研究者詳細 - 伊原木　聰一郎

論文 - 伊原木　聰一郎

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Low-intensity pulsed ultrasound stimulation promotes osteoblast differentiation through hedgehog signaling. 査読国際誌

Kenichi Matsumoto, Tsuyoshi Shimo, Naito Kurio, Tatsuo Okui, Soichiro Ibaragi, Yuki Kunisada, Kyoichi Obata, Masanori Masui, Pang Pai, Yuu Horikiri, Nobuyuki Yamanaka, Masaharu Takigawa, Akira Sasaki

Journal of cellular biochemistry 119 ( 6 ) 4352 - 4360 2018年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Low-intensity pulsed ultrasound (LIPUS) has been used as an adjunct to fracture healing therapies, but the mechanisms underlying its action are not known. We reported that sonic hedgehog (SHH) signaling was activated in osteoblasts at the dynamic remodeling site of a bone fracture. Mechanical stimulation is a crucial factor in bone remodeling, and it is related to the primary cilia as a sensor of hedgehog signaling. Here we observed that LIPUS promoted callus formation in accord with Gli2-positive cells after 14 days at the mouse femur fractured site compared with a control group. An immunofluorescence analysis showed that the numbers of primary cilia and cilia/osterix double-positive osteoblasts were increased at the fracture site by LIPUS. LIPUS stimulated not only the number and the length of primary cilia, but also the levels of ciliated protein, Ift88 mRNA, and SHH, Gli1, and Gli2 in MC3T3-E1 cells. Further experiments revealed that LIPUS stimulated osteogenic differentiation in the presence of smoothened agonist (SAG) treatment. These results indicate that LIPUS stimulates osteogenic differentiation and the maturation of osteoblasts by a primary cilium-mediated activation of hedgehog signaling.

DOI： 10.1002/jcb.26418

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Depletion of lipid efflux pump ABCG1 triggers the intracellular accumulation of extracellular vesicles and reduces aggregation and tumorigenesis of metastatic cancer cells 査読

Matsumoto K, Shimo T, Kurio N, Okui T, Ibaragi S, Kunisada Y, Obata K, Masui M, Pai P, Horikiri Y, Yamanaka N, Takigawa M, Sasaki A

Frontiers in Oncology 119 ( 6 ) 4352 - 4360 2018年6月

Basal cell adenoma arising in the minor salivary gland of the hard palate 査読

Tatsuo Okui, Soichiro Ibaragi, Keisuke Nakano, Yukiko Fujii, Akira Sasaki

Journal of Clinical and Diagnostic Research 12 ( 4 ) ZD04 - ZD05 2018年4月

放射線性下顎骨壊死に関する検討

松崎秀信, 勝井邦彰, 松崎久美子, 津村宗近, 池田篤司, 伊原木聰一郎, 水川展吉, 小野田友男, 浅海淳一, 木股敬裕

頭頸部癌 44 ( 1 ) 57 - 61 2018年4月

Ammonium tetrathiomolybdate enhances the antitumor effects of cetuximab via the suppression of osteoclastogenesis in head and neck squamous carcinoma. 査読国際誌

Ayaka Morisawa, Tatsuo Okui, Tsuyoshi Shimo, Soichiro Ibaragi, Yuka Okusha, Mitsuaki Ono, Thi Thu Ha Nguyen, Nur Mohammad Monsur Hassan, Akira Sasaki

International journal of oncology 52 ( 3 ) 989 - 999 2018年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

Head and neck squamous cell carcinoma (HNSCC) poses a significant challenge clinically where one of the mechanisms responsible for the invasion into facial bones occurs via the activation of osteoclasts. Copper has been demonstrated to play a key role in skeletal remodeling. However, the role of copper in cancer-associated bone destruction is thus far unknown. Lysyl oxidase (LOX) is a copper-dependent enzyme that promotes osteoclastogenesis. In the present study, we investigated the effects of copper on HNSCC with bone invasion by the copper chelator, ammonium tetrathiomolybdate (TM) in vitro and in vivo. We demonstrate that TM blocks the proliferation of HNSCC cells, inhibits LOX activation and decreases the expression of the receptor activator of nuclear factor-κB ligand (RANKL) in osteoblasts and osteocytes, subsequently suppressing bone destruction. These findings suggest that copper is a potential target for the treatment of HNSCCs associated with bone destruction.

DOI： 10.3892/ijo.2018.4242

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逆行性超選択的動注化学放射線療法中に腫瘍栄養動脈が閉塞し吻合枝から急速動注した舌癌の1例

伊原木聰一郎, 吉岡徳枝, 奥井達雄, 國定勇希, 志茂剛, 光藤健司, 藤内祝, 佐々木朗

日本口腔腫瘍学会誌 30 ( 1 ) 23 - 27 2018年3月

The Prognostic Implications of Bone Invasion in Gingival Squamous Cell Carcinoma 査読国際誌

Shoko Yoshida, Tsuyoshi Shimo, Yurika Murase, Kiyofumi Takabatake, Koji Kishimoto, Soichiro Ibaragi, Norie Yoshioka, Tatsuo Okui, Hitoshi Nagatsuka, Akira Sasaki

ANTICANCER RESEARCH 38 ( 2 ) 955 - 962 2018年2月

Ameloblastic fibro-odontoma in a 9-year-old boy 査読

Okui T, Ibaragi S, Shimo T, Takabatake K, Fujita M, Hassan NMM, Sasaki A

Stomatological Disease and Science 2 7 2018年

Clinical analysis of osteoradionecrosis of the mandible 査読

Hidenobu Matsuzaki, Kuniaki Katsui, Kumiko Matsuzaki, Munechika Tsumura, Atsushi Ikeda, Soichiro Ibaragi, Nobuyoshi Mizukawa, Tomoo Onoda, Jun-Ichi Asaumi, Yoshihiro Kimata

Japanese Journal of Head and Neck Cancer 44 ( 1 ) 57 - 61 2018年

Palonosetron Prevents Highly Emetogenic Chemotherapy-induced Nausea and Vomiting in Oral Cancer Patients. 査読国際誌

Shinya Sento, Naoya Kitamura, Tetsuya Yamamoto, Koichi Nakashiro, Hiroyuki Hamakawa, Soichiro Ibaragi, Akira Sasaki, Natsumi Takamaru, Yoji Miyamoto, Isamu Kodani, Kazuo Ryoke, Katsuaki Mishima, Yoshiya Ueyama

Anticancer research 37 ( 12 ) 6977 - 6981 2017年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND/AIM: To evaluate the efficacy of palonosetron in preventing acute and delayed nausea and vomiting in patients receiving highly emetogenic chemotherapy (HEC) in oral cancer patients. PATIENTS AND METHODS: Oral cancer patients receiving HEC were enrolled; among the 40 patients, 87 courses of chemotherapy were administered. On day 1, 0.75 mg palonosetron was intravenously administrated just before chemotherapy. RESULTS: The primary endpoint was the proportion of patients with a complete response (CR) and the secondary endpoint was the proportion of patients with complete control (CC) during the acute and delayed phase. During the acute phase, 86 of 87 courses (98.9%) had CR and 84 of 87 courses (96.6%) had CC. During the delayed phase, 84 of 87 courses (96.6%) had CR and 70 of 87 courses (80.5%) had CC. CONCLUSION: Palonosetron is effective at preventing HEC-induced chemotherapy-induced nausea and vomiting (CINV) in oral cancer chemotherapeutic regimens in the acute and delayed phases.

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Oral Squamous Cell Carcinoma-derived Sonic Hedgehog Promotes Angiogenesis. 査読国際誌

Hiromasa Kuroda, Naito Kurio, Tsuyoshi Shimo, Kenichi Matsumoto, Masanori Masui, Kiyofumi Takabatake, Tatsuo Okui, Soichiro Ibaragi, Yuki Kunisada, Kyoichi Obata, Norie Yoshioka, Koji Kishimoto, Hitoshi Nagatsuka, Akira Sasaki

Anticancer research 37 ( 12 ) 6731 - 6737 2017年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Sonic hedgehog (SHH) signaling is related to the pathogenesis of oral squamous cell carcinoma (OSCC), but its role in OSCC is not yet well understood. In this study, we analyzed the role of SHH signaling in OSCC. MATERIALS AND METHODS: We examined the expression pattern of SHH and its signal proteins in clinically resected OSCC samples by immunohistochemistry. We also evaluated the function of SHH signaling using the hedgehog signaling inhibitor cyclopamine in vivo and in vitro by proliferation, migration and angiogenesis analyses. RESULTS: We found that SHH was highly expressed in human tongue OSCC, whereas patched (PTCH1), glioma-associated oncogene 1 (GLI1) and GLI2 proteins were expressed in the microvascular cells in the tumor invasive front. Administration of cyclopamine to mice suppressed the growth and angiogenesis of OSCC xenografts in vivo. Moreover, cyclopamine inhibited endothelial cell proliferation and migration, and reduced aorta vascular length in the rat. CONCLUSION: These findings suggest that OSCC-derived SHH stimulates angiogenesis at the tumor invasive front.

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Maxillofacial Fractures in Elderly Patients 査読

Hiroaki Takakura, Tsuyoshi Shimo, Norie Yoshioka, Mayumi Yao, Kyoichi Obata, Soichiro Ibaragi, Tatsuo Okui, Yuki Kunisada, Ayaka Morisawa, Akane Shibata, Shoko Yoshida, Yurika Murase, Koji Kishimoto, Akiyoshi Nishiyama, Hiroshi Mese, Akira Sasaki

International Journal of Surgery & Surgical Procedures 2 ( 128 ) 1 - 5 2017年11月

Role of Neurokinin 3 Receptor Signaling in Oral Squamous Cell Carcinoma. 査読国際誌

Kyoichi Obata, Tsuyoshi Shimo, Tatsuo Okui, Kenichi Matsumoto, Hiroyuki Takada, Kiyofumi Takabatake, Yuki Kunisada, Soichiro Ibaragi, Norie Yoshioka, Koji Kishimoto, Hitoshi Nagatsuka, Akira Sasaki

Anticancer research 37 ( 11 ) 6119 - 6123 2017年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND/AIM: The neurokinin 3 receptor (NK-3R) is differentially expressed in the central nervous system including cases of human oral squamous cell carcinoma. However, the role of NK-3R signaling in oral squamous cell carcinoma is not well known. MATERIALS AND METHODS: NK-3R expression in surgically resected oral squamous cell carcinoma was examined immunohistochemically and the strength of the expression was quantified. We evaluated the function of NK-3R signaling using NK-3R antagonist in human oral squamous cell carcinoma bone invasion mouse model. RESULTS: NK-3R was significantly expressed in tumor cells that had invaded the bone matrix compared to the oral side tumor cells. SB222200, a selective antagonist of NK-3R, significantly suppressed the radiographic osteolytic lesion and tumorigenesis. CONCLUSION: NK-3R signaling is a potential target for the treatment of oral squamous cell carcinoma in cases of bone destruction.

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Perimandibular abscess associated with bisphosphonate-related osteonecrosis of the jaw. 査読

Kazuki Ocho, Masaya Iwamuro, Hideharu Hagiya, Soichiro Ibaragi, Fumio Otsuka

Journal of general and family medicine 18 ( 5 ) 305 - 306 2017年10月

Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma 査読国際誌

Hiroyuki Takada, Soichiro Ibaragi, Takanori Eguchi, Tatsuo Okui, Kyoichi Obata, Masanori Masui, Ayaka Morisawa, Kiyofumi Takabatake, Hotaka Kawai, Norie Yoshioka, Nur Mohammad Monsur Hassan, Tsuyoshi Shimo, Guo-Fu Hu, Hitoshi Nagatsuka, Akira Sasaki

INTERNATIONAL JOURNAL OF ONCOLOGY 51 ( 2 ) 625 - 632 2017年8月

岡山大学病院高度救命救急センターにおける頭部、顎顔面外傷患者の検討

奥井達雄, 伊原木聰一郎, 志茂剛, 森澤綾香, 藤井由紀子, 佐々木朗

岡山歯学会雑誌 36 ( 1 ) 13 - 16 2017年6月

下顎に発生した顎放線菌症の1例本邦における顎放線菌症の過去集計と現状との比較検討

小畑協一, 伊原木聰一郎, 矢尾真弓, 柴田茜, 吉岡徳枝, 志茂剛, 佐々木朗

日本口腔内科学会雑誌 23 ( 1 ) 23 - 27 2017年6月

セツキシマブ投与にてアナフィラキシー様のinfusion reactionを発症したマダニ咬傷既往のある口腔癌患者の1例

矢尾真弓, 志茂剛, 柴田茜, 小畑協一, 吉岡徳枝, 伊原木聰一郎, 藤井由起子, 岸本晃治, 佐々木朗

岡山歯学会雑誌 36 ( 1 ) 1 - 6 2017年6月

Examination of Diseases Requiring Oral Surgery Treated via Medical-Dental Cooperation in the Department of Oral and Maxillofacial Surgery (Biopathology), Okayama University Hospital 査読

Masanori Masui, Tsuyoshi Shimo, Norie Yoshioka, Soichiro Ibaragi, Tatsuo Okui, Yuki Kunisada, Mayumi Yao, Shoko Yoshida, Yurika Murase, Koji Kishimoto, Akiyoshi Nishiyama, Yoshihiko Soga, Akira Sasaki

2 ( 115 ) 1 - 7 2017年5月

Endoscope-Assisted Transoral Reduction and Internal Fixation of a Mandibular Subcondylar Fracture with a 3D - Shaped Plate 査読

Ibaragi Soichiro, Yoshioka Norie, Kishimoto Koji, Sasaki Akira

International Journal of Contemporary Medical Research 4 ( 2 ) 575 - 577 2017年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Society for Contemporary Medical Research

Introduction: Disadvantages of open reduction of subcondylar fractures include visible facial scars and potential facial nerve damage. Endoscope-assisted procedures have solved these problems, however the anatomical adaptation of osteosynthesis plates to the fractured area is difficult in the limited surgical field. Three-dimensional pre-shaped plates specialized for subcondylar fractures recently became available. They are originally not for endoscope-assisted procedures but it may be useful for endoscopic approach because they are very small and pre-shaped. Case report: This paper presents a case of 43-year-old male patient with subcondylar fracture. The treatment provided was open reduction and internal fixation of a subcondylar fracture with three-dimensional pre-shaped plates via transoral approach under endoscopic visualization. Conclusion: The paper highlights contemporary management of subcondylar fracture to avoid complications associated with open reduction and restore the post-operative functions.

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