研究者詳細 - 伊原木　聰一郎

論文 - 伊原木　聰一郎

分割表示 187 件中 21 - 40 件目／全件表示 >>

EpEX, the soluble extracellular domain of EpCAM, resists cetuximab treatment of EGFR-high head and neck squamous cell carcinoma. 査読国際誌

Koki Umemori, Kisho Ono, Takanori Eguchi, Hotaka Kawai, Tomoya Nakamura, Tatsuo Ogawa, Kunihiro Yoshida, Hideka Kanemoto, Kohei Sato, Kyoichi Obata, Shoji Ryumon, Hirokazu Yutori, Naoki Katase, Tatsuo Okui, Hitoshi Nagatsuka, Soichiro Ibaragi

Oral oncology 142 106433 - 106433 2023年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: Cetuximab (Cmab) is a molecularly targeted monoclonal antibody drug for head and neck squamous cell carcinoma (HNSC), although cetuximab resistance is a serious challenge. Epithelial cell adhesion molecule (EpCAM) is an established marker for many epithelial tumors, while the soluble EpCAM extracellular domain (EpEX) functions as a ligand for epidermal growth factor receptor (EGFR). We investigated the expression of EpCAM in HNSC, its involvement in Cmab action, and the mechanism by which soluble EpEX activated EGFR and played key roles in Cmab resistance. MATERIALS AND METHODS: We first examined EPCAM expression in HNSCs and its clinical significance by searching gene expression array databases. We then examined the effects of soluble EpEX and Cmab on intracellular signaling and Cmab efficacy in HNSC cell lines (HSC-3 and SAS). RESULTS: EPCAM expression was found to be enhanced in HNSC tumor tissues compared to normal tissues, and the enhancement was correlated with stage progression and prognosis. Soluble EpEX activated the EGFR-ERK signaling pathway and nuclear translocation of EpCAM intracellular domains (EpICDs) in HNSC cells. EpEX resisted the antitumor effect of Cmab in an EGFR expression-dependent manner. CONCLUSION: Soluble EpEX activates EGFR to increase Cmab resistance in HNSC cells. The EpEX-activated Cmab resistance in HNSC is potentially mediated by the EGFR-ERK signaling pathway and the EpCAM cleavage-induced nuclear translocation of EpICD. High expression and cleavage of EpCAM are potential biomarkers for predicting the clinical efficacy and resistance to Cmab.

DOI： 10.1016/j.oraloncology.2023.106433

The notch of the mandible: what do different fields call it? 査読国際誌

Norio Kitagawa, Keiko Fukino, Yuki Matsushita, Soichiro Ibaragi, R Shane Tubbs, Joe Iwanaga

Anatomy & cell biology 56 ( 3 ) 308 - 312 2023年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

The bony notch on the inferior border of the mandible, anterior to the attachment of the masseter muscle, where the facial vessels commonly pass, has been called different names in the literature, e.g., premasseteric notch, antegonial notch, and notch for the facial vessels. Interestingly, various disciplines have leaned toward different names for this notch. Therefore, to aid in consistent communication among professionals, the present study aimed to analyze usage of these varied terms and make recommendations for the best terminology. Based on the adjacent anatomical structures used to name this notch, three groups were analyzed in this study, a group using masseter in the term, a group using gonion in the term, and a group using facial vessels in the term. A literature search found that the group using gonion in the term was found most in the literature. The orthodontics field used gonion in the term the most (29.0%: 31/107) followed by the oral and maxillofacial surgery field (14.0%: 15/107), the plastic surgery field (4.7%: 5/107), and the anatomy field (3.7%: 4/107). The dental field used gonion in this term the most (43.9%: 47/107) and the medical field used facial vessels in the term the most (33.3%: 6/18). Based on these results, the use of gonial terms for this notch seems to be preferred.

DOI： 10.5115/acb.23.022

The Fungal Metabolite (+)-Terrein Abrogates Inflammatory Bone Resorption via the Suppression of TNF-α Production in a Ligature-Induced Periodontitis Mouse Model 査読国際誌

Hidefumi Sako, Kazuhiro Omori, Masaaki Nakayama, Hiroki Mandai, Hidetaka Ideguchi, Saki Yoshimura-Nakagawa, Kyosuke Sakaida, Chiaki Nagata-Kamei, Hiroya Kobayashi, Satoki Ishii, Mitsuaki Ono, Soichiro Ibaragi, Tadashi Yamamoto, Seiji Suga, Shogo Takashiba

Journal of Fungi 9 ( 3 ) 314 - 314 2023年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Current periodontal treatment focuses on the mechanical removal of the source of infection, such as bacteria and their products, and there is no approach to control the host inflammatory response that leads to tissue destruction. In order to control periodontal inflammation, we have previously reported the optimization of (+)-terrein synthesis methods and the inhibitory effect of (+)-terrein on osteoclast differentiation in vitro. However, the pharmacological effect of (+)-terrein in vivo in the periodontitis model is still unknown. In this study, we investigated the effect of synthetic (+)-terrein on inflammatory bone resorption using a ligature-induced periodontitis mouse model. Synthetic (+)-terrein (30 mg/kg) was administered intraperitoneally twice a week to the mouse periodontitis model. The control group was treated with phosphate buffer. One to two weeks after the induction of periodontitis, the periodontal tissues were harvested for radiological evaluation (micro-CT), histological evaluation (HE staining and TRAP staining), and the evaluation of inflammatory cytokine production in the periodontal tissues and serum (quantitative reverse-transcription PCR, ELISA). The synthetic (+)-terrein-treated group suppressed alveolar bone resorption and the number of osteoclasts in the periodontal tissues compared to the control group (p < 0.05). In addition, synthetic (+)-terrein significantly suppressed both mRNA expression of TNF-α in the periodontal tissues and the serum concentration of TNF-α (both p < 0.05). In conclusion, we have demonstrated that synthetic (+)-terrein abrogates alveolar bone resorption via the suppression of TNF-α production and osteoclast differentiation in vivo. Therefore, we could expect potential clinical effects when using (+)-terrein on inflammatory bone resorption, including periodontitis.

DOI： 10.3390/jof9030314

Lactate secreted via MCT4 from bone‑colonizing breast cancer excites sensory neurons via GPR81. 査読国際誌

Tatsuo Okui, Masahiro Hiasa, Kazuaki Hasegawa, Tomoya Nakamura, Kisho Ono, Soichiro Ibaragi, Takahiro Kanno, Akira Sasaki, Toshiyuki Yoneda

International journal of oncology 62 ( 3 ) 2023年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

Breast cancer (BC) bone metastasis causes bone pain (BP), which detrimentally damages the quality of life and outcome of patients with BC. However, the mechanism of BC‑BP is poorly understood, and effective treatments are limited. The present study demonstrated a novel mechanism of BC‑BP using a mouse model of bone pain, in which mouse (EO771) and human (MDA‑MB‑231) BC cells were injected in the bone marrow cavity of tibiae. Western blot analysis using sensory nerves, in vivo assessment of cancer pain and in vitro calcium flux analysis were performed. These mice developed progressive BC‑BP in tibiae in conjunction with an upregulation of phosphorylated pERK1/2 and cAMP‑response element‑binding protein (pCREB), which are molecular indicators of neuron excitation, in the dorsal root ganglia (DRG) of sensory nerves. Importantly, mice injected with BC cells, in which the expression of the lactic acid transporter monocarboxylate transporter 4 (MCT4) was silenced, exhibited decreased BC‑BP with downregulated expression of pERK1/2 and pCREB in the DRG and reduced circulating levels of lactate compared with mice injected with parental BC cells. Further, silencing of the cell‑surface orphan receptor for lactate, G protein‑coupled receptor 81 (GPR81), in the F11 sensory neuron cells decreased lactate‑promoted upregulation of pERK1/2 and Ca2+ influx, suggesting that the sensory neuron excitation was inhibited. These results suggested that lactate released from BC cells via MCT4 induced BC‑BP through the activation of GPR81 of sensory neurons. In conclusion, the activation of GPR81 of sensory neurons by lactate released via MCT4 from BC was demonstrated to contribute to the induction of BC‑BP, and disruption of the interactions among lactate, MCT4 and GPR81 may be a novel approach to control BC‑BP.

DOI： 10.3892/ijo.2023.5487

Lingual nerve impairment/injury after retrieval of the displaced mandibular third molar into the floor of the mouth. 査読国際誌

Joe Iwanaga, Tomotaka Kato, Kisho Ono, R Shane Tubbs, Soichiro Ibaragi

The British journal of oral & maxillofacial surgery 61 ( 3 ) 193 - 197 2023年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

Retrieval of the displaced mandibular third molar in the floor of the mouth is challenging as the lingual nerve is always at risk of injury. However, there are no available data to show the incidence of the injury caused by the retrieval. The goal of this review article is to provide the incidence of the iatrogenic lingual nerve impairment/injury caused by the retrieval based on the review of the existing literature. The retrieval cases were collected with the search words below using PubMed, Google Scholar, and CENTRAL Cochrane Library database on October 6, 2021. A total of 38 cases of lingual nerve impairment/injury in 25 studies were eligible and reviewed. Temporary lingual nerve impairment/injury due to retrieval was found in six cases (15.8%) and all recovered between three to six months after retrieval. General anaesthesia and local anaesthesia were used for retrieval in three cases each. The tooth was retrieved using a lingual mucoperiosteal flap in all six cases. The permanent iatrogenic lingual nerve impairment/injury due to retrieval of the displaced mandibular third molar is considered extremely rare as long as the appropriate surgical approach is chosen based on surgeons' clinical experience and anatomical knowledge.

DOI： 10.1016/j.bjoms.2023.01.002

Anatomical Study of the Communication Between the Mental Nerve and Marginal Mandibular Branch of the Facial Nerve 査読国際誌

Joe Iwanaga, Naotaka Kishimoto, Soichiro Ibaragi, Juan J Cardona, Arada Chaiyamoon, Mi-Sun Hur, Yoshiaki Nakamura, Jingo Kusukawa, R. Shane Tubbs

Cureus 15 ( 1 ) e33733 2023年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cureus, Inc.

Background Trigeminal-facial nerve communications have been recognized for over 100 years. More specifically, the mental nerve (MN) and marginal mandibular branch of the facial nerve (MMb) communication have been studied but the termination of these branches remains unclear. Therefore, we aim to classify the anatomical communication between the MN and MMb by its course. Methods Sixty sides from thirty adult cadaveric heads were dissected. The communicating branches were dissected and observed anatomically and histologically. Results Communication between the MN and MMb was found on all sides. Based on the course, the communication was classified into two types, superior and anterior. For the superior type, a small branch of the MN and MMb join and travel superiorly to reach the lower lip area. The communication was observed at the level of the mental foramen or above it. For the anterior type, a small branch of the MN and MMb join and travel anteriorly to reach the chin area. The termination was either in the subcutaneous tissue of the chin or in the mentalis. This communication was observed below the mental foramen. Histological observation revealed that these communications contained two or more perineuria. Conclusions Although the function of such neural communications is still unclear, this study helps better understand the anatomical variants of these unions and provides a novel classification system.

DOI： 10.7759/cureus.33733

舌扁平上皮癌と悪性リンパ腫の同時性重複がんに対し集学的な治療を行った1例

金本栄華, 小畑協一, 竜門省二, 岸本晃治, 伊原木聰一郎, 佐々木朗

日本口腔外科学会雑誌 69 ( 1 ) 15 - 21 2023年1月

含歯性嚢胞摘出後の顎骨欠損に起因する歯列不正に対し骨移植とともに矯正治療を行った1症例

橋本真奈, 田中敦子, 吉田祥子, 伊原木聰一郎, 上岡寛

岡山歯学会雑誌 41 ( 2 ) 35 - 42 2022年12月

What is a superior labial frenulum? An anatomical and histological study. 査読国際誌

Joe Iwanaga, Puhan He, Keiko Fukino, Mi-Sun Hur, Hee-Jin Kim, Aya Han, Koichi Watanabe, Soichiro Ibaragi, Norio Kitagawa, R Shane Tubbs

Clinical anatomy (New York, N.Y.) 36 ( 1 ) 161 - 169 2022年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Anatomy of the superior labial frenulum (SLF), at first glance, seems to be well established. However, existing studies on the SLF lack description of the incisivus labii superioris (ILS), which cannot be ignored when discussing the SLF. We believe that thorough understanding of the SLF necessitates the anatomical knowledge of the ILS. This study aimed to elucidate the anatomical relationship between the orbicularis oris (OO), ILS, and SLF. A total of twenty formalin fixed human cadaveric specimens were used for gross anatomical and/or histological observation. For histological observation, all specimens were stained with Masson-trichrome. The SLF was a mucosal fold between the gingival mucosa and alveolar mucosa with connective tissue deep to it. The connective tissue attached to the alveolar bone in the junction between the right and left ILS. Skeletal muscle fibers other than orbicularis oris was found in one specimen, which were considered the ILS. During a frenulectomy, removal of the connective tissue bundle is required to prevent recurrence of the high SLF insertion. This article is protected by copyright. All rights reserved.

DOI： 10.1002/ca.23973

Lip pleomorphic adenomas: case series and literature review 査読国際誌

Koki Umemori, Kisho Ono, Hideka Kanemoto, Kyoichi Obata, Hotaka Kawai, Tomoya Nakamura, Keisuke Nakano, Soichiro Ibaragi, Hitoshi Nagatsuka, Akira Sasaki

Gland Surgery 11 ( 10 ) 1730 - 1740 2022年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AME Publishing Company

BACKGROUND: Pleomorphic adenoma (PA) is the most frequent benign salivary gland tumor, but a lip PA is rare. Although this tumor may be definitively diagnosed by imaging or a tissue biopsy if it is reasonably large, PAs on the lip are relatively small, and they present findings that are similar to those of other lip lesions, which can make a preoperative diagnosis difficult. METHODS: We analyzed all PAs in the oral region and lesions on the lips treated in our department over the past 20 years, and we discuss them together with the relevant literature. RESULTS: We found that 11.8% (n=6) of the PAs occurred on a lip (upper lip: 9.8%, lower lip: 2.0%), and ~1% of all mass lesions of the lips were PAs. The average size of the lip PAs was 1.5±0.7 cm (range, 0.7-2.2 cm). For preoperative diagnostic assistance, ultrasonography (US) (n=4), magnetic resonance (MR) (n=3), or no imaging (n=2) was used. An excisional biopsy was performed in all cases, and to date, no recurrence or malignant transformation has been observed. CONCLUSIONS: Lip PA is relatively rare. Because almost all of these lesions are small, a preoperative diagnosis is more difficult compared to palatal lesions. This tumor is also prone to long-term neglect and has the potential for recurrence and malignant transformation. It is thus necessary to perform an excision that includes the capsule and surrounding tissues, and careful postoperative follow-up should be continued.

DOI： 10.21037/gs-22-308

Craniomaxillofacial Fibrous Dysplasia Improved Cosmetic and Occlusal Problem by Comprehensive Treatment: A Case Report and Review of Current Treatments. 査読国際誌

Kisho Ono, Norie Yoshioka, Yuki Kunisada, Tomoya Nakamura, Yuko Nakamura, Kyoichi Obata, Soichiro Ibaragi, Shogo Minagi, Akira Sasaki

Diagnostics (Basel, Switzerland) 12 ( 9 ) 2022年9月

記述言語：英語

Fibrous dysplasia (FD) is a fibrous lesion of immature bone, with an incidence of 10-20% in the head and neck region. Most cases are monostotic, but when a lesion occurs on the maxillofacial region and spreads to the surrounding bone, it is classified as polyostotic, despite its localized occurrence. In some cases, surgical intervention is required to improve the cosmetic or functional disturbance of a FD in the maxillofacial region, but it is necessary to confirm symmetry of the maxillofacial region in real time, and a surgical support system is required to compensate. Furthermore, prosthetic intervention is considered when postoperative acquired defects occur or further cosmetic or occlusal function improvement is needed. A comprehensive approach by an oral surgeon and a maxillofacial prosthodontist is necessary for the successful treatment and rehabilitation of such patients. In this article, we describe the case of a craniomaxillofacial FD patient with facial asymmetry and denture incompatibility with improved quality of life measures by integrating surgical treatment using a navigation system and postoperative prosthetic rehabilitation. We also discuss recent diagnostic methods and treatment strategies for craniomaxillofacial FD in the literature.

DOI： 10.3390/diagnostics12092146

Relationships between squamous cell carcinoma antigen and cytokeratin 19 fragment values and renal function in oral cancer patients 査読

K. Obata, H. Yutori, K. Yoshida, Y. Sakamoto, K. Ono, S. Ibaragi

International Journal of Oral and Maxillofacial Surgery 2022年9月

The Transoral Endoscope-Assisted Approach for Removal of a Dental Implant Displaced into the Maxillary Sinus: A Case Report and Review of the Literature. 査読国際誌

Yurika Murase, Shoko Yoshida, Koji Kishimoto, Rieko Shimizu, Soichiro Ibaragi, Akira Sasaki

Journal of maxillofacial and oral surgery 21 ( 2 ) 639 - 647 2022年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Purpose: A dental implant displaced into the maxillary sinus can be removed transorally or transnasally. There is no report investigating any potential positional limitations by the transoral endoscope-assisted approach. The implant's location within the maxillary sinus was reviewed to clarify indications for this approach. Case report: A 36-year-old man was referred to us for removal of a dental implant displaced into the right maxillary sinus. The implant changed position preoperatively, but the transoral endoscope-assisted approach proved successful. Methods: A literature search through October 2020 was performed in PubMed for cases of implant removal from the maxillary sinus via transoral endoscope-assisted and transnasal endoscopic approaches. Results: Sixty-two prior cases were identified, 20 cases by the transoral endoscope-assisted approach and 43 cases by one or two transnasal endoscopic approaches, including one duplicate case. There were no cases in which the implant was not identified by the transoral endoscope-assisted approach, but two cases in which the implant had moved to an unfavorable location and was not identified by only the initial transnasal endoscopic approach. Conclusion: Clinicians can preferentially choose the transoral endoscope-assisted approach, considering the possibility of unfavorable repositioning of the displaced implant within the maxillary sinus.

DOI： 10.1007/s12663-022-01703-8

Clinical Anatomy Research Association in Oral and Maxillofacial Surgery. 査読国際誌

Joe Iwanaga, Yuki Matsushita, Koichi Watanabe, Ikuo Kageyama, R Shane Tubbs, Soichiro Ibaragi

The Journal of craniofacial surgery 33 ( 3 ) 942 - 944 2022年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

ABSTRACT: Sufficient knowledge of anatomy is critical for oral and maxillofacial surgeons to provide the best treatment to their patients. The authors have recently established the "Clinical Anatomy Research Association in Oral and Maxillofacial Surgery." There is no doubt as to the benefits of collaboration between oral and maxillofacial surgeons/radiologists and anatomists. In this article, we share what was accomplished at the first annual online conference and discuss our mission for the future.

DOI： 10.1097/SCS.0000000000008053

Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival. 査読国際誌

Hailing Yang, Liang Yuan, Soichiro Ibaragi, Shuping Li, Robert Shapiro, Nil Vanli, Kevin A Goncalves, Wenhao Yu, Hiroko Kishikawa, Yuxiang Jiang, Alexander J Hu, Daniel Jay, Brent Cochran, Eric C Holland, Guo-Fu Hu

British journal of cancer 127 ( 3 ) 422 - 435 2022年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Angiogenin is a multifunctional secreted ribonuclease that is upregulated in human cancers and downregulated or mutationally inactivated in neurodegenerative diseases. A role for angiogenin in glioblastoma was inferred from the inverse correlation of angiogenin expression with patient survival but had not been experimentally investigated. METHODS: Angiogenin knockout mice were generated and the effect of angiogenin deficiency on glioblastoma progression was examined. Angiogenin and plexin-B2 genes were knocked down in glioblastoma cells and the changes in cell proliferation, invasion and vascular association were examined. Monoclonal antibodies of angiogenin and small molecules were used to assess the therapeutic activity of the angiogenin-plexin-B2 pathway in both genetic and xenograft animal models. RESULTS: Deletion of Ang1 gene prolonged survival of PDGF-induced glioblastoma in mice in the Ink4a/Arf-/-:Pten-/- background, accompanied by decreased invasion, vascular association and proliferation. Angiogenin upregulated MMP9 and CD24 leading to enhanced invasion and vascular association. Inhibition of angiogenin or plexin-B2, either by shRNA, monoclonal antibody or small molecule inhibitor, decreases sphere formation of patient-derived glioma stem cells, reduces glioblastoma proliferation and invasion and inhibits glioblastoma growth in both genetic and xenograft animal models. CONCLUSIONS: Angiogenin and its receptor, plexin-B2, are a pair of novel regulators that mediate invasion, vascular association and proliferation of glioblastoma cells. Inhibitors of the angiogenin-plexin-B2 axis have therapeutic potential against glioblastoma.

DOI： 10.1038/s41416-022-01814-6

Cutaneous branch of the nerve to the mylohyoid muscle: Potential cause of postoperative sensory alteration in the submental area. 査読国際誌

Joe Iwanaga, Soichiro Ibaragi, Tatsuo Okui, Vasu Divi, Yoshio Ohyama, Koichi Watanabe, Jingo Kusukawa, R Shane Tubbs

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 243 151934 - 151934 2022年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Previous studies suggest that the nerve to the mylohyoid muscle could have a cutaneous branch. However, its clinical relevance has rarely been discussed because there is insufficient evidence for it. Our aim in this study was to investigate the anatomy of the cutaneous branch of the nerve to the mylohyoid muscle and extend the discussion to surgical management. METHODS: Twenty sides from ten embalmed cadaveric heads were dissected to identify the cutaneous branch of the nerve to the mylohyoid muscle. The cutaneous branch was traced up to its termination. RESULTS: The cutaneous branch was observed in 90% and classified into types I and II. In type I, the terminal trunk reached the anterior belly of the digastric muscle. In type II there were two types of terminal trunks, superior and inferior branches, which were identified on all sides. The number of the terminal trunk was one in 23.1% (type I; 6/26) and two in 76.9% (type II; 20/26). The terminal points of the cutaneous branch were all located within a 3 cm × 2 cm rectangular segment in the center of the submental area. CONCLUSIONS: We propose a new dermatome including the nerve to the mylohyoid muscle in the center. Understanding the cutaneous branch of the nerve could help surgeons to prevent iatrogenic sensory loss of the submental area.

DOI： 10.1016/j.aanat.2022.151934

3D anatomy of the ostiomeatal complex: A challenging concept in dentistry. 査読国際誌

Joe Iwanaga, Yuki Matsushita, Soichiro Ibaragi, R Shane Tubbs

Journal of dental education 2022年3月

Subcutaneous Emphysema Related to Dental Treatment: A Case Series. 査読国際誌

Rieko Shimizu, Shintaro Sukegawa, Yuka Sukegawa, Kazuaki Hasegawa, Sawako Ono, Ai Fujimura, Izumi Yamamoto, Soichiro Ibaragi, Akira Sasaki, Yoshihiko Furuki

Healthcare (Basel, Switzerland) 10 ( 2 ) 2022年2月

記述言語：英語

Cervicofacial subcutaneous emphysema (SE) is primarily caused by dental treatment introducing gas into the subcutaneous tissue. Air rapidly dissects into the subcutaneous tissue with face and neck swelling, leading to respiratory distress, patient discomfort, and chest pain. Computed tomography (CT) can detect spreading SE patterns. However, the true volume of SE and the degree of air changes in the body over time remain unknown. We evaluated the healing process of SE and the temporal changes in the volume of emphysema in three cases detected using our hospital's electronic health record systems based on inclusion and exclusion criteria over the past 10 years, with CT and three-dimensional (3D) images. The first case was a 46-year-old woman who presented with complaints of swelling from her right eyelid to the neck and clavicles, pain on swallowing, respiratory distress, and hoarseness. The second case was a 35-year-old man who presented with complaints of swelling over the face. The third case was a 36-year-old man who presented with complaints of swelling from the left cheek to the neck. CT revealed SE and pneumomediastinum in all cases. All the patients were administered an antibacterial drug. The CT and 3D images showed an improvement in emphysema 3 days after the onset, with more than half of the volume reduction in emphysema. This made it possible to evaluate the changes in the air content of SE. Observation with CT until the healing process of SE is completed is crucial, and 3D images also help evaluate changes over time.

DOI： 10.3390/healthcare10020290

An anatomical study of the blood supply to the mylohyoid muscle: the so-called "mylohyoid branch" of the inferior alveolar artery is an arterial anastomosis. 査読国際誌

Joe Iwanaga, Soichiro Ibaragi, Tatsuo Okui, Mi-Sun Hur, Ikuo Kageyama, R Shane Tubbs

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 240 151852 - 151852 2022年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The aim of this study was to clarify the morphology of the mylohyoid branch of the inferior alveolar artery and the main blood supply to the mylohyoid muscle. METHODS: The maxillary artery (MA) and inferior alveolar artery (IAA) within the infratemporal fossa, the facial and submental arteries within the submandibular triangle, and the nerve to the mylohyoid muscle and related artery were dissected in twelve sides from embalmed cadaveric heads. The main blood supply to the extraoral (inferior) surface of the mylohyoid muscle was recorded. RESULTS: The mylohyoid branch of the inferior alveolar artery was an anastomosis of the descending branch of either the inferior alveolar or maxillary artery and the ascending branch of either the submental or facial artery. The anastomosis was classified into four types according to the origins of the arteries. The main blood supply to the extraoral surface of the mylohyoid muscle was the submental artery. CONCLUSIONS: The results of this study indicate that the mylohyoid branch of the IAA in human adults is an anastomosis of branches of the maxillary and facial arteries.

DOI： 10.1016/j.aanat.2021.151852

A narrative review and clinical anatomy of herpes zoster infection following COVID-19 vaccination. 査読国際誌

Joe Iwanaga, Hiroshi Fukuoka, Nobuko Fukuoka, Hirokazu Yutori, Soichiro Ibaragi, R Shane Tubbs

Clinical anatomy (New York, N.Y.) 35 ( 1 ) 45 - 51 2022年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: In this review, cases of herpes zoster (HZ) infection following receipt of COVID-19 vaccines will be analyzed. We also present two cases of oral HZ following the COVID-19 vaccine and discuss this clinical anatomy. MATERIALS AND METHODS: A database search using PubMed was conducted in August 2021 and 20 articles were found to be eligible for review. Patient data and vaccine information were analyzed. In addition, two cases of oral HZ infection following the receipt of COVID-19 vaccines are presented. RESULTS: A total of 399 cases were identified. The affected dermatomes mimicked the regular distribution of HZ. For the dermatomes of the face, the various reports used different ways to describe the areas involved; CNV, CNV1, CNV2, CNV3, lower jaw, forehead, and under the eyebrow (CNV, 2 cases; CNV1, 4 cases; CNV2, 3 cases; and CNV3, 3 cases). Some patients who had a history of varicella zoster virus vaccination had HZ following the COVID-19 vaccination. Two patients with oral HZ following vaccination were found to have involvement of the greater palatine nerve. CONCLUSIONS: Vaccine-related HZ cases have been reported worldwide. Although many studies with a larger number of cases are ongoing, detailed information can be obtained from case reviews as reported herein.

DOI： 10.1002/ca.23790

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