研究者詳細 - 太田　智之

論文 - 太田　智之

分割表示 >> ／全件表示 31 件中 1 - 31 件目

Development of a unique tissue-engineered in vitro vascular model with endothelial layer-inverted vascular tissue structure using a cell self-aggregation technique.

Shingo Hashimoto, Akihiko Sugiyama, Tomoyuki Ota, Hiroshi Matsumoto, Yoshihiro Kimata, Ryosuke Iwai

Journal of bioscience and bioengineering 2024年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Vascular-like tissues composed of cells maintaining their shape and structure at any position in a culture dish without the use of gels or other artificial materials are ideal vascular models to test the effects of candidate drugs on cells without adsorption by artificial materials and analysis of structural changes over time. In this study, we aimed to prepare fiber-shaped cell aggregates composed of human umbilical vein endothelial and mesenchymal stem cells as vascular pericytes anchored to the bottom of culture dishes at a defined location using our developed cell self-aggregation technique and dumbbell-shaped culture groove. The fiber-shaped cell aggregates maintained their shape for at least two weeks without rupture, and histological analysis revealed that they formed a unique tissue structure with a gapless endothelial layer on the outer surface and capillary-like structures oriented in the same direction as the long axis of the fiber in the medial side. Moreover, exposure to cadmium chloride, a vascular toxicant, elicited toxic responses in vascular endothelialized fiber-shaped tissues, with only their outer endothelial layer being disintegrated but their fiber shape remaining intact. Overall, our results suggest the developed vascular endothelialized fiber-shaped tissue construct as potential models for vascular toxicity testing, facilitating the evaluation of toxicity over time without any effects of gel adsorption.

DOI： 10.1016/j.jbiosc.2024.12.001

PubMed

researchmap

頭頸部癌治療後の顔貌変形に対する肋軟骨移植を用いた二次修正法

若崎昭太, 新田弘一朗, 太田智之, 松本洋

日本頭蓋顎顔面外科学会学術集会プログラム・抄録集 42回 143 - 143 2024年11月

Pneumocephalus with Inverted Papilloma in the Frontoethmoidal Sinus: Case Report and Literature Review. 査読

Seiichiro Makihara, Yoshihiro Otani, Kensuke Uraguchi, Sawako Ono, Aiko Shimizu, Ryosuke Ikemachi, Yosuke Okazaki, Tomoyuki Ota, Hiroshi Matsumoto, Shotaro Miyamoto, Munechika Tsumura, Seiya Hayashi, Michiari Umakoshi, Koji Hirashita, Mizuo Ando

Acta medica Okayama 78 ( 4 ) 337 - 343 2024年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Here, we describe the unique case of a pneumocephalus originating from an inverted papilloma (IP) in the frontoethmoidal sinus. A 71-year-old man with diabetes presented with headaches and altered consciousness. Imaging revealed the pneumocephalus together with bone destruction in the left frontal sinus. He underwent simultaneous endoscopic endonasal and transcranial surgery using an ORBEYE exoscope. Pathological diagnosis of the tumor confirmed IP. Post-surgery, the pneumocephalus was significantly resolved and the squamous cell carcinoma antigen level, which had been elevated, decreased. This case underscores the importance of a multidisciplinary approach and innovative surgical methods in treating complex sinonasal pathologies.

DOI： 10.18926/AMO/67550

PubMed

researchmap

主体性を育む専攻医の成長を促す週例カンファレンス

加藤基, 松本洋, 太田智之, 妹尾貴矢

医学教育 55 ( Suppl. ) 364 - 364 2024年7月

【顔の再建外科手術を仕上げる-touch up surgery-】上顎再建後の眼周囲touch up surgery

松本洋, 太田智之, 木股敬裕

形成外科 67 ( 7 ) 671 - 679 2024年7月

上顎再建遊離腓骨移植による上顎再建

松本洋, 太田智之, 加藤基, 武田斉子, 牧野琢丸, 安藤瑞生

頭頸部癌 50 ( 2 ) 105 - 105 2024年5月

頭頸部再建において二皮島化が有用となる条件二皮島化と前外側大腿皮弁の皮島デザインにおける柔軟性

加藤基, 松本洋, 太田智之, 木股敬裕

頭頸部癌 50 ( 2 ) 183 - 183 2024年5月

上顎再建遊離腓骨移植による上顎再建

松本洋, 太田智之, 加藤基, 武田斉子, 牧野琢丸, 安藤瑞生

頭頸部癌 50 ( 2 ) 105 - 105 2024年5月

喉頭癌放射線治療後のサルベージ手術における問題点と再建法

太田智之, 松本洋, 木股敬裕

頭頸部癌 50 ( 2 ) 147 - 147 2024年5月

頭頸部癌治療後の軟口蓋再建における咽頭弁の様々な配置法

松本洋, 太田智之, 加藤基, 木股敬裕

頭頸部癌 50 ( 2 ) 144 - 144 2024年5月

Combined simultaneous endoscopic endonasal and transcranial surgery using high-definition three-dimensional exoscope for malignant tumors of the anterior skull base. 査読国際誌

Seiichiro Makihara, Yoshihiro Otani, Kensuke Uraguchi, Aiko Shimizu, Aya Murai, Takaya Higaki, Naoki Akisada, Shohei Fujimoto, Takuma Makino, Joji Ishida, Kentaro Fujii, Takao Yasuhara, Tomoyuki Ota, Hiroshi Matsumoto, Mizuo Ando

Head & neck 2024年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Advanced surgical interventions are required to treat malignancies in the anterior skull base (ASB). This study investigates the utility of endoscopic endonasal and transcranial surgery (EETS) using a high-definition three-dimensional exoscope as an alternative to traditional microscopy. METHODS: Six patients with carcinomas of varying histopathologies underwent surgery employing the EETS maneuver, which synchronized three distinct surgical modalities: harvesting of the anterolateral thigh flap, initiation of the transnasal technique, and initiation of the transcranial procedure. RESULTS: The innovative strategy enabled successful tumor resection and skull base reconstruction without postoperative local neoplastic recurrence, cerebrospinal fluid leakage, or neurological deficits. CONCLUSION: The integration of the exoscope and EETS is a novel therapeutic approach for ASB malignancies. This strategy demonstrates the potential of the exoscope in augmenting surgical visualization, enhancing ergonomics, and achieving seamless alignment of multiple surgical interventions. This technique represents a progressive shift in the management of these complex oncological challenges.

DOI： 10.1002/hed.27724

PubMed

researchmap

Various arrangements of pharyngeal flap in soft palate reconstruction after cancer treatment. 査読国際誌

Hiroshi Matsumoto, Tomoyuki Ota, Motoi Kato, Takuma Makino, Seiichiro Makihara, Mizuo Ando, Yoshihiro Kimata

Head & neck 2024年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The pharyngeal flap (PF) is useful for reconstruction of soft palate defects, but effective arrangements of PF for various types of soft palate defects are controversial. Here, we classify three types of soft palate defects and discuss the arrangements of PF and their functional prognosis. METHODS: Reconstruction was performed based on the classification of the defects. Clinical details were collected, and postoperative function was analyzed. RESULTS: Eight patients were included in the study. The defect sizes ranged from 25 (width) × 40 (depth) to 40 × 60 mm. Six patients underwent pharyngeal flap reconstruction with free-flap reconstruction, and two underwent pharyngeal flap reconstruction. The pharyngeal flap was harvested at the maximum width of the posterior pharyngeal wall, ranging from 25 to 40 mm in length. Eating and speaking functions were maintained in all patients. CONCLUSIONS: Good postoperative function can be maintained by narrowing the velopharyngeal space with a pharyngeal flap.

DOI： 10.1002/hed.27712

PubMed

researchmap

当科における直近5年間の下顎腓骨再建症例の検討

光井恵麻, 松本洋, 太田智之, 木股敬裕

日本マイクロサージャリー学会学術集会プログラム・抄録集 50回 151 - 151 2023年12月

放射線照射症例における頭頸部再建術後の発熱、炎症マーカーについての検討

太田智之, 松本洋, 高尾総司, 池内綾介, 木股敬裕

日本マイクロサージャリー学会学術集会プログラム・抄録集 50回 154 - 154 2023年12月

Fabrication of shape-designable cartilage from human induced pluripotent stem cell-derived chondroprogenitors using a cell self-aggregation technique. 査読国際誌

Tomoyuki Ota, Tomoka Takao, Ryosuke Iwai, Takeshi Moriwaki, Yohei Kitaguchi, Yuki Fujisawa, Daisuke Yamada, Yoshihiro Kimata, Takeshi Takarada

Biomedical materials (Bristol, England) 2023年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

With the advancement of tissue engineering technologies, implantable materials have been developed for use in facial plastic surgery, including auriculoplasty and rhinoplasty. Tissue-engineered cartilage comprising only cells and cell-produced extracellular matrix is considered valuable as there is no need to consider problems associated with the absorption of scaffold materials and the generation of immune responses. However, it is exceedingly difficult to produce large-sized complex shapes of cartilage without the use of scaffolds. In this study, we describe the production of shape-designable cartilage using a novel cell self-aggregation technique (CAT) and chondroprogenitor cells derived from human induced pluripotent stem cells as the source. The method described does not require special equipment such as bio-3D printers, and the produced tissue can be induced into well-matured cartilage with abundant cartilage matrix in vitro. Using CAT, we were able to generate cartilage in the form of rings or tubes with adjustable inner diameter and curvature, over a range of several centimeters, without the use of scaffolds. The in vitro fabrication of shape-designable cartilage using CAT will undoubtedly contribute to developments in the field of facial plastic surgery.&#xD.

DOI： 10.1088/1748-605X/ad02d1

PubMed

researchmap

放射線再照射(Total 120Gy)後に生じた合併症により複数回の再建手術を要した頭頸部放射線障害の1例査読

松本洋, 太田智之, 木股敬裕

日本マイクロサージャリー学会会誌 36 ( 3 ) 131 - 139 2023年9月

放射線再照射(Total 120Gy)後に生じた合併症により複数回の再建手術を要した頭頸部放射線障害の1例

松本洋, 太田智之, 木股敬裕

日本マイクロサージャリー学会会誌 36 ( 3 ) 131 - 139 2023年9月

関節軟骨再生を指向したヒトiPS細胞に由来する板状軟骨組織体の開発

藤澤佑樹, たき平将太, 高尾知佳, 山田大祐, 太田智之, 北口陽平, 岩井良輔, 中田英二, 木股敬裕, 尾崎敏文, 宝田剛志

日本整形外科学会雑誌 97 ( 8 ) S1662 - S1662 2023年8月

胸部下部食道癌縦郭浸潤に対し拡大切除,遊離筋弁移植を行った1例縦郭再建における胸腔内血管吻合の経験査読

濱田龍正, 松本洋, 太田智之, 田邊俊介, 野間和広, 木股敬裕

日本マイクロサージャリー学会会誌 36 ( 1 ) 22 - 26 2023年3月

胸部下部食道癌縦郭浸潤に対し拡大切除,遊離筋弁移植を行った1例縦郭再建における胸腔内血管吻合の経験

濱田龍正, 松本洋, 太田智之, 田邊俊介, 野間和広, 木股敬裕

日本マイクロサージャリー学会会誌 36 ( 1 ) 22 - 26 2023年3月

Fabrication of scaffold-free mesenchyme tissue bands by cell self-aggregation technique for potential use in tissue regeneration. 査読国際誌

Tomoyuki Ota, Ryosuke Iwai, Yohei Kitaguchi, Takeshi Takarada, Yoshihiro Kimata

Biomedical materials (Bristol, England) 17 ( 6 ) 2022年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Three-dimensional (3D) cell constructs comprising only tissue-specific cells and extracellular matrix secreted by them would be ideal transplants, but their fabrication in a cell aggregation manner without cell scaffolds relies on random cell self-aggregation, making the control of their size and shape difficult. In this study, we propose a method to fabricate band-shaped tissues by inducing the self-aggregation of cell sheets using the developed cell self-aggregation technique (CAT). Acting as cell aggregation stoppers, silicone semicircular pillars were attached to two positions equidistant from both short ends of the rounded rectangular culture groove and coated with a specifically charged biomimetic polymer as a CAT-inducing surface. Mesenchymal stem cells, chondrocytes, and skeletal myoblast cells seeded on the surface of the culture grooves formed band-shaped aggregates between the two aggregation stoppers following spontaneous detachment with aggregation of the cell sheet from the outer edge of the grooves during day one of culture. The aggregated chondrocyte band matured into a rigid cartilage plate with an abundant cartilage matrix while retaining its band shape after two weeks of chondrogenic cultivation. Additionally, the aggregates of mesenchymal stem cells and myoblast cell bands could patch the induced collagen membrane derived from rat subcutaneous tissue like a bandage immediately after their formation and successfully mature into fat and muscle tissues, respectively. These results indicate that, depending on the cell type, scaffold-free band-shaped cell aggregates produced by CAT have the potential to achieve tissue regeneration that follows the shape of the defect via in vitro maturation culture or in vivo organization.

DOI： 10.1088/1748-605X/ac9c7f

PubMed

researchmap

Resection and immediate reconstruction of two pediatric intraosseous capillary mandibular malformations 査読

Hiroshi Matsumoto, Tomoyuki Ota, Sho Komagoe, Yohei Noda, Takuma Makino, Seiko Takeda, Nobuyoshi Mizukawa, Kohei Taniguchi, Tomoka Ikeda, Hiroyuki Yanai, Yoshihiro Kimata

European Journal of Plastic Surgery 45 ( 5 ) 831 - 839 2022年1月

Morphological Changes and Durability of Skin and Mucosal Flaps in Intraoral and Pharyngeal Reconstructions: Long-term Follow-up and Literature Review for Potential Second Carcinomas. 査読

Hiroshi Matsumoto, Yoshihiro Kimata, Tomoyuki Ota, Narushi Sugiyama, Satoshi Onoda, Takuma Makino, Seiko Takeda, Nobuyoshi Mizukawa

Acta medica Okayama 75 ( 6 ) 725 - 734 2021年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

The long-term changes in tissues implanted in the oral cavity and pharynx after head and neck reconstruction have not been fully evaluated. This study aimed to clarify the morphological changes, long-term durability, and potential for secondary carcinogenesis in such tissues. In our single-center study, the rough morphological changes in 54 cases of intraoral and pharyngeal skin and mucosal flaps were evaluated more than 10 years after flap transfer. In addition, the literature on the development of second carcinomas from skin flaps was reviewed. The mean follow-up period for transferred flaps was 148 months. The reconstruction areas and the probability of morphological changes were significantly correlated (p=0.006), especially in cases with tongue, lower gingiva, and buccal mucosal reconstruction. Free jejunal flap surfaces were well maintained, whereas tubed skin flaps showed severe morphological changes in cases with pharyngeal reconstruction. None of the flaps in our series developed second primary carcinomas. Skin flaps generally had good durability for > 10 years in intraoral environments, while mucosal flaps had better durability for pharyngeal reconstruction. Second squamous carcinomas arising from skin flaps are extremely rare; however, surgeons should take this possibility into consideration and conduct meticulous and long-term follow-up.

DOI： 10.18926/AMO/62813

PubMed

researchmap

Changes in Quality of Life After Secondary Closure of Palatal Defects: Prosthetic Obturation Versus Surgical Reconstruction. 査読国際誌

Hiroshi Matsumoto, Tomoyuki Ota, Seiko Takeda, Nobuyoshi Mizukawa, Yoshihiro Kimata

The Journal of craniofacial surgery 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The closure of palatal defects after tumor resection or irradiation is performed with either a prosthesis or autogenous tissue; however, there are no clear criteria regarding selection of the method. Thus, this study aimed to investigate the real-world situation and problems of palatal closure using prostheses, and examined patient opinion on how palatal closure using autogenous tissue improved their postoperative quality of life (QOL). METHODS: In 5 patients whose palatal defects resulted from treatment for head and neck cancer and were closed with a prosthesis, the palate was closed secondarily with autogenous tissue; a questionnaire on daily life was administered pre- and post-operatively. RESULTS: Functional improvements in terms of speech and eating were achieved in all and in 4 of 5 cases, respectively. In all cases, the QOL was better for palatal closure with autogenous tissue than with the prosthesis. CONCLUSIONS: As postoperative QOL was considered to be better when reconstructing the palate with autogenous tissue than with the prosthesis, we recommend to actively select autogenous tissue for palate reconstruction.

DOI： 10.1097/SCS.0000000000007969

PubMed

researchmap

Pyogenic Ventriculitis After Anterior Skull Base Surgery Treated With Endoscopic Ventricular Irrigation And Reconstruction Using a Vascularized Flap.

Yusuke Tomita, Yosuke Shimazu, Masato Kawakami, Hiroshi Matsumoto, Kentaro Fujii, Masahiro Kameda, Takao Yasuhara, Yasuki Suruga, Tomoyuki Ota, Yoshihiro Kimata, Kazuhiko Kurozumi, Isao Date

Acta medica Okayama 75 ( 2 ) 243 - 248 2021年4月

記述言語：英語

Ventriculitis is a rare, serious complication of neurosurgery. A 59-year-old man who had undergone a craniotomy for a paranasal adenocarcinoma, developed a right frontal cystic lesion. We performed a bifrontal craniotomy to remove the lesion. The dura was repaired with non-vascularized free fascia lata in watertight fashion. Ventriculitis occurred 3 days postoperatively. Ventricular drainage, craniectomy, and endoscopic irrigation were undertaken to remove an abscess. The dura and the resection cavity were reconstructed using a vascularized anterolateral thigh adipofascial flap. His symptoms disappeared, indicating that endoscopic irrigation and reconstruction can effectively address ventriculitis even in patients in critical clinical condition.

DOI： 10.18926/AMO/61908

PubMed

researchmap

頭頸部がん手術における形態・機能維持の工夫頭頸部形態再建における理想的な移植組織を考える

木股敬裕, 松本洋, 太田智之

日本耳鼻咽喉科学会会報 123 ( 4 ) 939 - 939 2020年9月

下歯槽神経鞘腫の一例

宮本なつみ, 松本洋, 太田智之, 木股敬裕

日本形成外科学会会誌 40 ( 6 ) 314 - 314 2020年6月

Nerve Switch for Reducing Synkinesis After Gracilis Muscle Transfer Innervated Via the Masseter Nerve. 査読国際誌

Ota T, Matsumoto H, Yamada K, Kimata Y

The Journal of craniofacial surgery 30 ( 1 ) e3 - e5 2019年1月

Raoultella planticola bacteremia-induced fatal septic shock following burn injury 査読

Tetsuya Yumoto, Hiromichi Naito, Hiromi Ihoriya, Kohei Tsukahara, Tomoyuki Ota, Toshiyuki Watanabe, Atsunori Nakao

Annals of Clinical Microbiology and Antimicrobials 17 ( 1 ) 19 2018年5月

Laser-Assisted Indocyanine Green Angiography Aids in the Reconstruction of Gustilo Grade IIIB Open Lower-Limb Fractures 査読

Seijiro Koshimune, Akira Shinaoka, Tomoyuki Ota, Satoshi Onoda, Yoshihiro Kimata

JOURNAL OF RECONSTRUCTIVE MICROSURGERY 33 ( 2 ) 143 - 150 2017年2月

Analysis of 10-Year Training Results of Medical Students Using the Microvascular Research Center Training Program 査読

Satoshi Onoda, Yoshihiro Kimata, Narushi Sugiyama, Eijiro Tokuyama, Kumiko Matsumoto, Tomoyuki Ota, Moe Thuzar

JOURNAL OF RECONSTRUCTIVE MICROSURGERY 32 ( 5 ) 336 - 341 2016年6月

　前のページ - 次のページ　

<太田 智之>

論文 - 太田 智之

<太田　智之>

論文 - 太田　智之