Faculty Profiles - KAGAWA Shunsuke

Papers - KAGAWA Shunsuke

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がん選択的生物製剤を用いた早期大腸癌の低侵襲治療の開発

菊地覚次, 岸本浩行, 田澤大, 西崎正彦, 香川俊輔, 浦田泰生, Hoffman Robert M., 藤原俊義

日本癌治療学会誌 48 ( 3 ) 1918 - 1918 2013.9

Selectively Replicating Oncolytic Adenoviruses Combined with Chemotherapy, Radiotherapy, or Molecular Targeted Therapy for Treatment of Human Cancers Reviewed

Shinji Kuroda, Shunsuke Kagawa, Toshiyoshi Fujiwara

Gene Therapy of Cancer: Translational Approaches from Preclinical Studies to Clinical Implementation: Third Edition 171 - 183 2013.8

Language：English Publishing type：Part of collection (book) Publisher：Elsevier Inc.

Oncolytic adenovirotherapy presents a novel approach for cancer therapy. Oncolytic adenoviruses are modified to replicate and induce oncolytic cell death in cancer cells but not in normal somatic cells. The first oncolytic adenovirus to be developed was ONYX-015, an E1B-55. kDa gene-deleted oncolytic adenovirus
after which many inventive oncolytic adenoviruses have followed. H101, an oncolytic adenovirus with very similar gene constructs as ONYX-015, was approved in China as the world's first adenovirus cancer treatment in humans in 2005. Many clinical trials have revealed that oncolytic adenoviruses produce synergistic antitumor effects in combination with conventional chemotherapeutic agents, radiation, and some molecular targeted agents, although monotherapy with oncolytic adenoviruses shows limited effects. In this chapter, we discuss the developments of oncolytic adenoviruses, focusing on their synergistic effects when combined with other treatment modalities. Then we discuss the problems that must be overcome for adenoviruses to become more attractive as cancer treatment agents and to expand their clinical applications. © 2014 Elsevier Inc. All rights reserved.

DOI： 10.1016/B978-0-12-394295-1.00012-3

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LADG、D2における神経解剖を軸とした膵上縁リンパ節郭清

黒田新士, 西崎正彦, 渡邊めぐみ, 石田道拡, 岸本浩行, 宇野太, 香川俊輔, 藤原俊義

日本消化器外科学会総会 68回 RV - 2 2013.7

腹腔鏡補助下噴門側胃切除術における郭清手技と「観音開き法」食道残胃吻合

西崎正彦, 黒田新士, 野間和広, 渡邉めぐみ, 岸本浩行, 香川俊輔, 白川靖博, 藤原俊義

日本消化器外科学会総会 68回 O - 6 2013.7

HER2陽性胃癌の臨床病理学的特徴と当院におけるtrastuzumabの使用経験

渡辺めぐみ, 香川俊輔, 石田道拡, 黒田新士, 岸本浩行, 宇野太, 西崎正彦, 藤原俊義

日本消化器外科学会総会 68回 RS - 2 2013.7

テロメラーゼ依存性増殖型アデノウイルス製剤を用いた早期大腸癌の低侵襲治療の開発

菊地覚次, 岸本浩行, 田澤大, 橋本悠里, 宇野太, 西崎正彦, 香川俊輔, 浦田泰生, ロバート・ホフマン, 藤原俊義

日本消化器外科学会総会 68回 RS - 2 2013.7

A novel synergistic effect of iron depletion on antiangiogenic cancer therapy

Toshiaki Ohara, Kazuhiro Noma, Shinichi Urano, Shinichiro Watanabe, Seishi Nishitani, Yasuko Tomono, Fumiaki Kimura, Shunsuke Kagawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara

INTERNATIONAL JOURNAL OF CANCER 132 ( 11 ) 2705 - 2713 2013.6

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

Iron is an essential element for both normal and cancer cells in humans. Treatment to reduce iron levels has been shown to suppress tumor growth in vivo. However, iron depletion monotherapy by iron decreased treatment has not been thought to be superior to ordinary chemotherapy and is not part of the standard therapeutic strategy for the treatment of cancer. Iron depletion is also known to reduce serum hemoglobin and oxygen supply to the tissue, which indicates that iron depletion may induce angiogenesis. Therefore, we hypothesized that iron depletion with antiangiogenic therapy can have a novel therapeutic effect in the treatment of cancer. Human nonsmall cell carcinoma cell lines A549 and H1299 were used in our study. An iron-deficient diet and an iron chelator were used to simulate an iron-depleted condition. The antitumor effects of iron depletion and antiangiogenic therapy were determined on A549 xenograft mice. The iron-depleted condition produced by an iron-deficient diet suppressed tumor growth. Tumor tissue from the iron-deficient diet group showed that cancer cell proliferation was suppressed and hypoxia was induced. Microvessel density of this group was increased which suggested that the iron-depleted condition induced angiogenesis. Bevacizumab administration had a synergetic effect on inhibiting the tumor growth on Day 39. An iron-depleted condition inhibited cancer cell proliferation and reciprocally induced angiogenesis. Bevacizumab synergistically enhanced the iron-depleted antitumor effect. Treatment to deplete iron levels combined with anti-angiogenic therapy could induce a novel therapeutic effect in the treatment of cancer.

DOI： 10.1002/ijc.27943

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Roux stasis syndromeの長期保存的加療に経胃瘻的空腸カテーテルを用いた1例

大岩雅彦, 香川俊輔, 重安邦俊, 金谷信彦, 宇野太, 岸本浩行, 西崎正彦, 藤原俊義

Gastroenterological Endoscopy 55 ( 5 ) 1650 - 1654 2013.5

Language：Japanese Publisher：(一社)日本消化器内視鏡学会

74歳男性。胃癌に対する幽門側胃切除、Roux-en-Y再建術後、胃空腸吻合部通過障害を生じた。再吻合を施行したが、通過障害は遷延し、Roux stasis syndrome(RSS)と診断した。胃減圧と長期栄養管理のため、経皮内視鏡的胃瘻造設術、percutaneous endoscopic gastrostomy(PEG)を施行し、経胃瘻的に空腸カテーテル(PEG-J)を留置した。134日後に食事摂取可能になりカテーテルを抜去した。PEG-Jにより中心静脈カテーテルや経鼻胃管の長期留置を回避できることからRSSに対する長期保存治療の1選択肢になりうると考えられた。(著者抄録)

DOI： 10.11280/gee.55.1650

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Application of percutaneous endoscopic gastrostomy with jejunal extension in a case of post-gastrectomy Roux Stasis syndrome

Masahiko Oiwa, Shunsuke Kagawa, Kunitoshi Shigeyasu, Nobuhiko Kanaya, Futoshi Uno, Hiroyuki Kishimoto, Masahiko Nishizaki, Toshiyoshi Fujiwara

Gastroenterological Endoscopy 55 ( 5 ) 1650 - 1654 2013.5

Language：Japanese Publishing type：Research paper (scientific journal)

We present herein on a 74-years-old man, who underwent distal gastrectomy and Roux-en-Y reconstruction for stomach cancer, and developed gastro-jejunostomy obstruction. Re-anastomosis, however, did not relieve the symptoms. Delayed gastric emptying without mechanical obstruction lead to a diagnosis of Roux stasis syndrome (RSS). To achieve both gastric decompression and nutritional therapy, a percutaneous endoscopic gastrostomy-jejunostomy (PEG-J) was performed in two steps. Firstly, a gastrostomy was placed endoscopically and then a jejunal catheter was inserted through the gastrostomy tube. This system can feed nutritional solution through the jejunal catheter while gastric juice is drained from the gastrostomy tube. The patient was spared an uncomfortable nasal gastric tube and long-term central-venous hyperalimentation, and his RSS was completely cleared 134 days later. This experience suggested that PEG-J can be one of the options in the conservative treatment of RSS.

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Multicenter phase II study of S-1 and docetaxel combination chemotherapy for advanced or recurrent gastric cancer patients with peritoneal dissemination

Kunitoshi Shigeyasu, Shunsuke Kagawa, Futoshi Uno, Masahiko Nishizaki, Hiroyuki Kishimoto, Akira Gochi, Toshikazu Kimura, Takaomi Takahata, Yasuyuki Nonaka, Motoki Ninomiya, Toshiyoshi Fujiwara

Cancer Chemotherapy and Pharmacology 71 ( 4 ) 937 - 943 2013.4

Language：English Publishing type：Research paper (scientific journal)

Purpose: Peritoneal dissemination is the most frequent and life-threatening mode of metastasis and recurrence in patients with gastric cancer. A multicenter phase II study was designed to evaluate the efficacy and tolerability of S-1 and docetaxel combination chemotherapy regimen for the treatment of advanced or recurrent gastric cancer patients with peritoneal dissemination. Methods: Nineteen patients with histologically confirmed unresectable or recurrent gastric cancer with peritoneal dissemination were enrolled. Oral S-1 at 80 mg/m2/day was administered twice daily for 2 weeks, followed by 1 drug-free week. Docetaxel infusion at 40 mg/m2 was performed on day 1, simultaneous with S-1 administration. The primary endpoints were overall survival (OS) and time to progression (TTP). The secondary endpoints were the response rates and safety status. Results: Patients received a median of 4 cycles of the S-1 and docetaxel regimen (range 1-43). The disease control rate was 73.7 % (14/19). Median overall survival was 459 days (15.3 months), while median time to progression was 212 days (7.1 months). Neutropenia was the most common type of toxicity (n = 7, 36.8 %). Conclusions: Combination chemotherapy with S-1 and docetaxel is a tolerable and effective treatment for advanced or recurrent gastric cancer patients with peritoneal dissemination. © 2013 Springer-Verlag Berlin Heidelberg.

DOI： 10.1007/s00280-013-2086-0

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癌微小リンパ節転移を標的とするテロメラーゼ特異的制限増殖型ウイルス製剤の開発

児島亨, 渡邉雄一, 橋本悠里, 黒田新士, 山崎泰源, 矢野修也, 田澤大, 宇野太, 香川俊輔, 田中紀章, 浦田泰生, 藤原俊義

岡山医学会雑誌 125 ( 1 ) 9 - 12 2013.4