研究者詳細 - 鈴木　越治

論文 - 鈴木　越治

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A population-based longitudinal study on glycated hemoglobin levels and new-onset chronic kidney disease among non-diabetic Japanese adults 査読国際誌

Yukari Okawa, Etsuji Suzuki, Toshiharu Mitsuhashi, Toshihide Tsuda, Takashi Yorifuji

Scientific Reports 13 ( 1 ) 13770 - 13770 2023年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Abstract

Chronic kidney disease (CKD) is a major global public health problem. Recent studies reported that diabetes and prediabetes are risk factors for developing CKD; however, the exact glycated hemoglobin (HbA1c) cut-off value for prediabetes remains controversial. In this study, we aimed to examine the relationship between HbA1c levels and subsequent CKD development in greater detail than previous studies. Longitudinal data of annual checkups of 7176 Japanese non-diabetic people (male: 40.4%) from 1998 to 2022 was analyzed. HbA1c values were categorized into < 5.0%, 5.0–5.4%, 5.5–5.9%, and 6.0–6.4%. CKD was defined as an estimated glomerular filtration rate < 60 ml/min/1.73 m². The descriptive statistics at study entry showed that higher HbA1c values were associated with male, older, overweight or obese, hypertensive, or dyslipidemic people. During a mean follow-up of 7.75 person-years, 2374 participants (male: 40.0%) developed CKD. The Weibull accelerated failure time model was selected because the proportional hazards assumption was violated. The adjusted time ratios of developing CKD for HbA1c levels of 5.5–5.9% and 6.0–6.4% compared with 5.0–5.4% were 0.97 (95% confidence interval: 0.92–1.03) and 1.01 (95% confidence interval: 0.90–1.13), respectively. There was no association between HbA1c in the prediabetic range and subsequent CKD development.

DOI： 10.1038/s41598-023-40300-8

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その他リンク： https://www.nature.com/articles/s41598-023-40300-8

Accuracy of ultrasound vs. Fourier-domain optic biometry for measuring preoperative axial length in cases of rhegmatogenous retinal detachment 査読国際誌

Shuhei Kimura, Mio Morizane Hosokawa, Yusuke Shiode, Ryo Matoba, Yuki Kanzaki, Yasuhito Goto, Keisuke Kanenaga, Etsuji Suzuki, Yuki Morizane

Japanese Journal of Ophthalmology 67 ( 6 ) 645 - 651 2023年8月

Exchangeability of measures of association before and after exposure status is flipped: its relationship with confounding in the counterfactual model 査読国際誌

Etsuji Suzuki, Michio Yamamoto, Eiji Yamamoto

Journal of Epidemiology 33 ( 8 ) 385 - 389 2023年8月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japan Epidemiological Association

BACKGROUND: The counterfactual definition of confounding is often explained in the context of exchangeability between the exposed and unexposed groups. One recent approach is to examine whether the measures of association (e.g., associational risk difference) are exchangeable when exposure status is flipped in the population of interest. We discuss the meaning and utility of this approach, showing their relationships with the concept of confounding in the counterfactual framework. METHODS: Three hypothetical cohort studies are used, in which the target population is the total population. After providing an overview of the notions of confounding in distribution and in measure, we discuss the approach from the perspective of exchangeability of measures of association (e.g., factual associational risk difference vs. counterfactual associational risk difference). RESULTS: In general, if the measures of association are non-exchangeable when exposure status is flipped, confounding in distribution is always present, although confounding in measure may or may not be present. Even if the measures of association are exchangeable when exposure status is flipped, there could be confounding both in distribution and in measure. When we use risk difference or risk ratio as a measure of interest and the exposure prevalence in the population is 0.5, testing the exchangeability of measures of association is equivalent to testing the absence of confounding in the corresponding measures. CONCLUSIONS: The approach based on exchangeability of measures of association essentially does not provide a definition of confounding in the counterfactual framework. Subtly differing notions of confounding should be distinguished carefully.

DOI： 10.2188/jea.JE20210352

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Impact of macular intraretinal hemorrhage and macular hole on the visual prognosis of submacular hemorrhage due to retinal arterial macroaneurysm rupture 査読国際誌

Shinichiro Doi, Shuhei Kimura, Shoko Saito, Makoto Inoue, Toshiya Sakurai, Akira Kobori, Toshio Hisatomi, Hisanori Imai, Shoji Kuriyama, Ippei Takasu, Mio Morizane Hosokawa, Yusuke Shiode, Ryo Matoba, Etsuji Suzuki, Yuki Morizane

Retina 43 ( 4 ) 585 - 593 2023年4月

Heat exposure following the rainy season is associated with an increased risk of cardiovascular emergency among the elderly in Japan 査読国際誌

Ryohei Fujimoto, Etsuji Suzuki, Saori Kashima, Kazufumi Nakamura, Hiromichi Naito, Atsunori Nakao, Hiroshi Ito, Takashi Yorifuji

Journal of the American Heart Association 12 ( 6 ) e027046 - e027046 2023年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Heart Association

Background Despite the impact of heat exposure caused by global warming, few studies have investigated the hourly effects of heat exposure and the risk of cardiovascular disease (CVD) in the elderly. We examined the associations between short-term heat exposure and the risk of CVD in the elderly in Japan and evaluated possible effect-measure modifications by rainy seasons that occur in East Asia. Methods and Results We conducted a time-stratified case-crossover study. The study included 6527 residents in Okayama City, Japan, aged ≥65 years who were transported to emergency hospitals between 2012 and 2019 for the onset of CVD during and a few months after the rainy seasons. We examined the linear associations between temperature and CVD-related emergency calls for each year and for hourly preceding intervals before the emergency call during the most relevant months. Heat exposure during 1 month after the end of the rainy season was associated with CVD risk; the odds ratio (OR) for a 1° C increase in temperature was 1.34 (95% CI, 1.29-1.40). When we further explored the nonlinear association by using the natural cubic spline model, we found a J-shaped relationship. Exposures 0 to 6 hours before the case event (preceding intervals 0-6 hours) were associated with CVD risk, particularly for the preceding interval 0 to 1 hour (OR, 1.33 [95% CI, 1.28-1.39]). For longer periods, the highest risk was at preceding intervals 0 to 23 hours (OR, 1.40 [95% CI, 1.34-1.46]). Conclusions Elderly individuals may be more susceptible to CVD after heat exposure during the month after the rainy season. As shown by finer temporal resolution analyses, short-term exposure to increasing temperature can trigger CVD onset.
【令和5年度岡山県医師会学術奨励賞受賞論文】

DOI： 10.1161/JAHA.122.027046

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Michiyo Yamakawa, Toshihide Tsuda, Keiko Wada, Chisato Nagata, Etsuji Suzuki

PLoS One 18 ( 2 ) e0279426 - e0279426 2023年2月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PLoS One

Despite an increasing number of students studying abroad worldwide, evidence about health risks while they are abroad is limited. Diarrhea is considered the most common travelers’ illness, which would also apply to students studying abroad. We examined diarrhea and related personal characteristics among Japanese students studying abroad. Japanese university students who participated in short-term study abroad programs between summer 2016 and spring 2018 were targeted (n = 825, 6–38 travel days). Based on a 2-week-risk of diarrhea (passing three or more loose or liquid stools per day) among travelers by country, the destination was separated into intermediate- and low-risk countries. After this stratification, the associations between personal characteristics and diarrhea during the first two weeks of their stay were evaluated using logistic regression models. Among participants in intermediate-risk countries, teenagers, males and those with overseas travel experience were associated with an elevated risk of diarrhea; the odds ratios (95% confidence intervals) were 2.42 (1.08–5.43) for teenagers (vs. twenties), 1.93 (1.08–3.45) for males (vs. females) and 2.37 (1.29–4.33) for those with overseas experience (vs. none). Even restricting an outcome to diarrhea during the first week did not change the results substantially. The same tendency was not observed for those in the low-risk countries. Teenage students, males and those with overseas travel experience should be cautious about diarrhea while studying abroad, specifically in intermediate-risk countries.

DOI： 10.1371/journal.pone.0279426

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Attributable fraction and related measures: Conceptual relations in the counterfactual framework 査読国際誌

Etsuji Suzuki, Eiji Yamamoto

Journal of Causal Inference 11 ( 1 ) 20210068 2023年2月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

The attributable fraction (population) has attracted much attention from a theoretical perspective and has been used extensively to assess the impact of potential health interventions. However, despite its extensive use, there is much confusion about its concept and calculation methods. In this article, we discuss the concepts of and calculation methods for the attributable fraction and related measures in the counterfactual framework, both with and without stratification by covariates. Generally, the attributable fraction is useful when the exposure of interest has a causal effect on the outcome. However, it is important to understand that this statement applies to the exposed group. Although the target population of the attributable fraction (population) is the total population, the causal effect should be present not in the total population but in the exposed group. As related measures, we discuss the preventable fraction and prevented fraction, which are generally useful when the exposure of interest has a preventive effect on the outcome, and we further propose a new measure called the attributed fraction. We also discuss the causal and preventive excess fractions, and provide notes on vaccine efficacy. Finally, we discuss the relations between the aforementioned six measures and six possible patterns using a conceptual schema.

DOI： 10.1515/jci-2021-0068

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Do complementary and alternative medicine users also use conventional medicine? A repeated cross-sectional study in Japan from 1995 to 2013 査読国際誌

Nobuyoshi Matsuki, Etsuji Suzuki, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

Journal of Integrative and Complementary Medicine 29 ( 2 ) 119 - 126 2023年2月

Breastfeeding at 6 months of age had a positive impact on overweight and obesity in Japanese adolescents at 15 years of age 査読国際誌

Tomoka Kadowaki, Naomi Matsumoto, Etsuji Suzuki, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

Acta Paediatrica 112 ( 1 ) 106 - 114 2023年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

AIM: A number of studies have indicated the potential benefits that breastfeeding has on reducing childhood obesity, but few studies have evaluated the effect on adolescent obesity. We examined the association between breastfeeding and overweight or obesity at 15 years of age using data from a large nationwide longitudinal study launched by the Japanese Government in 2001. METHODS: We analysed data for 26 164 participants with known infant feeding practices at 6 months of age, namely the duration of breastfeeding or formula feeding. Overweight or obesity at 15 years of age were calculated based on the subject's self-reported height and weight. Multinomial logistic regression analysis adjusted the data for child factors, namely sex, siblings, birth weight and physical activity clubs and the maternal factors of age, educational attainment and smoking status. RESULTS: Formula feeding was associated with an increased risk of overweight or obesity at 15 years of age. The adjusted odds ratios (95% confidence intervals) were 0.99 (0.89-1.09) for partial breastfeeding and 1.23 (1.02-1.48) for formula feeding, when exclusive breastfeeding was the reference category. CONCLUSION: Breastfeeding during infancy had potential benefits for overweight or obesity among 15-year-old adolescents. Our results provide further evidence of the importance of breastfeeding.

DOI： 10.1111/apa.16551

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/apa.16551

Erratum: Marginal Sufficient Component Cause Model: An Emerging Causal Model With Merits? 国際誌

Etsuji Suzuki, Eiji Yamamoto

Epidemiology 34 ( 1 ) e2 - e2 2023年1月

A general explanation of the counterfactual definition of confounding 査読国際誌

Etsuji Suzuki, Michio Yamamoto, Eiji Yamamoto

Journal of Clinical Epidemiology 148 189 - 192 2022年8月

Tumor size before image-guided brachytherapy is an important factor of local control after radiotherapy for cervical squamous cell carcinoma: analysis in cases using central shielding 査読国際誌

Kotaro Yoshio, Hiroki Ihara, Kazuhiro Okamoto, Etsuji Suzuki, Takeshi Ogata, Soichi Sugiyama, Keiichiro Nakamura, Shoji Nagao, Hisashi Masuyama, Takao Hiraki

Journal of Radiation Research 63 ( 5 ) 772 - 779 2022年7月

Three doses of mRNA COVID‐19 vaccine protects from SARS‐CoV‐2 infections in Japan 査読国際誌

Katsuyuki Hotta, Etsuji Suzuki, Eiki Ichihara, Katsuyuki Kiura

Journal of Internal Medicine 292 ( 4 ) 687 - 689 2022年6月

The primary importance of the research question: implications for understanding natural versus controlled direct effects 査読国際共著国際誌

Ian Shrier, Etsuji Suzuki

International Journal of Epidemiology 51 ( 4 ) 1041 - 1046 2022年5月

Incidence and clinical characteristics of spinal arteriovenous shunts: hospital-based surveillance in Okayama, Japan 査読国際誌

Masafumi Hiramatsu, Ryota Ishibashi, Etsuji Suzuki, Yuko Miyazaki, Satoshi Murai, Hiroki Takai, Yuji Takasugi, Yoko Yamaoka, Kazuhiko Nishi, Yu Takahashi, Jun Haruma, Tomohito Hishikawa, Takao Yasuhara, Masaki Chin, Shunji Matsubara, Masaaki Uno, Koji Tokunaga, Kenji Sugiu, Isao Date

Journal of Neurosurgery: Spine 36 ( 4 ) 670 - 677 2022年4月

Marginal sufficient component cause model: an emerging causal model with merits? 査読国際誌

Etsuji Suzuki, Eiji Yamamoto

Epidemiology 32 ( 6 ) 838 - 845 2021年11月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

For decades, the sufficient cause model and the counterfactual model have shaped our understanding of causation in biomedical science, and the link between these two models has enabled us to obtain a deeper understanding of causality. Recently, a new causal model-the marginal sufficient component cause model-was proposed and applied in the context of interaction or mediation. The proponents of this model have emphasized its utility in visualizing the presence of "agonism" (a subtype of mechanistic interaction) in the counterfactual framework, claiming that the concept of agonism has not been clearly defined in causal inference and that agonistic interaction cannot be visualized by the conventional sufficient cause model. In this article, we illustrate that careful scrutiny based on the conventional sufficient cause model yields further insights into the concept of agonism in a more biologic sense. We primarily focus on the following three points: (1) "agonism" defined in the counterfactual model can be visualized as sets of sufficient causes in the conventional sufficient cause model; (2) although the so-called independent competing assumption or no redundancy assumption may seem irrelevant in the marginal sufficient component cause model, researchers do need to assume that potential completion times of relevant marginal sufficient causes differ; and (3) possibly differing potential completion times of marginal sufficient causes cannot be discerned until their hidden mechanistic paths are considered in the conventional sufficient cause model. In this rapidly progressing field of research, decades after its introduction, the sufficient cause model retains its worth.

DOI： 10.1097/EDE.0000000000001411

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Is a sense of community belonging associated with problem gambling in Canada? 査読国際誌

Masato Izutsu, Etsuji Suzuki

Social Psychiatry and Psychiatric Epidemiology 56 ( 10 ) 1871 - 1880 2021年10月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

DOI： 10.1007/s00127-021-02040-w

Web of Science

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その他リンク： https://link.springer.com/article/10.1007/s00127-021-02040-w/fulltext.html

Strength in causality: discerning causal mechanisms in the sufficient cause model 査読国際誌

Etsuji Suzuki, Eiji Yamamoto

European Journal of Epidemiology 36 ( 9 ) 899 - 908 2021年9月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

DOI： 10.1007/s10654-021-00798-6

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その他リンク： https://link.springer.com/article/10.1007/s10654-021-00798-6/fulltext.html

Body mass index and ventilator dependence in critically ill patients in Japan: a cohort study using a nationwide database 査読国際誌

Jun Fujinaga, Etsuji Suzuki, Hiromasa Irie, Mutsuo Onodera

Respiratory Care 66 ( 9 ) 1433 - 1439 2021年9月

A simple prognostic benefit scoring system for sarcoma patients with pulmonary metastases: Sarcoma Lung Metastasis Score 査読国際誌

Haruchika Yamamoto, Hiromasa Yamamoto, Junichi Soh, Etsuji Suzuki, Kei Namba, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Takashi Yorifuji, Katsuhito Takahashi, Shinichi Toyooka

Annals of Surgical Oncology 28 ( 7 ) 3884 - 3890 2021年7月

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