Faculty Profiles - TANABE Shunsuke

MISC - TANABE Shunsuke

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内腔突出型GISTに対するClosed-LECSの長期成績と胃癌への適応拡大

菊地覚次, 西崎正彦, 賀島肇, 黒田新士, 垣内慶彦, 田辺俊介, 前田直見, 野間和広, 香川俊輔, 楳田祐三, 藤原俊義

日本内視鏡外科学会総会(Web) 36th 2023

根治性と安全性の両立を目指した食道癌上縦隔リンパ節郭清定型化の工夫

白川靖博, 白川靖博, 桂佑貴, 澤田鉱幸, 石田道拡, 佐藤太祐, 丁田泰宏, 吉満政義, 中野敢友, 松川啓義, 井谷史嗣, 塩崎滋弘, 前田直見, 田辺俊介, 野間和広, 藤原俊義

日本内視鏡外科学会総会(Web) 36th 2023

Perioperative infection control in elderly esophageal cancer patients as a team effort

田辺俊介, 野間和広, 河崎健人, 國友知義, 橋本将志, 加藤卓也, 前田直見, 白川靖博, 藤原俊義

日本外科感染症学会雑誌(Web) 20 ( 3 ) 2023

胃切除後ロイシン強化経口栄養剤投与による術後体重減少抑制効果

菊地覚次, 高田暢夫, 賀島肇, 庄司良平, 松三雄騎, 垣内慶彦, 黒田新士, 田辺俊介, 前田直見, 野間和広, 藤原俊義

Gastroenterological Endoscopy (Web) 65 ( Supplement2 ) 2023

ライフイベント時に本当に必要な支援とは?高いチーム力でダイバーシティとインクルージョンを目指す当院のキャリア支援

小林純子, 小林純子, 竹原裕子, 溝尾妙子, 菊地覚次, 菊地覚次, 三好健太郎, 三好健太郎, 黒田新士, 黒田新士, 田邊俊介, 田邊俊介, 楳田祐三, 楳田祐三, 小谷恭弘, 小谷恭弘, 杉本誠一郎, 杉本誠一郎, 岡崎幹生, 岡崎幹生, 枝園忠彦, 枝園忠彦, 豊岡伸一, 豊岡伸一, 藤原俊義, 藤原俊義, 笠原真悟, 笠原真悟

日本臨床外科学会雑誌 84 ( Supplement (Web) ) 2023

患者参加型継続的栄養指導による胃癌術後のサルコペニア予防効果

菊地覚次, 高田暢夫, 黒田新士, 田辺俊介, 前田直見, 賀島肇, 垣内慶彦, 野間和広, 香川俊輔, 高橋絢子, 楳田祐三, 四方賢一, 四方賢一, 藤原俊義

日本癌治療学会学術集会(Web) 60th 2022

Paraesophageal hernia repair can decrease BNP levels. Reviewed International journal

Shunsuke Tanabe, Yasuhiro Shirakawa, Naoaki Maeda, Kazufumi Sakurama, Kazuhiro Noma, Toshiyoshi Fujiwara

Surgical endoscopy 35 ( 12 ) 6921 - 6929 2021.12

Language：English

BACKGROUND: Although the main manifestation of giant paraesophageal hernia (PEH) is disordered meal passage due to gastric torsion, the contents of the hernia sometimes squeeze the heart and lungs and induce the symptoms of respiratory or heart failure. Furthermore, the quality of life (QOL) of patients with a heavy cardiac load deteriorates. In this study, changes in a heart failure marker and symptoms of cases with a giant PEH from before to after laparoscopic surgery were examined. METHODS: Levels of brain natriuretic peptide (BNP) as a heart failure marker were measured before and after radical laparoscopic surgery in cases of type III, IV type of giant PEH. Changes of the symptoms due to heart failure were also investigated. RESULTS: A total of 75 hiatal hernia surgeries were performed in 2012-2019. Of them, 50 had a giant PEH, and 20 (40.0%) had heart failure symptoms such as fatigue and exertional dyspnea. In the giant PEH cases, BNP could be measured before and after surgery to evaluate the presence of heart failure in 23 cases; postoperative BNP levels decreased from the preoperative values in 18 of them. Furthermore, in many cases, chest symptoms also improved. CONCLUSIONS: Radical laparoscopic surgery can reduce heart failure due to giant PEH. Therefore, in addition to conventional surgical indication criteria such as vomiting and food loss, increased cardiac load may be added to the new surgical indication criteria.

DOI： 10.1007/s00464-020-08202-2

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Initial introduction of robot-assisted, minimally invasive esophagectomy using the microanatomy-based concept in the upper mediastinum. Reviewed International journal

Yasuhiro Shirakawa, Kazuhiro Noma, Tomoyoshi Kunitomo, Masashi Hashimoto, Naoaki Maeda, Shunsuke Tanabe, Kazufumi Sakurama, Toshiyoshi Fujiwara

Surgical endoscopy 35 ( 12 ) 6568 - 6576 2021.12

Language：English

BACKGROUND: We have recently standardized upper mediastinal lymph node dissection (UMLND) using a microanatomy-based concept in thoracoscopic esophagectomy in the prone position (TEPP), and introduced robot-assisted minimally invasive esophagectomy (RAMIE) using the same concept as in TEPP while aiming at solo surgery. The purpose of this study was to investigate the outcomes of RAMIE using the microanatomy-based concept in the initial introduction phase. METHODS: We have performed more than 500 TEPP procedures as minimally invasive esophagectomy (MIE). After performing about 400 cases of MIE, we established a microanatomy-based standardization of UMLND. In October 2018, we introduced RAMIE, and have performed 75 procedures in 20 months. Two groups were analyzed: a group after microanatomy-based standardization in TEPP (100 cases after completing 400 cases of TEPP) and a RAMIE group (75 cases). Finally, 51 paired cases were matched using a propensity score. Furthermore, the change in postoperative short-term outcome for RAMIE in the initial introduction phase was analyzed. RESULTS: Although there were no significant differences between the two groups in the number of upper mediastinal lymph nodes dissected, there was a significant decrease (P = 0.036) in intraoperative blood loss volume with RAMIE, representing a definite benefit for patients. The thoracoscopic operative time for RAMIE decreased by almost 100 min following less than 50 cases of experience, reaching the same level as that for recent TEPP, but with only one-tenth the operator experience. There were no significant differences in the total postoperative morbidity rate including the recurrent laryngeal nerve palsy rate. CONCLUSION: RAMIE has been introduced safely and smoothly using the microanatomy-based concept established in TEPP.

DOI： 10.1007/s00464-020-08154-7

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Early intervention of the perioperative multidisciplinary team approach decreases the adverse events during neoadjuvant chemotherapy for esophageal cancer patients. Reviewed

Yasuhiro Shirakawa, Kazuhiro Noma, Naoaki Maeda, Shunsuke Tanabe, Kazufumi Sakurama, Ayumi Sonoyama-Hanaoka, Aiko Yoshitomi, Reiko Kohno-Yamanaka, Yoshihiko Soga, Toshiyoshi Fujiwara

Esophagus : official journal of the Japan Esophageal Society 18 ( 4 ) 797 - 805 2021.10

Language：English

BACKGROUND: Multidisciplinary team (MDT) approach has become a standard for perioperative patient care, including in esophageal cancer. In our institution, the Perioperative Management Center (PERiO) has been doing an MDT approach for patients undergoing esophageal cancer surgery since 2009. On the other hand, neoadjuvant therapy has also been becoming standard for many malignancies, including esophageal cancer. In Japan, neoadjuvant chemotherapy (NAC) for esophageal cancer is standard now. However, there have been no reports about when is the best time to start the MDT approach for patients with neoadjuvant therapy. In this study, the best start time for the MDT approach for esophageal cancer patients with NAC was examined from the perspective of adverse events during chemotherapy and perioperative period. METHODS: All cases underwent thoracoscopic esophagectomy in the prone position (TEPP) after NAC. The PERiO Intervention group that started before NAC (n = 100) was compared with the PERiO Intervention group that started after NAC (n = 77). Eventually, 54 paired cases were matched by propensity score matching. RESULTS: The adverse event rate during chemotherapy, especially oral complications, was significantly decreased in the PERiO Intervention started before the NAC group (P = 0.007). Furthermore, weight loss during the period from chemotherapy to surgery was significantly reduced in the group that started before NAC (P = 0.033). CONCLUSION: The MDT approach should be started before NAC in patients undergoing esophageal cancer surgery to prevent adverse events during chemotherapy and provide safe perioperative conditions.

DOI： 10.1007/s10388-021-00844-y

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Desquamative esophagitis followed by esophageal cancer in a stem cell transplant recipient. International journal

Masaya Iwamuro, Nobuharu Fujii, Shunsuke Tanabe, Hiroyuki Okada

Gastrointestinal endoscopy 2021.9

【分子標的治療の最前線】ウイルスによるがん治療食道がんに対するウイルス療法の現状と今後の展望

藤原俊義, 田澤大, 田辺俊介, 白川靖博

腫瘍内科 28 ( 2 ) 179 - 184 2021.8

Phase I dose-escalation study of endoscopic intratumoral injection of OBP-301 (Telomelysin) with radiotherapy in oesophageal cancer patients unfit for standard treatments. Reviewed International journal

Yasuhiro Shirakawa, Hiroshi Tazawa, Shunsuke Tanabe, Nobuhiko Kanaya, Kazuhiro Noma, Takeshi Koujima, Hajime Kashima, Takuya Kato, Shinji Kuroda, Satoru Kikuchi, Shunsuke Kagawa, Kuniaki Katsui, Susumu Kanazawa, Yasuo Urata, Toshiyoshi Fujiwara

European journal of cancer (Oxford, England : 1990) 153 98 - 108 2021.8

Language：English

PURPOSE: OBP-301 (Telomelysin) is an attenuated type-5 adenovirus that contains the human telomerase reverse transcriptase promoter to regulate viral replication. OBP-301 sensitises human cancer cells to ionising radiation by inhibiting DNA repair, and radiation enhances coxsackievirus and adenovirus receptor-mediated OBP-301 infection on the contrary. We assessed OBP-301 with radiotherapy in oesophageal cancer patients unfit for standard chemoradiation treatments. METHODS: A phase I dose-escalation study of OBP-301 with radiotherapy was conducted in 13 histologically confirmed oesophageal cancer patients deemed unfit to undergo surgery or chemotherapy. Study treatment consisted of OBP-301 administration by intratumoural needle injection using a flexible endoscope on days 1, 18 and 32. Radiotherapy was administered concurrently over 6 weeks, beginning on day 4, to a total of 60 Gy. RESULTS: Of the 13 patients, 7, 3 and 3 patients were treated with 1010, 1011 and 1012 virus particles, respectively. Study group comprised 10 males and 3 females, with a median age of 82 years (range, 53-91 years). All patients developed a transient, self-limited lymphopenia. Distribution studies revealed transient virus shedding in the plasma. Eight patients had local complete response (CR); all of them exhibited no pathologically viable malignant cells in biopsy specimens, and 3 patients had a partial response. The objective response rate was 91.7%. The clinical CR rate was 83.3% in stage I and 60.0% in stage II/III. Histopathological examination revealed massive infiltration of CD8+ cells and increased PD-L1 expression. CONCLUSION: Multiple courses of endoscopic intratumoural OBP-301 injection with radiotherapy are feasible and provide clinical benefits in patients with oesophageal cancer unfit for standard treatments.

DOI： 10.1016/j.ejca.2021.04.043

PubMed

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高齢者食道癌患者に対する治療戦略高齢者食道癌に対する包括的治療戦略

前田直見, 野間和広, 田辺俊介, 菊地覚次, 黒田新士, 櫻間教文, 楳田祐三, 寺石文則, 白川靖博, 藤原俊義

日本消化器外科学会総会 76回 O21 - 3 2021.7

Cadaverトレーニングの現状と課題岡山大学における過去8年のCSTの傾向から見たCSTプログラム作成における要点

近藤喜太, 前田直見, 黒田新士, 田辺俊介, 野間和広, 楳田祐三, 寺石文則, 西崎正彦, 香川俊輔, 藤原俊義

日本消化器外科学会総会 76回 PD1 - 1 2021.7

食道裂孔ヘルニア、逆流性食道炎に対する外科的治療法 80歳以上の高齢者に対する食道裂孔ヘルニア手術の安全性と有効性の検討

井上弘章, 野間和広, 前田直見, 菊池覚次, 田辺俊介, 黒田新士, 楳田祐三, 寺石文則, 白川靖博, 藤原俊義

日本消化器外科学会総会 76回 RS2 - 1 2021.7

【消化器癌;診断と治療のすべて】消化器癌の診断・病期分類・治療・成績食道癌外科治療と成績

野間和広, 田辺俊介, 藤原俊義

消化器外科 44 ( 6 ) 659 - 666 2021.5

ハイリスク食道癌手術症例に対する包括的治療戦略

前田直見, 野間和広, 國友知義, 田辺俊介, 櫻間教文, 白川靖博, 藤原俊義

日本外科学会定期学術集会抄録集 121回 SF - 8 2021.4

食道癌におけるこだわりの手術手技従来の胸腔鏡下手術における上縦隔微細解剖コンセプトを応用したロボット支援下食道悪性腫瘍手術

白川靖博, 大下航, 久保田哲史, 矢野琢也, 石田道拡, 佐藤太佑, 丁田泰宏, 吉満政義, 中野敢友, 松川哲義, 井谷史嗣, 塩崎滋弘, 岡島正純, 前田直見, 田辺俊介, 野間和広, 藤原俊義

日本外科学会定期学術集会抄録集 121回 PD - 3 2021.4

外科周術期管理におけるサルコペニア対策患者教育と栄養・運動強化プロトコールが胃癌術後体重減少に与える影響

高田暢夫, 菊地覚次, 黒田新士, 田辺俊介, 垣内慶彦, 西崎正彦, 香川俊輔, 藤原俊義

日本外科学会定期学術集会抄録集 121回 PD - 5 2021.4

外科生涯教育におけるCSTの果たす役割

近藤喜太, 前田直見, 黒田新士, 信岡大輔, 武田正, 重安邦俊, 菊地覚次, 矢野修也, 田辺俊介, 野間和広, 楳田祐三, 寺石文則, 香川俊輔, 白川靖博, 藤原俊義

日本外科学会定期学術集会抄録集 121回 SP - 4 2021.4

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