研究者詳細 - 太田　智之

論文 - 太田　智之

分割表示 31 件中 1 - 20 件目／全件表示 >>

Development of a unique tissue-engineered in vitro vascular model with endothelial layer-inverted vascular tissue structure using a cell self-aggregation technique.

Shingo Hashimoto, Akihiko Sugiyama, Tomoyuki Ota, Hiroshi Matsumoto, Yoshihiro Kimata, Ryosuke Iwai

Journal of bioscience and bioengineering 2024年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Vascular-like tissues composed of cells maintaining their shape and structure at any position in a culture dish without the use of gels or other artificial materials are ideal vascular models to test the effects of candidate drugs on cells without adsorption by artificial materials and analysis of structural changes over time. In this study, we aimed to prepare fiber-shaped cell aggregates composed of human umbilical vein endothelial and mesenchymal stem cells as vascular pericytes anchored to the bottom of culture dishes at a defined location using our developed cell self-aggregation technique and dumbbell-shaped culture groove. The fiber-shaped cell aggregates maintained their shape for at least two weeks without rupture, and histological analysis revealed that they formed a unique tissue structure with a gapless endothelial layer on the outer surface and capillary-like structures oriented in the same direction as the long axis of the fiber in the medial side. Moreover, exposure to cadmium chloride, a vascular toxicant, elicited toxic responses in vascular endothelialized fiber-shaped tissues, with only their outer endothelial layer being disintegrated but their fiber shape remaining intact. Overall, our results suggest the developed vascular endothelialized fiber-shaped tissue construct as potential models for vascular toxicity testing, facilitating the evaluation of toxicity over time without any effects of gel adsorption.

DOI： 10.1016/j.jbiosc.2024.12.001

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頭頸部癌治療後の顔貌変形に対する肋軟骨移植を用いた二次修正法

若崎昭太, 新田弘一朗, 太田智之, 松本洋

日本頭蓋顎顔面外科学会学術集会プログラム・抄録集 42回 143 - 143 2024年11月

Pneumocephalus with Inverted Papilloma in the Frontoethmoidal Sinus: Case Report and Literature Review. 査読

Seiichiro Makihara, Yoshihiro Otani, Kensuke Uraguchi, Sawako Ono, Aiko Shimizu, Ryosuke Ikemachi, Yosuke Okazaki, Tomoyuki Ota, Hiroshi Matsumoto, Shotaro Miyamoto, Munechika Tsumura, Seiya Hayashi, Michiari Umakoshi, Koji Hirashita, Mizuo Ando

Acta medica Okayama 78 ( 4 ) 337 - 343 2024年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Here, we describe the unique case of a pneumocephalus originating from an inverted papilloma (IP) in the frontoethmoidal sinus. A 71-year-old man with diabetes presented with headaches and altered consciousness. Imaging revealed the pneumocephalus together with bone destruction in the left frontal sinus. He underwent simultaneous endoscopic endonasal and transcranial surgery using an ORBEYE exoscope. Pathological diagnosis of the tumor confirmed IP. Post-surgery, the pneumocephalus was significantly resolved and the squamous cell carcinoma antigen level, which had been elevated, decreased. This case underscores the importance of a multidisciplinary approach and innovative surgical methods in treating complex sinonasal pathologies.

DOI： 10.18926/AMO/67550

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主体性を育む専攻医の成長を促す週例カンファレンス

加藤基, 松本洋, 太田智之, 妹尾貴矢

医学教育 55 ( Suppl. ) 364 - 364 2024年7月

【顔の再建外科手術を仕上げる-touch up surgery-】上顎再建後の眼周囲touch up surgery

松本洋, 太田智之, 木股敬裕

形成外科 67 ( 7 ) 671 - 679 2024年7月

上顎再建遊離腓骨移植による上顎再建

松本洋, 太田智之, 加藤基, 武田斉子, 牧野琢丸, 安藤瑞生

頭頸部癌 50 ( 2 ) 105 - 105 2024年5月

頭頸部再建において二皮島化が有用となる条件二皮島化と前外側大腿皮弁の皮島デザインにおける柔軟性

加藤基, 松本洋, 太田智之, 木股敬裕

頭頸部癌 50 ( 2 ) 183 - 183 2024年5月

上顎再建遊離腓骨移植による上顎再建

松本洋, 太田智之, 加藤基, 武田斉子, 牧野琢丸, 安藤瑞生

頭頸部癌 50 ( 2 ) 105 - 105 2024年5月

喉頭癌放射線治療後のサルベージ手術における問題点と再建法

太田智之, 松本洋, 木股敬裕

頭頸部癌 50 ( 2 ) 147 - 147 2024年5月

頭頸部癌治療後の軟口蓋再建における咽頭弁の様々な配置法

松本洋, 太田智之, 加藤基, 木股敬裕

頭頸部癌 50 ( 2 ) 144 - 144 2024年5月

Combined simultaneous endoscopic endonasal and transcranial surgery using high-definition three-dimensional exoscope for malignant tumors of the anterior skull base. 査読国際誌

Seiichiro Makihara, Yoshihiro Otani, Kensuke Uraguchi, Aiko Shimizu, Aya Murai, Takaya Higaki, Naoki Akisada, Shohei Fujimoto, Takuma Makino, Joji Ishida, Kentaro Fujii, Takao Yasuhara, Tomoyuki Ota, Hiroshi Matsumoto, Mizuo Ando

Head & neck 2024年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Advanced surgical interventions are required to treat malignancies in the anterior skull base (ASB). This study investigates the utility of endoscopic endonasal and transcranial surgery (EETS) using a high-definition three-dimensional exoscope as an alternative to traditional microscopy. METHODS: Six patients with carcinomas of varying histopathologies underwent surgery employing the EETS maneuver, which synchronized three distinct surgical modalities: harvesting of the anterolateral thigh flap, initiation of the transnasal technique, and initiation of the transcranial procedure. RESULTS: The innovative strategy enabled successful tumor resection and skull base reconstruction without postoperative local neoplastic recurrence, cerebrospinal fluid leakage, or neurological deficits. CONCLUSION: The integration of the exoscope and EETS is a novel therapeutic approach for ASB malignancies. This strategy demonstrates the potential of the exoscope in augmenting surgical visualization, enhancing ergonomics, and achieving seamless alignment of multiple surgical interventions. This technique represents a progressive shift in the management of these complex oncological challenges.

DOI： 10.1002/hed.27724

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Various arrangements of pharyngeal flap in soft palate reconstruction after cancer treatment. 査読国際誌

Hiroshi Matsumoto, Tomoyuki Ota, Motoi Kato, Takuma Makino, Seiichiro Makihara, Mizuo Ando, Yoshihiro Kimata

Head & neck 2024年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The pharyngeal flap (PF) is useful for reconstruction of soft palate defects, but effective arrangements of PF for various types of soft palate defects are controversial. Here, we classify three types of soft palate defects and discuss the arrangements of PF and their functional prognosis. METHODS: Reconstruction was performed based on the classification of the defects. Clinical details were collected, and postoperative function was analyzed. RESULTS: Eight patients were included in the study. The defect sizes ranged from 25 (width) × 40 (depth) to 40 × 60 mm. Six patients underwent pharyngeal flap reconstruction with free-flap reconstruction, and two underwent pharyngeal flap reconstruction. The pharyngeal flap was harvested at the maximum width of the posterior pharyngeal wall, ranging from 25 to 40 mm in length. Eating and speaking functions were maintained in all patients. CONCLUSIONS: Good postoperative function can be maintained by narrowing the velopharyngeal space with a pharyngeal flap.

DOI： 10.1002/hed.27712

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当科における直近5年間の下顎腓骨再建症例の検討

光井恵麻, 松本洋, 太田智之, 木股敬裕

日本マイクロサージャリー学会学術集会プログラム・抄録集 50回 151 - 151 2023年12月

放射線照射症例における頭頸部再建術後の発熱、炎症マーカーについての検討

太田智之, 松本洋, 高尾総司, 池内綾介, 木股敬裕

日本マイクロサージャリー学会学術集会プログラム・抄録集 50回 154 - 154 2023年12月

Fabrication of shape-designable cartilage from human induced pluripotent stem cell-derived chondroprogenitors using a cell self-aggregation technique. 査読国際誌

Tomoyuki Ota, Tomoka Takao, Ryosuke Iwai, Takeshi Moriwaki, Yohei Kitaguchi, Yuki Fujisawa, Daisuke Yamada, Yoshihiro Kimata, Takeshi Takarada

Biomedical materials (Bristol, England) 2023年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

With the advancement of tissue engineering technologies, implantable materials have been developed for use in facial plastic surgery, including auriculoplasty and rhinoplasty. Tissue-engineered cartilage comprising only cells and cell-produced extracellular matrix is considered valuable as there is no need to consider problems associated with the absorption of scaffold materials and the generation of immune responses. However, it is exceedingly difficult to produce large-sized complex shapes of cartilage without the use of scaffolds. In this study, we describe the production of shape-designable cartilage using a novel cell self-aggregation technique (CAT) and chondroprogenitor cells derived from human induced pluripotent stem cells as the source. The method described does not require special equipment such as bio-3D printers, and the produced tissue can be induced into well-matured cartilage with abundant cartilage matrix in vitro. Using CAT, we were able to generate cartilage in the form of rings or tubes with adjustable inner diameter and curvature, over a range of several centimeters, without the use of scaffolds. The in vitro fabrication of shape-designable cartilage using CAT will undoubtedly contribute to developments in the field of facial plastic surgery.&#xD.

DOI： 10.1088/1748-605X/ad02d1

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放射線再照射(Total 120Gy)後に生じた合併症により複数回の再建手術を要した頭頸部放射線障害の1例査読

松本洋, 太田智之, 木股敬裕

日本マイクロサージャリー学会会誌 36 ( 3 ) 131 - 139 2023年9月