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論文 - 柳　文修

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Dynamic contrast-enhanced MRI as a predictor of programmed death ligand-1 expression in patients with oral squamous cell carcinoma. 査読国際誌

Nouha Tekiki, Mariko Fujita, Tatsuo Okui, Hotaka Kawai, May Wathone Oo, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Yohei Takeshita, Majd Barham, Hitoshi Nagatsuka, Yoshinobu Yanagi, Jun-Ichi Asaumi

Oncology letters 22 ( 5 ) 778 - 778 2021年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Immune checkpoint inhibitors (ICIs) targeting programmed death ligand-1 (PD-L1) are highly promising therapies for oral squamous cell carcinoma (OSCC). The assessment of PD-L1 expression may help predicting the therapeutic effect of ICIs and, thus, benefit patient selection. Contrast index (CI) parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) have been proven as efficient to assess microvessel density (MVD) in OSCC. The present study aimed to determine the correlation between DCE-MRI parameters and MVD and between DCE-MRI parameters and PD-L1 expression to determine whether DCE-MRI could be used non-invasively to evaluate PD-L1 expression in patients with OSCC. A total of 21 patients with primary OSCC who had undergone a 3T MRI scan, including DCE-MRI, were included in the present study, and CI curve-derived parameters were examined. The MVD and PD-L1 expression in the surgically resected specimens were analyzed using immunohistochemistry (IHC) staining for CD31 and IHC staining for PD-L1, respectively. The results demonstrated that the expression levels of these markers were correlated with DCE-MRI parameters. PD-L1 expression levels were found to be significantly correlated with the maximum CI (CI-max; P=0.007), peak CI (CI-peak; P=0.007), maximum CI gain (CI-gain; P=0.006) and MVD (P=0.001) values. The mean CI-max, CI-peak, CI-gain and MVD values were significantly higher in tumors with high PD-L1 expression (P<0.05). MVD levels were also significantly correlated with the time of CI-max (T-max; P=0.003) and CI-gain (P=0.037). The mean CI-gain was significantly increased, and the mean T-max was significantly shorter in high MVD tumors (P<0.05 and P<0.01, respectively). In summary, the findings from the present study confirmed the correlation between CI parameters, derived from DCE-MRI, and MVD, and suggested that these parameters may be correlated with PD-L1 expression in OSCC tumor cells.

DOI： 10.3892/ol.2021.13039

Tooth Movement Efficacy of Retraction Spring Made of a New Low Elastic Modulus Material, Gum Metal, Evaluated by the Finite Element Method. 国際誌

Naohiko Tamaya, Jun Kawamura, Yoshinobu Yanagi

Materials (Basel, Switzerland) 14 ( 11 ) 2021年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

The aim of this study was to evaluate the tooth movement efficacy of retraction springs made of a new β-titanium alloy, "gum metal", which has a low Young's modulus and nonlinear super elasticity. Using double loop springs incorporated into an archwire made of gum metal (GUM) and titanium molybdenum alloy (TMA), the maxillary anterior teeth were moved distally to close an extraction space. The long-term movements were simulated by the finite element method. Its procedure was constructed of two steps, with the first step being the calculation of the initial tooth movement produced by elastic deformation of the periodontal ligament, and in the second step, the alveolar socket was moved by the initial tooth movement. By repeating these steps, the tooth moved by accumulating the initial tooth movement. The number of repeating calculations was equivalent to an elapsed time. In the GUM and TMA springs, the anterior teeth firstly tipped lingually, and then became upright. As a result of these movements, the canine could move bodily. The amount of space closure in GUM spring was 1.5 times that in TMA spring. The initial tipping angle of the canine in the GUM spring was larger than that in the TMA spring. The number of repeating calculations required for the bodily movement in the GUM spring was about two times that in the TMA spring. It was predicted that the speed of space closure in the GUM spring was smaller than that in the TMA spring.

DOI： 10.3390/ma14112934

Tooth Movement Efficacy of Retraction Spring Made of a New Low Elastic Modulus Material, Gum Metal, Evaluated by the Finite Element Method 査読

Naohiko Tamaya, Jun Kawamura, Yoshinobu Yanagi

Materials 14 ( 11 ) 2934 - 2934 2021年5月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

The aim of this study was to evaluate the tooth movement efficacy of retraction springs made of a new β-titanium alloy, “gum metal”, which has a low Young’s modulus and nonlinear super elasticity. Using double loop springs incorporated into an archwire made of gum metal (GUM) and titanium molybdenum alloy (TMA), the maxillary anterior teeth were moved distally to close an extraction space. The long-term movements were simulated by the finite element method. Its procedure was constructed of two steps, with the first step being the calculation of the initial tooth movement produced by elastic deformation of the periodontal ligament, and in the second step, the alveolar socket was moved by the initial tooth movement. By repeating these steps, the tooth moved by accumulating the initial tooth movement. The number of repeating calculations was equivalent to an elapsed time. In the GUM and TMA springs, the anterior teeth firstly tipped lingually, and then became upright. As a result of these movements, the canine could move bodily. The amount of space closure in GUM spring was 1.5 times that in TMA spring. The initial tipping angle of the canine in the GUM spring was larger than that in the TMA spring. The number of repeating calculations required for the bodily movement in the GUM spring was about two times that in the TMA spring. It was predicted that the speed of space closure in the GUM spring was smaller than that in the TMA spring.

DOI： 10.3390/ma14112934

美容整形手術2年後に生じた注入剤を原因とする右側頬部膿瘍の1例

久富美紀, 河津俊幸, 岡田俊輔, 竹下洋平, 藤田麻里子, 藤倉満美子, 吉田沙織, 柳文修, 浅海淳一

歯科放射線 61 ( 増刊 ) 50 - 50 2021年5月

歯科診療室における患者の行動を誘導するための情報提示システムのプロトタイピング査読

安原啓太、杉原太郎、柳文修、高柴正悟

研究報告ヒューマンコンピュータインタラクション（HCI） 192 ( 31 ) 1 - 6 2021年3月

Assessment of Hounsfield unit in the differential diagnosis of odontogenic cysts. 国際誌

Kyonori Uehara, Miki Hisatomi, Luciana Munhoz, Toshiyuki Kawazu, Yoshinobu Yanagi, Shunsuke Okada, Yohei Takeshita, Emiko Arita Saito, Junichi Asaumi

Dento maxillo facial radiology 50 ( 2 ) 20200188 - 20200188 2021年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BRITISH INST RADIOLOGY

OBJECTIVES: The purpose of this study was to evaluate the usefulness of Hounsfield unit (HU) assessment with multislice-CT in the differentiation of radicular cysts (RCs), dentigerous cysts (DCs) and odontogenic keratocysts (OKCs). METHODS: In total, 307 odontogenic cysts (RCs, DCs and OKCs) were included in this study. Cysts with lesion diameter <10 mm, cysts with artefacts affecting measurement of HU values, cysts involving infection and recurrent cysts were regarded as exclusion criteria. Images were acquired in three different types of CT scanners: Aquilion ONE, Discovery CT750 HD and SOMATOM Definition Flash. Differences in HU values among scanners and among types of odontogenic cysts were assessed using one-way analysis of variance; multiple comparisons were performed post hoc, using the Tukey-Kramer honestly significant difference test. RESULTS: In total, 164 cysts were analysed in this study (64 RCs, 57 DCs and 43 OKCs). Regardless of the type of lesion, the Aquilion ONE scanner demonstrated a significant difference in HU value, compared with the Discovery CT750 HD scanner. Regardless of CT scanner model, HU values significantly differed between DCs and OKCs (p < 0.0001), as well as between OKCs and RCs (p < 0.0001). CONCLUSIONS: HU values were found to vary among CT scanners and should always be associated with other lesion imaging features while interpreting and elaboration diagnostic hypothesis. Notably, the results suggested that OKCs might be able to be differentiated from DCs and RCs by using HU values.

DOI： 10.1259/dmfr.20200188

Application of diffusion-weighted magnetic resonance imaging in the diagnosis of odontogenic lesions: a systematic review. 国際誌

Luciana Munhoz, Danielle Ayumi Nishimura, Miki Hisatomi, Yoshinobu Yanagi, Junich Asaumi, Emiko Saito Arita

Oral surgery, oral medicine, oral pathology and oral radiology 130 ( 1 ) 85 - 100 2020年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE INC

OBJECTIVES: This systematic literature review addresses the use of diffusion-weighted magnetic resonance imaging (DWI) and apparent diffusion coefficient (ADC) for the evaluation of benign maxillomandibular odontogenic lesions. STUDY DESIGN: Databases were searched, and original research studies or case report manuscripts up to April 2019 were included, using the keyword "diffusion," combined with the keywords "maxillofacial pathology," "oral pathology," "odontogenic tumors," "dental tissue neoplasms," "odontogenic cysts," and the histologic denomination of benign odontogenic lesions, according to the World Health Organization classification. Only English language articles and studies pertaining to DWI were selected. RESULTS: Fifteen investigations (11 original articles and 4 case reports) of distinct benign odontogenic lesions were included. Most studies did not include exclusively odontogenic lesions in their samples. CONCLUSIONS: It is too early to reach a conclusion that DWI and ADC can provide useful information in the differentiation of the histologic type of some benign odontogenic lesions on the basis of available data in the literature.

DOI： 10.1016/j.oooo.2019.11.009

Application of diffusion-weighted magnetic resonance imaging in the diagnosis of odontogenic lesions: a systematic review. 国際誌

Luciana Munhoz, Danielle Ayumi Nishimura, Miki Hisatomi, Yoshinobu Yanagi, Junich Asaumi, Emiko Saito Arita

Oral surgery, oral medicine, oral pathology and oral radiology 130 ( 1 ) 85 - 100 2020年7月

記述言語：英語

OBJECTIVES: This systematic literature review addresses the use of diffusion-weighted magnetic resonance imaging (DWI) and apparent diffusion coefficient (ADC) for the evaluation of benign maxillomandibular odontogenic lesions. STUDY DESIGN: Databases were searched, and original research studies or case report manuscripts up to April 2019 were included, using the keyword "diffusion," combined with the keywords "maxillofacial pathology," "oral pathology," "odontogenic tumors," "dental tissue neoplasms," "odontogenic cysts," and the histologic denomination of benign odontogenic lesions, according to the World Health Organization classification. Only English language articles and studies pertaining to DWI were selected. RESULTS: Fifteen investigations (11 original articles and 4 case reports) of distinct benign odontogenic lesions were included. Most studies did not include exclusively odontogenic lesions in their samples. CONCLUSIONS: It is too early to reach a conclusion that DWI and ADC can provide useful information in the differentiation of the histologic type of some benign odontogenic lesions on the basis of available data in the literature.

DOI： 10.1016/j.oooo.2019.11.009

Incidental findings in the thyroid gland on computed tomography images of the oral and maxillofacial region. 国際誌

Abdullah Khasawneh, Yohei Takeshita, Miki Hisatomi, Toshiyuki Kawazu, Mariko Fujita, Shunsuke Okada, Yuri Namba, Yudai Shimizu, Yoshinobu Yanagi, Junichi Asaumi

Oncology letters 19 ( 3 ) 2005 - 2010 2020年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPANDIDOS PUBL LTD

The numbers of abnormal findings incidentally detected in adjacent regions are increasing with advances in imaging modalities. The present study aimed to examine the prevalence and characteristics of incidental findings in the thyroid gland on computed tomography (CT) images of the oral and maxillofacial region. CT scans of the oral and maxillofacial region in patients obtained between January 2012 and December 2016 were retrospectively reviewed. Images that revealed incidental findings in the thyroid gland, including nodules, were recorded, together with the sizes and characteristics of the findings. The Japan Association of Breast and Thyroid Sonology (JABTS) guidelines were used for classification. The rate of descriptions of these findings in the radiographic interpretation reports were also examined. Of the 1,135 patients examined, 326 (28.7%) had several types of incidental findings. In particular, 169 (14.9%) of the 1,135 patients had nodules >5 mm in diameter, for which further careful examination is recommended in the JABTS guideline. The description rate for nodules >5 mm in diameter in the radiographic interpretation reports was 30.8% (52/169 patients), of whom 17.3% (9/52 patients) were referred to the endocrinology department for further careful examination. Incidental findings in the thyroid gland were relatively common on CT images of the oral and maxillofacial region. Oral radiologists tend to focus specifically on the oral and maxillofacial region during diagnosis on oral and maxillofacial CT images, but should pay the same careful attention to observe adjacent regions, such as the thyroid gland.

DOI： 10.3892/ol.2020.11298

Application of diffusion-weighted magnetic resonance imaging in the diagnosis of salivary gland diseases: a systematic review. 国際誌

Luciana Munhoz, Erika Antonia Dos Anjos Ramos, Daniel Cho Im, Miki Hisatomi, Yoshinobu Yanagi, Junich Asaumi, Emiko Saito Arita

Oral surgery, oral medicine, oral pathology and oral radiology 128 ( 3 ) 280 - 310 2019年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE INC

OBJECTIVES: The aim of this systematic literature review was to focus on the use of diffusion-weighted magnetic resonance imaging (DWI) in the evaluation of salivary gland diseases. STUDY DESIGN: Databases were searched, and original research manuscripts up to 2018 were identified by using the keywords "diffusion" combined with "salivary gland," "salivary gland neoplasm," "sialadenitis," "parotid gland," "submandibular gland," "sublingual gland," "minor salivary gland," "salivary gland fistula," "salivary gland calculi," "salivary ducts," "xerostomia," and "sialorrhea." Only English language manuscripts and studies pertaining to DWI were selected. RESULTS: In all, 66 investigations regarding various salivary gland diseases, such as neoplasms, postirradiation changes, and inflammatory and autoimmune diseases, were included. Most study objectives involved the use of the apparent diffusion coefficient (ADC) in differentiating between benign lesions and malignant neoplasms. Histologic features of evaluated samples were heterogeneous. CONCLUSIONS: DWI may improve the differential diagnosis of salivary gland diseases, particularly in distinguishing between benign and malignant neoplasms. A unique ADC cutoff value could not be established because of the heterogeneity of the methods applied for ADC assessment and the heterogeneity of the diseases. DWI and the ADC are valuable tools in the diagnosis of salivary gland disease.

DOI： 10.1016/j.oooo.2019.02.020

Oropharyngeal adenoid cystic carcinoma invading the mandibular bone through the mandibular foramen. 査読

Yohei Takeshita, Shunsuke Okada, Miki Hisatomi, Hidenobu Matsuzaki, Hotaka Kawai, Yohei Noda, Jun Murakami, Mariko Fujita, Hitoshi Nagatsuka, Yoshinobu Yanagi, Junichi Asaumi

Oral radiology 35 ( 3 ) 335 - 340 2019年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

Adenoid cystic carcinoma (ACC) is a rare epithelial tumor of the head and neck region, and one of the most common malignant tumors of the salivary glands. ACC is a slow-growing tumor characterized by perineural invasion and often has a high-recurrence rate. We describe a case of oropharyngeal ACC invading the mandibular bone through the mandibular foramen that showed a rare pattern of origin and invasion. A 70-year-old woman complained of noise and pain around the right temporomandibular joint. Osteomyelitis was suspected on the initial imaging examinations, although the findings were slightly atypical. However, a mass was observed in the right oropharyngeal wall on subsequent imaging examinations, and mandibular bone invasion, rather than osteomyelitis, was additionally suspected. The mass in the right oropharyngeal wall and right mandible was surgically excised. On postoperative histopathological examination, the mass was finally diagnosed as ACC. As tumor cells were also observed around the inferior alveolar nerve, mandibular bone invasion through the mandibular foramen was suspected. An oropharyngeal ACC invading the mandibular bone through the mandibular foramen is extremely rare. The present case suggests that bone invasion should be considered carefully with several imaging examinations when a malignant tumor such as ACC is observed around the jaw bone.

DOI： 10.1007/s11282-018-0359-3

Application of diffusion-weighted magnetic resonance imaging in the diagnosis of salivary gland diseases: a systematic review. 国際誌

Luciana Munhoz, Erika Antonia Dos Anjos Ramos, Daniel Cho Im, Miki Hisatomi, Yoshinobu Yanagi, Junich Asaumi, Emiko Saito Arita

Oral surgery, oral medicine, oral pathology and oral radiology 128 ( 3 ) 280 - 310 2019年9月

記述言語：英語

OBJECTIVES: The aim of this systematic literature review was to focus on the use of diffusion-weighted magnetic resonance imaging (DWI) in the evaluation of salivary gland diseases. STUDY DESIGN: Databases were searched, and original research manuscripts up to 2018 were identified by using the keywords "diffusion" combined with "salivary gland," "salivary gland neoplasm," "sialadenitis," "parotid gland," "submandibular gland," "sublingual gland," "minor salivary gland," "salivary gland fistula," "salivary gland calculi," "salivary ducts," "xerostomia," and "sialorrhea." Only English language manuscripts and studies pertaining to DWI were selected. RESULTS: In all, 66 investigations regarding various salivary gland diseases, such as neoplasms, postirradiation changes, and inflammatory and autoimmune diseases, were included. Most study objectives involved the use of the apparent diffusion coefficient (ADC) in differentiating between benign lesions and malignant neoplasms. Histologic features of evaluated samples were heterogeneous. CONCLUSIONS: DWI may improve the differential diagnosis of salivary gland diseases, particularly in distinguishing between benign and malignant neoplasms. A unique ADC cutoff value could not be established because of the heterogeneity of the methods applied for ADC assessment and the heterogeneity of the diseases. DWI and the ADC are valuable tools in the diagnosis of salivary gland disease.

DOI： 10.1016/j.oooo.2019.02.020

Fourth molar: A retrospective study and literature review of a rare clinical entity. 査読国際誌

Babatunde O Bamgbose, Shunsuke Okada, Miki Hisatomi, Yoshinobu Yanagi, Yohei Takeshita, Zahrau Saleh Abdu, Edugie J Ekuase, Jun-Ichi Asaumi

Imaging science in dentistry 49 ( 1 ) 27 - 34 2019年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：KOREAN ACAD ORAL & MAXILLOFACIAL RADIOLOGY

Purpose: The prevalence of supernumerary teeth has been reported to be between 0.1% and 3.8%. The aim of this study was to determine the prevalence, clinical significance, and associated pathologies of fourth molars based on a retrospective study and a literature review. Materials and Methods: A 5-year retrospective prevalence study was conducted at the Department of Oral Diagnosis and Dentomaxillofacial Radiology of Okayama University Hospital, Okayama, Japan. The study involved extracting data from the digital records of patients from January 1, 2013 through December 31, 2017. The sampling frame included all patients who had panoramic radiographs, cone-beam computed tomography (CT), and multislice CT images during the period under review. Results: A total of 26,721 cases were reviewed and 87 fourth molars were identified. The prevalence of fourth molars in the 5-year study at Okayama was calculated as 0.32%. The mean age of patients with a fourth molar was 30.43 years, and the male-to-female ratio was 1:0.98. The vast majority of cases were in the maxilla (92%) and had normal shapes (89.7%); furthermore, 82.8% of cases were unerupted. Conclusion: The prevalence of fourth molars in the study population was found to be 0.32%, and fourth molars occurred with approximately equal frequency in males and females. Fourth molars were more common in the maxilla and were predominantly unerupted and small.

DOI： 10.5624/isd.2019.49.1.27

A case of sublingual adenoid cystic carcinoma involving the mandible presenting as a "skip lesion".

Mariko Fujita, Yoshinobu Yanagi, Arthur R G Cortes, Emiko Saito Arita, Tomoo Onoda, Hitoshi Nagatsuka, Jun-Ichi Asaumi

Oral radiology 34 ( 3 ) 281 - 287 2018年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

Adenoid cystic carcinoma (ACC) is a slowly growing malignant neoplasm with a propensity for perineural invasion. Microscopic invasion of ACC often prevents its detection on computed tomography (CT) or magnetic resonance imaging (MRI). We herein report a rare case of sublingual ACC presenting as a "skip lesion" that rapidly infiltrated the mandible after tumor resection. A 64-year-old man presented to Okayama University Hospital with an 18-month history of swelling in the right floor of the mouth. Clinical examination displayed an ulcerated swollen mass in that region. An enhanced mass was detected in the right sublingual space on CT and MRI. Bone surface erosion was observed at the inferior border of the mandible, but continuity with the sublingual mass or mass around that lesion was not detected by imaging. Sublingual tumor resection and selective neck dissection were performed by the pull-through method. Histopathologically, the surgical margins were free of cancer cells, and the tumor was diagnosed as ACC. Continuity with the sublingual mass and mandibular bone was not detected intraoperatively. However, marked bone resorption was detected in the anterior mandible 3 months after the operation. Biopsy was performed, and the findings indicated the same histological type of sublingual ACC. This case suggests that a malignant tumor close to the jaw bone requires the clinician to consider the possibility of bone invasion and to observe a wide region surrounding the tumor using imaging examination.

DOI： 10.1007/s11282-017-0306-8

Assessment of MRI findings and clinical symptoms in patients with temporomandibular joint disorders. 査読国際誌

Risa Matsubara, Yoshinobu Yanagi, Kazuhiro Oki, Miki Hisatomi, Karina Cp Santos, Babatunde O Bamgbose, Mariko Fujita, Shunsuke Okada, Shogo Minagi, Junichi Asaumi

Dento maxillo facial radiology 47 ( 4 ) 20170412 - 20170412 2018年5月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BRITISH INST RADIOLOGY

OBJECTIVES: To investigate the correlations among various temporomandibular joint (TMJ) findings on MRI and the relationships between MRI findings and symptoms. METHODS: 425 patients (850 TMJs) with temporomandibular joint disorders (TMDs) who underwent MRI were enrolled. Oblique sagittal proton density-weighted and T2 weighted images in open- and closed-mouth positions were evaluated. MRI findings included disc configuration, disc position, condylar morphology, bone marrow pattern, and joint effusion. Symptoms included TMJ pain, TMJ noise, and limitation of mouth opening. For statistical analyses, Spearman's rank correlation coefficient and logistic regression analysis were applied. RESULTS: Folded disc, disc displacement without reduction (DDWOR), and osteophytes had significant negative correlations with other normal MRI findings (p < 0.01). DDWOR and marrow edema were associated with TMJ pain. Conversely, osteophytes [odds ratio (OR): 0.52; 95% CI (0.30-0.90)] and combination-type condylar degeneration [OR: 0.45; 95% CI (0.24-0.83)] were associated with decreased risk of TMJ pain. Condylar flattening was positively associated with TMJ noise [OR: 5.25; 95% CI (1.44-19.07)] and negatively associated with limitation of mouth opening [OR: 0.34; 95% CI (0.11-0.99)]. High-grade joint effusion was significantly associated with TMJ pain and noise. CONCLUSIONS: DDWOR and high-grade joint effusion (an indicator of inflammation in the articular cavity) were associated with TMD symptoms. This finding suggests that treatment strategy for DDWOR and decreasing inflammation might lessen clinical TMD symptoms. Condylar degeneration was not associated with indicators of inflammation or TMJ symptoms. These results suggest that patients with TMD symptoms should undergo initial MRI to allow rapid selection of appropriate therapies.

DOI： 10.1259/dmfr.20170412

Incidental finding of papillary thyroid carcinoma on CT examination of mandibular lesion: Case report. 査読国際誌

Irfan Sugianto, Yoshinobu Yanagi, Hidenobu Konouchi, Miki Hisatomi, Shunsuke Okada, Babatunde O Bamgbose, Junichi Asaumi

Molecular and clinical oncology 8 ( 1 ) 183 - 187 2018年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPANDIDOS PUBL LTD

The number of significant incidental findings identified on radiographic examinations has increased. In total, 169 patients, 87 males and 82 females, with a mean age of 67.3 years (range, 17-92 years), as well as 65 patients (38.5%), 43 (66.2%) female and 22 (33.8%) male had abnormal findings in the thyroid for one year in our institution. Thyroid nodules are the most common incidental findings on oral and maxillofacial evaluations. Computed tomography (CT) and magnetic resonance imaging (MRI) examination are frequently used to detect thyroid abnormality. The present study reported a case of papillary thyroid carcinoma (PTC) detected following CT and MRI examination of a mandibular lesion. The CT examination of the oral and maxillofacial region included the thyroid, which must be examined carefully to detect various diseases, including PTC. Collaboration between radiologists and clinicians is important to manage these incidental findings.

DOI： 10.3892/mco.2017.1478

A Case of Schwannoma of the Submandibular Region. 査読国際誌

Babatunde O Bamgbose, Akiko Sato, Yoshinobu Yanagi, Miki Hisatomi, Yohei Takeshita, Irfan Sugianto, Junichi Asaumi

The open dentistry journal 12 12 - 18 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BENTHAM SCIENCE PUBL LTD

Background: We herein described a rare case of schwannoma of the hypoglossal nerve in the submandibular region with diagnostic imaging and histopathological findings. Case Report: A 31-years-old woman has had a palpable firm, rubbery, freely mobile mass in the submandibular region. Of imaging, MR images showed homogeneous isointensity on T1-weighted imaging (T1-WI), heterogeneous hypointensity on T2-WI, heterogeneous hyperintensity on short T1 inversion recovery (STIR), and heterogeneous enhancement on contrast-enhanced T1-WI. A clear capsule was observed on the margin and showed hypointense on T2-WI. Dynamic MRI showed heterogeneous gradual increased enhancement. The uptake of contrast medium was regionally slow. Diagnostic imaging using CT and MRI was suspected of salivary gland tumor or neurogenic tumor. In consideration of imaging diagnosis, a pleomorphic adenoma or a schwannoma was suspected. Final diagnosis was confirmed on the basis of histopathological finding and intraoperative findings. Conclusion: 1. Histopathologic examination is inevitable, because MR findings are not specific.2. Schwannomas were said to have specific MRI properties, including specific signs (split-fat sign, fascicular sign, target sign). However, they are not always observed.3. This case confirmed the differential diagnosis on the basis of the intraoperative finding that the tumor was continuous with the hypoglossal nerve.

DOI： 10.2174/1874210601812010012

Should incidental findings in diagnostic imaging be reported? 国際誌

Karina C Panelli Santos, Mariko Fujita, Jefferson X Oliveira, Yoshinobu Yanagi, Junichi Asaumi

Minerva stomatologica 66 ( 2 ) 75 - 80 2017年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Recent improvements in image quality have contributed to an increasing number of incidental findings (IF). Also called as "incidentalomas", this generic term refers to an entity discovered unexpectedly on an imaging examination performed for other reason. Commonly, normal variants, minor developmental anomalies and imaging artifacts are described as potential pathology. Some IF were reported in magnetic resonance imaging (MRI) exam of temporomandibular joint (TMJ), including IF in the brain, maxillary sinus, ethmoidal cells, mastoid cells, salivary glands, muscles. The aim of this study is to evaluate the prevalence of IF on MRI of TMJ from Japanese patients. METHODS: An image archive from 872 patients referred to MRI evaluation due to TMJ symptomatology was assessed. Three experienced radiologists evaluated all images, and the final diagnosis was achieved by consensus. The data regarding IF was recorded, considering only tumor and tumor-like lesions. RESULTS: A total of 12 (1.38%) of tumor and tumor-like lesions were observed from all 872 MRI exams evaluated. The most frequent lesion was arachnoid cyst (0.45%), followed by neoplastic lesions (0.22%). CONCLUSIONS: The question "should every IF be reported?" is still difficult to answer. Relevant IF are rare, and radiologists are expected to be reasonable: think about the adverse effects of reporting an IF, and, based on their own judgment, choose for a positive or a negative answer.

DOI： 10.23736/S0026-4970.17.03971-1

A case of adenoid cystic carcinoma associated with IgG4-related disease. 国際誌

Tsuyoshi Shimo, Mayumi Yao, Yuichiro Takebe, Yuko Ono, Kyoichi Obata, Naito Kurio, Soichiro Ibaragi, Norie Yoshioka, Koji Kishimoto, Yoshinobu Yanagi, Hitoshi Nagatsuka, Akira Sasaki

International journal of surgery case reports 10 12 - 6 2015年

記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition associated with elevated serum IgG4 levels and tissue infiltration by IgG4-expressing plasma cells. We present a case of adenoid cystic carcinoma (ACC) of the submandibular gland with possible involvement of IgG4-RD. PRESENTATION OF CASE: The patient was a 59-year-old man presenting with a swollen right submandibular gland. Laboratory tests revealed IgG4 levels of 176mg/dl (reference range: 4.8-105). An initial open biopsy for histological diagnosis showed chronic sialadenitis. The region was monitored on an outpatient basis, and finally the right submandibular was totally resected because malignant tumor could not be excluded. Histological examination of the submandibular gland showed an ACC with lymphocytic infiltration containing many IgG4-positive plasma cells in the tumor stroma. DISCUSSION: We have described a case that indicated a possible involvement of ACC with IgG4-RD. This allows us to speculate that longstanding IgG4-RD may progress to malignancy or infiltration of IgG4-positive plasma cells through the signals of tumor stimuli. Further investigations are required to determine the potential pathogenic mechanism underlying this unique tumor. CONCLUSION: This case underscores that caution is needed in the diagnosis of masses with high serum IgG4 levels, as the differential diagnosis includes malignancy.

DOI： 10.1016/j.ijscr.2015.01.022

Swelling of the floor of the mouth in an infant. 査読国際誌

Hidenobu Matsuzaki, Naoki Katase, Norifumi Moritani, Marina Hara, Yoshinobu Yanagi, Jun-Ichi Asaumi

Oral surgery, oral medicine, oral pathology and oral radiology 116 ( 4 ) 392 - 7 2013年10月

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