研究者詳細 - 神田　秀幸

論文 - 神田　秀幸

分割表示 213 件中 1 - 20 件目／全件表示 >>

The association between objectively measured physical activity and home blood pressure: a population-based real-world data analysis. 国際誌

Minako Kinuta, Takashi Hisamatsu, Kaori Taniguchi, Mari Fukuda, Noriko Nakahata, Hideyuki Kanda

Journal of human hypertension 2025年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Few studies have examined the association of objectively measured habitual physical activity (PA) and sedentary behavior with out-of-office blood pressure (BP). We investigated the associations of objectively measured PA intensity time, sedentary time, and step count with at-home BP. Using accelerometer-recorded PA indices and self-measured BP in 368 participants (mean age, 53.8 years; 58.7% women), we analyzed 115,575 records of each parameter between May 2019 and April 2024. PA intensities were categorized as light (2.0-2.9 metabolic equivalents [METs]); moderate (3.0-5.9 METs); vigorous (≥6.0 METs), or sedentary (<2.0 METs): the median [interquartile ranges] for these variables was 188 [146-232], 83 [59-114], 1 [0-2], 501 [428-579] minutes, respectively, and for step count, was 6040 [4164-8457]. Means [standard deviations] for systolic and diastolic BP were 116.4 [14.2] and 75.2 [9.3] mmHg, respectively. A mixed-effect model adjusted for possible confounders showed that 1-h longer in vigorous PA was associated with lower systolic and diastolic BP (-1.69 and -1.09 mmHg, respectively). A 1000-step increase in step count was associated with lower systolic and diastolic BP (-0.05 and -0.02 mmHg, respectively). Associations were more pronounced among men and participants aged <60 years. Sedentary time was positively associated with BP in men and participants aged <60 years, but inversely associated with BP in women and participants aged ≥60 years. Our findings suggest that more PA and less sedentary behavior were associated with BP reduction, particularly among men and participants aged <60 years. However, the clinical relevance of this effect remains uncertain because of its modest magnitude.

DOI： 10.1038/s41371-025-01014-8

PubMed

researchmap

Nicotine dependence based on the tobacco dependence screener among heated tobacco products users in Japan, 2022-2023: The JASTIS study. 国際誌

Takuma Kitajima, Takashi Hisamatsu, Hideyuki Kanda, Takahiro Tabuchi

Neuropsychopharmacology reports 45 ( 1 ) e12512 2025年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

Heated tobacco products (HTPs) are nicotine-containing products similar to cigarettes and are widely used in Japan. However, there has been insufficient research on nicotine dependence associated with HTP use. This study investigated the association of the types of individuals who smoked with the prevalence of nicotine dependence. We utilized data from the Japan Survey on Tobacco and Health (JASTIS). A total of 7969 participants who currently smokes was selected from the 2022 and 2023 survey respondents for the analysis. Nicotine dependence was defined as a score of 5 or higher on the Tobacco Dependence Screener (TDS). The prevalence of nicotine dependence was 43.0% (3473/8077) among all participants who smoked, 42.9% (1479/3447) among those who used cigarettes, 44.2% (760/1720) among those who used two products, and 43.0% (1206/2802) among those who used HTPs. The prevalence of nicotine dependence was statistically higher in the participants who used two products than in cigarettes (odds ratio [OR], 1.17; 95% confidence interval [CI], 1.04-1.33). When classified by temperature, participants who used of two products (high-temp and low-temp) and those using participants who used HTPs (high-temp) had higher ORs for prevalent nicotine dependence (OR, 1.31 [95% CI, 1.14-1.51]) and (OR, 1.12 [95% CI, 1.00-1.25], respectively) compared to participants who used cigarettes. Additionally, the ORs for prevalent nicotine dependence increased with the number of tobacco sticks smoked per day. These results suggest that HTP use, particularly high-temperature HTPs use, and a higher number of tobacco sticks smoked is associated with nicotine dependence.

DOI： 10.1002/npr2.12512

PubMed

researchmap

Association Between Alcohol Use Patterns and Insomnia Symptoms or Poor Sleep Quality Among Adult Women: An Internet Cross-Sectional Survey in Japan. 国際誌

Suguru Nakajima, Yuichiro Otsuka, Yoshitaka Kaneita, Osamu Itani, Yuki Kuwabara, Aya Kinjo, Ruriko Minobe, Hitoshi Maesato, Susumu Higuchi, Hideyuki Kanda, Hisashi Yoshimoto, Maki Jike, Hideaki Kasuga, Teruna Ito, Yoneatsu Osaki

Clocks & sleep 7 ( 1 ) 2025年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

It is unclear whether patterns of alcohol consumption are associated with sleep disturbance. We aimed to investigate the relationship between comprehensive alcohol-related factors and insomnia symptoms, as well as sleep quality, among adult women in Japan. Responses to an online cross-sectional survey were gathered from 12,000 women. The survey items included demographic characteristics, alcohol consumption (Alcohol Use Disorders Identification Test, nightcaps, years of drinking), sleep-related factors (sleep duration, insomnia symptoms, sleep quality), lifestyle-related factors, and mental health. Binary logistic regression was used to investigate the relationship between alcohol consumption and both insomnia symptoms and sleep quality. A total of 10,233 women were included in the final analysis. The results revealed that several alcohol-related behaviors, including the consumption of nightcaps and years of drinking, were significantly associated with insomnia symptoms and poor sleep quality. Specifically, nightcaps were significantly associated with all types of insomnia symptoms and poor sleep quality, with a higher odds ratio than other alcohol-related items. Our findings suggest that specific alcohol-related behaviors, particularly the consumption of nightcaps, are associated with insomnia symptoms and poor sleep quality among women. Intervention programs for alcohol consumption should be provided to prevent sleep problems among women.

DOI： 10.3390/clockssleep7010005

PubMed

researchmap

ChatGPT Responses to Clinical Questions in the Japan Atherosclerosis Society Guidelines for Prevention of Atherosclerotic Cardiovascular Disease 2022. 査読

Takashi Hisamatsu, Mari Fukuda, Minako Kinuta, Hideyuki Kanda

Journal of atherosclerosis and thrombosis 31 2024年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

AIMS: Artificial intelligence is increasingly used in the medical field. We assessed the accuracy and reproducibility of responses by ChatGPT to clinical questions (CQs) in the Japan Atherosclerosis Society Guidelines for Prevention Atherosclerotic Cardiovascular Diseases 2022 (JAS Guidelines 2022). METHODS: In June 2024, we assessed responses by ChatGPT (version 3.5) to CQs, including background questions (BQs) and foreground questions (FQs). Accuracy was assessed independently by three researchers using six-point Likert scales ranging from 1 ("completely incorrect") to 6 ("completely correct") by evaluating responses to CQs in Japanese or translated into English. For reproducibility assessment, responses to each CQ asked five times separately in a new chat were scored using six-point Likert scales, and Fleiss kappa coefficients were calculated. RESULTS: The median (25th-75th percentile) score for ChatGPT's responses to BQs and FQs was 4 (3-5) and 5 (5-6) for Japanese CQs and 5 (3-6) and 6 (5-6) for English CQs, respectively. Response scores were higher for FQs than those for BQs (P values ＜0.001 for Japanese and English). Similar response accuracy levels were observed between Japanese and English CQs (P value 0.139 for BQs and 0.586 for FQs). Kappa coefficients for reproducibility were 0.76 for BQs and 0.90 for FQs. CONCLUSIONS: ChatGPT showed high accuracy and reproducibility in responding to JAS Guidelines 2022 CQs, especially FQs. While ChatGPT primarily reflects existing guidelines, its strength could lie in rapidly organizing and presenting relevant information, thus supporting instant and more efficient guideline interpretation and aiding in medical decision-making.

DOI： 10.5551/jat.65240

PubMed

researchmap

Examination of yield, bacteriolytic activity and cold storage of linker deletion mutants based on endolysin S6_ORF93 derived from Staphylococcus giant bacteriophage S6. 査読国際誌

Sosuke Munetomo, Jumpei Uchiyama, Iyo Takemura-Uchiyama, Thamonwan Wanganuttara, Yumiko Yamamoto, Toshihiro Tsukui, Hideharu Hagiya, Shuji Kanamaru, Hideyuki Kanda, Osamu Matsushita

PloS one 19 ( 10 ) e0310962 2024年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Methicillin-resistant Staphylococcus spp. present challenges in clinical and veterinary settings because effective antimicrobial agents are limited. Phage-encoded peptidoglycan-degrading enzyme, endolysin, is expected to be a novel antimicrobial agent. The enzymatic activity has recently been shown to be influenced by the linker between functional domains in the enzyme. S6_ORF93 (ORF93) is one of the endolysins derived from previously isolated Staphylococcus giant phage S6. The ORF93 was speculated to have a catalytic and peptidoglycan-binding domain with a long linker. In this study, we examined the influence of linker shortening on the characteristics of ORF93. We produce wild-type ORF93 and the linker deletion mutants using an Escherichia coli expression system. These mutants were designated as ORF93-Δ05, ORF93-Δ10, ORF93-Δ15, and ORF93-Δ20, from which 5, 10, 15, and 20 amino acids were removed from the linker, respectively. Except for the ORF93-Δ20, ORF93 and its mutants were expressed as soluble proteins. Moreover, ORF93-Δ15 showed the highest yield and bacteriolytic activity, while the antimicrobial spectrum was homologous. The cold storage experiment showed a slight effect by the linker deletion. According to our results and other studies, linker investigations are crucial in endolysin development.

DOI： 10.1371/journal.pone.0310962

PubMed

researchmap

職場のアルコール問題査読

宋龍平, 神田秀幸

産業医学レビュー 37 ( 2 ) 44 - 68 2024年9月

IoT 技術を用いた家庭血圧管理研究の5年間の成果と時系列ビックデータ・AIを活用した今後の展望：益田研究査読

久松隆史, 絹田皆子, 福田茉莉, 谷口かおり, 中畑典子, 神田秀幸

岡山医学会雑誌 136 ( 2 ) 57 - 62 2024年8月

Home blood pressure measurement days and changes in urinary sodium-to-potassium ratio, estimated salt and potassium intakes and blood pressure: 1-year prospective study 査読

Minako Kinuta, Takashi Hisamatsu, Mari Fukuda, Kaori Taniguchi, Noriko Nakahata, Hideyuki Kanda

Blood Pressure Monitoring 29 ( 4 ) 188 - 194 2024年6月

担当区分：最終著者掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

Objective

Current international guidelines recommend home blood pressure (BP) measurement and low sodium and high potassium intakes for the management of hypertension. We hypothesized that increased home BP measurement may result in more effective management of sodium and potassium intakes and BP.

Methods

We examined associations of home BP measurement days with changes in the urinary sodium-to-potassium (Na/K) ratio, estimated salt and potassium intakes and BP. We included 209 healthy participants (mean age, 55.9 years; 56.5% women) from a prospective cohort study. We examined 1-year data on self-measured home BP and spot urine samples.

Results

Median (interquartile range) days of home BP measurement was 324 (225–358) over 1-year. Baseline mean (SD) Na/K ratio, salt and potassium intakes, morning and evening SBP, and morning and evening DBP were 3.8 (2.3), 8.5 (1.9) g/day, 1833.5 (416.5) mg/day, 120.4 (14.0) mmHg, 118.2 (14.2) mmHg, 79.2 (10.1) mmHg, and 76.2 (10.1) mmHg, respectively. In multivariable-adjusted linear regression , β (standard error) per 10 days increase in number of home BP measurement were −0.031 (0.017) for Na/K ratio, −0.036 (0.015) for salt intake, −1.357 (2.797) for potassium intake, −0.178 (0.064) for morning SBP, −0.079 (0.041) for morning DBP, −0.109 (0.067) for evening SBP and −0.099 (0.045) for evening DBP. Additionally, relationships persisted for men and women, but changes in salt intake were more pronounced among participants taking antihypertensive medication (interaction P = 0.002).

Conclusion

Continuous measurement of home BP may lead not only to self-monitoring of BP, but also to declines in salt intakes and some BP indices.

DOI： 10.1097/mbp.0000000000000705

researchmap

Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022. 査読

Tomonori Okamura, Kazuhisa Tsukamoto, Hidenori Arai, Yoshio Fujioka, Yasushi Ishigaki, Shinji Koba, Hirotoshi Ohmura, Tetsuo Shoji, Koutaro Yokote, Hiroshi Yoshida, Masayuki Yoshida, Juno Deguchi, Kazushige Dobashi, Akira Fujiyoshi, Hirotoshi Hamaguchi, Masumi Hara, Mariko Harada-Shiba, Takumi Hirata, Mami Iida, Yoshiyuki Ikeda, Shun Ishibashi, Hideyuki Kanda, Shinji Kihara, Kazuo Kitagawa, Satoru Kodama, Masahiro Koseki, Yoshiro Maezawa, Daisaku Masuda, Takashi Miida, Yoshihiro Miyamoto, Rimei Nishimura, Koichi Node, Midori Noguchi, Mitsuru Ohishi, Isao Saito, Shojiro Sawada, Hirohito Sone, Minoru Takemoto, Akihiko Wakatsuki, Hidekatsu Yanai

Journal of atherosclerosis and thrombosis 31 ( 6 ) 641 - 853 2024年6月

Secondhand Smoke Exposure and Smoking Prevalence Among Adolescents 査読

Yuki Kuwabara, Aya Kinjo, Hongja Kim, Ruriko Minobe, Hitoshi Maesato, Susumu Higuchi, Hisashi Yoshimoto, Maki Jike, Yuichiro Otsuka, Osamu Itani, Yoshitaka Kaneita, Hideyuki Kanda, Hideaki Kasuga, Teruna Ito, Yoneatsu Osaki

JAMA Network Open 6 ( 10 ) 2023年10月

Comparison of the responses of cross-sectional web- and paper-based surveys on lifestyle behaviors of Japanese adolescents 査読

Yuichiro Otsuka, Aya Kinjo, Yoshitaka Kaneita, Osamu Itani, Yuki Kuwabara, Ruriko Minobe, Hitoshi Maesato, Susumu Higuchi, Hideyuki Kanda, Hisashi Yoshimoto, Maki Jike, Hideaki Kasuga, Teruna Ito, Yoneatsu Osaki

Preventive Medicine Reports 36 2023年10月

eスポーツ部の男子高校生と他部活所属者とのゲーム利用や身体活動に関する比較

福田茉莉, 絹田皆子, 久松隆史, 神田秀幸

日本公衆衛生学会総会抄録集 82回 423 - 423 2023年10月

Associations among Preoperative Malnutrition, Muscle Loss, and Postoperative Walking Ability in Intertrochanteric Fractures: A Retrospective Study. 査読

Kohei Sato, Hironori Tsuji, Masanori Yorimitsu, Takenori Uehara, Yuki Okazaki, Shinichiro Takao, Toshiaki Hata, Shiro Fukuoka, Tomoyuki Noda, Hideyuki Kanda, Toshifumi Ozaki

Acta medica Okayama 77 ( 5 ) 511 - 516 2023年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Sarcopenia and malnutrition are increasing in older adults and are reported risk factors for functional impairment after hip fracture surgery. This study aimed to investigate the associations between skeletal muscle mass loss, malnutrition, and postoperative walking ability in patients with hip fracture. We retrospectively reviewed patients who underwent intertrochanteric fracture surgery at our institute. The psoas muscle index, controlling nutritional status score, and functional ambulation category (FAC) were used to evaluate skeletal muscle mass, nutritional status, and walking ability, respectively. Six months after surgery, walking ability was assessed as either "gait disturbance" or "independent gait". Multivariate binomial logistic regression analysis, with skeletal muscle mass, nutritional status, and other factors, was used to predict the risk of being assigned to the gait disturbance group. This study included 95 patients (mean age, 85.2 years; 70 women). Sixty-six patients had low skeletal muscle mass, 35 suffered from malnutrition, and 28 had both. Malnutrition and low skeletal muscle mass were significantly associated with postoperative gait disturbance (FAC < 3). Preoperative low skeletal muscle mass and malnutrition were risk factors for postoperative poor walking ability. Further preventive interventions focusing on skeletal muscle mass and nutritional status are required.

DOI： 10.18926/AMO/65973

PubMed

researchmap

家庭血圧測定日数と随時尿を用いた尿Na/K比、推定一日食塩・カリウム摂取量の変化に関する1年間の前向きパイロット研究益田研究

絹田皆子, 久松隆史, 福田茉莉, 谷口かおり, 中畑典子, 神田秀幸

日本高血圧学会総会プログラム・抄録集 45回 408 - 408 2023年9月

地域住民における家庭血圧測定アドヒアランスとその関連要因の検討 1年間の測定値に基づくトラジェクトリー分析

福田茉莉, 久松隆史, 絹田皆子, 谷口かおり, 中畑典子, 神田秀幸

日本高血圧学会総会プログラム・抄録集 45回 410 - 410 2023年9月

一般住民における客観的評価に基づく身体活動と家庭血圧との関連益田研究

田邉莉奈, 久松隆史, 絹田皆子, 谷口かおり, 福田茉莉, 中畑典子, 神田秀幸

日本高血圧学会総会プログラム・抄録集 45回 282 - 282 2023年9月

一般住民における客観的評価に基づく身体活動と家庭血圧との関連益田研究

田邉莉奈, 久松隆史, 絹田皆子, 谷口かおり, 福田茉莉, 中畑典子, 神田秀幸

日本高血圧学会総会プログラム・抄録集 45回 282 - 282 2023年9月

地域住民における家庭血圧測定アドヒアランスとその関連要因の検討 1年間の測定値に基づくトラジェクトリー分析

福田茉莉, 久松隆史, 絹田皆子, 谷口かおり, 中畑典子, 神田秀幸

日本高血圧学会総会プログラム・抄録集 45回 410 - 410 2023年9月

家庭血圧測定日数と随時尿を用いた尿Na/K比、推定一日食塩・カリウム摂取量の変化に関する1年間の前向きパイロット研究益田研究

絹田皆子, 久松隆史, 福田茉莉, 谷口かおり, 中畑典子, 神田秀幸

日本高血圧学会総会プログラム・抄録集 45回 408 - 408 2023年9月

At-risk internet addiction and related factors among senior high school teachers in Japan based on a Nationwide survey. 国際誌

Mari Fukuda, Mohammad Chowdhury, Tanvir Turin Chowdhury, Hideki Tsumura, Rina Tsuchie, Minako Kinuta, Takashi Hisamatsu, Hideyuki Kanda

Neuropsychopharmacology reports 2023年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Internet addiction (IA) has been drawing attention to mental health. However, few reports have been found on the related factors of at-risk IA among regular workers by a nationwide survey. The study aimed to evaluate the characteristics of at-risk IA and identify related factors among senior high school teachers in Japan. METHODS: This survey was a cross-sectional survey of high schools across Japan in 2017. There were 3189 teachers (2088 males and 1098 female) who participated in this survey. The questionnaire asked about their devices, both the time and the activities of using their internet, and sociodemographic factors. IA was measured by the internet addiction test (IAT) by which 40-79 points were classified as at-risk IA, and more as IA. We compared the related factors of at-risk IA and non-IA using descriptive analysis and multivariable regression analysis. RESULTS: The rates of IA and at-risk IA were 0.09% (n = 3) and 6.91% (n = 220), respectively. At-risk IA was positively associated with activities on the internet for gaming, entertainment, net-surfing, and younger ages. In addition, the at-risk IA group had a longer time spent on the internet than the non-IA group. CONCLUSIONS: Around 7% of high school teachers are at-risk IA in this survey, though they have regular work. Our results suggest that at-risk IA may be reinforced not only by the active internet use such as gaming, but also by purposeless behaviors, such as net-surfing. Managing time on the internet may support preventing at-risk IA among senior high school teachers.

DOI： 10.1002/npr2.12350

PubMed

researchmap

　前のページ - 次のページ　

<神田 秀幸>

論文 - 神田 秀幸

<神田　秀幸>

論文 - 神田　秀幸