研究者詳細 - 森松　博史

論文 - 森松　博史

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食道癌術後患者の周術期血糖変動と酸化ストレスの関係

江木盛時, 森松博史, 戸田雄一郎, 竹野内志保, 末盛智彦, 清水一好, 森田潔

日本集中治療医学会雑誌 18 ( Suppl. ) 260 - 260 2011年1月

小児心臓術後腎傷害(acute kidney injury;AKI)患者の遠隔予後

戸田雄一郎, 岩崎達雄, 清水一好, 末盛智彦, 杉本健太郎, 石井典子, 川瀬宏和, 森松博史, 江木盛時, 森田潔

日本集中治療医学会雑誌 18 ( Suppl. ) 269 - 269 2011年1月

ラット出血性ショック後急性肺障害に対するCO吸入の治療効果のメカニズム

川西進, 森松博史, 清水裕子, 小坂順子, 有森豊, 高橋徹, 森田潔

日本集中治療医学会雑誌 18 ( Suppl. ) 238 - 238 2011年1月

ICU患者において不整脈が発生する因子の検討

今川憲太郎, 戸田雄一郎, 森松博史, 江木盛時, 守屋佳恵, 清水一好, 谷真規子, 片山浩, 森田潔

日本集中治療医学会雑誌 18 ( Suppl. ) 245 - 245 2011年1月

Successful use of intravenous amiodarone for refractory ventricular fibrillation just after releasing aortic cross-clamp 査読

Satoshi Suzuki, Tatsuo Iwasaki, Hiroshi Morimatsu, Nagisa Yokoi, Mayuko Matsuoka, Tomohiko Suemori, Tomoyuki Kanazawa, Kazuyoshi Shimizu, Yuichiro Toda, Kiyoshi Morita

Japanese Journal of Anesthesiology 59 ( 10 ) 1266 - 1270 2010年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Amiodarone is widely used in Europe and the United States for refractory ventricular fibrillation (VF) in various situations, such as VF after myocardial infarction or out-of-hospital cardiac arrest. We report a case of successful treatment with amiodarone of refractory VF immediately after releasing aortic cross-clamp in cardiac surgery. A 66-year-old man suffering from severe aortic stenosis underwent aortic valve replacement (AVR). General anesthesia was induced with propofol and remifentanil, and subsequently AVR was performed under cardiopulmonary bypass. Just after releasing aortic cross-clamp, VF occurred, and it continued despite multiple trials of cardioversion with direct current (DC) shocks of 20 J or 30 J. Furthermore, some DC shocks of 30 J or 50 J after administering lidocaine 60 mg and 0.5 mol·l-1 magnesium sulfate 20 ml were also ineffective. Then, nifekalant 20 mg was administered and DC shocks of 50 J were repeated intermittently, but VF still persisted. Eventually, VF disappeared after a final DC shock of 50 J with intravenous amiodarone 125 mg. Overall duration of VF was 60 minutes. The patient's trachea was extubated three days after the surgery without any complications. Intravenous amiodarone may be one of the most useful remedies for some types of arrhythmias including persistent VF.

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腫瘍随伴性ネフローゼ症候群のため著しい低アルブミン血症を合併した患者の周術期管理

守屋佳恵, 森松博史, 熊田雄太, 小坂順子, 松三絢弥, 谷真規子, 賀来隆治, 森田潔

日本臨床麻酔学会誌 30 ( 6 ) S347 - S347 2010年10月

小児心疾患集中治療室における鎮静薬の人工呼吸・ICU滞在への影響

戸田雄一郎, 清水一好, 岩崎達雄, 末盛智彦, 鈴木聡, 森松博史, 江木盛時, 森田潔

日本集中治療医学会雑誌 17 ( Suppl. ) 291 - 291 2010年1月

重症患者における低AT3血症と患者死亡の関係

竹野内志保, 江木盛時, 森松博史, 戸田雄一郎, 清水一好, 松崎孝, 鈴木聡, 森田潔

日本集中治療医学会雑誌 17 ( Suppl. ) 312 - 312 2010年1月

食道癌術後患者に対する栄養プロトコール導入の効果

濱田暁, 江木盛時, 竹野内志保, 鈴木聡, 清水一好, 松崎孝, 戸田雄一郎, 森松博史, 佐藤健治, 森田潔

日本集中治療医学会雑誌 17 ( Suppl. ) 369 - 369 2010年1月

集中治療領域における厳格血糖管理を考える心臓手術周術期の血糖変動と酸化ストレスの関係持続血糖測定を用いた検討

江木盛時, 清水一好, 戸田雄一郎, 岩崎達雄, 森松博史, 森田潔

日本集中治療医学会雑誌 17 ( Suppl. ) 233 - 233 2010年1月

小児心臓手術における下垂体ホルモンの変動年齢による相違

清水一好, 森松博史, 戸田雄一郎, 江木盛時, 末盛智彦, 鈴木聡, 岩崎達雄, 森田潔

日本集中治療医学会雑誌 17 ( Suppl. ) 279 - 279 2010年1月

A comparison of observed versus estimated baseline creatinine for determination of RIFLE class in patients with acute kidney injury

Sean M. Bagshaw, Shigehiko Uchino, Dinna Cruz, Rinaldo Bellomo, Hiroshi Morimatsu, Stanislao Morgera, Miet Schetz, Ian Tan, Catherine Bouman, Etienne MacEdo, Noel Gibney, Ashita Tolwani, Heleen M. Oudemans-Van Straaten, Claudio Ronco, John A. Kellum

Nephrology Dialysis Transplantation 24 ( 9 ) 2739 - 2744 2009年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background. The RIFLE classification scheme for acute kidney injury (AKI) is based on relative changes in serum creatinine (SCr) and on urine output. The SCr criteria, therefore, require a pre-morbid baseline value. When unknown, current recommendations are to estimate a baseline SCr by the MDRD equation. However, the MDRD approach assumes a glomerular filtration rate of ∼75 mLmin1.73 m2. This method has not been validated.Methods. Data from the Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) study, a prospective observational study from 54 ICUs in 23 countries of critically ill patients with severe AKI, were analysed. The RIFLE class was determined by using observed (o) pre-morbid and estimated (e) baseline SCr values. Agreement was evaluated by correlation coefficients and Bland-Altman plots. Sensitivity analysis by chronic kidney disease (CKD) status was performed.Results. Seventy-six percent of patients (n = 1327) had a pre-morbid baseline SCr, and 1314 had complete data for evaluation. Forty-six percent had CKD. The median (IQR) values were 97 μmolL (79-150) for oSCr and 88 μmolL (71-97) for eSCr. The oSCr and eSCr determined at ICU admission and at study enrolment showed only a modest correlation (r = 0.49, r = 0.39). At ICU admission and study enrolment, eSCr misclassified 18.8 and 11.7 of patients as having AKI compared with oSCr. Exclusion of CKD patients improved the correlation between oSCr and eSCr at ICU admission and study enrolment (r = 0.90, r = 0.84) resulting in 6.6 and 4.0 being misclassified, respectively.Conclusions. While limited, estimating baseline SCr by the MDRD equation when pre-morbid SCr is unavailable would appear to perform reasonably well for determining the RIFLE categories only if and when pre-morbid GFR was near normal. However, in patients with suspected CKD, the use of MDRD to estimate baseline SCr overestimates the incidence of AKI and should not likely be used. Improved methods to estimate baseline SCr are needed.

DOI： 10.1093/ndt/gfp159

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Acid-base variables in patients with acute kidney injury requiring peritoneal dialysis in the pediatric cardiac care unit 査読

Hiroshi Morimatsu, Yuichiro Toda, Moritoki Egi, Kazuyoshi Shimizu, Takashi Matsusaki, Satoshi Suzuki, Tatsuo Iwasaki, Kiyoshi Morita

JOURNAL OF ANESTHESIA 23 ( 3 ) 334 - 340 2009年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER TOKYO

We aimed to clarify the acid-base abnormalities of patients with acute kidney injury (AKI) requiring peritoneal dialysis (PD) in pediatric cardiac care units.
A retrospective observational study was conducted in a pediatric cardiac care unit in a tertiary care university hospital. The subjects were 40 patients with AKI requiring PD between 2003 and 2005, and controls matched by type of surgery and body weight. Acid-base variables, including blood gas data and electrolytes, were assessed. The Stewart-Figge variables, including strong ion difference apparent (SIDa), strong ion difference effective (SIDe), and strong ion gap (SIG), were calculated.
Blood gas analyses showed that the PD group was more acidemic, with a lower mean bicarbonate and a lower mean base excess, typical features of metabolic acidosis. The strong ion analyses revealed that the PD group had lower mean sodium and albumin concentrations. Based on the Stewart-Figge methodology, SIDa was smaller in the PD group than in the control group, but SIG was similar in the two groups. Receiver-operating characteristic curve analyses showed that serum albumin was the only prognostic factor associated with PCCU mortality, even after adjustment for PD treatment.
Patients with AKI requiring PD in a pediatric cardiac care unit had significant metabolic acidosis compared to controls matched by the type of surgery and body weight. Hyponatremia and hypoalbuminemia were characteristics of these patients. The calculated SIDa was smaller in the PD than in the control group. Only the serum albumin had a significant prognostic value.

DOI： 10.1007/s00540-009-0747-2

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Site-specific induction of intestinal hypoxia-inducible factor-1α after hemorrhagic shock. 査読

Nishie H, Takahashi T, Inoue K, Shimizu H, Morimatsu H, Toda Y, Omori E, Akagi R, Katayama H, Morita K

Molecular medicine reports 2 ( 2 ) 149 - 152 2009年3月