Faculty Profiles - MATSUMOTO Yosuke

MISC - MATSUMOTO Yosuke

Division display 21 - 40 of about 119 ／ All the affair displays >>

トランスジェンダー、性別不合gender incongruence/性別違和の就労問題精神科外来で見聞するトランスジェンダーと職場の問題

松本洋輔

精神神経学雑誌 ( 2020特別号 ) S469 - S469 2020.9

【妊娠・出産と精神科臨床アップデート】てんかんと妊娠、出産

山田了士, 三島桃子, 深尾貴志, 松本洋輔

臨床精神医学 49 ( 7 ) 873 - 880 2020.7

【精神科診療のエビデンス-国内外の重要ガイドライン解説】(第15章)その他その他性同一性障害に関する診断と治療のガイドライン第4版改

松本洋輔

精神医学 62 ( 5 ) 779 - 785 2020.5

Language：Japanese Publisher：(株)医学書院

＜文献概要＞ガイドラインのポイント・性別違和を訴える者に対する診断と治療のガイドラインである。・1997年に初版が発行された。初版から精神科,産婦人科,泌尿器科,形成外科などの複数診療科が医療チームを結成して行う包括的な治療について記載されている。・エビデンスに基づく治療法の推奨というより,性別違和を持つ当事者に対して法的,倫理的に妥当な医療のあり方を提示しているものである。また,身体的治療を行う際の診療科間の連携手順書のような役割を持つ。・初版から精神科的な診断と治療のアプローチに加えて,ホルモン療法,乳房切除術,性別適合手術について記載されていたが,2012年に改訂された第4版では思春期を迎えた小児への身体的治療である二次性徴抑制療法が追加され,18歳からとされていたホルモン療法開始年齢を一部引き下げた。2018年4月から,このガイドラインに沿ってGID学会の認定施設で行われた手術は保険診療の対象となっている。

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00749&link_issn=&doc_id=20200609040052&doc_link_id=10.11477%2Fmf.1405206110&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1405206110&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

性別違和をもつ患者の診療情報から見える学校生活場面での困難さ

天野佑美, 佐々木新, 松本洋輔, 大守伊織

GID(性同一性障害)学会雑誌 12 ( 1 ) 193 - 195 2019.12

ジェンダークリニックから見えるセクシュアルマイノリティーの風景

松本洋輔

大学のメンタルヘルス 3 30 - 42 2019.11

トピラマート(TPM)が影響したと思われる幻覚妄想状態を呈した腫瘍切除後の側頭葉てんかんの1例

松本洋輔, 石川亮, 稲垣正俊, 川田清宏, 小林勝弘, 上利崇, 山田了士, 山田了士

てんかん研究 36 ( 1 ) 65‐66 2018

右中大脳動脈瘤に対する開頭クリッピング術後に一過性てんかん性健忘(Transient epileptic amnesia:TEA)を発症した1例

松本洋輔, 松本洋輔, 竹之下慎太郎, 山田了士

てんかん研究 36 ( 1 ) 90 - 90 2018

REGION-SPECIFIC IMPAIRMENTS IN PARVALBUMIN INTERNEURONS IN SOCIAL ISOLATION-REARED MICE

Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Motoi Okamoto, Yosuke Matsumoto, Takeshi Ishihara

NEUROSCIENCE 359 196 - 208 2017.9

Language：English Publisher：PERGAMON-ELSEVIER SCIENCE LTD

Many neuropsychiatric disorders show localized dysfunction in specific cortical regions. The mechanisms underlying such region-specific vulnerabilities are unknown. Post-mortem analyses have demonstrated a selective reduction in the expression of parvalbumin (PV) in GABAergic interneurons in the frontal rather than the sensory cortex of patients with neuropsychiatric disorders such as schizophrenia, autism spectrum disorders, and bipolar disorders. PV neurons are surrounded by perineuronal nets (PNNs), and are protected from oxidative stress. Previous studies have shown that the characteristics of PNNs are brain region-specific. Therefore, we hypothesized that PV neurons and PNNs may be targeted in region-specific lesions in the brain. Oxidative stress was induced in mice by rearing them in socially isolated conditions. We systemically examined the distribution of PV neurons and PNNs in the brains of these mice as well as a control group. Our results show that the regions frequently affected in neuropsychiatric disorders show significantly lower PV expression and a lower percentage of PV neurons surrounded by PNNs in the brains of socially isolated mice. These results indicate that PV neurons and PNNs exhibit region-specific vulnerabilities. Our findings may be useful for elucidating the mechanisms underlying region-specific disruption of the brain in neuropsychiatric disorders. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.neuroscience.2017.07.016

Web of Science

researchmap

SENSORY EXPERIENCE-DEPENDENT FORMATION OF PERINEURONAL NETS AND EXPRESSION OF CAT-315 IMMUNOREACTIVE COMPONENTS IN THE MOUSE SOMATOSENSORY CORTEX

Hiroshi Ueno, Shunsuke Suemitsu, Motoi Okamoto, Yosuke Matsumoto, Takeshi Ishihara

NEUROSCIENCE 355 161 - 174 2017.7

Language：English Publisher：PERGAMON-ELSEVIER SCIENCE LTD

Perineuronal nets (PNNs) are structures of extra cellular matrix molecules surrounding the cell bodies and proximal dendrites of certain neurons. While PNNs are present throughout the mouse cerebral cortex, recent studies have shown that the components differ among cortical sub-regions and layers, suggesting region-specific functions. Parvalbumin-expressing interneurons (PV neurons) may be important regulators of cortical plasticity during the early "critical period" that is sensitive to sensory input. Here we examined the distribution and developmental functions of PNN components associated with PV neurons in the somatosensory cortex during the critical period. Aggrecan, brevican, neurocan, phosphacan, and tenascin-R were identified as PNN components in the mouse somatosensory cortex. High-magnification analysis revealed that some lectin Wisteria floribunda agglutinin (WFA)-reactive molecules did not co-localize with monoclonal antibody Cat-315 recognition molecules around the cell body. During postnatal development, Cat-315-positive (Cat-315(+)) PNNs appeared later than PNNs binding to the lectin WFA (WFA(+) PNNs). These WFA(+) PNNs changed from granular-like to reticular like structures during normal cortical development, while this transition was delayed by sensory deprivation. This study indicates that the formation of reticular-like WFA(+) PNNs is dependent on sensory experience in the mouse somatosensory cortex. We suggest that Cat-315(+) molecules and WFA expression in PNNs are involved in the early critical period of input-dependent cortical plasticity. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.neuroscience.2017.04.041

Web of Science

researchmap

PARVALBUMIN NEURONS AND PERINEURONAL NETS IN THE MOUSE PREFRONTAL CORTEX

Hiroshi Ueno, Shunsuke Suemitsu, Motoi Okamoto, Yosuke Matsumoto, Takeshi Ishihara

NEUROSCIENCE 343 115 - 127 2017.2

Authorship：Lead author Language：English Publisher：PERGAMON-ELSEVIER SCIENCE LTD

The prefrontal cortex (PFC) plays a key role in cognitive functions, memory, and attention. Alterations in parvalbumin interneurons (PV neurons) and perineuronal nets (PNNs) within the PFC have been implicated in schizophrenia and autism spectrum disorder pathology. However, it remains unclear why PV neurons and PNNs in the PFC are selectively impaired. Here we aimed to clarify if PV neurons and PNNs in the PFC have region-specific features. We found that PV neurons and PNNs were increased in a region-specific manner in the PFC during postnatal development. In the mature PFC, the expression of PV protein is lower than in other parts of the cortex. Furthermore, PNNs in the mature PFC are not typical lattice-like structures and do not have the major components of PNNs and tenascin-R. The present study indicates that PV neurons and PNNs have region-specific features, and our results suggest that PV neurons and PNNs have structural vulnerability within the PFC. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.neuroscience.2016.11.035

Web of Science

researchmap

中年期・老年期のGIDに対する理解と支援加齢とライフサイクルに配慮した老年期の当事者支援－高齢者の健康と性差・性役割を考える－.

松本洋輔

GID(性同一性障害)学会雑誌 9 ( 1 ) 108 - 110 2017

精神科におけるてんかん診療－てんかんにおける気分障害と精神病性障害－.

山田了士, 松本洋輔

臨床精神医学 46 ( 7 ) 887 - 894 2017

Puberty Suppression for Adolescents with Gender Dysphona :A Japanese Perspective

119 ( 1 ) 42 - 51 2017