研究者詳細 - 森松　博史

論文 - 森松　博史

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Temporary hypotension and ventilation difficulty during endoscopic injection sclerotherapy for esophageal varices in a child with Fontan circulation: a case report. 査読国際誌

Nanako Yasutomi, Tatsuhiko Shimizu, Tomoyuki Kanazawa, Kazuyoshi Shimizu, Tatsuo Iwasaki, Hiroshi Morimatsu

JA clinical reports 8 ( 1 ) 48 - 48 2022年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Endoscopic procedures are rarely performed in children with congenital heart disease (CHD); therefore, the associated complications are unknown. We report an abrupt change in circulatory and respiratory condition during endoscopic injection sclerotherapy for esophageal varices. CASE PRESENTATION: A 9-year-old boy with a history of total anomalous pulmonary venous connection (TAPVC) repair and Fontan procedure for asplenia and a single ventricle with TAPVC underwent endoscopic injection sclerotherapy under general anesthesia for esophageal varices. Systolic blood pressure decreased from 70 to 50 mmHg following a sclerosant injection; a second injection reduced his peripheral oxygen saturation from 93 to 79% secondary to ventilation difficulty. Although we suspected anaphylaxis intraoperatively, postoperative imaging suggested that balloon dilation performed to prevent sclerosing agent leakage caused compression of the pulmonary venous chamber and trachea owing to the anomalous intrathoracic organ anatomy. CONCLUSION: Thorough understanding of the complex anatomy is important before performing endoscopic procedures in children with CHD to preoperatively anticipate possible intraoperative complications and select the optimal therapeutic approach and anesthesia management.

DOI： 10.1186/s40981-022-00538-z

投稿論文症例報告インヒビター保有血友病A患者に対する肝切除術後に出血を来した1症例

佐藤航貴, 松崎孝, 佐倉考信, 森松博史

麻酔 71 ( 6 ) 623 - 626 2022年6月

血液粘弾性検査によりヘパリン残存が術後止血困難の原因と特定できた心臓外科緊急手術の一症例

森松尭, 金澤伴幸, 岡原修司, 越智聡子, 佐倉考信, 清水一好, 森松博史

臨床モニター 33 ( Suppl. ) 117 - 117 2022年6月

Intrathecal Administration of the α1 Adrenergic Antagonist Phentolamine Upregulates Spinal GLT-1 and Improves Mirror Image Pain in SNI Model Rats. 査読

Kosuke Nakatsuka, Yoshikazu Matsuoka, Masako Kurita, Ruilin Wang, Chika Tsuboi, Nobutaka Sue, Ryuji Kaku, Hiroshi Morimatsu

Acta medica Okayama 76 ( 3 ) 255 - 263 2022年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs.

DOI： 10.18926/AMO/63719

Prediction Model of Extubation Outcomes in Critically Ill Patients: A Multicenter Prospective Cohort Study. 査読国際誌

Aiko Tanaka, Daijiro Kabata, Osamu Hirao, Junko Kosaka, Nana Furushima, Yuichi Maki, Akinori Uchiyama, Moritoki Egi, Ayumi Shintani, Hiroshi Morimatsu, Satoshi Mizobuchi, Yoshifumi Kotake, Yuji Fujino

Journal of clinical medicine 11 ( 9 ) 2022年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Liberation from mechanical ventilation is of great importance owing to related complications from extended ventilation time. In this prospective multicenter study, we aimed to construct a versatile model for predicting extubation outcomes in critical care settings using obtainable physiological predictors. The study included patients who had been extubated after a successful 30 min spontaneous breathing trial (SBT). A multivariable logistic regression model was constructed to predict extubation outcomes (successful extubation without reintubation and uneventful extubation without reintubation or noninvasive respiratory support) using eight parameters: age, heart failure, respiratory disease, rapid shallow breathing index (RSBI), PaO2/FIO2, Glasgow Coma Scale score, fluid balance, and endotracheal suctioning episodes. Of 499 patients, 453 (90.8%) and 328 (65.7%) achieved successful and uneventful extubation, respectively. The areas under the curve for successful and uneventful extubation in the novel prediction model were 0.69 (95% confidence interval (CI), 0.62-0.77) and 0.70 (95% CI, 0.65-0.74), respectively, which were significantly higher than those in the conventional model solely using RSBI (0.58 (95% CI, 0.50-0.66) and 0.54 (95% CI, 0.49-0.60), p = 0.004 and <0.001, respectively). The model was validated using a bootstrap method, and an online application was developed for automatic calculation. Our model, which is based on a combination of generally obtainable parameters, established an accessible method for predicting extubation outcomes after a successful SBT.

DOI： 10.3390/jcm11092520

Patients scheduled to undergo esophageal surgery should have the highest priority for perioperative oral management triage: a cross-sectional study.

Reiko Yamanaka-Kohno, Yasuhiro Shirakawa, Aya Yokoi, Mami Inoue-Minakuchi, Motomu Kobayashi, Kazuhiro Noma, Manabu Morita, Takuo Kuboki, Hiroshi Morimatsu, Yoshihiko Soga

General thoracic and cardiovascular surgery 70 ( 4 ) 378 - 385 2022年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

OBJECTIVES: An increasing number of patients visiting the dental office have a growing need for perioperative oral management (POM) to prevent postoperative complications. Therefore, it is necessary to determine which patients should receive preferential POM. This study investigated the dental status of patients scheduled to undergo surgery and addressed the priority for POM. METHODS: This retrospective study included a total of 150 patients who were scheduled to undergo surgery at the Department of Respiratory Surgery (DRS), Department of Neurological Surgery (DNS), Department of Gynecological Surgery (DGS), Department of Breast and Endocrine Surgery (DBES), and Department of Esophageal Surgery (DES) managed by the Perioperative Management Center of Okayama University Hospital. We compared the general and dental status of patients among the five groups. RESULTS: The DES group had significantly fewer teeth than the DBES group (p = 0.012), more severe periodontitis than both the DBES (p = 0.005) and DNS groups (p = 0.020), and poorer molar occlusal support status than both the DBES (p = 0.002) and DGS groups (p = 0.041). The DES group exhibited a significantly higher median age (p = 0.002), a higher ratio of males (p < 0.001), a higher prevalence of malignant tumors (p < 0.001), and higher proportions of smokers (p < 0.001) and drinkers (p < 0.001) than the other groups. CONCLUSION: Patients who underwent surgery at the DES had more dental problems than other surgery patients. Accordingly, these patients should be given the highest priority for POM triage.

DOI： 10.1007/s11748-021-01757-4

その他リンク： https://link.springer.com/article/10.1007/s11748-021-01757-4/fulltext.html

Ketamine Improves Desensitization of µ-Opioid Receptors Induced by Repeated Treatment with Fentanyl but Not with Morphine. 査読国際誌

Yusuke Mizobuchi, Kanako Miyano, Sei Manabe, Eiko Uezono, Akane Komatsu, Yui Kuroda, Miki Nonaka, Yoshikazu Matsuoka, Tetsufumi Sato, Yasuhito Uezono, Hiroshi Morimatsu

Biomolecules 12 ( 3 ) 426 2022年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

The issue of tolerance to continuous or repeated administration of opioids should be addressed. The ability of ketamine to improve opioid tolerance has been reported in clinical studies, and its mechanism of tolerance may involve improved desensitization of μ-opioid receptors (MORs). We measured changes in MOR activity and intracellular signaling induced by repeated fentanyl and morphine administration and investigated the effects of ketamine on these changes with human embryonic kidney 293 cells expressing MOR using the CellKey™, cADDis cyclic adenosine monophosphate, and PathHunter® β-arrestin recruitment assays. Repeated administration of fentanyl or morphine suppressed the second MOR responses. Administration of ketamine before a second application of opioids within clinical concentrations improved acute desensitization and enhanced β-arrestin recruitment elicited by fentanyl but not by morphine. The effects of ketamine on fentanyl were suppressed by co-treatment with an inhibitor of G-protein-coupled receptor kinase (GRK). Ketamine may potentially reduce fentanyl tolerance but not that of morphine through modulation of GRK-mediated pathways, possibly changing the conformational changes of β-arrestin to MOR.

DOI： 10.3390/biom12030426

Current status of delirium assessment tools in the intensive care unit: a prospective multicenter observational survey. 査読国際誌

Kenzo Ishii, Kosuke Kuroda, Chika Tokura, Masaaki Michida, Kentaro Sugimoto, Tetsufumi Sato, Tomoki Ishikawa, Shingo Hagioka, Nobuki Manabe, Toshiaki Kurasako, Takashi Goto, Masakazu Kimura, Kazuharu Sunami, Kazuyoshi Inoue, Takashi Tsukiji, Takeshi Yasukawa, Satoshi Nogami, Mitsunori Tsukioki, Daisuke Okabe, Masaaki Tanino, Hiroshi Morimatsu

Scientific reports 12 ( 1 ) 2185 - 2185 2022年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

Delirium is a critical challenge in the intensive care unit (ICU) or high care unit (HCU) setting and is associated with poor outcomes. There is not much literature on how many patients in this setting are assessed for delirium and what tools are used. This study investigated the status of delirium assessment tools of patients in the ICU/HCU. We conducted a multicenter prospective observational study among 20 institutions. Data for patients who were admitted to and discharged from the ICU/HCU during a 1-month study period were collected from each institution using a survey sheet. The primary outcome was the usage rate of delirium assessment tools on an institution- and patient-basis. Secondary outcomes were the delirium prevalence assessed by each institution's assessment tool, comparison of delirium prevalence between delirium assessment tools, delirium prevalence at the end of ICH/HCU stay, and the relationship between potential factors related to delirium and the development of delirium. Result showed that 95% of institutions used the Intensive Care Delirium Screening Checklist (ICDSC) or the Confusion Assessment Method for the ICU (CAM-ICU) to assess delirium in their ICU/HCU, and the remaining one used another assessment scale. The usage rate (at least once during the ICU/HCU stay) of the ICDSC and the CAM-ICU among individual patients were 64.5% and 25.1%, and only 8.2% of enrolled patients were not assessed by any delirium assessment tool. The prevalence of delirium during ICU/HCU stay was 17.9%, and the prevalence of delirium at the end of the ICU/HCU stay was 5.9%. In conclusion, all institutions used delirium assessment tools in the ICU/HCU, and most patients received delirium assessment. The prevalence of delirium was 17.9%, and two-thirds of patients had recovered at discharge from ICU/HCU.Trial registration number: UMIN000037834.

DOI： 10.1038/s41598-022-06106-w

肺切除術中の気管支出血肺静脈閉塞に伴う区域性肺うっ血から持続的な肺胞出血を来した1症例査読

照屋洋武, 松岡義和, 角森雅樹, 西本れい, 谷口新, 森松博史

麻酔 71 ( 1 ) 82 - 86 2022年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：克誠堂出版(株)

気管支出血は、肺切除術中にしばしば見られる合併症である。本症例では、術中の胸膜縫合閉鎖に伴う肺区域静脈の圧排により生じた肺うっ血によって、持続的な肺胞出血を認めた。泡沫状出血や区域性の気管支粘膜発赤といった特徴的な気管支鏡所見から、原因や部位を特定した。術中に介入することで止血でき、良好な転帰を得た。(著者抄録)

Preventative effects of bisoprolol transdermal patches on postoperative atrial fibrillation in high-risk patients undergoing non-cardiac surgery: A subanalysis of the MAMACARI study. 国際誌

Takayuki Iwano, Hironobu Toda, Kazufumi Nakamura, Kazuyoshi Shimizu, Kentaro Ejiri, Yoichiro Naito, Hisatoshi Mori, Takuro Masuda, Toru Miyoshi, Masashi Yoshida, Yukiko Hikasa, Hiroshi Morimatsu, Hiroshi Ito

Journal of cardiology 78 ( 5 ) 349 - 354 2021年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Perioperative atrial fibrillation (POAF) after non-cardiac surgery is a risk factor for cardiovascular events including stroke and death. The aim of this subanalysis of the MAMACARI study, a multicenter randomized control study on the effectiveness of a bisoprolol transdermal patch for prevention of perioperative myocardial injury in high-risk patients undergoing non-cardiac surgery, was to identify the predictors of POAF after non-cardiac surgery in high-risk patients and to determine changes in blood pressure and heart rate during bisoprolol patch administration in the perioperative period. METHODS AND RESULTS: Patients aged over 60 years with hypertension and a high revised cardiac risk index (≥2) who were scheduled to undergo non-cardiac surgery were randomly assigned to a bisoprolol patch group (n = 120) or a control group (n = 120). We divided the patients into two groups: patients with POAF (POAF group; n = 16) and patients without POAF (non-POAF group; n = 206). Multivariate analysis showed that bisoprolol patch therapy (OR: 0.30, 95% CI: 0.092-0.978) and surgery time of 250 min or more (OR: 4.99, 95% CI: 1.37-18.2) were independently associated with POAF. Although systolic blood pressure did not differ significantly between the two groups throughout the perioperative period, treatment with a bisoprolol patch significantly reduced heart rate throughout the perioperative period compared with that in the control group. CONCLUSIONS: Low dose of a bisoprolol patch in the perioperative period was effective for prevention of POAF after non-cardiac surgery in high-risk patients, while long surgery time was an independent risk factor for POAF. It is expected that low dose of a bisoprolol patch can prevent POAF without causing hypotension.

DOI： 10.1016/j.jjcc.2021.05.001

脊椎・脊髄、外傷 80歳以上の超高齢者脊椎脊髄症例に対する手術をいかに安全に行うか周術期管理センターの有用性

安原隆雄, 佐々田晋, 金恭平, 菱川朋人, 藤井謙太郎, 森松博史, 伊達勲

Geriatric Neurosurgery 34 67 - 70 2021年11月

記述言語：日本語出版者・発行元：日本老年脳神経外科学会

過去2年間の80歳以上の超高齢者脊椎脊髄に対する外科治療症例18例(男性11例、女性7例、80～89歳、中央値86歳)を対象に、患者背景、症状、治療、周術期の問題点、対策について検討を行った。初診時は全例が生活に重大な問題を生じており、8例は独歩不能であった。治療は頸椎病変11例全例に頸椎椎弓形成術、胸髄腫瘍1例に腫瘍摘出術、腰椎変性疾患は5例に片側進入両側開窓術、1例に後方腰椎椎体間固定術を行った。譫妄には抑肝散、食欲不振には六君子湯を用いた。術後、重篤な合併症なく17例で症状改善が得られた。

Extracellular Glutamate Concentration Increases Linearly in Proportion to Decreases in Residual Cerebral Blood Flow after the Loss of Membrane Potential in a Rat Model of Ischemia

Hirokazu Kawase, Yoshimasa Takeda, Ryoichi Mizoue, Sachiko Sato, Miki Fushimi, Satoshi Murai, Hiroshi Morimatsu

Journal of Neurosurgical Anesthesiology 33 ( 4 ) 356 - 362 2021年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Lippincott Williams and Wilkins

Background: Brain ischemia due to disruption of cerebral blood flow (CBF) results in increases in extracellular glutamate concentration and neuronal cell damage. However, the impact of CBF on glutamate dynamics after the loss of the membrane potential remains unknown. Materials and Methods: To determine this impact, we measured extracellular potential, CBF, and extracellular glutamate concentration in the parietal cortex in male Sprague-Dawley rats (n=21). CBF was reduced by bilateral occlusion of the common carotid arteries and exsanguination until loss of extracellular membrane potential was observed (low-flow group), or until CBF was further reduced by 5% to 10% of preischemia levels (severe-low-flow group). CBF was promptly restored 10 minutes after the loss of membrane potential. Histologic outcomes were evaluated 5 days later. Results: Extracellular glutamate concentration in the low-flow group was significantly lower than that in the severe-low-flow group. Moreover, increases in extracellular glutamate concentration exhibited a linear relationship with decreases in CBF after the loss of membrane potential in the severe-low-flow group, and the percentage of damaged neurons exhibited a dose-response relationship with the extracellular glutamate concentration. The extracellular glutamate concentration required to cause 50% neuronal damage was estimated to be 387 μmol/L, at 8.7% of preischemia CBF. Regression analyses revealed that extracellular glutamate concentration increased by 21 μmol/L with each 1% decrease in residual CBF and that the percentage of damaged neurons increased by 2.6%. Conclusion: Our results indicate that residual CBF is an important factor that determines the extracellular glutamate concentration after the loss of membrane potential, and residual CBF would be one of the important determinants of neuronal cell prognosis.

DOI： 10.1097/ANA.0000000000000666

An Evaluation of the Safety and Feasibility of Adenosine-assisted Clipping Surgery for Unruptured Cerebral Aneurysms: Study Protocol.

Tomohito Hishikawa, Satoshi Murai, Masafumi Hiramatsu, Jun Haruma, Kazuhiko Nishi, Yuki Ebisudani, Yu Sato, Takao Yasuhara, Kenji Sugiu, Kazuyoshi Shimizu, Motomu Kobayashi, Koji Nakagawa, Aya Kimura-Ono, Katsuyuki Hotta, Hiroshi Morimatsu, Isao Date

Neurologia medico-chirurgica 61 ( 7 ) 393 - 396 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

The effectiveness of adenosine-induced flow arrest in surgical clipping for the cerebral aneurysms with difficulties in temporary clip placement to the proximal main trunk has been reported. This is the first clinical trial to evaluate the safety and feasibility of adenosine-assisted clipping surgery for unruptured cerebral aneurysms (UCAs) in Japan. The inclusion criteria are as follows: patients over 20 years old, patients who agree to be enrolled in this study after providing informed consent, patients who undergo clipping surgery for UCA in our institute, and patients in whom the surgeons (T.H. or I.D.) judge that decompression of the aneurysm is effective. The primary endpoint is a modified Rankin Scale (mRS) score 30 days after surgery. We plan to enroll 10 patients in this study. The original protocol of adenosine administration was established in this trial. Herein, we present the study protocol.

DOI： 10.2176/nmc.st.2021-0018

Higher preoperative Qp/Qs ratio is associated with lower preoperative regional cerebral oxygen saturation in children with ventricular septal defect 査読

Aya Banno, Tomoyuki Kanazawa, Kazuyoshi Shimizu, Tatsuo Iwasaki, Kenji Baba, Shinichi Otsuki, Hiroshi Morimatsu

Journal of Anesthesia 35 ( 3 ) 442 - 445 2021年6月

Prognosis of patients with severe left ventricular dysfunction after transvenous lead extraction and the need for additional hemodynamic support in the perioperative period. 国際誌

Nobuhiro Nishii, Takashi Nishimoto, Tomofumi Mizuno, Takuro Masuda, Saori Asada, Masakazu Miyamoto, Satoshi Kawada, Koji Nakagawa, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Morimatsu, Shingo Kasahara, Hiroshi Ito

Heart rhythm 18 ( 6 ) 962 - 969 2021年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Transvenous lead extraction (TLE) is necessary because of system infection, lead malfunction, or system upgrade. Patients with severe left ventricular dysfunction (SLVD) undergoing TLE may be at a higher risk because hemodynamic parameters may change unfavorably during or after TLE; however, this has not yet been clarified. OBJECTIVE: The purpose of this study was to examine whether patients with SLVD undergoing TLE have higher mortality. METHODS: All patients who underwent TLE were stratified as follows: patients with ejection fraction ≤ 35% (SLVD group) and those with ejection fraction > 35% (non-SLVD group). RESULTS: We assessed the data of 200 patients (SLVD group, 36; non-SLVD group, 164). Brain natriuretic peptide level and cardiac resynchronization therapy rate were higher in the SLVD group than in the non-SLVD group. There were no significant between-group differences in major complications and clinical success rates. Patients with SLVD were more likely to require additional hemodynamic support, such as catecholamine infusion, temporary atrial-ventricle sequential pacing, and temporary cardiac resynchronization therapy pacing (27.8% vs 1.2%; P < .001). The survival rate was not significantly different between the groups at 30 days and 1 year after TLE (SLVD vs non-SLVD: 30 days: 97.2% vs 99.4%; P = .215; 1 year: 80.6% vs 91.5%; P = .053). Multivariate Cox regression analysis revealed log brain natriuretic peptide and serum hemoglobin levels as predictors for 1-year mortality. CONCLUSION: The prognosis after TLE was comparable between patients with and without SLVD. However, additional hemodynamic support was often necessary for patients with SLVD.

DOI： 10.1016/j.hrthm.2021.01.026

Histidine-rich glycoprotein as a prognostic biomarker for sepsis. 国際誌

Kosuke Kuroda, Kenzo Ishii, Yuko Mihara, Naoya Kawanoue, Hidenori Wake, Shuji Mori, Michihiro Yoshida, Masahiro Nishibori, Hiroshi Morimatsu

Scientific reports 11 ( 1 ) 10223 - 10223 2021年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

Various biomarkers have been proposed for sepsis; however, only a few become the standard. We previously reported that plasma histidine-rich glycoprotein (HRG) levels decreased in septic mice, and supplemental infusion of HRG improved survival in mice model of sepsis. Moreover, our previous clinical study demonstrated that HRG levels in septic patients were lower than those in noninfective systemic inflammatory response syndrome patients, and it could be a biomarker for sepsis. In this study, we focused on septic patients and assessed the differences in HRG levels between the non-survivors and survivors. We studied ICU patients newly diagnosed with sepsis. Blood samples were collected within 24 h of ICU admission, and HRG levels were determined using an enzyme-linked immunosorbent assay. Ninety-nine septic patients from 11 institutes in Japan were included. HRG levels were significantly lower in non-survivors (n = 16) than in survivors (n = 83) (median, 15.1 [interquartile ranges, 12.7-16.6] vs. 30.6 [22.1-39.6] µg/ml; p < 0.01). Survival analysis revealed that HRG levels were associated with mortality (hazard ratio 0.79, p < 0.01), and the Harrell C-index (predictive power) for HRG was 0.90. These results suggested that HRG could be a novel prognostic biomarker for sepsis.

DOI： 10.1038/s41598-021-89555-z

頭蓋咽頭腫摘出後の血清ナトリウム濃度変動により橋外性髄鞘崩壊症を生じた一小児例

松岡勇斗, 谷真規子, 清水一好, 金澤伴幸, 市川智継, 佐々木達也, 長谷川高誠, 森松博史

日本集中治療医学会雑誌 28 ( 3 ) 227 - 229 2021年5月

記述言語：日本語出版者・発行元：(一社)日本集中治療医学会

6歳男児。1年前に頭蓋咽頭腫に対して開頭腫瘍摘出術を施行された。今回、頭蓋咽頭腫の再発に対して再度摘出術を施行され、術後2日目に意識障害が出現し、血清Na値が182mmol/Lまで上昇した。中枢性尿崩症と考え、生理食塩水とバソプレシンの持続静注を開始した。術後3日目以降は意識レベルが回復していたが、7日目に意識障害が再度出現し、血清Na値が142mmol/Lまで低下していたため、浸透圧性脱髄症候群を鑑別に挙げて頭部MRIを施行し、橋外性髄鞘崩壊症と診断した。本例は頭蓋咽頭腫が視床下部に強く癒着しており、腫瘍摘出に伴い視床下部機能障害が生じたことで高Na血症が急速に進行したものと考えられた。

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J02874&link_issn=&doc_id=20210611380012&doc_link_id=10.3918%2Fjsicm.28_227&url=https%3A%2F%2Fdoi.org%2F10.3918%2Fjsicm.28_227&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

腹臥位胸腔鏡食道切除術後の同側肩の痛みと離床について

岩井賢司, 森松博史, 築山尚司, 太田晴之, 福田智美, 堅山佳美, 伊勢真人, 濱田全紀, 千田益生

The Japanese Journal of Rehabilitation Medicine 58 ( 特別号 ) 2 - 11 2021年5月

腹臥位胸腔鏡食道切除術後の同側肩の痛みと離床について

岩井賢司, 森松博史, 築山尚司, 太田晴之, 福田智美, 堅山佳美, 伊勢真人, 濱田全紀, 千田益生

The Japanese Journal of Rehabilitation Medicine 58 ( 特別号 ) 2 - 11 2021年5月

Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement 査読国際誌

Rei Nishimoto, Sandra Derouiche, Kei Eto, Aykut Deveci, Makiko Kashio, Yoshitaka Kimori, Yoshikazu Matsuoka, Hiroshi Morimatsu, Junichi Nabekura, Makoto Tominaga

Proceedings of the National Academy of Sciences 118 ( 17 ) e201289411 2021年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

ミクログリアの遊走は温度により調整されることが示唆されている．これまで，いくつかのイオンチャネルおよびトランスポータが遊走に関与することが知られているが，温度依存性による遊走の制御機構はまだ不明である．本研究は，実験を通じて，マウスのミクログリアがTRPPV4チャネルを介して温度依存性の運動を示すことを示したものである．
ミクログリアの動画像の自動トラッキング手法を開発し，ミクログリアの挙動解析を行った．

DOI： 10.1073/pnas.2012894118

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