Faculty Profiles - IDA Naoyuki

Papers - IDA Naoyuki

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放射線治療患者におけるShear Wave Elastography超音波を用いた腫瘍硬度の検討

松岡敬典, 中村圭一郎, 坂井裕樹, 依田尚之, 原賀順子, 久保光太郎, 春間朋子, 小川千加子, 鎌田泰彦, 増山寿

日本婦人科腫瘍学会雑誌 39 ( 1 ) 346 - 346 2021.1

エストロゲン症状を伴う巨大多房性嚢胞腫瘤として発見された輪状細管を伴う性索腫瘍の一例

春間朋子, 角南華子, 松岡敬典, 依田尚之, 原賀順子, 小川千加子, 中村圭一郎, 柳井広之, 増山寿

日本婦人科腫瘍学会雑誌 39 ( 1 ) 424 - 424 2021.1

当院の早期子宮体がんにおける低侵襲手術の現況

依田尚之, 久保光太郎, 岡本和浩, 松岡敬典, 春間朋子, 小川千加子, 中村圭一郎, 増山寿

日本産科婦人科内視鏡学会雑誌 36 ( Suppl.I ) [O - 464] 2020.11

当院における子宮体癌に対する低侵襲手術の変遷

久保光太郎, 楠元理恵, 依田尚之, 岡本和浩, 松岡敬典, 春間朋子, 小川千加子, 中村圭一郎, 増山寿

日本産科婦人科内視鏡学会雑誌 36 ( Suppl.I ) [O - 410] 2020.11

Histologic Appearance and Immunohistochemistry of DNA Mismatch Repair Protein and p53 in Endometrial Carcinosarcoma: Impact on Prognosis and Insights Into Tumorigenesis. International journal

Masayuki Saijo, Keiichiro Nakamura, Naoyuki Ida, Atsuko Nasu, Tadashi Yoshino, Hisashi Masuyama, Hiroyuki Yanai

The American journal of surgical pathology 43 ( 11 ) 1493 - 1500 2019.11

Language：English Publishing type：Research paper (scientific journal)

Endometrial carcinosarcoma (ECS) is a rare and aggressive mixed-type epithelial and mesenchymal tumor. This study focused on the histologic appearance, loss of DNA mismatch repair (MMR) protein expression, and aberrant p53 expression in the epithelial component, and overall prognosis of 57 cases with ECS. Histologically, 21 and 36 cases exhibited low-grade (endometrioid grade 1 and 2) and high-grade (others) epithelial components, respectively. In a Kaplan-Meier analysis, patients with a high-grade epithelial component exhibited worse progression-free survival (PFS), compared with those with a low-grade component. Although the former group also exhibited worse overall survival, the difference was not significant. Thirty-six cases exhibited aberrant p53 expression. Of these, 5 cases exhibited focally aberrant p53 expression in carcinomatous components with diffuse aberrant p53 expression in mesenchymal components. Aberrant expression of p53 did not show significant association with prognosis. Six patients with MMR deficiency exhibited relatively better PFS. In conclusion, a low-grade epithelial component is a superior predictor of the PFS of ECS, compared with MMR protein and p53 expression status. In some cases of ECS, TP53 mutation may be a late event associated with histogenesis of the sarcomatous component.

DOI： 10.1097/PAS.0000000000001353

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子宮全摘子宮頸癌放射線治療後残存に対するSalvage Surgeryの8例

小川千加子, 松原侑子, 松岡敬典, 依田尚之, 西田傑, 中村圭一郎, 増山寿

日本婦人科腫瘍学会雑誌 37 ( 3 ) 475 - 475 2019.6

当院の子宮頸癌症例におけるFIGO2018分類での検討

松原侑子, 中村圭一郎, 松岡敬典, 西條昌之, 依田尚之, 西田傑, 小川千加子, 増山寿

日本婦人科腫瘍学会雑誌 37 ( 3 ) 443 - 443 2019.6

当院で縮小手術を施行した75歳以上の子宮体癌患者の検討

依田尚之, 中村圭一郎, 松原侑子, 西條昌之, 松岡敬典, 西田傑, 小川千加子, 増山寿

日本婦人科腫瘍学会雑誌 37 ( 3 ) 503 - 503 2019.6

治療前サルコペニアは子宮頸癌の予後を反映しない

松岡敬典, 中村圭一郎, 松原侑子, 依田尚之, 西條昌之, 西田傑, 小川千加子, 増山寿

日本婦人科腫瘍学会雑誌 37 ( 3 ) 477 - 477 2019.6

Sarcopenia Is Not a Prognostic Factor of Outcome in Patients With Cervical Cancer Undergoing Concurrent Chemoradiotherapy or Radiotherapy. International journal

Hirofumi Matsuoka, Keiichiro Nakamura, Yuko Matsubara, Naoyuki Ida, Takeshi Nishida, Chikako Ogawa, Kuniaki Katsi, Susumu Kanazawa, Hisashi Masuyama

Anticancer research 39 ( 2 ) 933 - 939 2019.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND/AIM: The objective of this study was to determine if sarcopenia was a predictor of poor prognosis in patients with cervical cancer (CC) undergoing concurrent chemoradiation therapy (CCRT) or radiation therapy (RT). MATERIALS AND METHODS: A total of 236 patients with CC undergoing CCRT or RT were retrospectively examined. We determined if clinical characteristics and survival were correlated with pretreatment sarcopenia, measured as psoas muscle index (PI) or skeletal muscle index (SMI). RESULTS: Pretreatment PI and SMI were related to parametrial involvement with CC undergoing CCRT or RT (p=0.002, and, p=0.034, respectively). The median progression-free survival (PFS) and overall survival (OS) times in patients undergoing CCRT or RT were 29.0 and 34.5 months, respectively. Neither PI nor SMI were prognostic predictors in patients with CC undergoing CCRT or RT. CONCLUSION: Sarcopenia is not a predictive factor of outcome in patients with CC undergoing CCRT or RT.

DOI： 10.21873/anticanres.13196

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腹腔鏡下両側付属器切除後に判明した正常大卵巣の明細胞境界悪性腫瘍の一例

片山沙希, 久保光太郎, 松岡敬典, 依田尚之, 西田傑, 小川千加子, 中村圭一郎, 増山寿

日本産科婦人科学会雑誌 71 ( 臨増 ) S - 625 2019.2

上皮性卵巣癌患者の筋肉量と予後予測について

松原侑子, 中村圭一郎, 松岡敬典, 西條昌之, 依田尚之, 西田傑, 小川千加子, 増山寿

日本産科婦人科学会雑誌 71 ( 臨増 ) S - 604 2019.2

異なる転帰をたどった成熟嚢胞性奇形腫を伴う抗NMDA受容体抗体脳炎の2症例

西田傑, 松原侑子, 依田尚之, 松岡敬典, 西條昌之, 小川千加子, 中村圭一郎, 増山寿

日本産科婦人科学会雑誌 71 ( 臨増 ) S - 527 2019.2

婦人科がんサバイバーは健康的な生活を心掛けている Reviewed

中村圭一郎, 松岡敬典, 牧尉太, 西條昌之, 依田尚之, 増山寿

日本女性医学学会雑誌 26 ( Suppl. ) 237 - 237 2018.10

婦人科がんサバイバーは健康的な生活を心掛けているライフスタイル変化についてのアンケート調査結果より

中村圭一郎, 原賀順子, 西田傑, 依田尚之, 西條昌之, 小川千加子, 楠本知行, 増山寿

日本婦人科腫瘍学会雑誌 36 ( 4 ) 692 - 701 2018.10

Language：Japanese Publisher：(公社)日本婦人科腫瘍学会

婦人科癌は治療法の進歩によりがんサバイバーが増え、がんサバイバーにとって、再発や死亡を防ぐことが重要である。がん治療終了後生活は生活習慣(食事、喫煙、飲酒)、運動などに注意することが大切とされているが、未だ婦人科領域におけるがん治療終了後生活の現状は把握されていない。そこでがん治療を行った229名の婦人科癌患者を対象に16項目のアンケートを用い、がん治療後の生活実態を調査した。定期的な外来検診を行った健康的な婦人科癌患者に直接アンケートを配布し、ボックスにて回収を行った(99.9%回収)。その結果、がん治療後食事量が減少した患者は24.0%、脂肪摂取が減った患者は34.9%、塩分量が減少した患者は24.9%、緑黄色野菜が増えた患者は47.2%であり、禁煙や喫煙減少した患者は59.2%、禁酒や飲酒量減少した患者は46.8%を占めており、がん治療終了後健康的な生活を送ることに多くのがんサバイバーが心掛けていることを認識できた。(著者抄録)

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The Influence of Chemotherapy-Induced Peripheral Neuropathy on Quality of Life of Gynecologic Cancer Survivors. International journal

Hirofumi Matsuoka, Keiichiro Nakamura, Yuko Matsubara, Naoyuki Ida, Masayuki Saijo, Chikako Ogawa, Hisashi Masuyama

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 28 ( 7 ) 1394 - 1402 2018.9

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: The aim of this observational study was to investigate correlations between long-term chemotherapy-induced peripheral neurotoxicity (CIPN) and quality of life (physical well-being, social well-being, emotional well-being, and functional well-being [FWB]) among survivors of gynecologic cancer (GC). METHODS: We aimed to assess the correlation of quality of life and long-term CIPN with the temporal change in recurrence-free GC survival. Questionnaire responses and clinical data of 259 GC survivors were collected and assessed according to treatment received. The χ test was used to determine the significance of correlations. RESULTS: Of 165 evaluable patients treated by chemotherapy, 36 patients (21.8%) developed CIPN of Common Toxicity Criteria for Adverse Events grade 1 or higher during the study. Chemotherapy-induced peripheral neurotoxicity had significantly improved over time in the domain of FWB at 61 months or more after the end of chemotherapy (posttreatment 4) among GC survivors (P = 0.003). Furthermore, CIPN treated by more than 6 courses of the paclitaxel and carboplatin regimen among GC survivors showed significant improvement over time in the emotional well-being domain at 25 to 60 months and 61 months or more after the end of chemotherapy (posttreatments 3 and 4) (P = 0.037 and P = 0.023) and in FWB at posttreatment 4 (P < 0.001). CONCLUSIONS: Emotional and functional domains of CIPN improved over time among GC survivors treated by more than 6 courses of the paclitaxel and carboplatin regimen. Based on these results, further research is required to identify additional preventative or curative approaches.

DOI： 10.1097/IGC.0000000000001320

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Prognostic nutritional index as a predictor of survival in patients with recurrent cervical cancer. International journal

Naoyuki Ida, Keiichiro Nakamura, Masayuki Saijo, Tomoyuki Kusumoto, Hisashi Masuyama

Molecular and clinical oncology 8 ( 2 ) 257 - 263 2018.2

Language：English Publishing type：Research paper (scientific journal)

Systemic inflammatory responses (SIRs) can help predict survival in various cancers. The present study investigated the accuracy of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and prognostic nutritional index (PNI) in predicting survival for patients with recurrent cervical cancer. A retrospective review of prognoses examined the associations among NLR, PLR, and PNI, and clinical characteristics and survival in 79 patients with recurrent cervical cancer after undergoing concurrent chemoradiation therapy (CCRT) or radical hysterectomies with or without CCRT. The Mann-Whitney U-test was used for statistical analyses. In addition, 12-month, 24-month and overall survival were analyzed by the Kaplan-Meier method. Cox's proportional hazard regression was used for univariate and multivariate analyses. Median survival was 15.0 months over follow-up periods of 2-93 months. At the last follow-up point, 54 had succumbed to disease and 25 were alive with disease. In univariate analysis, NLR, PLR and PNI were significantly associated with 12-month, 24 month and overall survival (12 months: P=0.021, P=0.001 and P<0.001; 24 months: P=0.020, P=0.008 and P<0.001; overall; P=0.032, P=0.032 and P<0.001, respectively). In multivariate analyses, PNI was an independent prognostic factor for 12-month, 24-month and overall survival (P=0.001, P=0.001 and P<0.001, respectively). PNI is a useful predictor of survival of recurrent cervical cancer.

DOI： 10.3892/mco.2017.1508

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初期子宮体癌低侵襲手術における術式に関する検討

楠本知行, 依田尚之, 西條昌之, 西田傑, 原賀順子, 小川千加子, 中村圭一郎, 増山寿

日本産科婦人科学会雑誌 70 ( 2 ) 764 - 764 2018.2

婦人科悪性腫瘍手術後患者における大建中湯の有用性

藤田志保, 関典子, 西條昌之, 依田尚之, 大道千晶, 原賀順子, 西田傑, 小川千加子, 楠本知行, 鎌田泰彦, 中村圭一郎, 増山寿

日本産科婦人科学会雑誌 70 ( 2 ) 968 - 968 2018.2

サルコペニアは同時化学放射線療法を施行した子宮頸癌患者の予後不良因子になる

清時毅典, 中村圭一郎, 依田尚之, 西條昌之, 大道千晶, 原賀順子, 西田傑, 小川千加子, 楠本知行, 増山寿

日本産科婦人科学会雑誌 70 ( 2 ) 948 - 948 2018.2

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Papers - IDA Naoyuki