Faculty Profiles - HARUMA Jun

Papers - HARUMA Jun

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ラットくも膜下出血に対する抗HMGB-1抗体の有効性の評価

春間純, 菱川朋人, 劉克約, 西廣真吾, 新治有径, 高杉祐二, 平松匡文, 杉生憲志, 西堀正洋, 伊達勲

脳血管攣縮 32 74 - 74 2017.2

ラットSAH single injection modelにおいて超急性期の頭蓋内圧が皮質電位と脳波に及ぼす影響

高杉祐二, 菱川朋人, 西廣真吾, 新治有径, 春間純, 平松匡文, 杉生憲志, 武田吉正, 森松博史, 伊達勲

脳血管攣縮 32 77 - 77 2017.2

Anti-high mobility group box-1 (HMGB1) antibody attenuates delayed cerebral vasospasm and brain injury after subarachnoid hemorrhage in rats. International journal

Jun Haruma, Kiyoshi Teshigawara, Tomohito Hishikawa, Dengli Wang, Keyue Liu, Hidenori Wake, Shuji Mori, Hideo Kohka Takahashi, Kenji Sugiu, Isao Date, Masahiro Nishibori

Scientific reports 6 37755 - 37755 2016.11

Language：English Publishing type：Research paper (scientific journal)

Although delayed cerebral vasospasm (DCV) following subarachnoid hemorrhage (SAH) is closely related to the progression of brain damage, little is known about the molecular mechanism underlying its development. High mobility group box-1 (HMGB1) plays an important role as an initial inflammatory mediator in SAH. In this study, an SAH rat model was employed to evaluate the effects of anti-HMGB1 monoclonal antibody (mAb) on DCV after SAH. A vasoconstriction of the basilar artery (BA) associated with a reduction of nuclear HMGB1 and its translocation in vascular smooth muscle cells were observed in SAH rats, and anti-HMGB1 mAb administration significantly suppressed these effects. Up-regulations of inflammation-related molecules and vasoconstriction-mediating receptors in the BA of SAH rats were inhibited by anti-HMGB1 mAb treatment. Anti-HMGB1 mAb attenuated the enhanced vasocontractile response to thrombin of the isolated BA from SAH rats and prevented activation of cerebrocortical microglia. Moreover, locomotor activity and weight loss recovery were also enhanced by anti-HMGB1 mAb administration. The vasocontractile response of the BA under SAH may be induced by events that are downstream of responses to HMGB1-induced inflammation and inhibited by anti-HMGB1 mAb. Anti-HMGB1 mAb treatment may provide a novel therapeutic strategy for DCV and early brain injury after SAH.

DOI： 10.1038/srep37755

PubMed

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パーキンソン症候群を呈した静脈洞交会部硬膜動静脈瘻の一例

高杉祐二, 平松匡文, 杉生憲志, 菱川朋人, 春間純, 新治有径, 西廣真吾, 木谷尚哉, 本倉恵美, 山下徹, 阿部康二, 伊達勲

脳血管内治療 1 ( Suppl. ) S170 - S170 2016.11

後交通動脈を温存した内頸動脈後交通動脈分岐部瘤の塞栓術後の再発リスク

平松匡文, 杉生憲志, 菱川朋人, 春間純, 高杉祐二, 西廣真吾, 新治有径, 木谷尚哉, 高橋悠, 伊達勲

脳血管内治療 1 ( Suppl. ) S85 - S85 2016.11

高齢者頸動脈ステント留置術における頭蓋内血行動態の特徴と対応

菱川朋人, 西廣真吾, 高橋悠, 木谷尚哉, 新治有径, 高杉祐二, 春間純, 平松匡文, 杉生憲志, 伊達勲

脳循環代謝 28 ( 1 ) 174 - 174 2016.11

内頸動脈分岐部未破裂脳動脈瘤に同側内頸動脈低形成を伴いアプローチの選択に迷った1例

高橋悠, 杉生憲志, 菱川朋人, 平松匡文, 春間純, 高杉祐二, 新治有径, 西廣真吾, 木谷尚哉, 伊達勲

脳血管内治療 1 ( Suppl. ) S164 - S164 2016.11

高齢者頸動脈狭窄症に対するstaged angioplastyの有効性

菱川朋人, 西廣真吾, 高橋悠, 木谷尚哉, 新治有径, 高杉祐二, 春間純, 平松匡文, 杉生憲志, 伊達勲

脳血管内治療 1 ( Suppl. ) S103 - S103 2016.11

頸動脈ステント留置術後の急性期ステント内血症に対してステント留置術を追加した2例

西廣真吾, 杉生憲志, 菱川朋人, 平松匡文, 春間純, 高杉祐二, 新治有径, 木谷尚樹, 高橋悠, 伊達勲

脳血管内治療 1 ( Suppl. ) S229 - S229 2016.11

血管内治療における術中経頭蓋MEP(motor-evoked potential)モニタリングの有用性

高橋悠, 杉生憲志, 菱川朋人, 平松匡文, 春間純, 高杉祐二, 新治有径, 西廣真吾, 木谷尚哉, 大西巧真, 亀田雅博, 伊達勲

脳血管内治療 1 ( Suppl. ) S293 - S293 2016.11

ラット慢性脳虚血モデルに対するHMGB1を用いた間接バイパス術の治療効果の検討

西廣真吾, 菱川朋人, 杉生憲志, 平松匡文, 春間純, 高杉祐二, 新治有径, 木谷尚哉, 高橋悠, 檜垣佑輔, 伊達勲

脳循環代謝 28 ( 1 ) 236 - 236 2016.11

Pipelineの初期使用経験

木谷尚哉, 杉生憲志, 平松匡文, 菱川朋人, 春間純, 高杉祐二, 新治有径, 西廣真吾, 高橋悠, 伊達勲

脳血管内治療 1 ( Suppl. ) S113 - S113 2016.11

症候性未破裂脳動脈瘤に対するコイル塞栓術の治療成績

西廣真吾, 杉生憲志, 菱川朋人, 平松匡文, 春間純, 高杉祐二, 新治有径, 木谷尚哉, 高橋悠, 伊達勲

脳血管内治療 1 ( Suppl. ) S129 - S129 2016.11

開頭術当日のNBCAによる術前塞栓術が有用であった充実性小脳血管芽腫の2例

木谷尚哉, 杉生憲志, 市川智継, 菱川朋人, 平松匡文, 春間純, 高杉祐二, 新治有径, 西廣真吾, 高橋悠, 桑原研, 伊達勲

脳血管内治療 1 ( Suppl. ) S295 - S295 2016.11

テント部硬膜動静脈瘻の血管構築と治療

平松匡文, 杉生憲志, 菱川朋人, 春間純, 高杉祐二, 西廣真吾, 新治有径, 木谷尚哉, 高橋悠, 伊達勲

脳血管内治療 1 ( Suppl. ) S104 - S104 2016.11

ステント併用コイル塞栓術後の画像における"metal artifact reduction(MAR)"softwareの有用性

高杉祐二, 平松匡文, 杉生憲志, 菱川朋人, 春間純, 新治有径, 西廣真吾, 木谷尚哉, 高橋悠, 伊達勲

脳血管内治療 1 ( Suppl. ) S203 - S203 2016.11

[A Case of Traumatic Vertebral Arteriovenous Fistula Treated by Internal Trapping of the Vertebral Artery].

Shingo Nishihiro, Kenji Sugiu, Tomohito Hishikawa, Masafumi Hiramatsu, Jun Haruma, Yukei Shinji, Yuji Takasugi, Isao Date

No shinkei geka. Neurological surgery 44 ( 2 ) 135 - 41 2016.2

Language：Japanese Publishing type：Research paper (scientific journal)

BACKGROUND: Traumatic vertebral arteriovenous fistula (TVAVF) is an uncommon disease that occurs after traumatic injury. Here we report a case of TVAVF presenting with cervical bruit successfully treated by internal trapping using coils. CASE PRESENTATION: A 66-year-old man was transferred to our hospital after falling into a ditch. Initial CT revealed a C2 fracture into the right transverse foramen, and the patient had been treated with conservative management. A vascular abnormality was suspected because the patient exhibited cervical bruit on admission. CT angiography revealed right TVAVF at the V2 segment of the right vertebral artery (VA) near the C2 fracture. Digital subtraction angiography also revealed right TVAVF between the V2 segment of the right VA and the vertebral venous plexus, draining into the right internal jugular vein and the deep cervical vein as well as the intracranial venous system. The fistula was also opacified by retrograde flow from the contralateral VA through the union, while the flow in the basilar artery was antegrade. The patient was diagnosed with TVAVF with large transection of the right VA, and underwent endovascular treatment with internal trapping of the right VA using coils starting distal to the transection and proceeding in a proximal direction. After treatment, the right VAVF and right VA were completely occluded. The patient achieved clinical symptom resolution with no neurological deficits. CONCLUSION: Endovascular treatment with internal trapping of the VA using coils is safe and effective against TVAVF.

DOI： 10.11477/mf.1436203245

PubMed

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ラットくも膜下出血後脳血管攣縮に対する抗HMGB-1抗体の攣縮抑制効果造影CTと血中HMGB-1濃度

春間純, 菱川朋人, 劉克約, 西廣真吾, 新治有径, 高杉佑二, 平松匡文, 杉生憲志, 西堀正洋, 伊達勲

脳血管攣縮 31 64 - 64 2016.2

Single injectionによるラットくも膜下出血モデルの急性期におけるspreading depressionの可視化

高杉祐二, 菱川朋人, 清水智久, 西廣真吾, 新治有径, 春間純, 平松匡文, 杉生憲志, 伊達勲

脳血管攣縮 31 55 - 55 2016.2

外傷性椎骨動静脈瘻に対してinternal trappingで治療した1例

西廣真吾, 杉生憲志, 菱川朋人, 平松匡文, 春間純, 新治有径, 高杉祐二, 伊達勲

Neurological Surgery 44 ( 2 ) 135 - 141 2016.2

Language：Japanese Publisher：(株)医学書院

66歳男。岩場で伐採作業中に誤って5m下の溝に滑落して前額部を打撲受傷し、直ちにドクターヘリで当院へ搬送された。頭部CTでは頭蓋内出血は認めず、頸椎CTにてC2椎体骨折、C6頸椎の右外側塊に骨折線を認めたため、頸椎カラーを装着して保存的加療となった。入院後に頸部雑音が出現したため頭頸部MRA・CTAを行ったところ、C2椎体骨折に伴う外傷性椎骨動静脈瘻が確認されたため、血管内治療によるinternal trappingを行った。治療後に頸部雑音は消失し、神経症状なく受傷後17日目にリハビリテーション目的に転院となった。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2016&ichushi_jid=J01228&link_issn=&doc_id=20160219080011&doc_link_id=10.11477%2Fmf.1436203245&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1436203245&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

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