Faculty Profiles - HARUMA Jun

Mannitol enhances therapeutic effects of intra-arterial transplantation of mesenchymal stem cells into the brain after traumatic brain injury. International journal

Yu Okuma, Feifei Wang, Atsuhiko Toyoshima, Masahiro Kameda, Tomohito Hishikawa, Koji Tokunaga, Kenji Sugiu, Keyue Liu, Jun Haruma, Masahiro Nishibori, Takao Yasuhara, Isao Date

Neuroscience letters 554 156 - 61 2013.10

Language：English Publishing type：Research paper (scientific journal)

Traumatic brain injury (TBI) sustained in a traffic accident or a fall is a major cause of death that affects a broad range of ages. The aim of this study was to investigate the therapeutic effects of intra-arterial transplantation of mesenchymal stem cells (MSCs) combined with hypertonic glycerol (25%) or mannitol (25%) in a TBI model of rats. TBI models were produced with a fluid percussion device. At 24h after TBI, MSCs (1×10(6)cells/100μl) with glycerol or mannitol were administered via the right internal carotid artery. Rats were evaluated behaviorally and immunohistochemically, and hyperpermeability of the blood-brain barrier (BBB) induced by hypertonic solutions was explored. Compared to PBS or glycerol, the administration of mannitol resulted in increased BBB disruption. The mannitol-treated rats showed significant improvement in motor function. Intra-arterial transplantation of MSCs caused no thromboembolic ischemia. Immunohistochemically, more MSCs were observed in the injured brain tissues of mannitol-treated rats than in glycerol or PBS-treated rats at 24h after transplantation. Intra-arterial transplantation of MSCs combined with mannitol is an effective treatment in a TBI model of rats. This technique might be used for patients with diseases of the central nervous system including TBI.

DOI： 10.1016/j.neulet.2013.08.058

PubMed

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[Endovascular treatment of basilar artery aneurysms associated with fenestration].

Hisakazu Itami, Kenji Sugiu, Masafumi Hiramatsu, Koji Tokunaga, Jun Haruma, Yu Okuma, Tomohito Hishikawa, Ayumi Nishida, Isao Date

No shinkei geka. Neurological surgery 41 ( 7 ) 583 - 92 2013.7

Language：Japanese Publishing type：Research paper (scientific journal)

Aneurysms at the vertebrobasilar junction are often found with basilar artery(BA)fenestration. We encountered 10 consecutive cases of aneurysms associated with BA fenestration. The purpose of this study is to describe the frequency, clinical features, and outcome of these aneurysms treated by endovascular procedure. The incidence of these aneurysms in our series was 1.9%. All aneurysms were successfully treated by coil embolization. Half of them were treated by using simple technique, and the other half were treated by using adjunctive techniques such as balloon remodeling technique. 70% of these cases were ruptured, and all except one case showed good recovery at the time of discharge. We found 63 reported cases of this aneurysm in the literature between 2000 and 2012. 57 out of 63 aneurysms were treated by endovascular means with good clinical results. The usefulness of endovascular procedure is reported to be superior to surgical clipping because of their anatomical complexity and the difficulty of surgical exposure for clipping. We conclude that outcome of these aneurysms is favorable and endovascular procedure has become their standard treatment for these aneurysms.

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脳底動脈窓形成部動脈瘤に対する血管内治療の有用性

伊丹尚多, 杉生憲志, 平松匡文, 徳永浩司, 春間純, 大熊佑, 菱川朋人, 西田あゆみ, 伊達勲

Neurological Surgery 41 ( 7 ) 583 - 592 2013.7

Language：Japanese Publisher：(株)医学書院

血管内治療を行った脳動脈瘤539例中脳底動脈窓形成部動脈瘤10例(男性2例、女性8例、平均51.6歳)について検討した。発症頻度は1.9%、動脈瘤の最大径は平均4.6cmで、動脈瘤破裂が7例(平均47.7歳)であった。窓形成は9例で、椎骨脳底動脈(VA-BA)合流部に認め、全例で動脈瘤は窓形成部の近位側から発生していた。血管内治療方法は、5例でsimple technique、4例でballoon remodeling technique、1例でdouble-catheter techniqueによるコイル塞栓術を行った。画像上の塞栓結果は、8例がcomplete occlusion、2例がneck remnantであった。手技に伴う合併症は認めず、Glasgow Outcome Scaleによる退院時転帰は9例がgood recoveryであり、転帰不良の1例はクモ膜下出血による一次脳損傷のため、重篤な後遺症が残存したものであった。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J01228&link_issn=&doc_id=20130712110003&doc_link_id=10.11477%2Fmf.1436102031&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1436102031&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

[Surgical and endovascular treatment for superior cerebellar artery aneurysms: report of two cases].

Jun Haruma, Kenji Sugiu, Yosuke Shimazu, Hiroyuki Michiue, Koji Tokunaga, Isao Date

No shinkei geka. Neurological surgery 41 ( 1 ) 45 - 51 2013.1

Language：Japanese Publishing type：Research paper (scientific journal)

Aneurysms located on the superior cerebellar artery (SCA) are uncommon and their presentation, natural history, and clinical management are poorly understood. Reports related to the endovascular or surgical management of SCA aneurysms are rare. Herein, we report two cases of SCA aneurysm. The first is that of a 70-year-old woman who presented with subarachnoid hemorrhage (SAH). Surgical treatment (neck clipping) of the ruptured SCA aneurysm was performed, and the flow of the parent artery disappeared. The second is that of a 69-year-old woman with an unruptured SCA aneurysm who underwent endovascular surgery to occlude the parent artery. Neither patients exhibited any additional neurological deficits. SCA aneurysms often have either relatively wide or undefinable necks, so it is difficult to preserve the parent artery. According to several surgical reports, occlusion of the SCA appears well tolerated for a variety of reasons.

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Intra-cranial dural arteriovenous fistula: Classification and treatment

Kenji Sugiu, Masafumi Hiramatsu, Koji Tokunaga, Tomohito Hishikawa, Yu Ohkuma, Jun Haruma, Tomohisa Shimizu, Isao Date

Japanese Journal of Neurosurgery 22 ( 1 ) 37 - 43 2013

Publishing type：Research paper (scientific journal)

Intracranial dural arteriovenous fistulas (dAVFs) are pathologic dural-based shunts and distinguished from parenchymal AVM by the presence of a dural arterial supply and the absence of a parenchymal nidus. Their symptoms and prognosis are strongly related to the pattern of their venous drainage system. The presence of cortical venous reflux (CVR) is an aggressive feature indicating that there is a high risk of cerebral bleeding or progressive neurological deficits. Endovascular treatment has become the mainstream dAVF therapy. In general, trans-venous coil embolization is adapted to sinusal type dAVFs (i.e. cavernous sinus or transverse-sigmoid dAVFs) and trans-arterial glue embolization is applied to non-sinusal type dAVFs (i.e. anterior skull base or tentorial dAVFs). Direct surgery and stereotactic radiosurgery are indicated in cases in which endovascular approaches have failed or are not feasible.

DOI： 10.7887/jcns.22.37

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