Faculty Profiles - NAGATSUKA Hitoshi

MISC - NAGATSUKA Hitoshi

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Biological analysis of bone marrow stromal cells in vivo cell culture method(5th Asian Science Seminar,Session 1)

Lefevre Mathieu Bernard, Rodriguez Andrea Paola, Tsujigiwa Hidetsugu, Nagatsuka Hitoshi, Nagai Noriyuki

Journal of hard tissue biology 15 ( 3 ) 107 - 107 2006.12

Preferential expression of heparanase protein correlates with early invasion and progression of oral mucosal melanoma(5th Asian Science Seminar,Session 1)

Rivera Rosario Santos, Nagatsuka Hitoshi, Tamamura Ryo, Xiao Jing, Nagai Noriyuki

Journal of hard tissue biology 15 ( 3 ) 106 - 106 2006.12

Mechanism of new bone formation by using immature stem cell KUSA/A1 for bone tissue engineering in vivo study(5th Asian Science Seminar,Session 1)

Ara Sathi Gulsan, Rodriguez Andrea Paola, Tsujigiwa Hidetsugu, Nagatsuka Hitoshi, Nagai Noriyuki

Journal of hard tissue biology 15 ( 3 ) 107 - 107 2006.12

Mutation analysis of the EGFR pathway in head and neck squamous cell cancer(5th Asian Science Seminar,Session 1)

Ali Mahmoud AL Sheikh, Gunduz Mehmet, Nagatsuka Hitoshi, Cengiz Beyhan, Gunduz Esra, Tamamura Ryo, Nagai Noriyuki

Journal of hard tissue biology 15 ( 3 ) 106 - 107 2006.12

Runx2 expression in mandibular condylar cartilage development(15thAnnual Meeting of the Society for Hard Tissue Regenerative Biology,Session 2)

Shimizu Takako, Nagatsuka Hitoshi, Tsujigiwa Hidetsugu, Watanabe Takehiro, Okafuji Norimasa, Kurihara Saburo, Nagai Noriyuki, Kawakami Toshiyuki

Journal of hard tissue biology 15 ( 3 ) 109 - 109 2006.12

長期経過観察し得た下顎骨の若年性活動性化骨性線維腫の一例

小山貴弘, 西山明慶, 志茂剛, 合田健志, 長塚仁, 佐々木朗

日本口腔外科学会雑誌 52 ( Suppl. ) 118 - 118 2006.9

Gene and protein localization of heparanase in odontogenic cystic lesions.

片瀬直樹, 長塚仁, 辻極秀次, グンデゥズメーメット, ハンプープウィント, 玉村亮, 永井教之

Journal of Oral Biosciences 48 ( Suppl ) 195 2006.9

Wnt5a gene plays a role in mouse molar development by regulating its proliferation

肖晶, 長塚仁, 片瀬直樹, ルフェーブル・マシュー, シャティ・アラ, ロドリゲス・アンドレア, 永井教之

Journal of Oral Biosciences 48 ( Suppl. ) 153 - 153 2006.9

歯原性嚢胞におけるheparanaseの発現

片瀬直樹, 長塚仁, 辻極秀次, グンデゥズ・メーメット, ハンプー・プウィント, 玉村亮, 永井教之

Journal of Oral Biosciences 48 ( Suppl. ) 195 - 195 2006.9

歯原性腫瘍におけるヘパラナーゼの発現

長塚仁, Phuu Pwint Han, Siar Chong Huat, Gunduz Mehmet, 玉村亮, 片瀬直樹, 永井教之

日本病理学会会誌 95 ( 1 ) 289 - 289 2006.4

A Pigmented Compound Odontoma with Ghost cells: case report and brief review of literature

Phuu Pwint Han, 長塚仁, Siar Chong Huat, 片瀬直樹, Rivera Rosario, 岡内美佳, 永井教之

日本病理学会会誌 95 ( 1 ) 286 - 286 2006.4

A case of mucinous adenocarcinoma of the palate

MANO Takamitsu, UCHIDA Kenichiro, OKAFUJI Masaki, HORINAGA Daiju, NAGATSUKA Hitoshi, UEYAMA Yoshiya

Journal of Oral Surgery Society of Japan 52 ( 9 ) 507 - 510 2006

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Mucinous adenocarcinoma (MAC) arising in the oral cavity is extremely rare. We report a case of MAC originating in the palate.<BR>A 70-year-old man presented with an ulcer of the palate visited our hospital. A demarcated tumor arising in the right side of the palate with cervical lymph swelling on the same side were recognized. Histopathological examination revealed a MAC. Partial maxillectomy and radical neck dissection were immediately performed. After surgery, neck metastasis was detected on the contralateral side. Radical neck dissection was therefore performed. After that, recurrence in the right side of the neck and lung metastasis was detected. Bilateral radiotherapy was given to treat recurrence in the neck, and chemotherapy was administered to treat the lung metastasis. The patient died of respiratory insufficiency 2 years 5 months after the first examination.

DOI： 10.5794/jjoms.52.507

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Other Link： https://jlc.jst.go.jp/DN/JALC/00285663372?from=CiNii

Wnt5a Gene Plays a Role in Mouse Embryonic Orofacial Development(International Symposium of Maxillofacial & Oral Regenerative Biology in OKAYAMA 2005)

Xiao Jing, Zhu En-xin, Nagatsuka Hitoshi, Gunduz Mehmet, Li Changgong, Minoo Parviz, Nagai Noriyuki

Journal of hard tissue biology 14 ( 4 ) 355 - 356 2005.12

Language：English Publisher：The Society of Hard Tissue Biology

To determine if Wnt5a gene involved in orofacial development, especially secondary palate development, we checked Wnt5a protein and mRNA in wild-type mouse embryos, and also searched Wnt5a knockout mice palates. We found Wnt5a is expressed during orofacial development, especially necessary for normal secondary palate and tongue morphogenesis. Wnt5a deficient mice exhibit cleft palate and abnormal distortion tongue suggests Wnt5a is essential to the palate development. Our data suggested that defection of MEE proliferation in Wnt5a (-/-) secondary palate indicates Wnt5a gene may regulate palate growth.

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Effects of immobilized recombinant human bone morphogenetic protein-2/succinylated type I atelocollagen on cellular activity of ST2 cells. International journal

Hidetsugu Tsujigiwa, Hitoshi Nagatsuka, Mehmet Gunduz, Andrea Rodriguez, Rosario S Rivera, Racquel Z Legeros, Miho Inoue, Noriyuki Nagai

Journal of biomedical materials research. Part A 75 ( 1 ) 210 - 5 2005.10

Language：English Publisher：WILEY-LISS

The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) to induce ectopic bone formation requires a carrier. Type I atelocollagen, a biomaterial with a porous structure, excellent operational features, and biocompatibility, is an effective carrier for rhBMP-2. However, the conventionally used lyophilized rhBMP-2/collagen mixture does not necessarily give adequate bone-induction effect. In the present study, we examined the effect of immobilizing rhBMP-2 to type I atelocollagen on the cellular activity of ST2 cells. The following results were obtained: (1) rhBMP-2 was effectively immobilized to succinylated type I atelocollagen, indicating the usefulness of succinylated type I atelocollagen in immobilization; (2) studies of alkaline phosphatase activity confirmed the effectiveness of rhBMP-2 immobilized on succinylated atelocollagen in augmenting cellular activity.

DOI： 10.1002/jbm.a.30416

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マウス歯胚とヒト歯胚の基底膜におけるIV型コラーゲンα鎖の局在

片瀬直樹, 長塚仁, 中野敬介, 岡内美佳, グンデゥズ・メーメット, 玉村亮, 永井教之

Journal of Oral Bioscience 47 ( Suppl ) 122 2005.9

Erdheim-Chester Disease: a Rare Disease Presenting with Multiple Jaw Lesions in a Child

Morimoto Y, Han PP, Katase N, Tamamura R, Iamaroon A, Lee JK, Nagatuska H

Journal of Hard Tissue Biology 14 ( 2 ) 119 2005.9

口腔扁平上皮癌におけるCaspase-6の発現

神農泰生, 長塚仁, Gunduz Mehmet, Rodriguez Andrea, Han Phuu, 片瀬直樹, 岡内美佳, 永井教之

日本病理学会会誌 94 ( 1 ) 205 - 205 2005.3

Study of Amelogenin Gene Expression in Ameloblastoma

Hidetsugu Tsujigiwa, Hitoshi Nagatsuka, Mehmet Gunduz, Masao Yamada, Noriyuki Nagai, Shin Hong-In, Satoshi Ichihara

Journal of Hard Tissue Biology 14 ( 2 ) 192 - 193 2005.1

Language：English

Although it has been known that amelogenin gene is expressed in ameloblastoma, the precise expression pattem of X and Y amelogenin genes (AMGX, AMGY) in this tumor has not yet identified. In this study, we analyzed amelogenin gene expression in 19 samples (9 male, 10 female) of oral ameloblastomas by RT-PCR and detect the chromosomal origin of amelogenin mRNA by restriction enzyme digestion of the RT-PCR product. All tumor samples expressed amelogenin mRNA. We could detect increased level of AMGY expression in all male samples, higher than that of AMEX. It is an interesting finding as in normal male tooth development, the expression of AMGY is very much lower than that of AMGX. We postulate that epigenetic change of sex chromosomes may have some correlations with tumorigenesis of ameloblastoma. We also discuss the other possible mechanisms and points for future studies on this the change in expression pattern. © 2005, THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY. All rights reserved.

DOI： 10.2485/jhtb.14.192

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Study of Amelogenin Gene Expression in Ameloblastoma

Hidetsugu Tsujigiwa, Hitoshi Nagatsuka, Mehmet Gunduz, Masao Yamada, Noriyuki Nagai, Shin Hong-In, Satoshi Ichihara

Journal of Hard Tissue Biology 14 ( 2 ) 157 - 158 2005.1

Language：English

DOI： 10.2485/jhtb.14.157

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Expression of Notch Signal in the Regenerated Olfactory Epithelium after Damage

Orita Yorihisa, Nagatsuka Hitoshi, Yoshinobu Junko, Tsujigiwa Hidetsugu, Maeda Yukihide, Kakiuchi Masashi, Orita Saeko, Takeuchi Ayako, Takeda Yasushi, Nagai Noriyuki, Nishizaki Kazunori

Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology) 44 ( 2 ) 114 - 118 2005

Publisher：Japan Rhinologic Society

We studied the expression of Notch1, Math1, Jagged2 and Hes5 in the regenerated olfactory epithelium (OE) of adult mice. The OE was first destroyed by intranasal zinc sulfate irrigation and, after 7days, some regenerated areas were observed by in situ hybridization (ISH). In mice treated with zinc sulfate, Notch1 expression was sparsely observed in the regenerated OE and the number of Notch1-positive cells appeared to be lower than that in the OE of control cases. Math1 and Jagged2 expression was observed in the regenerated OE. These expression patterns appear to be the same as those in control cases. No Hes5 was observed in either the normal or regenerated OE. We concluded that Notch1 down-regulation in the damaged OE may play an important role in OE regeneration.

DOI： 10.7248/jjrhi1982.44.2_114

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