研究者詳細 - 湯浅　慎介

MISC - 湯浅　慎介

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Multiple roles for BMP signaling in cardiac development

Shinsuke Yuasa, Keiichi Fukuda

Drug Discovery Today: Therapeutic Strategies 5 ( 4 ) 209 - 214 2008年12月

記述言語：英語掲載種別：書評論文，書評，文献紹介等

The bone morphogenetic protein (BMP) family is the largest subfamily of the transforming growth factor-beta (TGF-β) superfamily. Some BMPs are expressed before cardioblast formation and throughout the late stages of heart development. BMPs have crucial roles in a broad range of biological events, including cellular proliferation, differentiation, migration and apoptosis during organ development. At least six BMPs (BMP2, 4, 5, 6, 7 and 10) are expressed in the heart, where they have both independent and redundant functions. Experiments on genetically modified mice have demonstrated the importance of BMP signaling for heart morphogenesis after the mid-gestation stage. Interestingly, BMPs play a dual role in heart development. Precise regulation of BMP inhibition and BMP stimulation is required for proper heart development during the early stage of cardiomyocyte differentiation. Knowledge of embryogenesis is frequently used in studies of stem cell biology. Through the application of BMP signal regulation in cardiac development, many systems for the differentiation of embryonic stem (ES) cells into cardiomyocytes are developed. These results reveal the crucial role of temporal and spatial regulation of BMPs and BMP antagonists in heart development. © 2009 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.ddstr.2008.12.001

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The Potent Angiogenic Factor Periostin Accelerates Degeneration and Sclerosis of the Cardiac Valve Complex

Daihiko Hakuno, Naritaka Kimura, Tokuhiro Kimura, Shinsuke Yuasa, Mitsushige Murata, Shinji Makino, Motoaki Sano, Yasunori Okada, Ryohei Yozu, Akira Kudo, Satoshi Ogawa, Keiichi Fukuda

CIRCULATION 118 ( 18 ) S456 - S456 2008年10月

Imprinting Gene-Modified Parthenogenic ES Cells Can be a Novel Autologous Cell Source for Generating Regenerative Cardiomyocytes

Toshimi Kageyama, Shinji Makino, Fumiyuki Hattori, Run Kaneda, Shinsuke Yuasa, Takeshi Onizuka, Sonhan Yun, Youhei Ohno, Jin Endo, Kenichirour Shimoji, Takohide Arai, Daihiko Hakuno, Tomofumi Tanaka, Kensuke Kimura, Hayashida Kentaro, Mitsushige Murata, Takaharu Katayama, Motoaki Sano, Tomoyuki Tokunaga, Tomohiro Kono, Satoshi Ogawa, Koichi Fukuda

CIRCULATION 118 ( 18 ) S491 - S492 2008年10月

Neural Crest Stem Cells Supply Intrinsic Cardiac Adrenergic Cells and Contribute to Reinnervation after Myocardial Infarction in Mice

Yuichi Tamura, Masaki Ieda, Keisuke Matsumura, Hideaki Kanazawa, Kensuke Kimura, Yasuyo Ieda, Jin Endo, Takahide Arai, Haruke Kawaguchi-Manabe, Yuichi Tomita, Shinsuke Yuasa, Motoaki Sano, Kazuto Kobayashi, Satoshi Ogawa, Keiichi Fukuda

CIRCULATION 118 ( 18 ) S395 - S395 2008年10月

DEXAMETHASONE INDUCES LATE PHASE OF CARDIOPROTECTION VIA A CYCLOOXYGENASE-2-DEPENDENT MECHANISM

Kayoko Tamaki, Ken Shinmura, Motoaki Sano, Satori Tokudome, Jin Endo, Takaharu Katayama, Kentaro Hayashida, Shinsuke Yuasa, Ruri Kaneda, Shinji Makino, Keiichi Fukuda

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 45 S32 - S32 2008年10月

Molecular Characterization, Safety and Feasibility of Induced Pluripotent Stem (iPS) Cell Derived Cardiomyocytes for Heart Regenerative Therapy

Yohei Ohno, Shinsuke Yuasa, Takeshi Onizuka, Toru Egashira, Kenichiro Shimoji, Sung Han Yoon, Takahide Arai, Jin Endo, Toshimi Kageyama, Hao Chan, Tomofumi Tanaka, Fumiyuki Hattori, Satoshi Ogawa, Shinya Yamanaka, Keiichi Fukuda

CIRCULATION 118 ( 18 ) S429 - S429 2008年10月

Dominant Negative Suppression of Red Leads to Intracellular Ca2+ Overload via Up-Regulation of Cardiac Ryanodine Receptor Activity

Mitsushige Murata, Hirotaka Yada, Hiroyuki Yamakawa, Yoshiyasu Aizawa, Shinsuke Yuasa, Daihlko Hakuno, Shinji Makino, Motoaki Sano, Mitsuru Murata, Satoshi Ogawa, Keiichi Fukuda

CIRCULATION 118 ( 18 ) S523 - S523 2008年10月

Sublethal Levels of Aldehydes Augmented Cardiac Anti-Oxidant Defense through Activation of elF2 alpha-ATF4 Pathway via GCN2 Kinase

Takaharu Katayama, Motoaki Sano, Jin Endo, Kentaro Hayashida, Tomohiro Matsuhashi, Satori Tokudome, Toshimi Kageyama, Shinsuke Yuasa, Takeshi Adachi, Makoto Suematsu, Kiyomi Nishimaki, Ikuroh Ohsawa, Shigeo Ohta, Satoshi Ogawa, Keiichi Fukuda

CIRCULATION 118 ( 18 ) S320 - S320 2008年10月

Activation of L-serine biosynthesis is indispensable for hormetic effects of aldehydes in the heart

Jin Endo, Motoaki Sano, Takaharu Katayama, Takeshi Adachi, Kentaro Hayashida, Shinsuke Yuasa, Shinji Makino, Makoto Suematsu, Keiichi Fukuda, Satoshi Ogawai

JOURNAL OF CARDIAC FAILURE 14 ( 7 ) S149 - S149 2008年9月

PJ-274 Wnt2 plays a key role in cardiac development via a non-canonical pathway(Development and differentiation(02)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Onizuka Takeshi, Yuasa Shinsuke, Shimoji Kenichiro, Sano Motoaki, Kimura Kensuke, Makino Shinji, Hakuno Daihiko, Murata Mitsushige, Kanazawa Hideaki, Yada Hirotaka, Hayashida Kentaro, Kageyama Toshimi, Katayama Takaharu, Endoh Jin, Ono Yohei, Arai Takahide, Fukuda Keiichi, Ogawa Satoshi

Circulation journal : official journal of the Japanese Circulation Society 72 580 - 580 2008年3月

OE-241 "Re-aggregation Method" Dramatically Improved the Survival of Purified Mouse and Monkey ES Cell-Derived Cardiomyocytes in Grafted Myocardium(Regeneration(angiogenesis/myocardial regeneration)(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Hattori Fumiyuki, Chen Hao, Li Weizhen, Yuasa Shinsuke, Onizuka Takeshi, Shimoji Kenichiro, Murata Mitsushige, Kimura Kensuke, Makino Shinji, Sano Motoaki, Fukuda Keiichi

Circulation journal : official journal of the Japanese Circulation Society 72 241 - 241 2008年3月

Inhalation of hydrogen gas protects the heart from ischemic reperfusion injury

Kekntaro Hayashida, Motoaki Sano, Kensuke Kimura, Jin Endo, Takaharu Katayama, Saori Tokudome, Takeshi Onizuka, Shinsuke Yuasa, Akio Kawamura, Satoshi Ogawa, Keiichi Fukuda

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 51 ( 10 ) A375 - A375 2008年3月

Genetic mutation of ALDH2 enhances cardiomyocyte tolerance to oxidative stress as a result of hormetic response to aldehydes

Jin Endo, Motoaki Sano, Takahanu Katayama, Satori Tokudome, Shinsuke Yuasa, Mitsushige Murata, Shinji Makino, Takeshi Adachi, Makoto Suematsu, Hiroki Nakanishi, Rye Taguchi, Ikurou Ohsawa, Shigeo Ohta, Satoshi Ogawa, Keiichi Fukuda

CIRCULATION 116 ( 16 ) 53 - 53 2007年10月

Neural crest stem cells supply cardiomyocytes for the physiological turnover and the regeneration after myocardial infarction

Keisuke Matsumura, Yuichi Tamura, Hideaki Kanazawa, Shinsuke Yuasa, Satoshi Ogawa, Keiichi Fukuda

CIRCULATION 116 ( 16 ) 258 - 258 2007年10月

Zac1 is an essential cardiac transcription factor

Shinsuke Yuasa, Takeshi Onizuka, Kenichiro Shimoji, Yohei Ohno, Jin Endo, Hideaki Kanazawa, Hirotaka Yada, Sung H. Yoon, Tomomi Kageyama, Takashi Kawakami, Satoshi Ogawa, Keiichi Fukuda

CIRCULATION 116 ( 16 ) 129 - 129 2007年10月

PPARγ coactivator 1αのタンパク質レベルでの量、核内局在、転写活性化作用は、ユビキチン・プロテアソーム系を介する分子内相互作用によって制御されている

佐野元昭, 徳留さとり, 吉川賢忠, 清水宣明, 片山隆晴, 遠藤仁, 湯浅慎介, 服部文幸, 牧野伸司, 田中廣壽, 福田恵一

日本ヒト細胞学会学術集会プログラム・抄録 25回 78 - 78 2007年8月

Zac1は心臓発生における必須の転写因子である

湯浅慎介, 鬼塚岳志, 下地顕一郎, 大野洋平, 遠藤仁, 金澤英明, 矢田浩崇, 木村成卓, 川上崇史, 影山智己, 片山隆晴, 荒井隆秀, 村田光繁, 伯野大彦, 木村謙介, 牧野伸司, 佐野元昭, 小川聡, 福田恵一

日本ヒト細胞学会学術集会プログラム・抄録 25回 85 - 85 2007年8月

PE-568 Contribution of Bone Marrow-derived Cells on Pressure Overload-induced Cardiac Hypertrophy and Perivascular Fibrosis in Mice(Regeneration (angiogenesis/myocardial regeneration)-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Endo Jin, Sano Motoaki, Fujita Jun, Hayashida Kentaro, Yuasa Shinsuke, Makino Shinji, Fukuda Keiichi, Ogawa Satoshi

Circulation journal : official journal of the Japanese Circulation Society 71 465 - 466 2007年3月

FRS-035 Pathological Angiogenesis in Human Cardiac Valves is Accompanied by Decreased ChM-I and Augmented VEGF-A and MMP Expression(Pathophysiology of Cardiovascular Disease, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Hakuno Daihiko, Yoshioka Masatoyo, Yuasa Shinsuke, Matsumura Keisuke, Kimura Kensuke, Shiomi Takayuki, Kimura Naritaka, Shukunami Chisa, Okada Yasunori, Mukai Makio, Shin Hankei, Yozu Ryohei, Ogawa Satoshi, Hiraki Yuji, Fukuda Keiichi

Circulation journal : official journal of the Japanese Circulation Society 71 124 - 124 2007年3月

PJ-402 Disruption of Chondromodulin-I Gene, a Potent Angioinhibitory Factor, Causes Aortic Valve Stenosis in Mice(Valvular herat disease/Pericarditis/Cardiac tumor-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Kimura Naritaka, Yuasa Shinsuke, Hakuno Daihiko, Kimura Kensuke, Matsumura Keisuke, Yozu Ryohei, Fukuda Keiichi

Circulation journal : official journal of the Japanese Circulation Society 71 572 - 572 2007年3月

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