Faculty Profiles - KANDA Hideyuki

Papers - KANDA Hideyuki

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Prevalence and Trends in Alcohol Dependence and Alcohol Use Disorders in Japanese Adults; Results from Periodical Nationwide Surveys. International journal

Yoneatsu Osaki, Aya Kinjo, Susumu Higuchi, Hiroshi Matsumoto, Takefumi Yuzuriha, Yoshinori Horie, Mitsuru Kimura, Hideyuki Kanda, Hisashi Yoshimoto

Alcohol and alcoholism (Oxford, Oxfordshire) 51 ( 4 ) 465 - 73 2016.7

Language：English Publishing type：Research paper (scientific journal)

AIMS: Nationwide surveys to clarify the characteristics and trends of the drinking behavior of Japanese adults were carried out in 2003, 2008, and 2013. METHODS: These were periodical cross-sectional surveys. Subjects were chosen through a stratified two-stage random sampling method. The surveys included drinking frequency and amount, ICD-10 alcoholism diagnostic standards, questionnaire for the determination of harmful alcohol use ( AUDIT: Alcohol Use Disorders Identification Test). In 2003, the surveys obtained responses from 2547 people (73% response rate); in 2008, 4123 people (55% response rate); and in 2013, 4153 people (59% response rate). RESULTS: The proportion of lifetime experience of alcohol dependence diagnosed by ICD-10 was 1.9% for male and 0.2% for female, and the estimated number of patients was 1.07 million. The declining trends were observed in the percentage of daily drinkers and the amount of alcohol consumed per week for male. The lowering of the age for consuming their first alcoholic drink and their first drunken experience was observed among female. The gender difference of prevalence of problem drinking is getting smaller. The binge drinking and heavy episodic drinking were observed especially younger generation. The only small proportion of patients with alcohol dependence had received specialized medical care, whereas the many of these visited medical institutions and health screening. CONCLUSIONS: The survey observed many hidden alcoholic patients, and showed the possibility that the healthcare facilities and health screening became the place of screening and intervention for alcohol dependence.

DOI： 10.1093/alcalc/agw002

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Anger and Impulsivity Among Japanese Adolescents: A Nationwide Representative Survey. International journal

Osamu Itani, Yoshitaka Kaneita, Takeshi Munezawa, Maki Ikeda, Yoneatsu Osaki, Susumu Higuchi, Hideyuki Kanda, Sachi Nakagome, Kenji Suzuki, Takashi Ohida

The Journal of clinical psychiatry 77 ( 7 ) e860-6 2016.7

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: This study aimed to clarify the prevalence of anger and impulsivity and its associated factors through a nationwide survey of junior and senior high school adolescent students in Japan. METHODS: A self-administered questionnaire covering (1) personal data, (2) lifestyle, (3) mental health status, and (4) feelings of anger and impulsivity was distributed to junior and senior high school students in Japan. Among the total of 10,955 junior high schools and 5,115 senior high schools nationwide, 130 and 110 were randomly selected, respectively. Of those, 92 junior and 80 senior high schools participated in the survey. The survey period was from December 2008 to the end of January 2009. A total of 95,680 questionnaires were collected. After excluding invalid responses, the remaining 94,777 responses (response rate: 62.3%) were analyzed. RESULTS: From the questions regarding anger and impulsivity, 8.7% (95% CI, 8.5%-8.9%) and 7.5% (95% CI, 7.3%-7.7%) of the participants were considered to have experienced intense anger and impulsivity, respectively. Logistic regression analysis indicated that the odds ratios for experiencing intense feelings of anger were significantly higher (all P values < .05) among students who smoked, consumed alcohol, skipped breakfast, did not wish to go to university, had short sleep duration, had decreased positive feelings, had increased depressive feelings, or used mobile phones for longer hours. The odds ratios for experiencing intense impulsivity were significantly higher among students who smoked, consumed alcohol, skipped breakfast, did not participate in club activities, had short sleep duration, had decreased positive feelings, had increased depressive feelings, or used mobile phones for longer hours. CONCLUSIONS: The results suggest that healthy lifestyle habits, good sleep habits, and improved mental health are important for preventing intense feelings of anger and impulsivity among adolescents.

DOI： 10.4088/JCP.15m10044

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Irritable bowel syndrome among Japanese adolescents: A nationally representative survey. International journal

Ryuichiro Yamamoto, Yoshitaka Kaneita, Yoneatsu Osaki, Hideyuki Kanda, Kenji Suzuki, Susumu Higuchi, Maki Ikeda, Shuji Kondo, Takeshi Munezawa, Takashi Ohida

Journal of gastroenterology and hepatology 30 ( 9 ) 1354 - 60 2015.9

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND AIM: No nationally representative survey of irritable bowel syndrome (IBS) among adolescents has ever been performed in Japan. In the present study, we aimed to clarify the prevalence of IBS among Japanese adolescents and the factors associated with it. METHODS: The items related to the diagnostic criteria for IBS based on the Rome III Diagnostic Criteria for Functional Gastrointestinal Disorders were included in a cross-sectional nationwide survey of "alcohol consumption and smoking habits among junior and senior high school students." The participating schools were sampled from among all junior and senior high schools in Japan using the cluster-sampling method, and self-administered questionnaires were sent to the selected schools by mail. Among 99 416 questionnaires that were collected, data from 98 411 valid responses were analyzed. RESULTS: The results showed that the prevalence of IBS was 18.6%. Although no sex difference was observed in the overall prevalence of IBS, the prevalence of diarrhea-predominant IBS was higher among boys than among girls, and the prevalence of constipation-predominant IBS was higher among girls than among boys. The prevalence of IBS increased with progression of the school grade, and there were the significant relationships between IBS and sleep-phase delay and insomnia symptoms. IBS was also significantly associated with poor mental health status. CONCLUSION: These results indicate that IBS is common among junior and senior high school students, and associated with lifestyle and mental health.

DOI： 10.1111/jgh.12974

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災害時の感染症への対応

高橋謙造, 神田秀幸

日本医事新報 ( 4770 ) 64 - 64 2015.9

Unhealthy lifestyle, poor mental health, and its correlation among adolescents: a nationwide cross-sectional survey. Reviewed International journal

Takeo Tanihata, Hideyuki Kanda, Yoneatsu Osaki, Takashi Ohida, Masumi Minowa, Kiyoshi Wada, Kenji Suzuki, Kenji Hayashi

Asia-Pacific journal of public health 27 ( 2 ) NP1557-65 2015.3

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: The objective was to study the relationship between mental health and lifestyles of adolescents using samples representative of Japanese adolescents nationwide. METHOD: The survey was conducted between December 2004 and January 2005 among students enrolled in randomly selected junior and senior high schools. Self-administered questionnaires addressed lifestyles, sleeping habits, and mental health status. Of 103 650 questionnaires collected, 85 158 were analyzed. RESULTS: Population characteristics associated with poor mental health were being female, being a senior high school student, skipping breakfast, not participating in extracurricular activities, not consulting parents about personal matters, parental smoking, students' smoking or alcohol use, poor subjective sleep assessment, and short or long sleeping duration. CONCLUSION: Smoking and anxiety disorders are associated with an elevation in acculturative stress in adolescents. Prepossessing adolescents are in subclinical depression. Results suggest that lifestyles approaches in preventions that target students can be effective in reaching high-risk populations.

DOI： 10.1177/1010539512452753

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EFFECT OF CYP2A6*4 GENETIC POLYMORPHISMS ON SMOKING BEHAVIORS AND NICOTINE DEPENDENCE IN A GENERAL POPULATION OF JAPANESE MEN.

Teruna Ito, Masayoshi Tsuji, Yayoi Mori, Hideyuki Kanda, Tomoo Hidaka, Takeyasu Kakamu, Tomohiro Kumagai, Takehito Hayakawa, Yoneatsu Osaki, And Tetsuhito Fukushima

Fukushima journal of medical science 61 ( 2 ) 125 - 30 2015

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: Nicotine in cigarettes is metabolized primarily by CYP2A6-catalyzed oxidation. The CYP2A6*4 allele, in which CYP2A6 is a homozygous whole-deletion variant, completely lacks enzyme activity. The aim of this study was to examine the effects of CYP2A6*4 genetic polymorphism on smoking behavior and nicotine dependence in a general population of Japanese men. METHODS: The subjects were 124 healthy Japanese men who gave informed consent to give saliva samples. The survey items included general information, smoking behaviors and nicotine dependence. The polymerase chain reaction restriction fragment length polymorphism method was used to analyze the genetic polymorphisms of CYP2A6. The subjects were classified into two groups: Group W (CYP2A6*4 absence: *1A/*1A, *1A/*1B and *1B/*1B) and Group D (CYP2A6*4 presence: *1B/*4A, *4A/*4A, *1A/*4A or *1B/*4D, and *1A/*4D). We analyzed the differences in the survey items between the two groups. RESULTS: There were no significant differences in smoking behaviors between the two groups. However, Group D tended to have less difficulty in refraining from smoking after waking in the morning compared to Group W (p=0.051). CONCLUSIONS: CYP2A6*4 genetic polymorphisms may not strongly affect smoking behavior but may possibly have an effect on nicotine dependence.

DOI： 10.5387/fms.2015-14

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地理情報システムを用いた首都圏某市における社会健康格差の検討

飯島崇善, 菅谷渚, 神田秀幸, 高橋謙造, 水嶋春朔

日本公衆衛生学会総会抄録集 73回 484 - 484 2014.10

健康松戸21III計画のための市民アンケート分析(5報) 高齢者における運動の習慣化

橘知之, 齋藤京子, 菅谷渚, 神田秀幸, 高橋謙造, 水嶋春朔

日本公衆衛生学会総会抄録集 73回 326 - 326 2014.10

健康松戸21III計画のための市民アンケートと既存資料分析(第4報)

二宮恵子, 飯野幸子, 渡辺節子, 石川有希子, 山田香織, 大関まり子, 菅谷渚, 神田秀幸, 高橋謙造, 水嶋春朔, 藤内圭一, 中澤豊, 長谷川明美

日本公衆衛生学会総会抄録集 73回 326 - 326 2014.10

健康松戸21III計画のための市民アンケートと既存資料分析(第3報)

石川有希子, 渡辺節子, 飯野幸子, 二宮恵子, 山田香織, 大関まり子, 菅谷渚, 神田秀幸, 高橋謙造, 水嶋春朔, 古畑公, 中澤豊, 長谷川明美

日本公衆衛生学会総会抄録集 73回 326 - 326 2014.10

健康松戸21III計画のための市民アンケートと既存資料分析(第2報)

渡辺節子, 飯野幸子, 石川有希子, 二宮恵子, 山田香織, 大関まり子, 菅谷渚, 神田秀幸, 高橋謙造, 水嶋春朔, 中澤豊, 長谷川明美

日本公衆衛生学会総会抄録集 73回 325 - 325 2014.10

健康松戸21III計画のための市民アンケートと既存資料分析(第1報)

飯野幸子, 渡辺節子, 石川有希子, 二宮恵子, 山田香織, 大関まり子, 菅谷渚, 神田秀幸, 高橋謙造, 水嶋春朔, 中澤豊, 長谷川明美

日本公衆衛生学会総会抄録集 73回 325 - 325 2014.10

Internet usage and knowledge of radiation health effects and preventive behaviours among workers in Fukushima after the Fukushima Daiichi nuclear power plant accident. International journal

Hideyuki Kanda, Kenzo Takahashi, Nagisa Sugaya, Shunsaku Mizushima, Kikuo Koyama

Emergency medicine journal : EMJ 31 ( e1 ) e60-5 2014.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The Fukushima Daiichi nuclear power plant accident (FDNPPA) was the world's second largest nuclear power plant accident. At the time that it occurred, internet usage prevalence in Japan was as high as 80%. OBJECTIVES: To compare health knowledge on radiation and preventive behaviour between internet users and non-users among adults employed in industries in Fukushima after the nuclear disaster. METHODS: We conducted a cross-sectional questionnaire study among adults employed in industries in Fukushima 3-5 months after the FDNPPA. Targets were 1394 regular workers who took part in health seminars provided by the Fukushima Occupational Health Promotion Center. After applying the selection criteria, there were 1119 eligible participants. The questionnaire asked for personal characteristics and main sources of information about the FDNPPA, as well as health knowledge on radiation and preventive behaviours following the nuclear accident. We assessed the contribution of each variable using logistic regression analysis. RESULTS: Among the eligible respondents, 637 workers (56.9%) were internet users and 482 (43.1%) were non-users. Internet users had more health knowledge than non-users (average 4.6 radiation-related health conditions in internet users vs 3.6 conditions in non-users) and more preventive behaviours (average 2.6 behaviours in internet users vs 1.9 in non-users). According to logistic regression analyses, internet usage was positively associated with greater health knowledge on radiation (OR 1.13; 95% CI 1.08 to 1.20) and more preventive behaviours (OR 1.14; 95% CI 1.07 to 1.23). CONCLUSIONS: Internet usage was significantly and positively associated with greater health knowledge and more preventive behaviours. The internet is a useful method of distributing information to the general public in emergency situations such as a nuclear disaster.

DOI： 10.1136/emermed-2013-202955

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神奈川県内某特別養護老人ホームにおける施設内看取りの現状

西口翔, 菅谷渚, 神田秀幸, 水嶋春朔

日本公衆衛生学会総会抄録集 73回 470 - 470 2014.10

Japan's emerging challenge for child abuse: system coordination for early prevention of child abuse is needed.

Kenzo Takahashi, Hideyuki Kanda, Nagisa Sugaya

Bioscience trends 8 ( 4 ) 240 - 1 2014.8

Language：English Publishing type：Research paper (scientific journal)

At the end of 2013, a Japanese newspaper reported that 4,173 children were unidentified or missing in Japan. The article concluded that child abuse was a matter of national concern. In examining the strengths and weaknesses of Japan's welfare system in regard to child abuse, it would seem that a weakness exists with regard to its ambiguity on the roles of different officers who contact suspected cases. Although three types of officer (health, welfare, and police officers) can take charge, child abuse cases might be missed because the division of labor varies between the different types of officer. However, a strength exists in the periodical pediatric health check system that is in place in each of Japan's 1,742 municipalities. To efficiently implement early intervention for child abuse, it is necessary to rearrange the division of labor among the three types of officers to clarify who should intervene in suspected cases.

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思春期の"早寝早起き朝ご飯"に関する疫学研究

池田真紀, 兼板佳孝, 山本隆一郎, 井谷修, 近藤修治, 尾崎米厚, 神田秀幸, 鈴木健二, 樋口進, 中込祥, 大井田隆

日本睡眠学会定期学術集会プログラム・抄録集 39回 239 - 239 2014.7

わが国におけるアルコール依存症の患者数および未治療の潜在患者数の推計

尾崎米厚, 神田秀幸, 樋口進, 松本博志, 杠岳文, 堀江義則, 木村充, 吉本尚, 近藤陽子, 田原文

日本衛生学雑誌 69 ( Suppl. ) S257 - S257 2014.5

Sleep environments of Japanese adolescents: An epidemiological study

Maki Ikeda, Yoshitaka Kaneita, Ryuichiro Yamamoto, Osamu Itani, Shuji Kondo, Yoneatsu Osaki, Hideyuki Kanda, Susumu Higuchi, Takashi Ohida

SLEEP AND BIOLOGICAL RHYTHMS 12 ( 2 ) 116 - 126 2014.4

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

We conducted an epidemiological study to examine the associations between sleep environments and sleep habits in Japanese adolescents. The targets were students attending junior and senior high schools throughout Japan. Sample schools were selected by cluster sampling. Self-reported anonymous questionnaires were then sent to the schools for all students to complete. A total of 99416 adolescents responded, with an overall response rate of 64.0%. A total of 96861 questionnaires were subjected to analysis. Associations between sleep environments (type of bed, lighting during sleep, sharing a bedroom) and sleep duration, bedtimes, wake-up times, sleep quality, or symptoms of insomnia were examined. In total, 65.5% of the adolescents surveyed slept on a bed, and 33.0% slept on a futon laid on the floor or tatami. In total, 66.6% slept with the light off, 31.0% slept with a dim light on, and 2.0% slept with the light on. Of those surveyed, 69.3% had their own bedrooms, 17.1% shared a bedroom with one other person, 8.0% shared a bedroom with three people, and 5.0% shared a bedroom with four people or more. The factors with high odds ratios with regard to insomnia were use of a futon laid on the floor or tatami, sleeping with the light on, and not sharing a bedroom. Sleep environments are associated with insomnia. Type of bed, lighting, and sharing a bedroom should be considered as factors that affect the sleep of adolescents.

DOI： 10.1111/sbr.12050

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Factors affecting unhappiness at school among Japanese adolescents: an epidemiological study. International journal

Hisayoshi Morioka, Osamu Itani, Yoshitaka Kaneita, Hajime Iwasa, Maki Ikeda, Ryuichiro Yamamoto, Yoneatsu Osaki, Hideyuki Kanda, Sachi Nakagome, Takashi Ohida

PloS one 9 ( 11 ) e111844 2014

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Unhappiness at school is one of the main reasons for truancy among adolescents. In order to assess this problem more thoroughly in the context of Japanese adolescents, the present study examined the associations between feelings of unhappiness at school and lifestyle habits, school life realities, and mental health status. METHOD: This study was designed as a cross-sectional survey. A self-administered questionnaire was provided to students enrolled in randomly selected junior and senior high schools throughout Japan. We calculated the percentages of both junior and senior high school students who felt unhappy at school based on factors related to school life, lifestyle habits, and mental health status. Multiple logistic regression analyses were performed in order to examine the associations between those factors and students' feelings of unhappiness at school. RESULTS: A total of 98,867 valid responses were analysed, 7.9% (Boys: 8.4%, Girls: 7.4%) of which came from students who responded that they felt unhappy at school. For both junior and senior high school students, the percentages of those who felt unhappy at school were significantly higher among those who had not yet decided on their future life course, who did not participate in extracurricular activities, did not eat breakfast every day, went to bed late, had used tobacco or alcohol in the previous 30 days, and had poor mental health compared with others. The results of multiple logistic regression analyses indicated that the adjusted odds ratios for feeling unhappy at school with regard to the above-mentioned factors were significantly high for both junior and senior high school students. CONCLUSIONS: The present results suggest that school employees and administrators must provide health guidance to students, considering that irregular lifestyle habits, lower school engagement, smoking, drinking alcohol, and poor mental health status are all associated with maladaptation to school among adolescents.

DOI： 10.1371/journal.pone.0111844

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Correlations among heavy metals in blood and urine and their relations to depressive symptoms in Parkinson's disease patients.

Tetsuhito Fukushima, Xiaodong Tan, Yunwen Luo, Puqing Wang, Jinhui Song, Hideyuki Kanda, Takehito Hayakawa, Tomohiro Kumagai, Takeyasu Kakamu, Masayoshi Tsuji, Tomoo Hidaka, Yayoi Mori

Fukushima journal of medical science 60 ( 2 ) 108 - 15 2014

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: From our previous results, manganese (Mn) and iron (Fe) in the blood of Parkinson's disease (PD) patients without depression were higher than those of both the PD patients with depression and controls, the hypothesis that "two types of PD exist-PD without depression and affected by Mn and Fe, and PD with depression and unaffected by Mn or Fe" was induced. To investigate the hypothesis, correlations among blood and urine metals were compared in the subjects. METHODS: Subjects comprised PD patients with depression, PD patients without depression and controls recruited from an outpatient clinic in China. Morning blood and urine samples were used to measure concentrations of metals. RESULTS: In the controls, Mn, Fe and zinc (Zn) levels in blood strongly correlated with each other. The correlation coefficient between Mn and Zn in blood was significant in the PD patients with depression and the controls, but not in the PD patients without depression. Correlations of Fe between blood and urine in the PD patients without depression were significant, but not in the PD patients with depression and the controls. CONCLUSIONS: A common route of simultaneous intake of Mn, Fe and Zn could exist in our subjects, however in PD patients without depression, a large intake of Mn may have been from another route. Some results of the PD patients without depression were different from those of the PD patients with depression and the controls. Thus, two types of PD may exist.

DOI： 10.5387/fms.2014-8

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