Faculty Profiles - NAGATSUKA Hitoshi

MISC - NAGATSUKA Hitoshi

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Sequential Expression of Notch1, HES5, Jagged2, and Math1 in Molar Tooth Germ of Mouse(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)

Borkosky Silvia Susana, Han Phuu Pwint, Tian Xin-Xin, Missana Liliana, Nishikawa Hiroyuki, Yoshinobu Junko, Nishizaki Kazunori, Nagatsuka Hitoshi

Journal of hard tissue biology 14 ( 2 ) 128 - 129 2005

rhBMP-2/コラーゲン複合体による耳小骨再生

辻極秀次, 武田靖志, 長塚仁, Phuu Han, Rosario Rivera, 市川和男, 西崎和則, 永井教之

Journal of oral biosciences 46 ( 5 ) 421 - 421 2004.9

Loss of Heterozygosity Analysis of Chromosomal 2q22-37 Region in Oral Cancers(Asian Science Seminar/III-2, The 3^<rd> Asian Science Seminar)

Cengiz Beyhan, Gunduz Mehmet, Nagatsuka Hitoshi, Gunduz Esra, Tsujigiwa Hidetsugu, Shinno Yasuo, Tamamura Ryo, Nagai Noriyuki

Journal of hard tissue biology 13 ( 2 ) 99 - 99 2004.9

Localization of CD31, CD34, and CD105 as a Measure of Microvessel Density in Cervix Neoplasms(Asian Science Seminar/III-3, The 3^<rd> Asian Science Seminar)

Roan Cheng Hsiung, Setsu Kojun, Inoue Masahisa, Nagatsuka Hitoshi, Nagai Noriyuki

Journal of hard tissue biology 13 ( 2 ) 99 - 99 2004.9

BMP Family Play Regulatory Roles in Determining the Shape Development of Odontogenic Tumors(Asian Science Seminar/I-4, The 3^<rd> Asian Science Seminar)

Palmario Georgina, Jahara Lim Diampo, Tamamura Ryo, Santos Rivera Rosario, Inoue Masahisa, Nagatsuka Hitoshi

Journal of hard tissue biology 13 ( 2 ) 98 - 98 2004.9

Gene Expression of Matrix Proteins in Cbfal-Knockout Mice(Asian Science Seminar/I-1, The 3^<rd> Asian Science Seminar)

Borkosky Silvia Susana, Tsujigiwa Hidetsugu, Lee You jin, Rodriguez Andrea Paola, Rivera Rosario, Komori Yoshifumi, Nagatsuka Hitoshi

Journal of hard tissue biology 13 ( 2 ) 97 - 97 2004.9

Analysis of Amelogenin Gene (AMGX, AMGY) Expression in Ameloblastoma(Asian Science Seminar/III-1, The 3^<rd> Asian Science Seminar)

Han Phuu Pwint, Siar Chong Huat, Tsujigiwa Hidetsugu, Nagatsuka Hitoshi

Journal of hard tissue biology 13 ( 2 ) 98 - 99 2004.9

Wnt5a Participates in the Mouse Embryonic Maxillary-Mandible Development(Asian Science Seminar/I-3, The 3^<rd> Asian Science Seminar)

Xiao Jing, Tsujigiwa Hidetsugu, Nagatsuka Hitoshi, Zhu En xin, Tan Jun, Nagai Noriyuki

Journal of hard tissue biology 13 ( 2 ) 97 - 97 2004.9

Gene Expression of Matrix Proteins in Cbfa1-Knockout Mice

Nagatsuka Hitoshi, Siar Chong Huat, Kitamura Yoshiko, Tsujigiwa Hidetsugu, Lee You-jin, Gunduz Mehmet, Tamamura Ryo, Komori Toshifumi, Lefevre Mathieu, Nagai Noriyuki

Journal of hard tissue biology 13 ( 1 ) 37 - 45 2004.6

Language：English Publisher：The Society of Hard Tissue Biology

Odontogenesis and osteogenesis are two distinct yet closely related processes that share common signalling pathways including regulatory control by Cbfal. Although Cbfal is well-recognized as the master regulator of osteoblastic differentiation, little is known of its precise role during odontogenesis. We sought to clarify this by examining morphogenesis of teeth and matrix protein gene expression in cbfal-knock-out mice at ed 17.5 and day 0 of birth, and comparing it with presumptive mandible bone-forming site. Results demonstrated morphological and functional differentiation differences between these two processes: incisor tooth germ showed morphological and functional differentiation of odontoblasts with expression of osteopontin and osteocalcin whereas the presumptive mandible bone-forming site showed lack of osteoblastic differentiation, and no expression of these two matrix proteins. Stage-specific and cytodifferentiation differences were also observed between incisor and molar tooth germs: incisor tooth germ progressed to the bell stage with odontoblast and ameloblast differentiation, and expression of tooth-specific proteins, amelogenin and dentine sialophosphoprotein, whereas molar tooth germ showed marurational arrest at bud to cap stage. Present findings suggest that 1. The transcription factor Cbfa-1 is associated with morphogenesis of teeth and matrix protein gene expression. 2. Compared to the incisor tooth germ, the molar tooth germ is more strongly subjected to control by Cbfal, and 3. In Cbfal-knockout mice, the odontoblast-like cells in the incisor and the spindle cells in the presumptive mandible forming region showed different patterns of gene expression of matrix proteins common to teeth and bones.

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Other Link： http://search.jamas.or.jp/link/ui/2006100288

7.エナメル上皮腫におけるAmelogenin遺伝子(AMELX,AMELY)発現の解析(第12回硬組織生物学会学術大会)

プーハン, 辻極秀次, 長塚仁, 大井田新一郎, エスラグンデゥズ, 玉村亮, 神農泰生, アンドレアロドリゲス, 永井敏之

Journal of hard tissue biology 12 ( 3 ) 93 - 93 2004.3

口腔扁平上皮癌の組織型におけるIV型コラーゲンα１〜６鎖とMMPの局在に関する研究.

玉村亮, 長塚仁, You-Jin Lee, Jing Xiao, 内藤一郎, 佐渡義一, 川上敏行, 永井教之

J Hard Tissue Biol 2004

口腔扁平上皮癌の癌化過程におけるIV型コラーゲンα１〜６鎖とMMPの局在に関する研究.

玉村亮, 長塚仁, You-Jin Lee, Jing Xiao, 内藤一郎, 佐渡義一, 川上敏行, 永井教之

J Hard Tissue Biol 2004

ヒト歯胚と歯原性腫瘍基底膜におけるIV型コラーゲンα鎖の局在に関する免疫組織化学的研究.

藤井英貴, 長塚仁, You-Jin Lee, 神農泰生, 玉村亮, Jing Xiao, 内藤一郎, 佐渡義一, 中川敏浩, 永井教之

J Hard Tissue Biol 2004

Cell Differentiation of MDPC-23 Cells Derived from Mouse Papilla Tissues

Ichikawa Kazuo, Nagatsuka Hitoshi, Tsujigiwa Hidetsugu, Nagai Noriyuki

Journal of hard tissue biology 13 ( 3 ) 131 - 135 2004

Language：Japanese Publisher：The Society of Hard Tissue Biology

For the purpose of developing a hybrid type dentin with periodontal membrane implant, we conducted in vitro and in vivo experiments using a mouse dental papilla-derived cell line MDPC-23 to study anatomical and functional differentiation. Our results show that MDPC-23 cells possess dentin-inducing characteristics and differentiate into odontoblast-like cells extending cytoplasmic projection unilaterally.

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悪性歯原性腫瘍基底膜におけるIV型コラーゲンα鎖の局在に関する免疫組織化学的研究.

藤井英貴, 長塚仁, You-Jin Lee, 神農泰生, 玉村亮, Jing Xiao, 内藤一郎, 佐渡義一, 中川敏浩, 永井教之

J Hard Tissue Biol 2004

7.Analysis of Amelogenin Gene(AMELX, AMELY) Expression in Ameloblastoma(12th Annual Meeting of the Society of Hard Tissue Biology)

Pwint Han Phuu, Tsujigiwa Hidetsugu, Nagatsuka Hitoshi, Oida Shinichiro, Esra gunduz, Tamamura Ryou, Shinnou yasuo, Andrea rodriguez, Nagai noriyuki

Journal of hard tissue biology 12 ( 2 ) 64 - 64 2003.12

Efficacy of Collagen Scaffold in bone formation using KUSA-A1 cells(2nd ASIAN SCIENCE SEMINAR IN OKAYAMA 2003)

Andrea Rodriguez, Nagatsuka Hitoshi, Tsujigiwa Hidetsugu, L Missana, Nagai Noriyuki

Journal of hard tissue biology 12 ( 2 ) 73 - 74 2003.12

Immunohistochemical study of BMP family in odontogenic tumors(2nd ASIAN SCIENCE SEMINAR IN OKAYAMA 2003)

Tamamura Ryo, Nagatsuka Hitoshi, Tsujigiwa Hidetsugu, Shinno Yasuo, Inoue Masahisa, Siar Chong Huat, Nagai Noriyuki

Journal of hard tissue biology 12 ( 2 ) 71 - 71 2003.12

Frequent deletion and increased mRNA expression of a candidate tumor suppressor gene at 19p13 region, BRG1, in oral cancers(2nd ASIAN SCIENCE SEMINAR IN OKAYAMA 2003)

Gunduz Esra, Gunduz Mehmet, Nagatsuka Hitoshi, Tsujigiwa Hidetsugu, Ouchida Mamoru, Shinnou Yasuo, Cengiz Beyhan, Shimizu Kenji, Nagai Noriyuki

Journal of hard tissue biology 12 ( 2 ) 73 - 73 2003.12

Gene expression of matrix proteins in Cbfal- knockout mice(2nd ASIAN SCIENCE SEMINAR IN OKAYAMA 2003)

Rivera Rosario, Nagatsuka Hitoshi, Tsujigiwa Hidetsugu, Nakano Keisuke, Huang Bingzhen, Nagai Noriyuki

Journal of hard tissue biology 12 ( 2 ) 73 - 73 2003.12

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