研究者詳細 - 太田　智之

論文 - 太田　智之

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Fabrication of scaffold-free mesenchyme tissue bands by cell self-aggregation technique for potential use in tissue regeneration. 査読国際誌

Tomoyuki Ota, Ryosuke Iwai, Yohei Kitaguchi, Takeshi Takarada, Yoshihiro Kimata

Biomedical materials (Bristol, England) 17 ( 6 ) 2022年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Three-dimensional (3D) cell constructs comprising only tissue-specific cells and extracellular matrix secreted by them would be ideal transplants, but their fabrication in a cell aggregation manner without cell scaffolds relies on random cell self-aggregation, making the control of their size and shape difficult. In this study, we propose a method to fabricate band-shaped tissues by inducing the self-aggregation of cell sheets using the developed cell self-aggregation technique (CAT). Acting as cell aggregation stoppers, silicone semicircular pillars were attached to two positions equidistant from both short ends of the rounded rectangular culture groove and coated with a specifically charged biomimetic polymer as a CAT-inducing surface. Mesenchymal stem cells, chondrocytes, and skeletal myoblast cells seeded on the surface of the culture grooves formed band-shaped aggregates between the two aggregation stoppers following spontaneous detachment with aggregation of the cell sheet from the outer edge of the grooves during day one of culture. The aggregated chondrocyte band matured into a rigid cartilage plate with an abundant cartilage matrix while retaining its band shape after two weeks of chondrogenic cultivation. Additionally, the aggregates of mesenchymal stem cells and myoblast cell bands could patch the induced collagen membrane derived from rat subcutaneous tissue like a bandage immediately after their formation and successfully mature into fat and muscle tissues, respectively. These results indicate that, depending on the cell type, scaffold-free band-shaped cell aggregates produced by CAT have the potential to achieve tissue regeneration that follows the shape of the defect via in vitro maturation culture or in vivo organization.

DOI： 10.1088/1748-605X/ac9c7f

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Resection and immediate reconstruction of two pediatric intraosseous capillary mandibular malformations 査読

Hiroshi Matsumoto, Tomoyuki Ota, Sho Komagoe, Yohei Noda, Takuma Makino, Seiko Takeda, Nobuyoshi Mizukawa, Kohei Taniguchi, Tomoka Ikeda, Hiroyuki Yanai, Yoshihiro Kimata

European Journal of Plastic Surgery 45 ( 5 ) 831 - 839 2022年1月

Morphological Changes and Durability of Skin and Mucosal Flaps in Intraoral and Pharyngeal Reconstructions: Long-term Follow-up and Literature Review for Potential Second Carcinomas. 査読

Hiroshi Matsumoto, Yoshihiro Kimata, Tomoyuki Ota, Narushi Sugiyama, Satoshi Onoda, Takuma Makino, Seiko Takeda, Nobuyoshi Mizukawa

Acta medica Okayama 75 ( 6 ) 725 - 734 2021年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

The long-term changes in tissues implanted in the oral cavity and pharynx after head and neck reconstruction have not been fully evaluated. This study aimed to clarify the morphological changes, long-term durability, and potential for secondary carcinogenesis in such tissues. In our single-center study, the rough morphological changes in 54 cases of intraoral and pharyngeal skin and mucosal flaps were evaluated more than 10 years after flap transfer. In addition, the literature on the development of second carcinomas from skin flaps was reviewed. The mean follow-up period for transferred flaps was 148 months. The reconstruction areas and the probability of morphological changes were significantly correlated (p=0.006), especially in cases with tongue, lower gingiva, and buccal mucosal reconstruction. Free jejunal flap surfaces were well maintained, whereas tubed skin flaps showed severe morphological changes in cases with pharyngeal reconstruction. None of the flaps in our series developed second primary carcinomas. Skin flaps generally had good durability for > 10 years in intraoral environments, while mucosal flaps had better durability for pharyngeal reconstruction. Second squamous carcinomas arising from skin flaps are extremely rare; however, surgeons should take this possibility into consideration and conduct meticulous and long-term follow-up.

DOI： 10.18926/AMO/62813

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Changes in Quality of Life After Secondary Closure of Palatal Defects: Prosthetic Obturation Versus Surgical Reconstruction. 査読国際誌

Hiroshi Matsumoto, Tomoyuki Ota, Seiko Takeda, Nobuyoshi Mizukawa, Yoshihiro Kimata

The Journal of craniofacial surgery 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The closure of palatal defects after tumor resection or irradiation is performed with either a prosthesis or autogenous tissue; however, there are no clear criteria regarding selection of the method. Thus, this study aimed to investigate the real-world situation and problems of palatal closure using prostheses, and examined patient opinion on how palatal closure using autogenous tissue improved their postoperative quality of life (QOL). METHODS: In 5 patients whose palatal defects resulted from treatment for head and neck cancer and were closed with a prosthesis, the palate was closed secondarily with autogenous tissue; a questionnaire on daily life was administered pre- and post-operatively. RESULTS: Functional improvements in terms of speech and eating were achieved in all and in 4 of 5 cases, respectively. In all cases, the QOL was better for palatal closure with autogenous tissue than with the prosthesis. CONCLUSIONS: As postoperative QOL was considered to be better when reconstructing the palate with autogenous tissue than with the prosthesis, we recommend to actively select autogenous tissue for palate reconstruction.

DOI： 10.1097/SCS.0000000000007969

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Pyogenic Ventriculitis After Anterior Skull Base Surgery Treated With Endoscopic Ventricular Irrigation And Reconstruction Using a Vascularized Flap.

Yusuke Tomita, Yosuke Shimazu, Masato Kawakami, Hiroshi Matsumoto, Kentaro Fujii, Masahiro Kameda, Takao Yasuhara, Yasuki Suruga, Tomoyuki Ota, Yoshihiro Kimata, Kazuhiko Kurozumi, Isao Date

Acta medica Okayama 75 ( 2 ) 243 - 248 2021年4月

記述言語：英語

Ventriculitis is a rare, serious complication of neurosurgery. A 59-year-old man who had undergone a craniotomy for a paranasal adenocarcinoma, developed a right frontal cystic lesion. We performed a bifrontal craniotomy to remove the lesion. The dura was repaired with non-vascularized free fascia lata in watertight fashion. Ventriculitis occurred 3 days postoperatively. Ventricular drainage, craniectomy, and endoscopic irrigation were undertaken to remove an abscess. The dura and the resection cavity were reconstructed using a vascularized anterolateral thigh adipofascial flap. His symptoms disappeared, indicating that endoscopic irrigation and reconstruction can effectively address ventriculitis even in patients in critical clinical condition.

DOI： 10.18926/AMO/61908

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頭頸部がん手術における形態・機能維持の工夫頭頸部形態再建における理想的な移植組織を考える

木股敬裕, 松本洋, 太田智之

日本耳鼻咽喉科学会会報 123 ( 4 ) 939 - 939 2020年9月

下歯槽神経鞘腫の一例

宮本なつみ, 松本洋, 太田智之, 木股敬裕

日本形成外科学会会誌 40 ( 6 ) 314 - 314 2020年6月

Nerve Switch for Reducing Synkinesis After Gracilis Muscle Transfer Innervated Via the Masseter Nerve. 査読国際誌

Ota T, Matsumoto H, Yamada K, Kimata Y

The Journal of craniofacial surgery 30 ( 1 ) e3 - e5 2019年1月

Raoultella planticola bacteremia-induced fatal septic shock following burn injury 査読

Tetsuya Yumoto, Hiromichi Naito, Hiromi Ihoriya, Kohei Tsukahara, Tomoyuki Ota, Toshiyuki Watanabe, Atsunori Nakao

Annals of Clinical Microbiology and Antimicrobials 17 ( 1 ) 19 2018年5月

Laser-Assisted Indocyanine Green Angiography Aids in the Reconstruction of Gustilo Grade IIIB Open Lower-Limb Fractures 査読

Seijiro Koshimune, Akira Shinaoka, Tomoyuki Ota, Satoshi Onoda, Yoshihiro Kimata

JOURNAL OF RECONSTRUCTIVE MICROSURGERY 33 ( 2 ) 143 - 150 2017年2月

Analysis of 10-Year Training Results of Medical Students Using the Microvascular Research Center Training Program 査読

Satoshi Onoda, Yoshihiro Kimata, Narushi Sugiyama, Eijiro Tokuyama, Kumiko Matsumoto, Tomoyuki Ota, Moe Thuzar

JOURNAL OF RECONSTRUCTIVE MICROSURGERY 32 ( 5 ) 336 - 341 2016年6月

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