Faculty Profiles - NAKAMURA Kazufumi

Papers - NAKAMURA Kazufumi

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Diastolic Dysfunction Is a Risk of Perioperative Myocardial Injury Assessed by High-Sensitivity Cardiac Troponin T in Elderly Patients Undergoing Non-Cardiac Surgery. Reviewed

Hironobu Toda, Kazufumi Nakamura, Koji Nakagawa, Atsuyuki Watanabe, Toru Miyoshi, Nobuhiro Nishii, Kazuyoshi Shimizu, Masao Hayashi, Hiroshi Morita, Hiroshi Morimatsu, Hiroshi Ito

Circulation journal : official journal of the Japanese Circulation Society 82 ( 3 ) 775 - 782 2018.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: High-sensitivity cardiac troponin T (hs-cTnT) is useful for detecting myocardial injury and is expected to become a prognostic marker in patients undergoing non-cardiac surgery. The aim of this pilot study evaluating the efficacy of β-blocker therapy in a perioperative setting (MAMACARI study) was to assess perioperative myocardial injury (PMI) in elderly patients with preserved ejection fraction (EF) undergoing non-cardiac surgery.Methods and Results:In this prospective observational cohort study of 151 consecutive patients with preserved EF and aged >60 years who underwent non-cardiac surgery, serum levels of hs-cTnT were measured before and on postoperative days 1 and 3 after surgery. PMI was defined as postoperative hs-cTnT >0.014 ng/mL and relative hs-cTnT change ≥20%. A total of 36 (23.8%) of the patients were diagnosed as having PMI. The incidence of a composite of cardiovascular events within 30 days after surgery, including myocardial infarction, stroke, worsening heart failure, atrial fibrillation and pulmonary embolism, was significantly higher in patients with PMI than in patients without PMI (odds ratio (OR) 9.25, P<0.001, 95% confidence interval (CI) 2.65-32.3). Multivariate analysis revealed that left ventricular diastolic dysfunction defined by echocardiography was independently associated with PMI (OR: 3.029, 95% CI: 1.341-6.84, P=0.008). CONCLUSIONS: PMI is frequently observed in elderly patients undergoing non-cardiac surgery. Diastolic dysfunction is an independent predictor of PMI.

DOI： 10.1253/circj.CJ-17-0747

PubMed

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Impact of premature activation of the right ventricle with programmed stimulation in Brugada syndrome

Koji Nakagawa, Satoshi Nagase, Hiroshi Morita, Tadashi Wada, Masamichi Tanaka, Masato Murakami, Atsuyuki Watanabe, Nobuhiro Nishii, Kazufumi Nakamura, Kengo F. Kusano, Hiroshi Ito, Tohru Ohe

Journal of Cardiovascular Electrophysiology 29 ( 1 ) 71 - 78 2018.1

顕性蛋白尿をきたした腎動脈狭窄症に対するPTRAの腎保護効果についての検討 Reviewed

戸田洋伸, 内田治仁, 竹内英実, 江尻健太郎, 大塚寛昭, 中川晃志, 渡邊敦之, 西井伸洋, 三好亨, 中村一文, 森田宏, 和田淳, 伊藤浩

脈管学 57 ( Suppl. ) S138 - S138 2017.10

左冠動脈主幹部に起始異常を認め、その物理的圧迫による心筋虚血にて数年間にわたり失神を繰り返した若年者の1症例

網岡尚史, 渡邊敦之, 大塚寛昭, 赤木達, 麻植浩樹, 中川晃志, 中村一文, 森田宏, 小谷恭弘, 新井禎彦, 笠原真悟, 佐野俊二, 伊藤浩

心臓 49 ( Suppl.1 ) 110 - 110 2017.8

チアノーゼ型心疾患術後に生じた肺動静脈瘻のAmplatzer Vascular Plug IIによる塞栓術

三木崇史, 赤木禎治, 高谷陽一, 麻植浩樹, 中川晃志, 中村一文, 森田宏, 伊藤浩

日本成人先天性心疾患学会雑誌 5 ( 1 ) 114 - 114 2016.1

下肢動脈血栓塞栓症に対するEVTと外科的血栓除去の選択について Reviewed

戸田洋伸, 江尻健太郎, 大澤晋, 藤井泰宏, 武本梨佳, 内田治仁, 中村一文, 伊藤浩

脈管学 55 ( Suppl. ) S216 - S216 2015.10

Are beta-blockers effective or contraindicated in pulmonary arterial hypertension?

Kazufumi Nakamura, Hideki Fujio, Satoshi Akagi, Aya Miura, Toshihiro Sarashina, Nobuhiro Nishiand Hiroshi Ito

Recent Developments in Beta-Blockers Research 101 - 108 2015.4

Language：English Publishing type：Part of collection (book) Publisher：Nova Science Publishers, Inc.

Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by progressively elevated pulmonary vascular resistance. Sustained elevation of pulmonary vascular resistance causes severe right ventricular hypertrophy and failure. Sympathetic nerve activity is increased in patients with left ventricular failure, and treatment with beta-adrenergic receptor blockers was found to improve survival rate and cardiac function of patients with left ventricular failure. Sympathetic nerve activity is also increased in patients with PAH. Muscle sympathetic nerve activity in patients with PAH was correlated with heart rate and NYHA class. These findings indicate that treatment with adrenergic receptor blockers may be effective in patients with PAH. However, neurohormonal modulation with beta-adrenergic receptor blockers carries the risks of decreased cardiac contractility and cardiac output. The safety of treatment with beta-adrenergic receptor blockers in clinical settings has been uncertain. Meanwhile, several experimental studies have shown beneficial effects of adrenergic receptor blockers in PAH. Carvedilol inhibited the exaggerated proliferation of pulmonary artery smooth muscle cells of patients with idiopathic PAH. Treatment with carvedilol improved survival of rats with monocrotaline-induced PAH. Bisoprolol also delays progression to right heart failure in rats with PAH. Careful use of beta blockers in selected patients might be beneficial. Further studies are needed to determine whether beta-adrenergic receptor blockers are tolerable and effective in patients with PAH.

Scopus

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Pioglitazone prevents the endothelial dysfunction induced by ischemia and reperfusion in healthy subjects. International journal

Yuka Sakatani, Toru Miyoshi, Hiroki Oe, Yoko Noda, Yuko Ohno, Kazufumi Nakamura, Yukihiro Saito, Kazuhiro Osawa, Hiroshi Morita, Kunihisa Kohno, Hiroshi Ito

Journal of cardiovascular pharmacology 64 ( 4 ) 326 - 31 2014.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: No study has investigated whether pioglitazone (an agonist of peroxisome proliferator-activated receptor gamma) protects against ischemia and reperfusion (IR)-induced endothelial dysfunction in humans. METHODS AND RESULTS: In the first crossover study, 20 volunteers were randomized to 1 week of pioglitazone (30 mg/d, postoperatively) or control (no treatment). In the second single-arm study, 15 volunteers received pioglitazone and the cyclooxygenase-2 inhibitor meloxicam for 1 week. On day 7, endothelium-dependent flow-mediated dilation (FMD) of the distal brachial artery was measured before and after IR (15 minutes of ischemia followed by 15 minutes of reperfusion in the proximal upper arm). Pre-IR brachial-artery diameter and FMD were similar across the 2 sessions (control, pioglitazone) in protocol 1 and between the 2 protocols. IR significantly blunted FMD after no treatment (pre-IR FMD: 10.2% ± 2.6%; post-IR FMD: 3.5% ± 1.9%, P < 0.01) but not after pioglitazone administration (pre-IR FMD: 9.7% ± 2.5%; post-IR FMD: 8.8% ± 2.9%, P = 0.11). This protective effect was accompanied by an increase in serum levels of the antioxidant enzyme extracellular superoxide dismutase and was not affected by concomitant administration of the cyclooxygenase-2 inhibitor meloxicam (P = 0.10). CONCLUSIONS: In humans, pioglitazone provides potent protection against IR-induced endothelial dysfunction.

DOI： 10.1097/FJC.0000000000000124

PubMed

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Omega-3 fatty acids improve postprandial lipemia and associated endothelial dysfunction in healthy individuals - a randomized cross-over trial. International journal

Toru Miyoshi, Yoko Noda, Yuko Ohno, Hiroki Sugiyama, Hiroki Oe, Kazufumi Nakamura, Kunihisa Kohno, Hiroshi Ito

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 68 ( 8 ) 1071 - 7 2014.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Postprandial elevation of triglycerides impairs endothelial function and contributes to the development of atherosclerosis. We investigated the effects of omega-3 fatty acids on postprandial endothelial function and lipid profiles. METHODS: Healthy volunteers [10] were given supplementation at 4g/day omega-3 fatty acids (or were not treated) for 4 weeks in a randomised crossover study. Postprandial levels of various lipids were monitored and endothelial function assessed by brachial artery flow-mediated dilation during fasting and after a standard cookie test. RESULTS: Omega-3 fatty acids reduced postprandial endothelial dysfunction compared with the control diet (flow-mediated dilation at 4h=-0.5±1.2 vs. -2.0±1.6%, P=0.03). Postprandial levels of triglycerides, apolipoprotein B-48, and remnant lipoprotein-cholesterol increased in untreated subjects, peaked at 2-4h, and returned to baseline at 8h, whereas low-density lipoprotein-cholesterol levels did not change. Supplementation with omega-3 fatty acids significantly suppressed postprandial elevation of triglycerides (incremental area under the curve=220±209 vs. 374±216mg/h/dL, P=0.04) and remnant lipoprotein-cholesterol (incremental area under the curve=21.7±13.8 vs. 13.3±12.9mg/h/dL, P=0.04). Supplementation with omega-3 fatty acids significantly suppressed the increase in triglyceride content in chylomicrons as well as in very-low-density lipoproteins from baseline to 4h after the cookie test. CONCLUSION: Omega-3 fatty acids significantly decreased postprandial triglyceride elevation and postprandial endothelial dysfunction, suggesting that omega-3 fatty acids may have vascular protective effects in postprandial state.

DOI： 10.1016/j.biopha.2014.10.008

PubMed

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左室側壁心外膜側に不整脈基質が存在すると考えられたJ波症候群の1例

中川晃志, 永瀬聡, 和田匡史, 田中正道, 西井伸洋, 寒川睦子, 河野晋久, 中村一文, 森田宏, 草野研吾, 伊藤浩, 湯本晃久, 向原直木, 大江透

臨床心臓電気生理 37 127 - 135 2014.5

Language：Japanese Publisher：臨床心臓電気生理研究会

症例は52歳、男性。以前より心電図にて早期再分極が認められていた。心室細動自然発作を来たしたため、当院入院。心電図ではI、II、aVl、aVf、V4-6にJ波を認めた。心臓電気生理学的検査において、多極カテーテルにて経冠静脈的に左室側壁心外膜側の電位を記録すると、単極および双極誘導において体表面心電図のJ波に相当する成分が記録され、この成分は心房頻回刺激およびisoproterenolにて減高し、pilsicainideにて増強を示した。一方、前室間静脈、中心静脈、左室側壁心内膜側からの記録ではJ波に相当する成分は記録されず、また心室プログラム刺激にて心室細動は右室心尖部、右室流出路、左室心内膜側からは誘発されず、左室側壁心外膜側からのみ誘発された。Pilsicainide投与後は左室心外膜側起源と思われる期外収縮が散発し、Brugada型波形は出現しなかった。本例はJ波症候群Type 1+2と考えられ、左室側壁心外膜側の電気的異常が病態の成因に関与することが示唆された興味深い1例と考えられたので報告する。(著者抄録)

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心房中隔欠損症に対するカテーテル閉鎖術下大静脈縁の有無による治療成績の検討

木島康文, 赤木禎治, 中川晃志, 高谷陽一, 池田まどか, 渡辺修久, 麻植浩樹, 中村一文, 伊藤浩

超音波医学 41 ( Suppl. ) S715 - S715 2014.4

食道再建後の心房中隔欠損症に対してカテーテル閉鎖術を施行した一例

木島康文, 赤木禎治, 中川晃志, 高谷陽一, 池田まどか, 渡辺修久, 麻植浩樹, 中村一文, 伊藤浩

超音波医学 41 ( Suppl. ) S721 - S721 2014.4

心臓突然死予知への挑戦サルコイドーシスにおけるlateral領域のfragmented QRSは心室頻拍の予測因子となる

武寛, 森田宏, 伴場主一, 廣畑敦, 中村一文, 草野研吾, 山本桂三, 大江透, 伊藤浩

心電図 34 ( Suppl.2 ) S - 35 2014.3

卵円孔開存に対するAmplatzer PFO Occluderを用いたカテーテル閉鎖術

木島康文, 赤木禎治, 中川晃志, 高谷陽一, 上岡亮, 麻植浩樹, 中村一文, 佐野俊二, 伊藤浩

日本成人先天性心疾患学会雑誌 3 ( 1 ) 80 - 80 2014.1

A successful epicardial ablation from the middle cardiac vein for ventricular tachycardia with prior inferior myocardial infarction

Wada Tadashi, Nagase Satoshi, Tanaka Masamichi, Nakagawa Koji, Nishii Hironobu, Kohno Yoshihisa, Nakamura Kazufumi, Morita Hiroshi, Ito Hiroshi

Shinzo 46 ( 3 ) S3_203 - S3_211 2014

An unsuccessful case of PAH-specific therapy in patient with pulmonary hypertension associated with ventricular septal defect

Akagi Satoshi, Sarashina Toshihiro, Kusano Kengo, Suzuki Hideyuki, Nakamura Kazufumi, Ito Hiroshi

Shinzo 46 ( 6 ) 812 - 815 2014

右室単発早期刺激により明瞭なcoved型そしてsaddleback型心電図が得られたBrugada症候群の1例

中川晃志, 永瀬聡, 和田匡史, 田中正道, 西井伸洋, 渡邊敦之, 中村一文, 森田宏, 河野晋久, 草野研吾, 大江透, 伊藤浩

心臓 45 ( Suppl.3 ) 143 - 148 2013.12

Language：Japanese Publisher：(公財)日本心臓財団

症例は62歳、男性。早朝の苦悶様呼吸に続く呼吸停止疑いのため近医受診し、Brugada症候群疑いにて当院紹介入院。心電図では完全右脚ブロックを合併することもありBrugada型心電図との診断が容易ではなかった。電気生理学的検査時、ピルジカイニド1mg/kgを投与したが、やはり明瞭なBrugada型波形が得られないため、完全右脚ブロックの状態を是正する目的で右室心尖部より単発早期刺激を加えた。すると刺激間隔の短縮に伴いcoved型そしてsaddleback型の比較的明瞭なBrugada型心電図を得ることができた。完全右脚ブロックを伴いBrugada型心電図の診断が困難であったが右室心尖部単発早期断激によりBrugada型心電図が明瞭化され、また、相対的な右室伝導遅延の改善に伴いcoved型からsaddleback型に心電図が変化したBrugada症候群の1例を経験したので報告する。(著者抄録)

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2013&ichushi_jid=J00679&link_issn=&doc_id=20131216220028&doc_link_id=10.11281%2Fshinzo.45.S3_143&url=https%3A%2F%2Fdoi.org%2F10.11281%2Fshinzo.45.S3_143&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

LQT1において血清カリウム値がQT間隔および不整脈イベントに及ぼす影響

杉山洋樹, 中村一文, 森田宏, 三浦大志, 永瀬聡, 河野晋久, 草野研吾, 大江透, 伊藤浩

心電図 33 ( Suppl.4 ) S - 194 2013.9

うっ血性心不全に対するトルバプタンの効果予測因子に関する検討

戸田洋伸, 中村一文, 渡邊敦之, 中濱一, 寺坂律子, 草野研吾, 伊藤浩

日本心臓病学会誌 8 ( Suppl.I ) 299 - 299 2013.9

CPAを発症したLQTS症例の臨床像の特徴

寒川睦子, 森田宏, 河野晋久, 永瀬聡, 西井伸洋, 中村一文, 草野研吾, 伊藤浩, 大江透, 氏家良人

心電図 33 ( Suppl.4 ) S - 172 2013.9

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Papers - NAKAMURA Kazufumi