研究者詳細 - 鈴木　越治

論文 - 鈴木　越治

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Effect modification in settings with “truncation by death” 査読国際共著国際誌

Bronner P. Gonçalves, Etsuji Suzuki

Epidemiology 36 ( 3 ) 374 - 380 2025年5月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

Epidemiologic studies recruiting individuals with higher-than-population-average mortality can be affected by “truncation by death”, whereby the outcome of interest (e.g. quality of life) is considered not to be defined for individuals who die before the end of follow-up. Here, we use the potential outcomes framework and principal stratification to derive conditions under which the survivor average causal effect, an estimand defined for the “always-survivors” stratum, is modified by a variable that represents a possible common cause of survival and the outcome of interest, and by a variable that only affects survival. Further, we show that this principal effect can be expressed as a weighted average of this treatment effect for individuals with each level of these variables, and that these weights depend not only on the relative frequencies of the levels in the total population, but also in the “always-survivors” principal stratum. We also discuss the implications of this work for the transportability of the survivor average causal effect.

DOI： 10.1097/ede.0000000000001834

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Unraveling causality: Innovations in epidemiologic methods 招待査読国際誌

Etsuji Suzuki

JMA Journal 8 ( 2 ) 323 - 337 2025年4月

Management strategies for truncus arteriosus: a comparative analysis of staged vs. primary repair 査読国際誌

Yasuyuki Kobayashi, Shunji Sano, Yuto Narumiya, Ayari Kimura, Etsuji Suzuki, Shingo Kasahara, Yasuhiro Kotani

Pediatric Cardiology 2025年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Abstract

We reviewed the outcomes of truncus arteriosus repair (primary vs. staged repair incorporating bilateral pulmonary artery banding), focusing on survival, reintervention, and functional data. We analyzed 39 patients who underwent a first intervention for truncus arteriosus (staged, n = 19; primary, n = 20) between 1992 and 2022. The median follow-up period was 8.0 (2.2–13.2) years. Survival, freedom from reoperation, and freedom from catheter intervention were estimated using the Kaplan–Meier method. High-risk patients were defined as those with a weight ≤ 2.5 kg, ≥ moderate truncal valve regurgitation, interrupted aortic arch, or preoperative shock. In the staged group, patients with a median weight of 2.6 kg had a median intensive care unit stay of 5 days and no hospital mortality after bilateral pulmonary artery banding. At repair, the staged group had a larger conduit for the right ventricular outflow tract (14 vs. 12 mm; P = .008). Catheter intervention on the branch pulmonary artery was required in 67% of patients in the staged group, but right ventricular end-diastolic pressure at follow-up was comparable between the groups (P = .541). Survival rates were higher among high-risk patients in the staged group (87.5% vs. 21.4% at 15 years; P = .004) but were comparable between groups for standard-risk patients (P = 1.000). Bilateral pulmonary artery banding was a safe, effective procedure. Reintervention for branch pulmonary artery was common but did not affect functional outcomes. Staged repair may play a pivotal role regarding survival in high-risk patients, and risk stratification is vital.

DOI： 10.1007/s00246-025-03790-z

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その他リンク： https://link.springer.com/article/10.1007/s00246-025-03790-z/fulltext.html

Family ties and social capital among grand slam tennis champions 査読国際共著国際誌

Dario Novak, Mario Oršolić, Petar Barbaros, Etsuji Suzuki, S.V. Subramanian

International Review for the Sociology of Sport 2025年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SAGE Publications

As a competitive sport, tennis demands a comprehensive understanding of the factors which contribute to success at different levels of performance. In order to clarify the aforementioned, the aim of this study was to explore and understand the perspective of tennis players, at differing levels of success, and the impact of social capital on their sporting careers. A particular emphasis was put on an elite group of tennis players who succeeded in reaching the pinnacle of success by winning a Grand Slam title. Semistructured interviews were conducted with 30 tennis players, including 10 Grand Slam winners. Upon transcription, the interviews were analyzed by using reflexive thematic analysis. Family presence and support during the challenges faced by tennis players emerged as a clear research topic following the research analysis. The perspectives of tennis players on the influence of social capital on long-term sports development and achievements revealed that the family plays a key role in the process of raising and supporting tennis players. In order to improve the long-term sports development of tennis players, families must ensure and provide a more significant role in the accrual of social capital, however it is not necessarily a sufficient condition to success.

DOI： 10.1177/10126902241298498

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その他リンク： https://journals.sagepub.com/doi/full-xml/10.1177/10126902241298498

Volunteering in young adulthood: Complex associations with later health and well-being outcomes 査読国際共著国際誌

Julia S. Nakamura, Renae Wilkinson, Marisa A. Nelson, Etsuji Suzuki, Tyler J. VanderWeele

American Journal of Health Promotion 39 ( 1 ) 39 - 51 2025年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SAGE Publications

Purpose

To investigate whether changes in volunteering from adolescence to young adulthood are associated with subsequent health and well-being outcomes in adulthood.

Design

Longitudinal cohort study.

Setting

National Longitudinal Study of Adolescent to Adult Health.

Subjects

U.S. adults from Wave IV (2008/2009; N = 12,234) and Wave V (2016-2018; N = 9,971).

Measures

Any volunteering and nine types of volunteering (independent variables) and 41 health and well-being outcomes (dependent variables) using an outcome-wide approach with multiple linear-, logistic-, and generalized linear regressions.

Results

Volunteering in young adulthood was associated with better health behaviors (e.g., 34% decreased risk of binge drinking, 95% CI [0.54, 0.81]) and improved psychosocial and civic outcomes (e.g., lower depressive symptoms (β = −0.08, 95% CI [−0.14, −0.02]) in adulthood. Volunteering showed little evidence of associations with other health and well-being outcomes (e.g., loneliness, (β = −0.04, 95% CI [−0.09, 0.01])). Assessing volunteering by organization types showed a range of positive and negative outcomes. For example, volunteering in hospitals/nursing homes was associated with a 36% increased risk of high cholesterol (95% CI [1.06, 1.73]) and volunteering with political clubs was associated with a 52% increased risk of an anxiety diagnosis (95% CI [1.13, 2.05]).

Conclusion

Our findings suggest more work is needed to determine the conditions under which volunteering is health promoting and to minimize potential adverse effects associated with some types of volunteering.

DOI： 10.1177/08901171241273424

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その他リンク： https://journals.sagepub.com/doi/full-xml/10.1177/08901171241273424

Area Deprivation and Health Outcomes in Preschool Children in Japan: A Nationwide Cohort Study 査読国際共著国際誌

Naomi Matsumoto, Etsuji Suzuki, Soshi Takao, Tomoki Nakaya, Ichiro Kawachi, Takashi Yorifuji

Journal of Epidemiology 2025年

Aspartate/alanine aminotransferase ratio and development of chronic kidney disease in non-diabetic men and women: a population-based longitudinal study in Kagawa, Japan 査読国際誌

Yukari Okawa, Toshiharu Mitsuhashi, Etsuji Suzuki

Clinical and Experimental Nephrology 2024年12月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

DOI： 10.1007/s10157-024-02601-8

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その他リンク： https://link.springer.com/article/10.1007/s10157-024-02601-8/fulltext.html

Job strain and adverse pregnancy outcomes: A scoping review and meta‐analysis 査読国際共著国際誌

Kota Nakayama, Etsuji Suzuki, Natalie Slopen, Ichiro Kawachi

American Journal of Industrial Medicine 67 ( 11 ) 971 - 979 2024年11月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

Abstract

Background

Previous studies have shown that job strain is associated with low birthweight (LBW), preterm birth (PTB), and small for gestational age (SGA). We conducted a scoping review and meta‐analysis to assess the association between job strain and adverse pregnancy outcomes.

Methods

A literature search was performed on PubMed. We included English‐language studies that examined the association between job strain (based on the Karasek demand‐control model) and pregnancy outcomes. We excluded letters, posters, reviews, and qualitative studies. Random effects meta‐analysis was performed. Heterogeneity was assessed using τ² and I² statistics. Potential bias was assessed using standard funnel plots. Asymmetry was evaluated by Egger's test. Leave‐one‐out analysis was performed for sensitivity analyses.

Results

Three eligible studies were found for LBW, seven for PTB, and four for SGA. The number of subjects ranged from 135 to 4889, and the prevalence of high job strain ranged from 6.64% to 33.9%. The pooled odds ratio and 95% confidence interval (CI) for LBW, PTB, and SGA were 1.23 (95% CI: 0.97, 1.56), 1.10 (95% CI: 1.00, 1.22), and 1.16 (95% CI: 0.97, 1.39) respectively, indicating modest associations. Heterogeneity for LBW and PTB may not be important but may be moderate for SGA. No publication bias was detected for LBW and PTB, but possible publication bias exists for SGA.

Conclusion

We found a modest association between job strain and PTB. Since job strain is only one of the many aspects of an unhealthy work environment, interventions that improve working conditions more broadly are needed.

DOI： 10.1002/ajim.23655

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Re: “Defining and identifying local average treatment effects” 査読国際誌

Etsuji Suzuki, Eiji Yamamoto

American Journal of Epidemiology 193 ( 11 ) 1641 - 1642 2024年11月

Preventable fraction in the context of disease progression 査読国際共著国際誌

Bronner P. Gonçalves, Etsuji Suzuki

Epidemiology 35 ( 6 ) 801 - 804 2024年11月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

The relevance of the epidemiologic concept of preventable fraction to the study of the population-level impact of preventive exposures is unequivocal. Here, we discuss how the preventable fraction can be usefully understood for the class of outcomes that relate to disease progression (e.g., clinical severity given diagnosis), and, under the principal stratification framework, derive an expression for this quantity for this type of outcome. In particular, we show that, in the context of disease progression, the preventable fraction is a function of the effect on the postdiagnosis outcome in the principal stratum in the unexposed group who would have disease regardless of exposure status. This work will facilitate an understanding of the contribution of principal effects to the impact of preventive exposures at the population level.

DOI： 10.1097/ede.0000000000001770

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Re: Bias in calculation of attributable fractions using relative risks from nonsmokers only 査読国際誌

Etsuji Suzuki, Eiji Yamamoto

Epidemiology 35 ( 6 ) e21 - e22 2024年11月

Survey of pharyngeal foreign bodies in Japan: An ecological study using the nationwide claims data 査読国際誌

Shintaro Tanaka, Kensuke Uraguchi, Etsuji Suzuki, Naomi Matsumoto, Munechika Tsumura, Shohei Fujimoto, Shotaro Miyamoto, Takashi Yorifuji, Mizuo Ando

International Journal of Pediatric Otorhinolaryngology 184 112055 - 112055 2024年9月

Errors in the calculation of the population attributable fraction 査読国際誌

Etsuji Suzuki, Eiji Yamamoto

Epidemiology 35 ( 4 ) 469 - 472 2024年7月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

One of the common errors in the calculation of the population attributable fraction (PAF) is the use of an adjusted risk ratio in the Levin formula. In this article, we discuss the errors visually using wireframes by varying the standardized mortality ratio (SMR) and associational risk ratio (aRR) when the prevalence of exposure is fixed. When SMR >1 and SMR > aRR, the absolute bias is positive, and its magnitude increases as the difference between SMR and aRR increases. By contrast, when aRR > SMR > 1, the absolute bias is negative and its magnitude is relatively small. Moreover, when SMR > aRR, the relative bias is larger than one, whereas when SMR < aRR, the relative bias is smaller than one. Although the target population of the PAF is the total population, the target of causation of the PAF is not the total population but the exposed group.

DOI： 10.1097/ede.0000000000001731

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An Internet-based survey of hepatitis B vaccination status among acupuncturists in Japan 査読国際誌

Nobuyoshi Matsuki, Etsuji Suzuki, Toshihide Tsuda, Hiroyuki Doi, Takashi Yorifuji

Japanese Acupuncture and Moxibustion 18 8 - 14 2024年7月

Aspartate/alanine aminotransferase ratio and development of chronic kidney disease in non-diabetic Japanese men and women

Yukari Okawa, Toshiharu Mitsuhashi, Etsuji Suzuki

2024年5月

担当区分：最終著者出版者・発行元：Cold Spring Harbor Laboratory

AimThe objective of this study was to explore the relationship between serum aspartate/alanine aminotransferase ratio (AST/ALT) and subsequent development of chronic kidney disease (CKD) in non-diabetic Japanese men and women in a 25-year follow-up study.MethodsThe study included all middle-aged and older non-diabetic Japanese citizens who received health check-ups in Zentsuji, Kagawa, Japan (1998–2023). AST/ALT was classified into three categories: <1.0 (reference), 1.0–<1.5, and ≥1.5. Participant characteristics were compared by AST/ALT categories. The Weibull accelerated failure time model was used to examine the association between AST/ALT categories and subsequent CKD onset because the proportional hazards assumption was violated.ResultsOf 6309 men and 9192 women, 2966 men and 4395 women remained in the final cohort. After a mean follow-up of 7.50 years for men and 8.34 years for women, 33.7% of men and 34.0% of women developed CKD. Women had higher AST/ALT than men. In women, a dose-response relationship was observed, with a 9% shorter survival time to CKD onset for AST/ALT ≥1.5 compared with AST/ALT <1.0. In contrast, men had a shorter survival time to CKD onset by point estimates, but the 95% confidence intervals crossed 1 in all models.ConclusionsIn this study comparing the risks of CKD development in non-diabetic men and women by AST/ALT levels, a dose-response relationship was only observed in women. Differences in the distribution of AST/ALT by sex may have affected the results. Therefore, in non-diabetic Japanese women, AST/ALT may be used as an indicator of future CKD development.

DOI： 10.1101/2024.05.20.24307032

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Staged repair for complete atrioventricular septal defect in patients weighing less than 4.0 kg 査読国際誌

Yasuyuki Kobayashi, Shingo Kasahara, Shunji Sano, Hiroyuki Suzuki, Etsuji Suzuki, Takashi Yorifuji, Yasuhiro Kotani

The Journal of Thoracic and Cardiovascular Surgery 167 ( 3 ) 1136 - 1144 2024年3月

Prenatal Exposure to Opioids and Neurodevelopmental Disorders in Children: A Bayesian Mediation Analysis 査読国際共著国際誌

Shuang Wang, Gavino Puggioni, Jing Wu, Kimford J Meador, Aisling Caffrey, Richard Wyss, Jonathan L Slaughter, Etsuji Suzuki, Kristina E Ward, Adam K Lewkowitz, Xuerong Wen

American Journal of Epidemiology 193 ( 2 ) 308 - 322 2024年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

This study explores natural direct and joint natural indirect effects (JNIE) of prenatal opioid exposure on neurodevelopmental disorders (NDDs) in children mediated through pregnancy complications, major and minor congenital malformations, and adverse neonatal outcomes, using Medicaid claims linked to vital statistics in Rhode Island, United States, 2008–2018. A Bayesian mediation analysis with elastic net shrinkage prior was developed to estimate mean time to NDD diagnosis ratio using posterior mean and 95% credible intervals (CrIs) from Markov chain Monte Carlo algorithms. Simulation studies showed desirable model performance. Of 11,176 eligible pregnancies, 332 had ≥2 dispensations of prescription opioids anytime during pregnancy, including 200 (1.8%) having ≥1 dispensation in the first trimester (T1), 169 (1.5%) in the second (T2), and 153 (1.4%) in the third (T3). A significant JNIE of opioid exposure was observed in each trimester (T1, JNIE = 0.97, 95% CrI: 0.95, 0.99; T2, JNIE = 0.97, 95% CrI: 0.95, 0.99; T3, JNIE = 0.96, 95% CrI: 0.94, 0.99). The proportion of JNIE in each trimester was 17.9% (T1), 22.4% (T2), and 56.3% (T3). In conclusion, adverse pregnancy and birth outcomes jointly mediated the association between prenatal opioid exposure and accelerated time to NDD diagnosis. The proportion of JNIE increased as the timing of opioid exposure approached delivery.

DOI： 10.1093/aje/kwad183

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その他リンク： https://academic.oup.com/aje/article-pdf/193/2/308/56556096/kwad183.pdf

Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people 査読国際共著国際誌

Yuriko N. Koyanagi, Masahiro Nakatochi, Shinichi Namba, Isao Oze, Hadrien Charva, Akira Narita, Takahisa Kawaguchi, Hiroaki Ikezaki, Asahi Hishida, Megumi Hara, Toshiro Takezaki, Teruhide Koyama, Yohko Nakamura, Sadao Suzuki, Sakurako Katsuura-Kamano, Kiyonori Kuriki, Yasuyuki Nakamura, Kenji Takeuchi, Atsushi Hozawa, Kengo Kinoshita, Yoichi Sutoh, Kozo Tanno, Atsushi Shimizu, Hidemi Ito, Yumiko Kasugai, Yukino Kawakatsu, Yukari Taniyama, Masahiro Tajika, Yasuhiro Shimizu, Etsuji Suzuki, Yasuyuki Hosono, Issei Imoto, Yasuharu Tabara, Meiko Takahashi, Kazuya Setoh, Koichi Matsuda, Shiori Nakano, Atsushi Goto, Ryoko Katagiri, Taiki Yamaji, Norie Sawada, Shoichiro Tsugane, Kenji Wakai, Masayuki Yamamoto, Makoto Sasaki, Fumihiko Matsuda, Yukinori Okada, Motoki Iwasaki, Paul Brennan, Keitaro Matsuo

Science Advances 10 ( 4 ) eade2780 - eade2780 2024年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Association for the Advancement of Science (AAAS)

An East Asian–specific variant on aldehyde dehydrogenase 2 ( ALDH2 rs671, G>A) is the major genetic determinant of alcohol consumption. We performed an rs671 genotype-stratified genome-wide association study meta-analysis of alcohol consumption in 175,672 Japanese individuals to explore gene-gene interactions with rs671 behind drinking behavior. The analysis identified three genome-wide significant loci ( GCKR , KLB , and ADH1B ) in wild-type homozygotes and six ( GCKR , ADH1B , ALDH1B1 , ALDH1A1 , ALDH2 , and GOT2 ) in heterozygotes, with five showing genome-wide significant interaction with rs671. Genetic correlation analyses revealed ancestry-specific genetic architecture in heterozygotes. Of the discovered loci, four ( GCKR , ADH1B , ALDH1A1 , and ALDH2 ) were suggested to interact with rs671 in the risk of esophageal cancer, a representative alcohol-related disease. Our results identify the genotype-specific genetic architecture of alcohol consumption and reveal its potential impact on alcohol-related disease risk.

DOI： 10.1126/sciadv.ade2780

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Complementary and alternative medicine use, cancer screening, and medical checkups in Japan from 2001 to 2013: A repeated cross-sectional study 査読国際共著国際誌

Nobuyoshi Matsuki, Etsuji Suzuki, Toshiharu Mitsuhashi, S.V. Subramanian, Soshi Takao, Takashi Yorifuji

Journal of Integrative and Complementary Medicine 30 ( 1 ) 47 - 56 2024年1月

Fine particulate matter and diabetes prevalence in Okayama, Japan 査読国際誌

Yasunari Tani, Saori Kashima, Toshiharu Mitsuhashi, Etsuji Suzuki, Soshi Takao, Takashi Yorifuji

Acta Medica Okayama 77 ( 6 ) 607 - 612 2023年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

Many studies have shown an association between long-term exposure to particulate matter having an aerodynamic diameter of 2.5 μm or less (PM2.5) and diabetes mellitus (DM), but few studies have focused on Asian subjects. We thus examined the association between long-term exposure to PM2.5 and DM prevalence in Okayama City, Japan. We included 76,591 participants who had received basic health checkups in 2006 and 2007. We assigned the census-level modeled PM2.5 data from 2006 and 2007 to each participant and defined DM using treatment status and the blood testing. PM2.5 was associated with DM prevalence, and the prevalence ratio (95% confidence interval) was 1.10 (1.00-1.20) following each interquartile range increase (2.1 μg/m3) in PM2.5. This finding is consistent with previous results and suggests that long-term exposure to PM2.5 is associated with an increased prevalence of DM in Okayama City, Japan, where the PM2.5 level is lower than in other cities in Asian countries.

DOI： 10.18926/AMO/66152

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