Faculty Profiles - HANAYAMA Yoshihisa

Papers - HANAYAMA Yoshihisa

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大塚勇輝, 西村義人, 原田洸, 岡浩介, 長谷川功, 小川弘子, 三好智子, 花山宜久, 枝園忠彦, 平沢晃, 大塚文男

日本内分泌学会雑誌 96 ( 2 ) 549 - 549 2020.10

Clinical and biochemical characteristics of patients having general symptoms with increased serum IgG4 Reviewed

Kou Hasegawa, Yoshihisa Hanayama, Mikako Obika, Tomoko Miyoshi, Hiroko Ogawa, Eisei Kondo, Hitomi Kataoka, Yasuharu Sato, Fumio Otsuka

Modern Rheumatology 30 ( 4 ) 721 - 728 2020.7

Authorship：Corresponding author Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

Objective: To differentiate patients with IgG4-related diseases (RD) from patients with other hyper IgG4 conditions who visit general medicine department. Methods: Fifty-six patients with high serum IgG4 levels (>135 mg/dL) were classified into three groups based on the final diagnosis: definite and possible IgG4-RD and others. Clinical and laboratory characteristics of the three groups of patients were retrospectively analyzed. Results: Major manifestations were renal dysfunction and general malaise, while thirst was the most frequent symptom in the definite group, in which submandibular glands and lymph nodes were likely to be affected. Biopsy of minor salivary glands was the least diagnostic for IgG4-RD despite the high frequency of biopsy. In the definite group, serum levels of IgG4 and IgG, IgG4/IgG ratio and basophil number were increased, while serum levels of CRP, IgA and complements were decreased. A negative correlation between serum levels of IgG4 and IgM was found in the definite group. Conclusion: The results indicated that in patients with renal dysfunction, malaise, thirst or weight loss, measurements of the levels of basophils, immunoglobulins and complements are helpful for diagnosing IgG4-RD. Considering distribution of affected tissues and localization of diagnostic biopsies, physical examination and laboratory workup are required for early diagnosis.

DOI： 10.1080/14397595.2019.1642291

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【総合診療から高齢者医療の在り方を探る】総合診療医育成の場で行う老年医学教育 Invited

花山宜久, 横田雄也, 萩谷英大, 小比賀美香子, 大塚文男

Geriatric Medicine 58 ( 7 ) 591 - 598 2020.7

Comparison of the clinical characteristics of TAFRO syndrome and idiopathic multicentric Castleman disease in general internal medicine: a 6‐year retrospective study Reviewed

Yoshito Nishimura, Yoshihisa Hanayama, Nobuharu Fujii, Eisei Kondo, Fumio Otsuka

Internal Medicine Journal 50 ( 2 ) 184 - 191 2020.2

Clinical Relevance of Blood Glucose and Gastroesophageal Reflux Symptoms to Depressive Status in Patients with Type 2 Diabetes Mellitus. Reviewed

Hiroyuki Honda, Yoshihisa Hanayama, Mikako Obika, Kou Hasegawa, Jun Hamahara, Masayuki Kishida, Hideharu Hagiya, Hiroko Ogawa, Hitomi Kataoka, Fumio Otsuka

Acta medica Okayama 74 ( 1 ) 33 - 40 2020.2

Language：English Publishing type：Research paper (scientific journal)

A relationship between diabetes and depression is apparent. To clarify the clinical relevance of diabetic patients' gastroesophageal symptoms to their psychological status, we retrospectively analyzed the data from a Selfrating Depression Scale (SDS) and a Frequency Scale for Symptoms of Gastroesophageal reflux disease (FSSG) among 143 type 2 diabetic patients who visited a general medicine department. Among the 45 Japanese patients enrolled, the group with relatively high SDS scores (≥ 36) showed higher (FSSG) dysmotility symptom scores versus the low-SDS (< 36) group, although the 2 groups' characteristics and laboratory data were not significantly different. Positive correlations of postprandial plasma glucose (PPG) levels with FSSG scores (R=0.321, p<0.05), particularly with reflux scores (R=0.455, p<0.01) were revealed. PPG and HbA1c levels were not correlated with SDS scores. The patients' SDS scores were significantly correlated with their FSSG scores (R=0.41, p<0.01), suggesting that depressive status is linked to GERD-related manifestations. Considering that the patients' PPG levels were correlated with GERD-related symptoms, diabetic patients' blood glucose levels are associated with depressive status. Collectively, key symptoms related to GERD and glucose level values would be helpful.

DOI： 10.18926/AMO/57950

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数年来,慢性疲労症候群として加療されていたACTH単独欠損症の1例

筒井ほのか, 徳増一樹, 原田洸, 安田美帆, 長谷川功, 萩谷英大, 花山宜久, 大塚文男

日本病院総合診療医学会雑誌 16 ( 臨増1 ) 113 - 113 2020.2

繰り返しセルブロック標本を作製することにより原発性滲出性リンパ腫様リンパ腫と診断した1例

長谷井稜子, 佐住洋祐, 徳増一樹, 長谷川功, 萩谷英大, 藤井伸治, 花山宜久, 大塚文男

日本病院総合診療医学会雑誌 16 ( 臨増1 ) 166 - 166 2020.2

Correlations between Depressive Condition and Gastroesophageal Reflux Symptoms in Patients Visiting a Department of General Medicine. Reviewed

Yu Suganami, Kosuke Oka, Yoshihisa Hanayama, Hiroyuki Honda, Jun Hamahara, Mikako Obika, Kazuya Kariyama, Masayuki Kishida, Fumio Otsuka

Acta medica Okayama 73 ( 6 ) 479 - 486 2019.12

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

To clarify the potential relevance of patients' chief complaints at a general medicine department to their self-rating depression scale (SDS) and frequency scale for symptoms of gastroesophageal reflux disease (GERD) (FSSG) scores, we analyzed data of 478 patients who visited our general medicine department. The chief complaints (553 symptoms of 447 patients) were categorized into major symptom-based groups: respiratory (31%), circulatory (3%), gastrointestinal (GI) tract (26%), neurology (8%), orthopedic and skin (10%), and systemic (22%) symptoms. The SDS score tended to be higher in females and younger patients. The FSSG score did not differ by gender but was higher in younger patients. The patients receiving social welfare had higher SDS and FSSG scores. A close inter-relationship between the FSSG (including both degrees of reflux and dysmotility) and SDS was observed in all patients. Although the averages of the SDS and FSSG scores were not significantly different among the symptom-based categories, we observed significantly positive correlations between the FSSG and SDS in each category, suggesting that depressive status may be closely related to GERD-related symptoms regardless of the patients' chief complaints. An initial checkup of patients' psychological condition and/or GERD-like symptoms could help screen for latent disorders in outpatients with uncertain complaints.

DOI： 10.18926/AMO/57711

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治療抵抗性リンパ増殖性好酸球増多症候群の1例 Reviewed

加藤あずさ, 三宅智子, 濱田利久, 花山宜久, 森実真, 岩月啓氏

臨床皮膚科 73 ( 12 ) 983 - 989 2019.11

侵襲性肺炎球菌感染症の治療中に発症した感染性腹部大動脈瘤の一例

福島伸乃介, 原田洸, 徳増一樹, 長谷川功, 萩谷英大, 花山宜久, 大塚文男

日本病院総合診療医学会雑誌 15 ( 6 ) 587 - 587 2019.11

リンパ節の再生検からHodgkinリンパ腫の診断に至った不明熱の1例

荒木晴, 徳増一樹, 原田洸, 山本晃, 高原政宏, 長谷川功, 萩谷英大, 花山宜久, 大塚文男

日本病院総合診療医学会雑誌 15 ( 6 ) 602 - 602 2019.11

Risk Factors for Low Bone Mineral Density Determined in Patients in a General Practice Setting. Reviewed

Akemi Ando, Toshiharu Mitsuhashi, Mitsugi Honda, Yoshihisa Hanayama, Kou Hasegawa, Mikako Obika, Hitomi Kataoka, Fumio Otsuka

Acta medica Okayama 73 ( 5 ) 403 - 411 2019.10

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

Osteoporosis increases the risk of bone fractures. It is diagnosed based on an individual's bone mineral density (BMD) or a fracture without trauma. BMD is usually measured by the dual energy X-ray absorptiometry (DXA) method. Here we investigated factors for the earliest possible prediction of decreased BMD by examining the relationships between patients' BMD values and changes in the patients' physical and laboratory values. We retrospectively reviewed the medical records of 149 patients who visited our department in 2014-2015 for a variety of reasons and underwent an area BMD examination by DXA. We analyzed the relationships between decreasing BMD and the patients' gender, age, body mass index (BMI), medical background, hemoglobin, electrolytes, and thyroid function. Thirty-nine of the patients were diagnosed with osteoporosis based on their T-scores. An adjusted analysis showed that female gender, aging, and increased serum calcium level were significantly related to decreasing femoral BMD, whereas high BMI was associated with an increase in femoral BMD. Collectively the results indicate that for the early detection of low BMD, it is important for general-practice physicians to consider conducting a BMD checkup when treating female and elderly patients with a low BMI and/or elevated serum calcium level.

DOI： 10.18926/AMO/57370

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2型糖尿病患者における血糖値・胃食道逆流症状とうつ状態の関連

本多寛之, 花山宜久, 小比賀美香子, 岸田雅之, 安田美帆, 長谷川功, 小川弘子, 三好智子, 大塚文男

日本内分泌学会雑誌 95 ( 2 ) 753 - 753 2019.10