Faculty Profiles - KAGAWA Shunsuke

Papers - KAGAWA Shunsuke

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術前補助化学療法によりpCRが得られた高度進行胃癌の1例

菊地覚次, 香川俊輔, 久保田哲史, 桒田和也, 黒田新士, 西﨑正彦, 田中健大, 藤原俊義

癌と化学療法 41 ( 12 ) 2282 - 2284 2014

Biological Ablation of Sentinel Lymph Node Metastasis in Submucosally Invaded Early Gastrointestinal Cancer

Kikuchi Satoru, Kishimoto Hiroyuki, Tazawa Hiroshi, Hashimoto Yuuri, Kuroda Shinji, Nishizaki Masahiko, Nagasaka Takeshi, Shirakawa Yasuhiro, Kagawa Shunsuke, Urata Yasuo, Robert M Hoffman, Fujiwara Toshiyoshi

Molecular Therapy doi: 10.1038/mt.2014.244 2014

縮小手術のコツとピットフォール① 噴門側胃切除術（観音開き法）

西﨑正彦, 黒田新士, 松村年久, 高嶌寛年, 加藤大, 菊池覚次, 桒田和也, 香川俊輔, 藤原俊義

臨床外科 69 ( 13 ) 1464 - 1471 2014

化学療法後に切除しpCRを得たStageⅣ胃癌の２例

久保田哲史, 香川俊輔, 菊地覚次, 黒田新士, 西﨑正彦, 藤原俊義

癌と化学療法 41 ( 12 ) 2308 - 2310 2014

ロボット支援下噴門側胃切除術後のロボットによる体腔内手縫い吻合

西﨑正彦, 黒田新士, 岸本浩行, 野間和広, 香川俊輔, 白川靖博, 藤原俊義

癌の臨床 60 ( 3 ) 311 - 317 2014

Language：Japanese Publisher：(株)篠原出版新社

胃上部に限局する内視鏡的粘膜下層剥離術適応外のcStage IA早期胃癌2例に対し、ロボット支援下噴門側胃切除術(RAPG)後に完全体腔内ロボット手縫い吻合による[観音開き法]食道残胃吻合による再建を行った。RAPG後の体腔内手縫い吻合は、腹腔鏡補助下噴門側胃切除術(LAPG)より平均手術時間や体腔内吻合時間が大幅に延長したが、平均出血量は少量で、開腹手縫いと同等に安全で正確な吻合を行うことができた。RAPG後の体腔内ロボット手縫い吻合は、低侵襲手技として機能温存を試みる際に再評価される可能性があると思われた。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J00297&link_issn=&doc_id=20140730100010&doc_link_id=%2Fad7gnrsc%2F2014%2F006003%2F010%2F0311-0317%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fad7gnrsc%2F2014%2F006003%2F010%2F0311-0317%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

A Case of Gastric Cancer with Stable Disease Controlled Recurrence of Gastrointestinal Stromal Tumor with Imatinib

Uno Futoshi, Kishimoto Hiroyuki, Kagawa Shunsuke, Fujiwara Toshiyoshi

Nihon Gekakei Rengo Gakkaishi (Journal of Japanese College of Surgeons) 39 ( 1 ) 45 - 51 2014

Language：Japanese Publisher：Japanese College of Surgeons

A case was 81-year-old woman with gastrointestinal stromal tumor (GIST) of stomach accompanied by liver metastases, who underwent partial gastrectomy and hepatectomy. Multiple liver metastases were diagnosed 8 months after R0 surgery. While metastases disease was well controlled with administration of imatinib for 4 years, gastric cancer in remnant stomach was diagnosed. Total gastrectomy was undergone, pathological findings were that well differentiated tubular adenocarcinoma cells were localized in mucosa and no lymph node metastases was found but local recurrence of GIST was pointed out. One month after total gastrectomy, she resumed administration of imatinib and she has no sign of progression with neither gastric cancer nor GIST. Only 11 synchronous GIST cases of 685 gastric cancer cases were found and it is first case for our institution that gastric cancer was occurred during imatinib therapy for recurrence GIST. But secondary cancer should be concern because of long survival time for unresectable metastases GIST patients with imatinib.

DOI： 10.4030/jjcs.39.45

DOI： 10.3919/jjsa.81.2225_references_DOI_HvAPNRy8vi3arMN5Gv9eBAuRYyx

CiNii Article

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Oncolytic Adenovirus-Induced Autophagy: Tumor-Suppressive Effect and Molecular Basis

Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara

ACTA MEDICA OKAYAMA 67 ( 6 ) 333 - 342 2013.12

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the El-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses.

DOI： 10.18926/AMO/52006

Web of Science

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A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem-like Cells in S/G(2)/M Phases

Shuya Yano, Hiroshi Tazawa, Yuuri Hashimoto, Yasuhiro Shirakawa, Shinji Kuroda, Masahiko Nishizaki, Hiroyuki Kishimoto, Futoshi Uno, Takeshi Nagasaka, Yasuo Urata, Shunsuke Kagawa, Robert M. Hoffman, Toshiyoshi Fujiwara

CLINICAL CANCER RESEARCH 19 ( 23 ) 6495 - 6505 2013.12

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER ASSOC CANCER RESEARCH

Purpose: Because chemoradiotherapy selectively targets proliferating cancer cells, quiescent cancer stem-like cells are resistant. Mobilization of the cell cycle in quiescent leukemia stem cells sensitizes them to cell death signals. However, it is unclear that mobilization of the cell cycle can eliminate quiescent cancer stem-like cells in solid cancers. Thus, we explored the use of a genetically-engineered telomerase-specific oncolytic adenovirus, OBP-301, to mobilize the cell cycle and kill quiescent cancer stem-like cells.
Experimental Design: We established CD133(+) cancer stem-like cells from human gastric cancer MKN45 and MKN7 cells. We investigated the efficacy of OBP-301 against quiescent cancer stem-like cells. We visualized the treatment dynamics of OBP-301 killing of quiescent cancer stem-like cells in dormant tumor spheres and xenografts using a fluorescent ubiquitination cell-cycle indicator (FUCCI).
Results: CD133(+) gastric cancer cells had stemness properties. OBP-301 efficiently killed CD133(+) cancer stem-like cells resistant to chemoradiotherapy. OBP-301 induced cell-cycle mobilization from G(0)-G(1) to S/G(2)/M phases and subsequent cell death in quiescent CD133(+) cancer stem-like cells by mobilizing cell-cycle-related proteins. FUCCI enabled visualization of quiescent CD133(+) cancer stem-like cells and proliferating CD133(-) non-cancer stem-like cells. Three-dimensional visualization of the cell-cycle behavior in tumor spheres showed that CD133(+) cancer stem-like cells maintained stemness by remaining in G(0)-G(1) phase. We showed that OBP-301 mobilized quiescent cancer stem-like cells in tumor spheres and xenografts into S/G(2)/M phases where they lost viability and cancer stem-like cell properties and became chemosensitive.
Conclusion: Oncolytic adenoviralinfection is an effective mechanism of cancer cell killing in solid cancer and can be a new therapeutic paradigm to eliminate quiescent cancer stem-like cells. Clin Cancer Res; 19(23); 6495-505. (C) 2013 AACR.

DOI： 10.1158/1078-0432.CCR-13-0742

Web of Science

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Genetically engineered oncolytic adenovirus induces autophagic cell death through an E2F1-microRNA-7-epidermal growth factor receptor axis

125 ( 3 ) 195 - 199 2013.12

当科における進行食道癌における合理的胸腔鏡下手術の試み Reviewed

野間和広, 白川靖博, 前田直見, 二宮卓之, 大原利章, 田辺俊介, 櫻間教文, 西崎正彦, 香川俊輔, 藤原俊義

日本内視鏡外科学会雑誌 18 ( 7 ) 549 - 549 2013.11

胃癌切除 #8〜#13の郭清法(開腹術と同等に行えるか) 神経解剖を軸とした膵上縁郭清の工夫と実際

黒田新士, 西崎正彦, 堀直人, 岸本浩行, 香川俊輔, 藤原俊義

日本内視鏡外科学会雑誌 18 ( 7 ) 371 - 371 2013.11

Closed LECSの開発と臨床応用

西崎正彦, 加藤大, 黒田新士, 田邊俊介, 堀直人, 岸本浩行, 香川俊輔, 白川靖博, 藤原俊義

日本内視鏡外科学会雑誌 18 ( 7 ) 499 - 499 2013.11

Advances in adenovirus-mediated p53 cancer gene therapy

Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara

Expert Opinion on Biological Therapy 13 ( 11 ) 1569 - 1583 2013.11

Language：English Publishing type：Research paper (scientific journal)

Introduction: The tumor suppressor p53 gene regulates diverse cellular processes, such as cell-cycle arrest, senescence, apoptosis and autophagy, and it is frequently inactivated by genetic alterations in ∼ 50% of all types of human cancers. To restore wild-type p53 function in p53-inactivated tumors, adenovirus-mediated p53 gene therapy has been developed as a promising antitumor strategy in preclinical experiments and clinical studies. Areas covered: This review focuses on the clinical relevance of replication-deficient adenovirus vectors that carry the wild-type p53 gene (Ad-p53
Advexin, Gendicine and SCH-58500) in clinical studies of patients with various cancers and the future perspectives regarding conditionally replicating adenovirus vectors expressing the wild-type p53 gene (CRAd-p53
AdDelta24-p53, SG600-p53, OBP-702) in preclinical experiments. Moreover, the recent advances in our understanding of the molecular basis for the p53-mediated tumor suppression network induced by Ad-p53 and CRAd-p53 vectors and the combination therapies for promoting the therapeutic potential of adenovirus-mediated p53 gene therapy are discussed. Expert opinion: Exploration of the molecular mechanism underlying the p53-mediated tumor suppression network and the effective strategy for enhancing the p53-mediated cell death signaling pathway would provide novel insights into the improvement of clinical outcome in p53-based cancer gene therapy. © 2013 Informa UK, Ltd.

DOI： 10.1517/14712598.2013.845662

Scopus

PubMed

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腹腔鏡下有茎直腸による腟形成術の3例

永坂岳司, 宇野太, 稲田涼, 杉本盛人, 母里淑子, 近藤喜太, 黒田新二, 浅野博昭, 岸本浩行, 西崎正彦, 佃和憲, 香川俊輔, 長谷川健二郎, 難波祐三郎, 藤原俊義

日本内視鏡外科学会雑誌 18 ( 7 ) 757 - 757 2013.11

成人Bochdalek孔ヘルニアを合併した胃癌に対し腹腔鏡手術にて一期的に根治手術し得た1例

堀直人, 香川俊輔, 黒田信士, 岸本浩行, 西崎正彦, 藤原俊義

日本内視鏡外科学会雑誌 18 ( 7 ) 639 - 639 2013.11

胃癌患者の腹腔洗浄液における蛍光発現ウイルス試薬による新たな生物学的診断(Biological assessment of peritoneal lavage cytology of gastric cancer by fluorescence-expressing virus TelomeScan)

香川俊輔, 石田道拡, 渡邉めぐみ, 田澤大, 黒田新士, 岸本浩行, 橋本悠里, 西崎正彦, 藤原俊義

日本癌学会総会記事 72回 187 - 187 2013.10

早期大腸癌のリンパ節転移制御に向けた新規治療(Novel strategy for eradicating lymph node metastasis of earlystage colorectal cancers)

菊地覚次, 岸本浩行, 田澤大, 橋本悠里, 宇野太, 西崎正彦, 香川俊輔, 浦田泰生, ロバート・ホフマン, 藤原俊義

日本癌学会総会記事 72回 178 - 178 2013.10

進行胃癌に対する手術進行胃癌に対し自律神経解剖を郭清範囲決定に応用したD2郭清

西崎正彦, 黒田新士, 堀直人, 岸本浩行, 香川俊輔, 藤原俊義

日本臨床外科学会雑誌 74 ( 増刊 ) 461 - 461 2013.10

HER2遺伝子導入技術を用いたHER2陰性癌細胞に対する分子標的光免疫療法(Neotargeting HER2 negative cancer cells with photoimmunotherapy by virally transduction of HER2- extracellular domain)

石田道拡, 香川俊輔, 下山京子, 竹原清人, 野間和広, 田澤大, 黒田新士, 岸本浩行, 田邊俊介, 松岡順治, 小林久隆, 篠原俊義

日本癌学会総会記事 72回 495 - 495 2013.10

蛍光標識による血中遊離癌細胞のLiquid Biopsy技術のバイオマーカー解析への応用 Reviewed

重安邦俊, 橋本悠里, 竹原清人, 宇野太, 永坂岳司, 田澤大, 香川俊輔, 浦田泰生, 藤原俊義

日本癌治療学会誌 48 ( 3 ) 2759 - 2759 2013.9

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Papers - KAGAWA Shunsuke