Faculty Profiles - HANAYAMA Yoshihisa

Papers - HANAYAMA Yoshihisa

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【DIHS】臨床例 DIHS発症後皮膚にGVHD様反応が長期に続いた例 Reviewed

三宅智子, 木村摩耶, 花山宜久, 青山裕美, 岩月啓氏, 森実真

皮膚病診療 41 ( 3 ) 245 - 248 2019.3

Changes in Serum Biochemical Markers in Relation to Chief Complaints and Aging in General Medicine. Reviewed

Daisuke Omura, Asuka Sato, Kosuke Oka, Yoshihisa Hanayama, Hiroko Ogawa, Mikako Obika, Fumio Otsuka

Acta medica Okayama 72 ( 6 ) 553 - 562 2018.12

Language：English Publishing type：Research paper (scientific journal)

To clarify potential relationships between chief complaints of patients and laboratory data with a focus on aging-related changes, we retrospectively analyzed the data of 843 patients who visited a general medicine department for the first time. Their chief complaints were classified into 8 major symptoms: visceral pain, somatic pain, fever, cough, dizziness, fatigue, appetite loss, and edema. We compared the laboratory data obtained from the patients with complaints with the data of symptom-free (control) patients. The serum sodium and potassium levels in the fever group were decreased compared to those in the control group. In the fever group, the serum sodium level was inversely correlated with age. The ratio of serum urea nitrogen to creatinine (UN/Cr) was increased in the appetite-loss group. There were significant age-dependent increases in the UN/Cr ratio in the appetite-loss and edema groups. Of note, serum levels of free thyroxin were lower in the dizziness group compared to the control group. In addition, the free thyroxin level was inversely correlated with age in the dizziness group but not in the asymptomatic control group. Collectively, the results indicated that osmolality-related laboratory data are strongly associated with individual primary symptoms at the first visit regardless of the final diagnosis. The consideration of age-dependent changes of these markers is helpful for diagnosing latent disorders based on various primary symptoms.

DOI： 10.18926/AMO/56372

PubMed

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巨大な機能性甲状腺結節にBasedow病を合併した1例

塩飽孝宏, 安田美帆, 岡浩介, 長谷川功, 三好智子, 小比賀美香子, 花山宜久, 片岡仁美, 大塚文男

日本病院総合診療医学会雑誌 14 ( 6 ) 617 - 617 2018.11

Clinical Characteristics of Febrile Outpatients : Possible Involvement of Thyroid Dysfunction in Febrile Tachycardia. Reviewed

Kosuke Oka, Yoshihisa Hanayama, Asuka Sato, Daisuke Omura, Miho Yasuda, Ko Hasegawa, Mikako Obika, Fumio Otsuka

Acta medica Okayama 72 ( 5 ) 447 - 456 2018.10

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

We retrospectively analyzed the cases of 148 febrile patients whose body temperature (BT) was ≥ 37.5°C at our hospital. We categorized them into seven groups; those with bacterial and viral infection, nonspecific inflammation, neoplasm, connective tissue disease (CTD), drug-induced disease, and unidentified causes. Our analysis revealed that the patient's BT at the 1st visit (BT-1st visit) and highest BT during the febrile period (BT-max) differed significantly among all categories except neoplasm. The greatest difference between BT-1st visit and BT-max was highest in the CTD group (1.5°C). Positive correlations of heart rate and C-reactive protein (CRP) level with BT-max and a negative correlation between serum sodium level with BT-max were uncovered. The serum thyroid-stimulating hormone (TSH) level and the ratio of TSH/free thyroxine were negatively correlated with BT-max, especially in the viral infection group, suggesting the existence of occult thyrotoxicosis in accord with a febrile condition, possibly leading to febrile tachycardia. A febrile gap between BT-1st visit and BT-max (except in the neoplasm group) was shown, in which BT-max was correlated with thyroid function. Clinicians should recognize the fluctuation of BT when diagnosing febrile patients, and tachycardia in such febrile patients may be, at least in part, associated with subclinical thyroid dysfunction.

DOI： 10.18926/AMO/56242

PubMed

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Enterovaginal and colovesical fistulas as late complications of pelvic radiotherapy Reviewed

Masaya Iwamuro, Kou Hasegawa, Yoshihisa Hanayama, Hitomi Kataoka, Takehiro Tanaka, Yoshitaka Kondo, Fumio Otsuka

Journal of General and Family Medicine 19 ( 5 ) 166 - 169 2018.9

巨大な甲状腺腫を呈したMarine-Lenhart症候群の1例

安田美帆, 岡浩介, 長谷川功, 三好智子, 小比賀美香子, 花山宜久, 枝園忠彦, 大塚文男

日本内分泌学会雑誌 94 ( 2 ) 696 - 696 2018.9

外来発熱患者における体温の特徴と頻脈及び臨床パラメーターとの関連

岡浩介, 花山宜久, 小比賀美香子, 片岡仁美, 大塚文男

日本病院総合診療医学会雑誌 14 ( 4 ) 388 - 388 2018.7

Clinical relevance of low androgen to gastroesophageal reflux symptoms Reviewed

Ko Harada, Yoshihisa Hanayama, Miho Yasuda, Kou Hasegawa, Mikako Obika, Hitomi Kataoka, Koichi Itoshima, Ken Okada, Fumio Otsuka

Endocrine Journal 65 ( 10 ) 1039 - 1047 2018

バセドウ病の増悪を契機に中枢性尿崩症を来した1例

中道晶子, 大重和樹, 岡浩介, 安田美帆, 長谷川功, 小比賀美香子, 花山宜久, 頼冠名, 大塚文男

日本内分泌学会雑誌 93 ( 4 ) 1232 - 1232 2017.12

The Clinical and Hormonal Characteristics of Primary Adrenal Lymphomas: The Necessity of Early Detection of Adrenal Insufficiency Reviewed

Ko Harada, Kosuke Kimura, Masaya Iwamuro, Tomohiro Terasaka, Yoshihisa Hanayama, Eisei Kondo, Eiko Hayashi, Tadashi Yoshino, Fumio Otsuka

Internal Medicine 56 ( 17 ) 2261 - 2269 2017.9

Successful treatment with glucocorticoid for secondary Fanconi syndrome caused by sarcoidosis

Daisuke Omura, Hideharu Hagiya, Yoshihisa Hanayama, Kou Hasegawa, Hiroshi Morinaga, Atsue Kikuta, Hitomi Kataoka, Fumio Otsuka

Modern Rheumatology 27 ( 3 ) 545 - 547 2017.5

Practical efficacy of olmesartan versus azilsartan in patients with hypertension Reviewed

Yuki Kakio, Haruhito A. Uchida, Ryoko Umebayashi, Hidemi Takeuchi, Yuka Okuyama, Yoshihisa Hanayama, Jun Wada

Blood Pressure Monitoring 22 ( 2 ) 59 - 67 2017.4

Idiopathic adult ileo-colonic intussusception Reviewed

Masaya Iwamuro, Takahiro Nada, Kosuke Kimura, Yoshihisa Hanayama, Fumio Otsuka

Journal of General and Family Medicine 18 ( 2 ) 94 - 95 2017.4

Paroxysmal Hypertension Induced by an Insulinoma Reviewed

Ko Harada, Yoshihisa Hanayama, Kou Hasegawa, Masaya Iwamuro, Hideharu Hagiya, Ryuichi Yoshida, Fumio Otsuka

Internal Medicine 56 ( 4 ) 413 - 417 2017.4

Hypersensitivity Pneumonitis Caused by a Home Ultrasonic Humidifier Contaminated with <i>Candida guilliermondii</i> Reviewed

Akemi Ando, Hideharu Hagiya, Takahiro Nada, Kosuke Kimura, Koichi Waseda, Kammei Rai, Yoshihisa Hanayama, Fumio Otsuka

Internal Medicine 56 ( 22 ) 3109 - 3112 2017

A Rare Case of Diffuse Large B-cell Lymphoma in a Patient with IgG4-Related Autoimmune Pancreatitis Reviewed

Nishimura Yoshito, Iwamuro Masaya, Ocho Kazuki, Hasegawa Kou, Kimura Kosuke, Hanayama Yoshihisa, Kondo Eisei, Tanaka Takehiro, Otsuka Fumio

Acta Medica Okayama 70 ( 4 ) 279 - 283 2016.8

Reactivation of Human Herpes Virus-6 in the Renal Tissue of a Patient with Drug-induced Hypersensitivity Syndrome/Drug Rash with Eosinophilia and Systemic Symptoms (DIHS/DRESS) Reviewed

Hideharu Hagiya, Masaya Iwamuro, Takehiro Tanaka, Kou Hasegawa, Yoshihisa Hanayama, Maya Kimura, Fumio Otsuka

Internal Medicine 55 ( 13 ) 1769 - 1774 2016.7

Increased Serum KL-6 Levels Induced by Pulmonary Mycobacterium Avium Complex Infection in a Patient with RA-associated Lung Disease Reviewed

Waseda Koichi, Ocho Kazuki, Hasegawa Kou, Kimura Kosuke, Iwamuro Masaya, Hanayama Yoshihisa, Kondo Eisei, Miyahara Nobuaki, Otsuka Fumio

Acta Medica Okayama 70 ( 3 ) 217 - 221 2016.6

An Uncommon Manifestation of Fitz-Hugh-Curtis Syndrome with Right-side Chest Pain Reviewed

Harada Ko, Iwamuro Masaya, Hanayama Yoshihisa, Otsuka Fumio

Acta Medica Okayama 70 ( 2 ) 145 - 149 2016.4

Pheochromocytoma Manifesting Persistent Right Shoulder Pain and Hypochondralgia

Hideharu Hagiya, Eri Nakamura, Tomohiro Terasaka, Kou Hasegawa, Kikuko Asano, Takahiro Nada, Kosuke Kimura, Koichi Waseda, Yoshihisa Hanayama, Fumio Otsuka

Journal of General and Family Medicine 16 ( 4 ) 292 - 296 2015.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley-Blackwell

We report a 42-year-old female who initially complained of sub-acute onset of right upper quadrant abdominal pain with right shoulder pain. A CT scan incidentally revealed an adrenal tumor, and a final diagnosis of pheochromocytoma was made on the basis of endocrinological examinations. Symptomatically, the pheochromocytoma in our patient mimicked a hepato-biliary disease by presenting abdominal pain accompanying right shoulder pain that was assumed to be referred pain via the right phrenic nerve. Physicians may need to consider the possibility of pheochromocytoma in patients with abdominal symptoms.

DOI： 10.14442/jgfm.16.4_292

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Papers - HANAYAMA Yoshihisa