研究者詳細 - 伊原木　聰一郎

論文 - 伊原木　聰一郎

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Orthognathic surgery during breast cancer treatment-A case report 査読国際誌

Tsuyoshi Shimo, Norie Yoshioka, Masahiro Nakamura, Soichiro Ibaragi, Tatsuo Okui, Yuki Kunisada, Masanori Masui, Mayumi Yao, Koji Kishimoto, Shoko Yoshida, Akiyoshi Nishiyama, Hiroshi Kamioka, Akira Sasaki

INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS 31 30 - 34 2017年

Tachykinin Receptor 3 Distribution in Human Oral Squamous Cell Carcinoma. 査読国際誌

Kyoichi Obata, Tsuyoshi Shimo, Tatsuo Okui, Kenichi Matsumoto, Hiroyuki Takada, Kiyofumi Takabatake, Yuki Kunisada, Soichiro Ibaragi, Hitoshi Nagatsuka, Akira Sasaki

Anticancer research 36 ( 12 ) 6335 - 6341 2016年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Tachykinin 3 (TAC3) and its preferred tachykinin receptor 3 (TACR3) that are prominently detected in the central nervous system, play significant roles in physiological development and specifically in the human reproductive system. The roles of TAC3/TACR3 in oral squamous cell carcinoma are unknown. MATERIALS AND METHODS: We examined the expression pattern of TAC3/TACR3 in clinically-resected oral squamous cell carcinoma samples using immunohistochemistry and immunofluorescence analysis. RESULTS: We found that even though the expression level of TACR3 was negative in the normal epithelium, it was highly elevated in tumor cells. A more intense signal was observed in the invasive front of tumor cells that had migrated into the mandible bone matrix. TAC3 was not detected in tumor cells, but was expressed in PGP-9.5-positive sensory nerves in the mandible. CONCLUSION: Our results suggest that peripheral sensory nerve-derived TAC3 may affect gingival oral squamous cell carcinoma cells through TACR3 in the bone matrix.

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Beckwith-Wiedemann症候群による巨舌に起因する著明な開咬に対して顎矯正手術を施行した1例

吉岡徳枝, 西山明慶, 高橋巧, 伊原木聰一郎, 銅前昇平, 志茂剛, 佐々木朗

日本顎変形症学会雑誌 26 ( 3 ) 228 - 236 2016年8月

Autologous Blood Injection for the Treatment of Recurrent Temporomandibular Joint Dislocation 査読

Norie Yoshioka, Tsuyoshi Shimo, Soichiro Ibaragi, Akira Sasaki

ACTA MEDICA OKAYAMA 70 ( 4 ) 291 - 294 2016年8月

Novel Midkine Inhibitor iMDK Inhibits Tumor Growth and Angiogenesis in Oral Squamous Cell Carcinoma. 査読国際誌

Masanori Masui, Tatsuo Okui, Tsuyoshi Shimo, Kiyofumi Takabatake, Takuya Fukazawa, Kenichi Matsumoto, Naito Kurio, Soichiro Ibaragi, Yoshio Naomoto, Hitoshi Nagatsuka, Akira Sasaki

Anticancer research 36 ( 6 ) 2775 - 81 2016年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Midkine is a heparin-binding growth factor highly expressed in various human malignant tumors. However, its role in the growth of oral squamous cell carcinoma is not well understood. In this study, we analyzed the antitumor effect of a novel midkine inhibitor (iMDK) against oral squamous cell carcinoma. Administration of iMDK induced a robust antitumor response and suppressed cluster of differentiation 31 (CD31) expression in oral squamous cell carcinoma HSC-2 cells and SAS cells xenograft models. iMDK inhibited the proliferation of these cells dose-dependently, as well as the expression of midkine and phospho-extracellular signal-regulated kinase in HSC-2 and SAS cells. Moreover, iMDK significantly inhibited vascular endothelial growth factor and induced tube growth of human umbilical vein endothelial cells in a dose-dependent fashion. These findings suggest that midkine is critically involved in oral squamous cell carcinoma and iMDK can be effectively used for the treatment of oral squamous cell carcinoma.

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当科における舌扁平上皮癌Stage I・II症例の頸部リンパ節後発転移に関する臨床的検討

吉田祥子, 岸本晃治, 村瀬友里香, 銅前昇平, 伊原木聰一郎, 柳文修, 松崎秀信, 志茂剛, 佐々木朗

岡山歯学会雑誌 35 ( 1 ) 13 - 18 2016年6月

福山市民病院歯科口腔外科でのインプラント治療における病診連携の状況について

目瀬浩, 山本大介, 木村周子, 大月要, 伊原木聰一郎, 岸本晃治, 佐々木朗

岡山歯学会雑誌 35 ( 1 ) 19 - 22 2016年6月

Synthetic Terrein Inhibits Progression of Head and Neck Cancer by Suppressing Angiogenin Production. 査読国際誌

Akane Shibata, Soichiro Ibaragi, Hiroki Mandai, Toki Tsumura, Koji Kishimoto, Tatsuo Okui, Nur Mohammad Monsur Hassan, Tsuyoshi Shimo, Kazuhiro Omori, Guo-Fu Hu, Shogo Takashiba, Seiji Suga, Akira Sasaki

Anticancer research 36 ( 5 ) 2161 - 8 2016年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND/AIM: Head and neck cancers are the fifth most common cancer type worldwide, affecting more than half a million patients annually. Development of effective therapeutic drugs is, therefore, required for this type of disease. This study assessed the effects of synthetic terrein on head and neck cancer. MATERIALS AND METHODS: Synthetic terrein was prepared by using the modified Altenhach's procedure. The effect of synthetic terrein on cell proliferation of head and neck cancer cells and HUVECs was assessed. Angiogenin secretion and ribosome biogenesis were examined by ELISA and silver staining of the nucleolar organizer region. A mouse xenograft model was prepared by inoculating mice with suspensions of cells of the human head and neck cancer cell line OSC-19 subcutaneously into the dorsal region of each mouse. Ki-67, CD31 and angiogenin expression in xenografted tumors was examined by immunohistochemistry. RESULTS: Synthetic terrein inhibited the growth of various head and neck cancer cells. In addition, an in vivo experiment revealed that synthetic terrein inhibited a xenograft tumor growth in athymic mice. Immunohistochemical analysis revealed that expression of Ki-67, CD31 and ANG was down-regulated in synthetic terrein-treated tumors, compared to controls. Synthetic terrein suppressed the ANG secretion and ribosome biogenesis in cancer cells, and cell proliferation in vascular endothelial cells. CONCLUSION: The mechanism underlying the anti-tumor effects of synthetic terrein against head and neck cancer consists of the inhibition of both tumor cell proliferation and angiogenesis via the suppression of ANG production.

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ガミースマイルを伴った上顎前突に対して馬蹄形骨切り併用4分割Le Fort I型上顎骨切りを行った1例

西山明慶, 伊原木聰一郎, 銅前昇平, 吉岡徳枝, 田井規能, 佐々木朗

日本顎変形症学会雑誌 26 ( 2 ) 129 - 129 2016年5月

The Role of Sonic Hedgehog Signaling in Osteoclastogenesis and Jaw Bone Destruction 査読国際誌

Tsuyoshi Shimo, Kenichi Matsumoto, Kiyofumi Takabatake, Eriko Aoyama, Yuichiro Takebe, Soichiro Ibaragi, Tatsuo Okui, Naito Kurio, Hiroyuki Takada, Kyoichi Obata, Pai Pang, Masahiro Iwamoto, Hitoshi Nagatsuka, Akira Sasaki

PLOS ONE 11 ( 3 ) e0151731 2016年3月

Detection of sonic hedgehog in patients undergoing orthognathic surgery 査読

Yuki Kunisada, Tsuyoshi Shimo, Masanori Masui, Norie Yoshioka, Soichiro Ibaragi, Kenichi Matsumoto, Tatsuo Okui, Naito Kurio, Shohei Domae, Koji Kishimoto, Akiyoshi Nishiyama, Akira Sasaki

International Journal of Surgery Open 5 1 - 4 2016年

Expression pattern of sonic hedgehog signaling and calcitonin gene-related peptide in the socket healing process after tooth extraction. 査読国際誌

Pai Pang, Tsuyoshi Shimo, Hiroyuki Takada, Kenichi Matsumoto, Norie Yoshioka, Soichiro Ibaragi, Akira Sasaki

Biochemical and biophysical research communications 467 ( 1 ) 21 - 6 2015年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Sonic Hedgehog (SHH), a neural development inducer, plays a significant role in the bone healing process. Calcitonin gene-related peptide (CGRP), a neuropeptide marker of sensory nerves, has been demonstrated to affect bone formation. The roles of SHH signaling and CGRP-positive sensory nerves in the alveolar bone formation process have been unknown. Here we examined the expression patterns of SHH signaling and CGRP in mouse socket by immunohistochemistry and immunofluorescence analysis. We found that the expression level of SHH peaked at day 3 and was then decreased at 5 days after tooth extraction. CGRP, PTCH1 and GLI2 were each expressed in a similar pattern with their highest expression levels at day 5 and day 7 after tooth extraction. CGRP and GLI2 were co-expressed in some inflammatory cells and bone forming cells. In some areas, CGRP-positive neurons expressed GLI2. In conclusion, SHH may affect alveolar bone healing by interacting with CGRP-positive sensory neurons and thus regulate the socket's healing process after tooth extraction.

DOI： 10.1016/j.bbrc.2015.09.139

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Familial adenoid cystic carcinoma of sublingual salivary glands 査読

Norie Yoshioka, Hiroshi Mese, Tatsuo Okui, Soichiro Ibaragi, Akira Sasaki

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY 27 ( 3 ) 353 - 356 2015年5月

早期見学実習の一環として実施した振り返りを取り入れたエスコート実習の評価過去8年間の検討

吉田登志子, 山中玲子, 菅原康代, 伊原木聰一郎, 村上隆, 村田尚道, 志茂剛, 柳田剛志, 縄稚久美子, 星加知宏

日本歯科医学教育学会雑誌 31 ( 1 ) 16 - 24 2015年4月

Expression and Roles of CCN2 in Dental Epithelial Cells 査読

Tsuyoshi Shimo, Eiki Koyama, Naito Kurio, Kenichi Matsumoto, Tatsuo Okui, Soichiro Ibaragi, Norie Yoshioka, Akira Sasaki

IN VIVO 29 ( 2 ) 189 - 195 2015年3月

A case of adenoid cystic carcinoma associated with IgG4-related disease 査読国際誌

Tsuyoshi Shimo, Mayumi Yao, Yuichiro Takebe, Yuko Ono, Kyoichi Obata, Naito Kurio, Soichiro Ibaragi, Norie Yoshioka, Koji Kishimoto, Yoshinobu Yanagi, Hitoshi Nagatsuka, Akira Sasaki

INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS 10 12 - 16 2015年

岡山大学病院口腔がん専門外来と岡山市歯科医師会の連携による口腔がん検診研修会の概要とアンケート結果について

岸本晃治, 岡崎景, 西山明慶, 居樹秀明, 松村達志, 伊原木聰一郎, 銅前昇平, 吉岡徳枝, 栗尾奈愛, 矢尾真弓, 小畑協一, 尾野裕子, 志茂剛, 壺内智郎, 飯田征二, 佐々木朗

岡山歯学会雑誌 33 ( 2 ) 23 - 28 2014年12月

Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts. 査読国際誌

Hiroki Mandai, Kazuhiro Omori, Daisuke Yamamoto, Toki Tsumura, Kyouta Murota, Satoshi Yamamoto, Koichi Mitsudo, Soichiro Ibaragi, Akira Sasaki, Hiroshi Maeda, Shogo Takashiba, Seiji Suga

Bioorganic & medicinal chemistry 22 ( 19 ) 5338 - 44 2014年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Interleukin (IL)-6 is a proinflammatory cytokine that performs a wide variety of biological functions, including important roles in the progression of chronic inflammatory diseases such as periodontal disease. (+)-Terrein, a secondary bioactive fungal metabolite isolated from Aspergillus terreus, has various biological activities; however, its anti-inflammatory effects are still unknown. The purpose of this study was to examine the effect of synthetic (+)-terrein on IL-6 signaling and related protein production in human gingival fibroblasts. To our knowledge, this study is the first to report that synthetic (+)-terrein is not cytotoxic at concentrations less than 20 μM and suppresses IL-6/soluble IL-6 receptor (sIL-6R)-induced phosphorylation of signal transducer and activator of transcription-3, extracellular signal-regulated kinase 1/2, and c-jun N-terminal kinase 1/2-signaling proteins that are downstream of IL-6 signaling. In addition, synthetic (+)-terrein suppresses IL-6/sIL-6R-induced vascular endothelial growth factor (VEGF) secretion in a concentration-dependent manner (p<0.01). These data suggest that synthetic (+)-terrein has potential anti-IL-6 signaling activity and suppresses VEGF-associated inflammatory disease progression.

DOI： 10.1016/j.bmc.2014.07.047

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Neamine inhibits oral cancer progression by suppressing angiogenin-mediated angiogenesis and cancer cell proliferation. 査読国際誌

Koji Kishimoto, Shoko Yoshida, Soichiro Ibaragi, Norie Yoshioka, Guo-Fu Hu, Akira Sasaki

Anticancer research 34 ( 5 ) 2113 - 21 2014年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Angiogenin undergoes nuclear translocation and stimulates ribosomal RNA transcription in both endothelial and cancer cells. Consequently, angiogenin has a dual effect on cancer progression by inducing both angiogenesis and cancer cell proliferation. The aim of this study was to assess whether neamine, a blocker of nuclear translocation of angiogenin, possesses antitumor activity toward oral cancer. MATERIALS AND METHODS: The antitumor effect of neamine on oral cancer cells was examined both in vitro and in vivo. RESULTS: Neamine inhibited the proliferation of HSC-2, but not that of SAS oral cancer cells in vitro. Treatment with neamine effectively inhibited growth of HSC-2 and SAS cell xenografts in athymic mice. Neamine treatment resulted in a significant decrease in tumor angiogenesis, accompanied by a decrease in angiogenin- and proliferating cell nuclear antigen-positive cancer cells, especially of HSC-2 tumors. CONCLUSION: Neamine effectively inhibits oral cancer progression through inhibition of tumor angiogenesis. Neamine also directly inhibits proliferation of certain types of oral cancer cells. Therefore, neamine has potential as a lead compound for oral cancer therapy.

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骨髄移植後の慢性GVHD患者に発生した多発性口腔扁平上皮癌の1例

奥井達雄, 目瀬浩, 伊原木聰一郎, 吉岡徳枝, 志茂剛, 佐々木朗

日本口腔外科学会雑誌 60 ( 3 ) 151 - 155 2014年3月

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