論文 - 長塚　仁

General rules for clinical and pathological studies on oral cancer (2nd edition): a synopsis

Yoshihide Ota, Tadahide Noguchi, Eiichiro Ariji, Chihiro Fushimi, Nobukazu Fuwa, Hiroyuki Harada, Takafumi Hayashi, Ryuichi Hayashi, Yoshitaka Honma, Masahiko Miura, Taisuke Mori, Hitoshi Nagatsuka, Masaya Okura, Michihiro Ueda, Narikazu Uzawa, Kazuhiro Yagihara, Hisao Yagishita, Masashi Yamashiro, Souichi Yanamoto, Tadaaki Kirita

International Journal of Clinical Oncology   26 ( 4 )   623 - 635   2021年4月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：シュプリンガー・ジャパン(株)  

For doctors and other medical staff treating oral cancer, it is necessary to standardize the basic concepts and rules for oral cancer to achieve progress in its treatment, research, and diagnosis. Oral cancer is an integral part of head and neck cancer and is treated in accordance with the general rules for head and neck cancer. However, detailed rules based on the specific characteristics of oral cancer are essential. The objective of this article was to contribute to the development of the diagnosis, treatment, and research of oral cancer, based on the correct and useful medical information of clinical, surgical, pathological, and imaging findings accumulated from individual patients at various institutions. Our general rules were revised as the UICC was revised for the 8th edition and were published as the Japanese second edition in 2019. In this paper, the English edition of the “Rules” section is primarily presented.

DOI： 10.1007/s10147-020-01812-9

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顎顔面手術においてbone lid法を用いた治療法成功の要因 予備研究(Factors of Successful Treatment Using the Bone Lid Technique in Maxillofacial Surgery: A Pilot Study)

Sukegawa Shintaro, Yamamoto Norio, Matsuyama Tamamo, Takabatake Kiyofumi, Kawai Hotaka, Nagatsuka Hitoshi, Furuki Yoshihiko

Journal of Hard Tissue Biology   30 ( 2 )   193 - 198   2021年4月

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記述言語：英語   出版者・発行元：硬組織再生生物学会  

bone lid(BL)法による顎顔面手術を2014年1月〜2019年12月に受けた患者30名(男19名、女11名)を対象として、顎顔面におけるBL法の成功要因を後向きコホート研究で検討した。予測変数は臨床因子で構成し、属性(年齢、性別)、健康状態(喫煙、飲酒)、解剖学(上顎/下顎側、左/右側、皮質骨幅)、病巣(病巣サイズ、位置、病理診断)、治療状態(吸収性骨接合材料の差)に分類した。結果変数は術後のBL壊死とし、術後BL壊死に対する危険因子について統計的に検討した。その結果、術後BL壊死は3名(10.0%)に認められたが、その属性、解剖学、治療状態に有意差は認められなかった。健康状態変数である喫煙と飲酒に有意差を認め、病巣変数における歯槽頂からの病巣距離にも有意差を認めた。以上より、喫煙と飲酒はBL壊死の危険因子であり、歯槽頂への近接も病巣発達の危険因子であると考えられた。

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口腔扁平上皮癌におけるシスプラチン-CXCR4阻害剤併用療法の有効性

吉田 沙織, 河合 穂高, 長塚 仁, 竹下 洋平, 岡田 俊輔, 藤倉 満美子, 久富 美紀, 河津 俊幸, 浅海 淳一, 柳 文修

日本病理学会会誌   110 ( 1 )   275 - 275   2021年3月

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記述言語：日本語   出版者・発行元：(一社)日本病理学会  

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CCL2-CCR2 axisを介した癌関連線維芽細胞による骨髄由来細胞の動員

河合 穂高, メイ・ワトウ, 高畠 清文, 大森 悠加, 中野 敬介, 長塚 仁

日本病理学会会誌   110 ( 1 )   241 - 241   2021年3月

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記述言語：日本語   出版者・発行元：(一社)日本病理学会  

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A Case Report of Spindle Cell Carcinoma with Osteoid and Cartilage Formation in the Tongue

Sawako Ono, Takuma Makino, Hiroyuki Yanai, Hotaka Kawai, Kiyofumi Takabatake, Keisuke Nakano, Kenji Nishida, Kohei Taniguchi, Tomohiro Toji, Hitoshi Nagatsuka, Tadashi Yoshino

Reports   4 ( 1 )   5 - 5   2021年2月

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掲載種別：研究論文（学術雑誌）   出版者・発行元：MDPI AG  

Spindle cell carcinoma (SCSCC) with osteoid and/or cartilage formation in the head and neck is rare; only one case was reported in the tongue. Herein, we report an SCSCC with osteoid and cartilage formation of the tongue developed in an 85-year-old man, and then review the report.

DOI： 10.3390/reports4010005

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A Case Report of Primordial Odontogenic Tumor That Required Distinction from a Dentigerous Cyst

Sawako Ono, Hotaka Kawai, Shintaro Sukegawa, Kiyofumi Takabatake, Keisuke Nakano, Hitoshi Nagatsuka, Tadashi Yoshino

Reports   4 ( 1 )   4 - 4   2021年2月

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掲載種別：研究論文（学術雑誌）   出版者・発行元：MDPI AG  

Primordial odontogenic tumor (POT) is a rare odontogenic tumor characterized by a variably cellular loose fibrous tissue with areas similar to the dental papilla and covered by cuboidal to columnar epithelium. We herein report a case of POT in a 14-year-old boy. Computed tomography (CT) exhibited a round cavity with a defined cortical border circumscribing the tooth of the second molar. However, the gross finding was a solid mass, not a cyst. Histologically, the tumor consisted of dental papillalike myxoid connective tissue covered by columnar epithelium. Therefore, although the clinical diagnosis was dentigerous cyst (DC), we diagnosed POT based on histologic findings. Clinical findings of POT resemble DC, but the clinical behavior of POT is different to DC, such as cortical expansion and root resorption of teeth. Therefore, histological differentiation of POT from DC is critical for accurate diagnosis.

DOI： 10.3390/reports4010004

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Homeobox transcription factor engrailed homeobox 1 is a possible diagnostic marker for adenoid cystic carcinoma and polymorphous adenocarcinoma 国際誌

Shunichi Baba, Takumi Akashi, Kou Kayamori, Tomoyuki Ohuchi, Ikuko Ogawa, Nobuhisa Kubota, Keisuke Nakano, Hitoshi Nagatsuka, Hiromasa Hasegawa, Kenichi Matsuzaka, Shohei Tomii, Keisuke Uchida, Noriko Katsuta, Takahiro Sekiya, Noboru Ando, Keiko Miura, Hironori Ishibashi, Yousuke Ariizumi, Takahiro Asakage, Yasuyuki Michi, Hiroyuki Harada, Kei Sakamoto, Yoshinobu Eishi, Kenichi Okubo, Tohru Ikeda

Pathology International   71 ( 2 )   113 - 123   2021年2月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：John Wiley & Sons Australia, Ltd  

Diagnostic utility of a homeobox transcription factor, engrailed homeobox 1 (En1) in the histopathology of salivary gland neoplasms was studied. The expression of En1 was immunohistochemically examined in 51 cases of adenoid cystic carcinoma (AdCC) and 143 cases of other salivary gland neoplasms. In all 51 AdCCs, En1 was expressed in 30–100% of tumor cells. In eight of nine polymorphous adenocarcinomas (PACs), En1 was expressed in 40–100% of tumor cells. Less than 5% of tumor cells expressed En1 in three of 12 epithelial–myoepithelial carcinomas, one of 17 basal cell adenomas (BCAs), and one of 34 pleomorphic adenomas (PAs). Among 55 other carcinoma cases, 1–30% of tumor cells expressed En1 in three salivary duct carcinomas (SDCs) ex PA. None of the myoepitheliomas and Warthin tumors expressed En1. When the cut-off value of the percentage of En1-expressing cells was set to 25%, all 51 AdCCs, eight of nine PACs and one SDC ex PA were En1-positive and the others were En1-negative. En1 is expressed consistently in AdCCs, frequently in PACs, but rarely in other salivary gland neoplasms. En1 is a possible diagnostic marker for AdCC and PAC in the histopathology of salivary gland neoplasms.

DOI： 10.1111/pin.13050

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Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process 国際誌

Hotaka Kawai, May Wathone Oo, Hidetsugu Tsujigiwa, Keisuke Nakano, Kiyofumi Takabatake, Shintaro Sukegawa, Hitoshi Nagatsuka

International Journal of Medical Sciences   18 ( 8 )   1824 - 1830   2021年

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells with immunosuppressive functions; these cells play a key role in infection, immunization, chronic inflammation, and cancer. Recent studies have reported that immunosuppression plays an important role in the healing process of tissues and that Treg play an important role in fracture healing. MDSCs suppress active T cell proliferation and reduce the severity of arthritis in mice and humans. Together, these findings suggest that MDSCs play a role in bone biotransformation. In the present study, we examined the role of MDSCs in the bone healing process by creating a bone injury at the tibial epiphysis in mice. MDSCs were identified by CD11b and GR1 immunohistochemistry and their role in new bone formation was observed by detection of Runx2 and osteocalcin expression. Significant numbers of MDSCs were observed in transitional areas from the reactionary to repair stages. Interestingly, MDSCs exhibited Runx2 and osteocalcin expression in the transitional area but not in the reactionary area. And at the same area, cllagene-1 and ALP expression level increased in osteoblast progenitor cells. These data is suggesting that MDSCs emerge to suppress inflammation and support new bone formation. Here, we report, for the first time (to our knowledge), the role of MDSCs in the initiation of bone formation. MDSC appeared at the transition from inflammation to bone making and regulates bone healing by suppressing inflammation.

DOI： 10.7150/ijms.51946

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A case of large adenomatoid odontogenic tumor in the posterior region of the mandible showing root resorption

Atsushi Fujita, Yoshiya Ueyama, Hitoshi Nagatsuka, Hitoshi Kawamata

Journal of Oral Medicine and Oral Surgery   27 ( 2 )   2021年

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掲載種別：研究論文（学術雑誌）  

Introduction: Adenomatoid odontogenic tumor (AOT) is a rare tumor of epithelial origin, and usually presents as a unilocular radiolucency in the maxillary anterior region in adolescent females. Observation: A 31-year-old Japanese male, having a large adenomatoid odontogenic tumor from the right molar region to the left anterior region of the mandible showing root resorption of the neighboring teeth, was presented to the hospital. The lesion was totally resected under general anesthesia. Commentary: AOT may cause displacement of the neighboring teeth. But root resorption is a very rare finding. AOTs are relatively small in size. Conclusion: The patient was under follow-up and had not shown any signs of recurrence 12 months after surgery.

DOI： 10.1051/mbcb/2020053

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Factors of successful treatment using the bone lid technique in maxillofacial surgery: A pilot study

Shintaro Sukegawa, Norio Yamamoto, Tamamo Matsuyama, Kiyofumi Takabatake, Hotaka Kawai, Hitoshi Nagatsuka, Yoshihiko Furuki

Journal of Hard Tissue Biology   30 ( 2 )   193 - 198   2021年

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：JOURNAL HARD TISSUE BIOLOGY  

This study aimed to investigate the success factors of the bone lid surgery technique in the maxillofacial region. A retrospective cohort study was performed on 30 maxillofacial patients who underwent bone lid surgery between January 2014 and December 2019 at our hospital. The predictor variables consisted of clinical factors that were classified as attribute (age and sex), health status (smoking and alcohol intake), anatomical (maxillary/mandibular site, left/right side, and cortical bone thickness), lesion (lesion size, location, and pathological diagnosis), and treatment variables (differences in ab-sorbable osteosynthesis materials). The outcome variable was the incidence of bone lid necrosis after surgery. Various risk factors for postoperative bone lid necrosis were investigated statistically. A p value <0.05 was considered statistically signif-icant. Postoperative bone lid necrosis was observed in three patients (10.0%). No significant differences in the attribute, an-atomical, and treatment status variables were noted. Significant differences were observed between smoking (p=0.005) and alcohol intake (p=0.003) in the health status variables. There was a significant difference in the distance of the lesion from the alveolar bone crest in the lesion variables (p=0.037). Smoking and alcohol consumption were the health status variables found to be risk factors for bone lid necrosis. In addition, proximity to the alveolar crest was also a risk factor for lesion de-velopment.

DOI： 10.2485/jhtb.30.193

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Endoscopic-assisted resection of pleomorphic adenoma in the accessory parotid gland.

Kazuaki Hasegawa, Shintaro Sukegawa, Sawako Ono, Midori Ando, Akane Shibata, Yuka Sukegawa-Takahashi, Ai Fujimura, Tamamo Matsuyama, Soichiro Ibaragi, Hitoshi Nagatsuka, Koichi Mizobuchi, Akira Sasaki, Yoshihiko Furuki

The journal of medical investigation : JMI   68 ( 3.4 )   376 - 380   2021年

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Background : An accessory parotid gland (APG) is a common anatomical structure that occurs in 10%-56% of individuals. Pleomorphic adenomas are the most common benign tumors of the APG, and their ideal treatment is surgical excision, although there is a risk for aesthetic disorders and facial nerve damage due to the site of origin. Moreover, despite being benign, these tumors are known to recur. Therefore, it is necessary to achieve both reliable excision and avoidance of facial nerve damage. Case presentation : We report a case of a 49-year-old Japanese man with a mass in his left cheek. The lesion was diagnosed as a benign salivary gland tumor derived from the APG by computed tomography imaging, magnetic resonance imaging and fine needle aspiration cytology. We resected the tumor using modified high submandibular incision under the endoscopic-assisted field of view. Discussion and Conclusions : The tumor was less invasive and reliably resected using an endoscope. In surgical treatment, the endoscopic-assisted technique is very useful to achieve complete tumor resection and prevent relapse while avoiding serious complications due to surgical procedures. J. Med. Invest. 68 : 376-380, August, 2021.

DOI： 10.2152/jmi.68.376

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Feasibility of navigation-assisted bone lid surgery for deeply impacted maxillary tooth - A case report

Shintaro Sukegawa, Ai Fujimura-Sato, Keisuke Nakano, Hitoshi Nagatsuka, Yoshihiko Furuki

Annals of Maxillofacial Surgery   11 ( 1 )   176 - 176   2021年

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掲載種別：研究論文（学術雑誌）   出版者・発行元：Medknow  

DOI： 10.4103/ams.ams_370_20

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がん治療患者の口腔機能管理における歯性感染病巣（歯のう蝕，歯周病，歯性感染症）管理：システマティックレビューに基づいた指針 査読

栗田 浩, 梅田 正博, 植野 高章, 鵜澤 成一, 渋谷 恭之, 中村 典史, 長塚 仁, 林 孝文, 溝口 到, 冨原 圭, 池上 由美子, 野口 一馬, 滝口 裕一, 山本 信之

日本口腔科学会雑誌   70 ( 4 )   279 - 289   2021年

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記述言語：日本語   出版者・発行元：特定非営利活動法人 日本口腔科学会  

DOI： 10.11277/stomatology.70.279

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A case of oral cancer with delayed occipital lymph node metastasis: Case report 国際誌

Kisho Ono, Norie Yoshioka, Masanori Masui, Kyoichi Obata, Yuki Kunisada, Tatsuo Okui, Soichiro Ibaragi, Hotaka Kawai, Hitoshi Nagatsuka, Akira Sasaki

Clinical Case Reports   8 ( 12 )   2469 - 2475   2020年12月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Consideration of unexpected metastasis in patients who have undergone neck dissection with advanced tumors must be anticipated with careful follow-up.

DOI： 10.1002/ccr3.3086

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Geometrical structure of honeycomb TCP to control dental pulp-derived cell differentiation 国際誌

Kiyofumi Takabatake, Hidetsugu Tsujigiwa, Keisuke Nakano, Yasunori Inada, Shan Qiusheng, Hotaka Kawai, Shintaro Sukegawa, Shigeko Fushimi, Hitoshi Nagatsuka

Materials   13 ( 22 )   1 - 10   2020年11月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MDPI  

Recently, dental pulp has been attracting attention as a promising source of multipotent mesenchymal stem cells (MSCs) for various clinical applications of regeneration fields. To date, we have succeeded in establishing rat dental pulp-derived cells showing the characteristics of odontoblasts under in vitro conditions. We named them Tooth matrix-forming, GFP rat-derived Cells (TGC). However, though TGC form massive dentin-like hard tissues under in vivo conditions, this does not lead to the induction of polar odontoblasts. Focusing on the importance of the geometrical structure of an artificial biomaterial to induce cell differentiation and hard tissue formation, we previously have succeeded in developing a new biomaterial, honeycomb tricalcium phosphate (TCP) scaffold with through-holes of various diameters. In this study, to induce polar odontoblasts, TGC were induced to form odontoblasts using honeycomb TCP that had various hole diameters (75, 300, and 500 µm) as a scaffold. The results showed that honeycomb TCP with 300-µm hole diameters (300TCP) differentiated TGC into polar odontoblasts that were DSP positive. Therefore, our study indicates that 300TCP is an appropriate artificial biomaterial for dentin regeneration.

DOI： 10.3390/ma13225155

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Effect of honeycomb β-TCP geometrical structure on bone tissue regeneration in skull defect 国際誌

Toshiyuki Watanabe, Kiyofumi Takabatake, Hidetsugu Tsujigiwa, Satoko Watanabe, Ryoko Nakagiri, Keisuke Nakano, Hitoshi Nagatsuka, Yoshihiro Kimata

Materials   13 ( 21 )   1 - 13   2020年11月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MDPI  

The effect of the geometric structure of artificial biomaterials on skull regeneration remains unclear. In a previous study, we succeeded in developing honeycomb β-tricalcium phosphate (β-TCP), which has through-and-through holes and is able to provide the optimum bone microenvironment for bone tissue regeneration. We demonstrated that β-TCP with 300-µm hole diameters induced vigorous bone formation. In the present study, we investigated how differences in hole directions of honeycomb β-TCP (horizontal or vertical holes) influence bone tissue regeneration in skull defects. Honeycomb β-TCP with vertical and horizontal holes was loaded with BMP-2 using Matrigel and Collagen gel as carriers, and transplanted into skull bone defect model rats. The results showed that in each four groups (Collagen alone group, Matrigel alone group, Collagen + BMP group and Matrigel + BMP-2), vigorous bone formation was observed on the vertical β-TCP compared with horizontal β-TCP. The osteogenic area was larger in the Matrigel groups (with and without BMP-2) than in the Collagen group (with and without BMP-2) in both vertical β-TCP and horizontal β-TCP. However, when BMP-2 was added, the bone formation area was not significantly different between the Collagen group and the Matrigel group in the vertical β-TCP. Histological finding showed that, in vertical honeycomb β-TCP, new bone formation extended to the upper part of the holes and was observed from the dura side to the periosteum side as added to the inner walls of the holes. Therefore, we can control efficient bone formation by creating a bone microenvironment provided by vertical honeycomb β-TCP. Vertical honeycomb β-TCP has the potential to be an excellent biomaterial for bone tissue regeneration in skull defects and is expected to have clinical applications.

DOI： 10.3390/ma13214761

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Deep learning for osteoporosis classification using hip radiographs and patient clinical covariates 国際誌

Norio Yamamoto, Shintaro Sukegawa, Akira Kitamura, Ryosuke Goto, Tomoyuki Noda, Keisuke Nakano, Kiyofumi Takabatake, Hotaka Kawai, Hitoshi Nagatsuka, Keisuke Kawasaki, Yoshihiko Furuki, Toshifumi Ozaki

Biomolecules   10 ( 11 )   1 - 13   2020年11月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MDPI  

This study considers the use of deep learning to diagnose osteoporosis from hip radiographs, and whether adding clinical data improves diagnostic performance over the image mode alone. For objective labeling, we collected a dataset containing 1131 images from patients who underwent both skeletal bone mineral density measurement and hip radiography at a single general hospital between 2014 and 2019. Osteoporosis was assessed from the hip radiographs using five convolutional neural network (CNN) models. We also investigated ensemble models with clinical covariates added to each CNN. The accuracy, precision, recall, specificity, negative predictive value (npv), F1 score, and area under the curve (AUC) score were calculated for each network. In the evaluation of the five CNN models using only hip radiographs, GoogleNet and EfficientNet b3 exhibited the best accuracy, precision, and specificity. Among the five ensemble models, EfficientNet b3 exhibited the best accuracy, recall, npv, F1 score, and AUC score when patient variables were included. The CNN models diagnosed osteoporosis from hip radiographs with high accuracy, and their performance improved further with the addition of clinical covariates from patient records.

DOI： 10.3390/biom10111534

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Impact of the stroma on the biological characteristics of the parenchyma in oral squamous cell carcinoma 国際誌

Kiyofumi Takabatake, Hotaka Kawai, Haruka Omori, Shan Qiusheng, May Wathone Oo, Shintaro Sukegawa, Keisuke Nakano, Hidetsugu Tsujigiwa, Hitoshi Nagatsuka

International Journal of Molecular Sciences   21 ( 20 )   1 - 15   2020年10月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MDPI  

Solid tumors consist of the tumor parenchyma and stroma. The standard concept of oncology is that the tumor parenchyma regulates the tumor stroma and promotes tumor progression, and that the tumor parenchyma represents the tumor itself and defines the biological characteristics of the tumor tissue. Thus, the tumor stroma plays a pivotal role in assisting tumor parenchymal growth and invasiveness and is regarded as a supporter of the tumor parenchyma. The tumor parenchyma and stroma interact with each other. However, the influence of the stroma on the parenchyma is not clear. Therefore, in this study, we investigated the effect of the stroma on the parenchyma in oral squamous cell carcinoma (OSCC). We isolated tumor stroma from two types of OSCCs with different invasiveness (endophytic type OSCC (ED-st) and exophytic type OSCC (EX-st)) and examined the effect of the stroma on the parenchyma in terms of proliferation, invasion, and morphology by co-culturing and co-transplanting the OSCC cell line (HSC-2) with the two types of stroma. Both types of stroma were partially positive for alpha-smooth muscle actin. The tumor stroma increased the proliferation and invasion of tumor cells and altered the morphology of tumor cells in vitro and in vivo. ED-st exerted a greater effect on the tumor parenchyma in proliferation and invasion than EX-st. Morphological analysis showed that ED-st changed the morphology of HSC-2 cells to the invasive type of OSCC, and EX-st altered the morphology of HSC-2 cells to verrucous OSCC. This study suggests that the tumor stroma influences the biological characteristics of the parenchyma and that the origin of the stroma is strongly associated with the biological characteristics of the tumor.

DOI： 10.3390/ijms21207714

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Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology 国際誌

Shintaro Sukegawa, Sawako Ono, Keisuke Nakano, Kiyofumi Takabatake, Hotaka Kawai, Hitoshi Nagatsuka, Yoshihiko Furuki

Diagnostic Pathology   15 ( 1 )   107 - 107   2020年9月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BMC  

Background: This study was conducted to compare the histological diagnostic accuracy of conventional oral-based cytology and liquid-based cytology (LBC) methods. Methods: Histological diagnoses of 251 cases were classified as negative (no malignancy lesion, inflammation, or mild/moderate dysplasia) and positive [severe dysplasia/carcinoma in situ (CIS) and squamous cell carcinoma (SCC)]. Cytological diagnoses were classified as negative for intraepithelial lesion or malignancy (NILM), oral low-grade squamous intraepithelial lesion (OLSIL), oral high-grade squamous intraepithelial lesion (OHSIL), or SCC. Cytological diagnostic results were compared with histology results. Results: Of NILM cytology cases, the most frequent case was negative [LBC n = 50 (90.9%), conventional n = 22 (95.7%)]. Among OLSIL cytodiagnoses, the most common was negative (LBC n = 34; 75.6%, conventional n = 14; 70.0%). Among OHSIL cytodiagnoses (LBC n = 51, conventional n = 23), SCC was the most frequent (LBC n = 31; 60.8%, conventional n = 7; 30.4%). Negative cases were common (LBC n = 13; 25.5%, conventional n = 14; 60.9%). Among SCC cytodiagnoses SCC was the most common (LBC n = 16; 88.9%, conventional n = 14; 87.5%). Regarding the diagnostic results of cytology, assuming OHSIL and SCC as cytologically positive, the LBC method/conventional method showed a sensitivity of 79.4%/76.7%, specificity of 85.1%/69.2%, false-positive rate of 14.9%/30.7%, and false-negative rate of 20.6%/23.3%. Conclusions: LBC method was superior to conventional cytodiagnosis methods. It was especially superior for OLSIL and OHSIL. Because of the false-positive and false-negative cytodiagnoses, it is necessary to make a comprehensive diagnosis considering the clinical findings.

DOI： 10.1186/s13000-020-01027-6

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下顎臼後部歯肉に発生した周辺性エナメル上皮腫の1例

武田 斉子, 山近 英樹, 高畠 清文, 中野 敬介, 長塚 仁, 飯田 征二

日本口腔科学会雑誌   69 ( 3 )   239 - 240   2020年9月

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記述言語：日本語   出版者・発行元：(NPO)日本口腔科学会  

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