kobayashi N, Matsuo K, Koide N, Kusaka K, Shimizu K, Date H

Molecular medicine reports 1 667 - 671 2008.9

生体肺移植後の長期予後について

佐野由文, 山根正修, 豊岡伸一, 岡崎幹生, 岡崎恵, 大藤剛宏, 伊達洋至

移植 43 ( 総会臨時 ) 398 - 398 2008.9

Sirolimus amelioration of clinical symptoms of recurrent lymphangioleiomyomatosis after living-donor lobar lung transplantation. Reviewed

Sugimoto R, Nakao A, Yamane M, Toyooka S, Okazaki M, Aoe M, Seyama K, Date H, Oto T, Sano Y

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 27 ( 8 ) 921 - 924 2008.8

縦隔巨大軟骨肉腫に対して外科的切除を施行し得た1例

平野豊, 枝園和彦, 古川公之, 野上智弘, 山本寛斉, 岡崎幹生, 山根正修, 豊岡伸一, 大藤剛宏, 佐野由文

岡山医学会雑誌 120 ( 2 ) 246 - 246 2008.8

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