Faculty Profiles - HARUMA Jun

Papers - HARUMA Jun

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当院におけるStaged carotid artery stenting(Staged-CAS)の検討

春間純, 杉生憲志, 菱川朋人, 平松匡文, 清水智久, 高杉祐二, 新治有径, 西廣真吾, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 218 - 218 2014.12

前交通動脈瘤に対するコイル塞栓術の治療成績

西廣真吾, 杉生憲志, 菱川朋人, 新治有径, 高杉祐二, 清水智久, 春間純, 平松匡文, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 272 - 272 2014.12

脳動脈瘤コイル塞栓術後の再発評価における頭部単純X線検査の有用性

冨田祐介, 杉生憲志, 菱川朋人, 西廣真吾, 新治有径, 高杉祐二, 清水智久, 春間純, 平松匡文, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 264 - 264 2014.12

内頸動脈前脈絡叢動脈分岐部動脈瘤に対するコイル塞栓術の治療成績

西廣真吾, 杉生憲志, 菱川朋人, 新治有径, 高杉祐二, 清水智久, 春間純, 平松匡文, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 273 - 273 2014.12

内頸動脈-上下垂体動脈瘤(IC-SHA動脈瘤)に対する血管内治療 100例の検討

春間純, 杉生憲志, 菱川朋人, 西廣真吾, 新治有径, 高杉祐二, 清水智久, 平松匡文, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 272 - 272 2014.12

コイル塞栓術後再発脳動脈瘤に対するコイル塞栓術の治療成績

菱川朋人, 杉生憲志, 平松匡文, 春間純, 清水智久, 高杉祐二, 新治有径, 西廣真吾, 徳永浩司, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 206 - 206 2014.12

バルーン閉塞試験その判定方法とバイパス術の適応内頸動脈閉塞試験(balloon test occlusion:BTO)における合併症と妥当性の検討

清水智久, 杉生憲志, 菱川朋人, 平松匡文, 春間純, 高杉祐二, 新治有径, 西廣真吾, 冨田祐介, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 184 - 184 2014.12

大型・巨大脳動脈瘤に対するコイル塞栓術の治療成績

高杉祐二, 杉生憲志, 菱川朋人, 平松匡文, 春間純, 清水智久, 新治有径, 西廣真吾, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 210 - 210 2014.12

椎骨動脈解離性動脈瘤に対する血管内治療(internal trapping)後の延髄梗塞は高率に発生するのか?

清水智久, 杉生憲志, 菱川朋人, 平松匡文, 春間純, 高杉祐二, 新治有径, 西廣真吾, 冨田祐介, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 210 - 210 2014.12

症候性海綿静脈洞部内頸動脈瘤に対するコイル塞栓術と直達術の比較検討

菱川朋人, 杉生憲志, 平松匡文, 春間純, 清水智久, 高杉祐二, 新治有径, 西廣真吾, 徳永浩司, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 211 - 211 2014.12

dAVFに対するTVEとTAE OnyxによるTAEは有効か? 硬膜動静脈瘻(dAVF)に対する経動脈的塞栓術(TAE) 液体塞栓物質の有用性と問題点

杉生憲志, 菱川朋人, 平松匡文, 春間純, 清水智久, 高杉祐二, 新治有径, 西廣真吾, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 180 - 180 2014.12

ラット慢性脳虚血モデルに対する血行再建術におけるVEGFおよびapelin遺伝子の血管新生効果についての検討

平松匡文, 杉生憲志, 菱川朋人, 西廣真吾, 春間純, 清水智久, 高杉祐二, 新治有径, 伊達勲, 徳永浩司, 木戸屋浩康, 高倉伸幸

脳循環代謝 26 ( 1 ) 225 - 225 2014.11

再灌流障害と急性期血管内治療急性期脳梗塞に対する血管内再開通療法の現状

杉生憲志, 菱川朋人, 平松匡文, 春間純, 清水智久, 高杉祐二, 西廣真吾, 新治有径, 伊達勲

脳循環代謝 26 ( 1 ) 118 - 118 2014.11

ラットくも膜下出血後脳血管攣縮に対する抗HMGB-1抗体の攣縮抑制効果の検討

春間純, 菱川朋人, 劉克約, 西廣真吾, 新治有径, 高杉佑二, 清水智久, 平松匡文, 杉生憲志, 西堀正洋, 伊達勲

脳循環代謝 26 ( 1 ) 178 - 178 2014.11

ADH蛍光によるラットくも膜下出血急性期におけるspreading depressionの可視化及びその組織学的検討

清水智久, 菱川朋人, 高杉祐二, 新治有径, 西廣真吾, 春間純, 平松匡文, 杉生憲志, 武田吉正, 森松博史, 伊達勲

脳循環代謝 26 ( 1 ) 183 - 183 2014.11

Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction. International journal

Yu Okuma, Keyue Liu, Hidenori Wake, Rui Liu, Yoshito Nishimura, Zhong Hui, Kiyoshi Teshigawara, Jun Haruma, Yasuhiko Yamamoto, Hiroshi Yamamoto, Isao Date, Hideo K Takahashi, Shuji Mori, Masahiro Nishibori

Neuropharmacology 85 18 - 26 2014.10

Language：English Publishing type：Research paper (scientific journal)

Glycyrrhizin (GL) is a major constituent of licorice root and has been suggested to inhibit the release of high mobility group box-1 (HMGB1), a protein considered representative of damage-associated molecular patterns. We found that GL bound HMGB1 but not RAGE with a moderate equilibrium dissociation constant value based on surface plasmon resonance analysis. This complex formation prevented HMGB1 from binding to RAGE in vitro. The effects of glycyrrhizin on traumatic brain injury (TBI) induced by fluid percussion were examined in rats or mice in the present study. GL was administered intravenously after TBI. Treatment of rats with GL dose-dependently suppressed the increase in BBB permeability and impairment of motor functions, in association with the inhibition of HMGB1 translocation in neurons in injured sites. The beneficial effects of GL on motor and cognitive functions persisted for 7 days after injury. The expression of TNF-α, IL-1β and IL-6 in injured sites was completely inhibited by GL treatment. In RAGE-/- mice, the effects of GL were not observed. These results suggested that GL may be a novel therapeutic agent for TBI through its interference with HMGB1 and RAGE interaction.

DOI： 10.1016/j.neuropharm.2014.05.007

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Nationwide survey of the nature and risk factors of complications in embolization of meningiomas and other intracranial tumors: Japanese Registry of NeuroEndovascular Therapy 2 (JR-NET2). International journal

Tomohito Hishikawa, Kenji Sugiu, Masafumi Hiramatsu, Jun Haruma, Koji Tokunaga, Isao Date, Nobuyuki Sakai

Neuroradiology 56 ( 2 ) 139 - 44 2014.2

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: Embolization of intracranial tumor is widely performed in Japan, mainly before neurosurgical resection. A retrospective, multicenter, observational study in Japan was conducted to clarify the nature, frequency, and risk factors of complications in intracranial tumor embolization. METHODS: Patients were derived from the Japanese Registry of NeuroEndovascular Therapy 2 (JR-NET2). A total of 20,854 patients were enrolled in JR-NET2, of which 1,018 patients (4.88 %) with intracranial tumors underwent embolization. The primary end point was the proportion of patients with a modified Rankin scale (mRS) score of 0-2 (independency) at 30 days. The secondary end point was the occurrence of complications related to the procedures. The risk factors of the occurrence of complications were studied. RESULTS: The proportion of patients with mRS scores ≤2 at 30 days after procedure was 91.3 %. Complications occurred in 15 of the 1,012 patients (1.48 %). Multivariate analysis showed that embolization for tumors other than meningioma (OR, 4.626; 95 % CI, 1.347-14.59; p = 0.0105) was significantly associated with the development of complications. CONCLUSION: The frequency of complications after intracranial tumor embolization was relatively low in this large Japanese cohort. Embolization for tumors other than meningioma was the only significant risk factor for the occurrence of complications.

DOI： 10.1007/s00234-013-1300-4

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Epidemiology of dural arteriovenous fistula in Japan: Analysis of Japanese Registry of Neuroendovascular Therapy (JR-NET2).

Masafumi Hiramatsu, Kenji Sugiu, Tomohito Hishikawa, Jun Haruma, Koji Tokunaga, Isao Date, Naoya Kuwayama, Nobuyuki Sakai

Neurologia medico-chirurgica 54 ( 1 ) 63 - 71 2014

Language：English Publishing type：Research paper (scientific journal)

We developed the Japanese Registry of Neuroendovascular Therapy 2 (JR-NET2) database and used the information for a retrospective, nation-wide multicenter, observational study to clarify the clinical characteristics, current status of procedures, and outcome of patients treated by neuroendovascular therapy in Japan. In this report, we analyzed the clinical characteristics of dural arteriovenous fistulas (dAVFs) in the JR-NET2 database. All patients with dAVFs treated with endovascular therapy in 150 Japanese hospitals were included. Patient characteristics, clinical presentations, and imaging characteristics were analyzed. A total of 1,075 patients with dAVFs underwent 1,520 endovascular procedures. Of 1,075 patients, 45% were men and 55% were women. The mean age was 65 ± 13 years. The most frequent location of dAVFs was the cavernous sinus (43.6%), followed by the transverse-sigmoid sinus (TSS) (33.4%). Twelve percent of the patients had intracranial hemorrhage, 9% had venous infarction, and 3% had convulsion. The statistically significant independent risk factors of intracranial hemorrhage were TSS, superior sagittal sinus (SSS), tentorium, anterior cranial fossa, cranio-cervical junction, cortical venous reflux (CVR), and varix. Risk factors of venous infarction were age older than 60 years, male sex, TSS, SSS, and CVR. Risk factors of convulsion were male sex, SSS, and CVR. This is the largest nationwide report, to date, of the clinical characteristics of dAVFs treated by neuroendovascular therapy. CVR was a major risk factor of aggressive symptoms.

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Epidemiology of Dural Arteriovenous Fistula in Japan: Analysis of Japanese Registry of Neuroendovascular Therapy (JR-NET2).

Masafuni Hiramatsu, Kenji Sugiu, Tomohito Hishikawa, Jun Haruma, Koji Tokunaga, Isao Date, Naoya Kuwayama, Nobuyuki Sakai

Neurologia medico-chirurgica 54 Suppl 2 63 - 71 2014

Language：English Publishing type：Research paper (scientific journal)

We developed the Japanese Registry of Neuroendovascular Therapy 2 (JR-NET2) database and used the information for a retrospective, nation-wide multicenter, observational study to clarify the clinical characteristics, current status of procedures, and outcome of patients treated by neuroendovascular therapy in Japan. In this report, we analyzed the clinical characteristics of dural arteriovenous fistulas (dAVFs) in the JR-NET2 database. All patients with dAVFs treated with endovascular therapy in 150 Japanese hospitals were included. Patient characteristics, clinical presentations, and imaging characteristics were analyzed. A total of 1,075 patients with dAVFs underwent 1,520 endovascular procedures. Of 1,075 patients, 45% were men and 55% were women. The mean age was 65±13 years. The most frequent location of dAVFs was the cavernous sinus (43.6%), followed by the transverse-sigmoid sinus (TSS) (33.4%). Twelve percent of the patients had intracranial hemorrhage, 9% had venous infarction, and 3% had convulsion. The statistically significant independent risk factors of intracranial hemorrhage were TSS, superior sagittal sinus (SSS), tentorium, anterior cranial fossa, cranio-cervical junction, cortical venous reflux (CVR), and varix. Risk factors of venous infarction were age older than 60 years, male sex, TSS, SSS, and CVR. Risk factors of convulsion were male sex, SSS, and CVR. This is the largest nationwide report, to date, of the clinical characteristics of dAVFs treated by neuroendovascular therapy. CVR was a major risk factor of aggressive symptoms.

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Cerebral vasospasm in patients over 80 years treated by coil embolization for ruptured cerebral aneurysms. International journal

Tomohito Hishikawa, Yuji Takasugi, Tomohisa Shimizu, Jun Haruma, Masafumi Hiramatsu, Koji Tokunaga, Kenji Sugiu, Isao Date

BioMed research international 2014 253867 - 253867 2014

Language：English Publishing type：Research paper (scientific journal)

OBJECT: The effect on clinical outcomes of symptomatic vasospasm after aneurysmal subarachnoid hemorrhage (SAH) in patients over 80 years who underwent coil embolization was evaluated. METHODS: Forty-four cases were reviewed and divided into two groups according to patient age: Group A, 79 years or younger, and Group B, 80 or older. Patient characteristics, prevalence of symptomatic vasospasm, modified Rankin Scale (mRS) scores at discharge and frequency of symptomatic vasospasm in patients with mRS scores of 3-6 were analyzed. RESULTS: Thirty-two (73%) of the 44 cases were categorized as Group A and 12 (27%) as Group B. Group B had a significantly higher prevalence of symptomatic vasospasm compared to Group A (P=0.0040). mRS scores at discharge were significantly higher in Group B than in Group A (P=0.0494). Among cases with mRS scores of 3-6, there was a significantly higher frequency of symptomatic vasospasm in Group B than in Group A (P=0.0223). CONCLUSIONS: In our cohort of aneurysmal SAH patients treated by coil embolization, patients over 80 years of age were more likely to suffer symptomatic vasospasm, which significantly correlated with worse clinical outcomes, than those 79 years and under.

DOI： 10.1155/2014/253867

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