Faculty Profiles - HANAYAMA Yoshihisa

Papers - HANAYAMA Yoshihisa

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新型コロナワクチン3回目接種後に菊池病を発症した1例

目瀬修, 山本幸近, 福島伸乃介, 大國皓平, 長谷川功, 萩谷英大, 花山宜久, 大塚文男

日本病院総合診療医学会雑誌 18 ( 臨増2 ) 210 - 210 2022.8

コロナ罹患後症状の特徴と内分泌機能の変化に関する検討

砂田匠彦, 本多寛之, 中野靖浩, 山本絋一郎, 徳増一樹, 櫻田泰江, 松田祐依, 長谷川徹, 大塚勇輝, 小比賀美香子, 花山宜久, 萩谷英大, 植田圭吾, 片岡仁美, 大塚文男

日本病院総合診療医学会雑誌 18 ( 臨増2 ) 244 - 244 2022.8

新型コロナワクチン3回目接種後に菊池病を発症した1例

目瀬修, 山本幸近, 福島伸乃介, 大國皓平, 長谷川功, 萩谷英大, 花山宜久, 大塚文男

日本病院総合診療医学会雑誌 18 ( 臨増2 ) 210 - 210 2022.8

Influence of protein intake on the changes in skeletal muscle mass after kidney transplantation. International journal

Akihiro Kosoku, Tomoaki Iwai, Takuma Ishihara, Kazuya Kabei, Shunji Nishide, Keiko Maeda, Yoshiko Hanayama, Eiji Ishimura, Junji Uchida

Clinical nutrition (Edinburgh, Scotland) 41 ( 9 ) 1881 - 1888 2022.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND & AIMS: Skeletal muscle mass decreases in patients with chronic kidney disease, especially those on dialysis with end-stage kidney disease. On the other hand, the recovery of renal function due to successful kidney transplantation (KT) improves skeletal muscle mass loss. However, low protein intake may influence the changes in skeletal muscle mass after KT. The aim of the present study is to examine the association of the changes in skeletal muscle mass with protein intake in kidney transplant recipients (KTRs). METHODS: A cohort study was conducted in KTRs and living-kidney donors (LKDs). Skeletal muscle mass index (SMI) was measured using bioelectrical impedance analysis before KT and at 1 month and 12 months after KT. Protein intake was calculated with 24-h urine urea nitrogen from the Maroni formula at 12 months after KT. To evaluate the association between protein intake and the changes in SMI during the first year after KT, we performed a multivariable regression analysis adjusted for covariates including age, sex, cumulative glucocorticoids, cumulative hospitalization, diabetes mellitus, and SMI before KT. RESULTS: In KTRs (n = 64), the median SMI was 7.26 kg/m2 before KT, which decreased to 7.01 kg/m2 at 1 month after KT and increased to 7.55 kg/m2 at 12 months after KT. In LKDs (n = 17), the median SMI was 6.24 kg/m2 before KT which increased to 6.40 kg/m2 at 1 month after KT and further increased to 6.95 kg/m2 at 12 months after KT. The changes in SMI during the 1-year period after KT exhibited a positive correlation with protein intake (p = 0.015) after adjustment. The predicted value of protein intake in KTRs, whose values of SMI before KT and at 12 months after KT were the same, was 0.72 g/kg ideal body weight (IBW)/day using the multivariable non-linear regression model. CONCLUSIONS: In KTRs, insufficient protein intake adversely affected the recovery from skeletal muscle mass loss after KT. Therefore, a protein intake of at least more than 0.72 g/kg IBW/day, the predicted value obtained in the present study, might be recommended for KTRs suffering from skeletal muscle mass loss.

DOI： 10.1016/j.clnu.2022.07.028

PubMed

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Takayasu Arteritis Mimicking Phlegmon Reviewed

Yuki Taira, Yasuhiro Nakano, Yoshihisa Hanayama, Fumio Otsuka

Internal Medicine 2022.6

Droopy eyelid due to IgG4-related dacryoadenitis. Reviewed

Takase R, Hagiya H, Tokumasu K, Nishimura Y, Sakurai A, Hasegawa K, Hanayama Y, Otsuka F.

Postgraduate Medical Journal 97 ( 1147 ) 333 - 334 2022.5

Clinical utility of urinary levels of catecholamines and their fraction ratios related to heart rate and thyroid function Reviewed

Naruhiko Sunada, Yoshihisa Hanayama, Koichiro Yamamoto, Yasuhiro Nakano, Takahiro Nada, Hiroyuki Honda, Kou Hasegawa, Hideharu Hagiya, Fumio Otsuka

Endocrine Journal 69 ( 4 ) 417 - 425 2022.4

Relationship between patients’ characteristics and efficacy of calcimimetics for primary hyperparathyroidism in the elderly Reviewed

Koichiro Yamamoto, Yasuhiro Nakano, Kazuki Tokumasu, Hiroyuki Honda, Kou Hasegawa, Asuka Sato, Hiroko Ogawa, Mikako Obika, Yoshihisa Hanayama, Fumio Otsuka

Clinical Case Reports 10 ( 4 ) 2022.4

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

Calcimimetic treatment has been reported to be effective for primary hyperparathyroidism (PHPT). Nine elderly PH PT patients who had been treated with calcimimetics were retrospectively analyzed. It was found that calcimimetics can reduce elevated serum calcium levels in elderly PHPT patients with low femoral DEXA %YAM and low urinary cAMP levels.

DOI： 10.1002/ccr3.5713

Web of Science

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ccr3.5713

精巣副腎遺残腫瘍に関連し性腺機能低下を来した21-水酸化酵素欠損症の2例

山本紘一郎, 本多寛之, 中野靖浩, 徳増一樹, 長谷川功, 小比賀美香子, 花山宜久, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 401 - 401 2022.4

原発性副甲状腺機能亢進症に対するカルシウム受容体作動薬の効果と関連因子

山本紘一郎, 中野靖浩, 徳増一樹, 本多寛之, 長谷川功, 小比賀美香子, 三好智子, 小川弘子, 花山宜久, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 374 - 374 2022.4

21-水酸化酵素欠損症(21-OHD)の経過中に性腺機能低下を生じた2例から

山本紘一郎, 本多寛之, 中野靖浩, 徳増一樹, 長谷川功, 小比賀美香子, 花山宜久, 大塚文男

ACTH RELATED PEPTIDES 33 17 - 18 2022.4

21-水酸化酵素欠損症(21-OHD)の経過中に性腺機能低下を生じた2例から

山本紘一郎, 本多寛之, 中野靖浩, 徳増一樹, 長谷川功, 小比賀美香子, 花山宜久, 大塚文男

ACTH RELATED PEPTIDES 33 17 - 18 2022.4

Detection of Male Hypogonadism in Patients with Post COVID-19 Condition Reviewed

Yukichika Yamamoto, Yuki Otsuka, Naruhiko Sunada, Kazuki Tokumasu, Yasuhiro Nakano, Hiroyuki Honda, Yasue Sakurada, Hideharu Hagiya, Yoshihisa Hanayama, Fumio Otsuka

Journal of Clinical Medicine 11 ( 7 ) 1955 - 1955 2022.3

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

The pathogenesis and prognosis of post COVID-19 condition have remained unclear. We set up an outpatient clinic specializing in long COVID in February 2021 and we have been investigating post COVID-19 condition. Based on the results of our earlier study showing that “general fatigue” mimicking myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is the most common symptom in long COVID patients, a retrospective analysis was performed for 39 male patients in whom serum free testosterone (FT) levels were measured out of 61 male patients who visited our clinic. We analyzed the medical records of the patients’ backgrounds, symptoms and laboratory results. Among the 39 patients, 19 patients (48.7%) met the criteria for late-onset hypogonadism (LOH; FT < 8.5 pg/mL: LOH group) and 14 patients were under 50 years of age. A weak negative correlation was found between age and serum FT level (r = −0.301, p = 0.0624). Symptoms including general fatigue, anxiety, cough and hair loss were more frequent in the LOH group than in the non-LOH group (FT ≥ 8.5 pg/mL). Among various laboratory parameters, blood hemoglobin level was slightly, but significantly, lower in the LOH group. Serum level of FT was positively correlated with the levels of blood hemoglobin and serum total protein and albumin in the total population, whereas these interrelationships were blurred in the LOH group. Collectively, the results indicate that the incidence of LOH is relatively high in male patients, even young male patients, with post COVID-19 and that serum FT measurement is useful for revealing occult LOH status in patients with long COVID.

DOI： 10.3390/jcm11071955

Web of Science

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非機能性下垂体腺腫を伴った偽性クッシング症候群の1例

山本紘一郎, 花山宜久, 中野靖浩, 大村大輔, 本多寛之, 長谷川功, 大塚文男

日本内分泌学会雑誌 97 ( 5 ) 1262 - 1262 2022.3

非機能性下垂体腺腫を伴った偽性クッシング症候群の1例

山本紘一郎, 花山宜久, 中野靖浩, 大村大輔, 本多寛之, 長谷川功, 大塚文男

日本内分泌学会雑誌 97 ( 5 ) 1262 - 1262 2022.3

Serial Changes of Long COVID Symptoms and Clinical Utility of Serum Antibody Titers for Evaluation of Long COVID Reviewed

Yasue Sakurada, Naruhiko Sunada, Hiroyuki Honda, Kazuki Tokumasu, Yuki Otsuka, Yasuhiro Nakano, Yoshihisa Hanayama, Masanori Furukawa, Hideharu Hagiya, Fumio Otsuka

Journal of Clinical Medicine 11 ( 5 ) 1309 - 1309 2022.2

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Background: Various symptoms persist even after the acute symptoms in about one third of patients with COVID-19. In February 2021, we established an outpatient clinic in a university hospital for patients with long COVID and started medical treatment for sequelae that persisted one month or more after infection. Methods: To determine the key factors that affect the onset and clinical course of sequelae, a retrospective analysis was performed at Okayama University Hospital (Japan) between February and July 2021. We focused on changes in the numbers of symptoms and the background of the patients during a three-month period from the first outpatient visit. We also examined the relationship with SARS-CoV-2 antibody titers. Results: Information was obtained from medical records for 65 patients. The symptoms of sequelae were diverse, with more than 20 types. The most frequent symptoms were general malaise, dysosmia, dysgeusia, sleeplessness, and headache. These symptoms improved in about 60% of the patients after 3 months. Patients who required hospitalization and had a poor condition in the acute phase and patients who received oxygen/dexamethasone therapy had higher antibody titers at the time of consultation. Patients with antibody titers ≥200 U/mL showed significantly fewer improvements in long COVID symptoms in 1 month, but they showed improvements at 3 months after the first visit. Conclusion: Long COVID symptoms were improved at 3 months after the initial visit in more than half of the patients. Serum antibody titers were higher in patients who experienced a severe acute phase, but the serum antibody titers did not seem to be directly related to the long-term persistence of long COVID symptoms.

DOI： 10.3390/jcm11051309

Web of Science

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Aging-related Characteristics of Subclinical Hypothyroidism Detected in General Practice.

Masao Takami, Koichiro Yamamoto, Yoshihisa Hanayama, Yasuhiro Nakano, Kou Hasegawa, Mikako Obika, Hideharu Hagiya, Masanori Furukawa, Fumio Otsuka

Acta medica Okayama 76 ( 1 ) 7 - 15 2022.2

Language：English Publishing type：Research paper (scientific journal)

Subclinical hypothyroidism (SCH) is diagnosed when serum thyrotropin (TSH) is elevated despite a normal thyroxine level and is known to increase the risk of metabolic disorders. This study was conducted to identify potential laboratory markers suspicious for latent SCH. We retrospectively reviewed 958 outpatients in whom thyroid functions had been examined. Eighty-five (9.1%) of the 939 analyzed subjects had SCH (73% females). In the SCH group, median serum TSH and FT4 levels were 5.04 μU/ml and 1.19 ng/dl, respectively, and auto-thyroid antibodies were detected in 53.8% of patients. SCH group patients were significantly older than patients in the euthyroid group, while there was no intergroup difference in BMI. However, 56.5% of the SCH patients were asymptomatic. In the SCH group, serum aspartate aminotransferase and low-density lipoprotein cholesterol (LDL-C) levels were significantly higher, and the estimated glomerular filtration rate (eGFR) was significantly lower than in the euthyroid group. Among patients less than 65 years of age, SCH patients tended to have lower eGFR and higher LDL-C than euthyroid patients. Age-dependent reductions of red blood cells and serum albumin were more prominent in the SCH than the euthyroid group. Biochemical changes with aging are useful as potential clues for suspecting latent SCH.

DOI： 10.18926/AMO/63203

PubMed

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カルシウム受容体作動薬で治療した原発性副甲状腺機能亢進症患者の臨床的特徴

山本紘一郎, 中野靖浩, 徳増一樹, 本多寛之, 長谷川功, 小比賀美香子, 三好智子, 小川弘子, 花山宜久, 大塚文男

日本内科学会雑誌 111 ( Suppl. ) 173 - 173 2022.2

蓄尿中カテコールアミン比測定の有用性と臨床的意義の検討

砂田匠彦, 花山宜久, 灘隆宏, 徳増一樹, 山本紘一郎, 中野靖浩, 長谷川功, 萩谷英大, 小比賀美香子, 大塚文男

日本病院総合診療医学会雑誌 18 ( 臨増1 ) O - 083 2022.2

蓄尿中カテコールアミン比測定の有用性と臨床的意義の検討

砂田匠彦, 花山宜久, 灘隆宏, 徳増一樹, 山本紘一郎, 中野靖浩, 長谷川功, 萩谷英大, 小比賀美香子, 大塚文男

日本病院総合診療医学会雑誌 18 ( 臨増1 ) O - 083 2022.2

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