Updated on 2024/04/01

写真a

 
Hirotaka Ueda
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Assistant Professor
Position
Assistant Professor
External link

Degree

  • 博士（歯学） ( 岡山大学 )

Research Interests

  • Cleft lip and palate

  • Orthodontics

  • Neurophysiology

Research Areas

  • Life Science / Developmental dentistry  / Orthodontics

  • Life Science / Neuroscience-general  / Neurophysiology

Education

  • Okayama University   Graduate School of Medicine, Dentistry and Pharmaceutical Sciences (Doctor's Course)   Department of Orthodontics, Science of Functional Recovery and Reconstruction

    2005.4 - 2009.3

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    Country： Japan

  • Okayama University   Dental school   Dentistry course

    1999.4 - 2005.3

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    Country： Japan

Research History

  • Okayama University   Graduate School of Medicine , Dentistry and Pharmaceutical Sciences   Assistant Professor

    2017.7

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  • Kagoshima University   Graduate School of Medical and Dental Sciences   Assistant Professor

    2014.4 - 2017.6

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  • 鹿児島大学病院 発達系歯科センター 矯正歯科   助教

    2010.4 - 2014.3

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  • 岡山大学病院 矯正歯科   医員

    2009.4 - 2010.3

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  • Okayama University   Graduate School of Medicine , Dentistry and Pharmaceutical Sciences

    2005.4 - 2009.3

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  • Okayama University   School of Dentistry, Dental School

    1999.4 - 2005.3

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Professional Memberships

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Papers

  • A comparative study of post operative morphological changes of hard and soft tissue following MASDO and mandibular osteotomy in patients with cleft lip and palate Reviewed

    YASUTOMI Narumi, UEDA Hirotaka, ARIMURA Yuki, MORITANI Norifumi, MATSUMURA Tatsushi, KAMIOKA Hiroshi, IIDA Seiji

    The Journal of Chu-shikoku Orthodontic Society   35 ( 1 )   37 - 50   2023.8

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  • Improvement of anterior disc displacement on the mandibular deviated side after intraoral vertical ramus osteotomy in a patient with facial asymmetry: a case report Reviewed International journal

    Hirotaka Ueda, Naoki Oka, Tsuyoshi Shimo, Akira Sasaki, Takashi Yamashiro, Hiroshi Kamioka

    Clinical and Investigative Orthodontics   81 ( 1 )   58 - 67   2022.3

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  • 下顎枝垂直骨切り術後に顎関節症状の改善と偏位側への側方滑走運動の改善を認めた顔面非対称症例 Reviewed

    植田 紘貴, 岡 直毅, 上岡 寛

    中・四国矯正歯科学会雑誌 32巻 1号 （頁 51 ～ 64）   32 ( 1 )   51 - 64   2020.8

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    Authorship：Lead author   Language：Japanese   Publisher：中・四国矯正歯科学会  

    本症例では、顎関節症状と下顎骨の左方偏位を伴う顔面非対称症例に対して、下顎枝垂直骨切り術を伴う外科的矯正治療を行い、顎関節症状の改善と偏位側への側方滑走運動の改善を認めたので報告する。患者は19歳女性で、下顎の左方偏位と右側顎関節の開閉口時の疼痛を主訴に来院した。上顎骨は標準範囲内で後方位傾向、下顎骨は標準範囲内で前方位傾向にあり、骨格性III級を示した。大臼歯関係はAngle III級で、上顎前歯歯軸は唇側傾斜、下顎前歯歯軸は標準範囲内で舌側傾斜傾向を示し、上下顎前歯部に叢生を認めた。顔面正中に対して上顎歯列正中は一致、下顎歯列正中は5.0mm左方に偏位していた。初診時の顎口腔機能検査所見では、左方への側方滑走運動の制限と左右下顎頭の開閉口路の不一致を認めた。以上から、上下顎前歯部叢生、下顎骨の左方偏位と偏位側への側方滑走運動の制限を伴う顔面非対称の骨格性下顎前突症例と診断し、下顎枝垂直骨切り術により遠位骨片を右側で6.0mm、左側で1.0mm後方移動し、顔面非対称が改善された。治療終了時の顎口腔機能検査所見では、右側下顎頭の疼痛が消退し、左右下顎頭と下顎前歯の運動経路のばらつきが減少するとともに、偏位側への側方滑走運動量が増加した。以上から、偏位側への側方滑走運動の制限を伴う顔面非対称症例において、下顎枝垂直骨切り術を伴う外科的矯正治療を行い、正貌・側貌の形態的改善だけでなく、顎関節症状や偏位側への側方滑走運動の改善等、機能的な改善が得られることが示された。(著者抄録)

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  • A case with anterior open bite, tongue thrusting and mandibular deviation orthodontically treated by using miniscrews for intrusion and distalization of mandibular molars Reviewed

    Mayu Suga, Hirotaka Ueda, Sayuri Yamanishi, Shouich Miyawaki

    Journal of The Kyushu Orthodontic Society   14 ( 1 )   25 - 31   2019.3

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  • Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats Reviewed International journal

    Yoshihiro Mitoh, Hirotaka Ueda, Hiroyuki Ichikawa, Masako Fujita, Motoi Kobashi, Ryuji Matsuo

    AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL   206   1 - 7   2017.9

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

    The superior salivatory nucleus (SSN) contains parasympathetic preganglionic neurons innervating the sub mandibular and sublingual salivary glands. Cevimeline, a muscarinic acetylcholine receptor (mAChR) agonist, is a sialogogue that possibly stimulates SSN neurons in addition to the salivary glands themselves because it can cross the blood-brain barrier (BBB). In the present study, we examined immunoreactivities for mAChR subtypes in SSN neurons retrogradely labeled with a fluorescent tracer in neonatal rats. Additionally, we examined the effects of cevimeline in labeled SSN neurons of brainstem slices using a whole-cell patch-clamp technique. Mainly M1 and M3 receptors were detected by immunohistochemical staining, with low-level detection of M4 and M5 receptors and absence of M2 receptors. Most (110 of 129) SSN neurons exhibited excitatory responses to application of cevimeline. In responding neurons, voltage-clamp recordings showed that 84% (101/120) of the neurons exhibited inward currents. In the neurons displaying inward currents, the effects of the mAChR antagonists were examined. A mixture of M1 and M3 receptor antagonists most effectively reduced the peak amplitude of inward currents, suggesting that the excitatory effects of cevimeline on SSN neurons were mainly mediated by M1 and M3 receptors. Current-clamp recordings showed that application of cevimeline induced membrane depolarization (9/9 neurons). These results suggest that most SSN neurons are excited by cevimeline via M1 and M3 muscarinic receptors.

    DOI： 10.1016/j.autneu.2017.05.010

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  • Vagal afferent activation induces salivation and swallowing-like events in anesthetized rats. Reviewed International journal

    Hirotaka Ueda, Mayu Suga, Takakazu Yagi, Ikue Kusumoto-Yoshida, Hideki Kashiwadani, Tomoyuki Kuwaki, Shouichi Miyawaki

    American journal of physiology. Regulatory, integrative and comparative physiology   311 ( 5 )   R964-R970 - R970   2016.11

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    The aim of this study was to clarify the effect of vagal afferent activation on salivation and swallowing-like events. Salivation is part of a reflex induced by stimulation of the oral area during feeding or chewing. Recently, we reported that nausea induced by gastroesophageal reflux (GER) activation produced salivation and swallowing in humans. Here, we investigated the ability of visceral sensation to enhance salivation and swallowing in rodents in order to inform the mechanism of GER-mediated stomatognathic activation. First, we administered LiCl to anesthetized male rats to induce nausea. LiCl significantly increased salivation and increased the activity of the vagal afferent nerve. Next, we simultaneously recorded salivation and swallowing using an electrode attached to the mylohyoid muscle during vagal afferent stimulation in a physiological range of frequencies. Vagal afferent stimulation significantly increased salivation and swallowing-like events in a frequency-dependent manner. A muscle relaxant, vecuronium bromide, diminished the swallowing-like response but did not affect salivation. These results indicate that visceral sensation induces salivation and swallowing-like events in anesthetized rodents through vagal afferent activation.

    DOI： 10.1152/ajpregu.00292.2016

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  • A Class II patient with bimaxillary protrusion and mandibular inclined third molars treated with orthodontic anchoring screws: A case report Reviewed

    Mayu Suga, Hirotaka Ueda, Fumiaki Kitashima, Shouich Miyawaki

    Orthodontic Waves   74 ( 4 )   112 - 119   2015.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier Ltd  

    This article reports successful use of orthodontic anchoring screws to treat bimaxillary protrusion and mandibular inclined third molars in a 25-year-old woman with complaints of crowded anterior teeth and polishing difficulties of third molars. She was diagnosed with skeletal Class II malocclusion with bimaxillary protrusion and mesial inclination of mandibular bilateral third molars. The maxillary first and mandibular second premolars were extracted, and two orthodontic anchoring screws were implanted in the buccal area of the maxillary molars. The total active treatment period was 24 months. After treatment, the facial profile and occlusion, including third molars, successfully improved, and stomatognathic functions were maintained after orthodontic treatment. Over a 24-month retention period, the satisfactory facial profile and adequate occlusion were maintained.

    DOI： 10.1016/j.odw.2015.04.001

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  • The roles of salivary secretion, brain-gut peptides, and oral hygiene in obesity Reviewed International journal

    Hirotaka Ueda, Takakazu Yagi, Haruka Amitani, Akihiro Asakawa, Satoshi Ikeda, Shouichi Miyawaki, Akio Inui

    OBESITY RESEARCH & CLINICAL PRACTICE   7 ( 5 )   E321 - E329   2013.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCI LTD  

    Obesity has a prevalence of 15-30% among European and American populations. It is an incurable chronic disease associated with considerable mortality and co-morbidity. The co-morbidity risk can be reduced substantially by a moderate weight loss of 5-15%. Notably, additional weight gain exacerbates the morbidity of any concurrent disease. Obesity is also recognized as the basis for metabolic syndrome. Recent research has shown that adipocytes secrete various hormones and cytokines that contribute to obesity. Leptin is an adipostatic hormone that acts on receptors in the hypothalamus to suppress food intake and increase energy consumption. Reduced sensitivity to this molecule can trigger the onset of obesity. Neuropeptides such as leptin also affect salivary secretion. Various neuropeptides have been identified in saliva; the associated receptors are located in the salivary glands or in the nerves innervating the salivary glands. Obesity is associated with hyposalivation and thereby related to several aspects of oral health, such as caries and periodontitis. Hyposalivation is a severe morbidity that can lead to a precipitous decline in oral hygiene, which further leads to multifocal dental caries and periodontitis, or even cardiac disorders. In this article, we review the relationship between salivary secretion and neuropeptides known to play a role in obesity. (C) 2013 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

    DOI： 10.1016/j.orcp.2013.05.001

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  • The role of ghrelin in patients with functional dyspepsia and its potential clinical relevance (Review). Reviewed International journal

    Takakazu Yagi, Akihiro Asakawa, Hirotaka Ueda, Shouichi Miyawaki, Akio Inui

    International journal of molecular medicine   32 ( 3 )   523 - 31   2013.9

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    Functional dyspepsia (FD) is a functional gastrointestinal disorder (FGID). According to the Rome III consensus, FD is divided into 2 subgroups: epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS). Although multiple mechanisms of FD pathogenesis have been suggested, its underlying etiology and pharmacological therapy remain unclear. Ghrelin is a gut-derived peptide found in the stomach. It plays a role in the regulation of gastric motility and appetite. The ghrelin gene encodes 3 molecular forms, acyl ghrelin, des-acyl ghrelin and obestatin. Acyl ghrelin acts as an endogenous ligand for growth hormone secretagogue receptor; furthermore, it is orexigenic, with effects on food intake, energy homeostasis and gastrointestinal motility. Des-acyl ghrelin exerts an opposite effect to acyl ghrelin. Obestatin exerts an inhibitory effect on the motor activity of the antrum and duodenum in fed animals. These peptides exert differential effects on gut motility and food intake. The therapeutic potential of ghrelin has attracted attention due to its varied bioactivities. Certain studies have shown that total ghrelin levels are significantly lower in patients with FD compared with healthy volunteers and that the acyl ghrelin levels of patients with FD are higher compared with healthy volunteers. However, a recent study demonstrated that acyl ghrelin levels in patients with PDS were lower compared with healthy volunteers; the association between FD and other ghrelin family gene products also remains unclear. Although certain studies have demonstrated the beneficial effects of acyl ghrelin administration and its agonist in patients with FD, only a few clinical reports exist. Further studies are required in order to examine the effects of ghrelin on FD.

    DOI： 10.3892/ijmm.2013.1418

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  • The role of zinc in the treatment of taste disorders. Reviewed International journal

    Takakazu Yagi, Akihiro Asakawa, Hirotaka Ueda, Satoshi Ikeda, Shouichi Miyawaki, Akio Inui

    Recent patents on food, nutrition & agriculture   5 ( 1 )   44 - 51   2013.4

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    In the 1990s the number of patients diagnosed with taste disorders in the USA and Japan was over one million people each year, and the number is increasing annually. Taste disorders are caused by several factors such as genetic disease, head trauma, structural changes, glossodynia, cancer, change of lifestyle, and more. The role of zinc in the treatment of taste disorders has been studied since the oral administration of zinc by patients was reported to improve their taste disorders. Carbonic anhydrase (CA), a zinc metalloenzyme, has also been studied in association with taste disorders, since the regulation of serum CA levels was shown to influence the effect of orally administrated zinc in the treatment of taste disorders. Zinc is an essential trace element that contributes to the active center of approximately 300 enzymes. Studies have revealed that zinc is involved in various physiological functions. Moreover, some medications have been shown to induce a zinc deficiency, which has been associated with a variety of clinical conditions. Hence, since the relationship between taste disorder and serum zinc concentration has been discussed for long time, taste disorder may be useful in diagnosing zinc deficiency. Moreover, it appears that medicines of the zinc-containing supplement type contribute to the treatment of taste disorders caused by zinc deficiency. Orally administered zinc has been shown to directly stimulate food intake via neuropeptide in the hypothalamus. Therefore, zinc administration may potentially be used to treat taste disorders, as well as several other diseases by stimulating feeding. The article presents some promising patents on the role of zinc in the treatment of taste disorders.

    DOI： 10.2174/2212798411305010007

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  • The role of ghrelin, salivary secretions, and dental care in eating disorders. Reviewed International journal

    Takakazu Yagi, Hirotaka Ueda, Haruka Amitani, Akihiro Asakawa, Shouichi Miyawaki, Akio Inui

    Nutrients   4 ( 8 )   967 - 89   2012.8

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    Eating disorders, including anorexia and bulimia nervosa, are potentially life-threatening syndromes characterized by severe disturbances in eating behavior. An effective treatment strategy for these conditions remains to be established, as patients with eating disorders tend to suffer from multiple relapses. Because ghrelin was originally discovered in the stomach mucosa, it has been widely studied over the past decade in an effort to uncover its potential roles; these studies have shed light on the mechanism by which ghrelin regulates food intake. Thus, studying ghrelin in the context of eating disorders could improve our understanding of the pathogenesis of eating disorders, possibly resulting in a promising new pharmacological treatment strategy for these patients. In addition, early detection and treatment of eating disorders are critical for ensuring recovery of young patients. Oral symptoms, including mucosal, dental, and saliva abnormalities, are typically observed in the early stages of eating disorders. Although oral care is not directly related to the treatment of eating disorders, knowledge of the oral manifestations of eating disorder patients may aid in early detection, resulting in earlier treatment; thus, oral care might contribute to overall patient management and prognosis. Moreover, ghrelin has also been found in saliva, which may be responsible for oral hygiene and digestion-related functions. This review discusses the pharmacological potential of ghrelin in regulating food-intake and the role of saliva and oral care in young patients with eating disorders.

    DOI： 10.3390/nu4080967

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  • Regulative roles of ghrelin in ingestive behavior, upper gastrointestinal motility, and secretion Reviewed

    Hirotaka Ueda, Takakazu Yagi, Haruka Amitani, Akihiro Asakawa, Shouichi Miyawaki, Akio Inui

    Current Nutrition and Food Science   8 ( 3 )   188 - 195   2012

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    Ghrelin was recently identified as the first endogenous ligand for growth hormone secretagogue receptors (previously known as orphan receptors). Two major molecular forms of ghrelin are found in the stomach and plasma: acyl ghrelin with O-n-octanoylated serine at position 3 and des-acyl ghrelin. Interestingly, these distinct molecular forms play contrasting roles in ingestive behavior, upper gastrointestinal motility, and gastric acid secretion. Acyl ghrelin stimulates food intake both in fed and fasted rodents and induces adiposity, alleviates ingestive behavior, stimulates gastrointestinal motor activity and gastric acid secretion, and accelerates gastric emptying in several species. In contrast, des-acyl ghrelin has been demonstrated to disrupt gastric motility in rats and delay gastric emptying in mice and rats. Thus, acyl ghrelin is a potent stimulator of ingestive behavior, gastrointestinal motility, and gastric acid secretion, whereas des-acyl ghrelin exerts opposing effects on ingestive behavior and gastrointestinal motility but does not affect gastric acid secretion. Ghrelin is expected to be used in various applications such as therapeutic strategies for obesity, anorexia, cachexia, and cardiovascular disease in the clinical setting. In this article, we review the evidence on the roles of acyl ghrelin and des-acyl ghrelin in the regulation of ingestive behavior, upper gastrointestinal motility, and gastric acid secretion in mammals
    moreover, we mention the effects of ghrelin on oral functions. © 2012 Bentham Science Publishers.

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  • Muscarinic receptor immunoreactivity in the superior salivatory nucleus neurons innervating the salivary glands of the rat Reviewed International journal

    Hirotaka Ueda, Yoshihiro Mitoh, Masako Fujita, Motoi Kobashi, Takashi Yamashiro, Tomosada Sugimoto, Hiroyuki Ichikawa, Ryuji Matsuo

    NEUROSCIENCE LETTERS   499 ( 1 )   42 - 46   2011.7

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER IRELAND LTD  

    The superior salivatory nucleus (SSN) contains preganglionic parasympathetic neurons to the submandibular and sublingual salivary glands. Cevimeline, a muscarinic acetylcholine receptor agonist, stimulates the salivary glands and is presently used as sialogogue in the treatment of dry mouth. Since cevimeline passes through the blood-brain barrier, it is also able to act on muscarinic acetylcholine receptors in the central nervous system. Our preliminary experiment using the whole-cell patch-clamp technique has shown that cevimeline excites SSN neurons in rat brain slices, suggesting that SSN neurons have muscarinic acetylcholine receptors; however, it is unclear which subtypes of muscarinic acetylcholine receptors exist in SSN neurons. In the present study, we investigated immunohistochemically muscarinic acetylcholine receptor subtypes, M1 receptor (M1R), M2R, M3R, M4R, and M5R in SSN neurons. SSN neurons innervating the salivary glands, retrogradely labeled with a fluorescent tracer from the chorda-lingual nerve, mostly expressed M3R immunoreactivity (-ir) (92.3%) but not M1R-ir. About half of such SSN neurons also showed M2R- (40.1%), M4R- (54.0%) and M5R-ir (46.0%); therefore, it is probable that SSN neurons co-express M3R-ir with at least two of the other muscarinic receptor subtypes. This is the first report to show that SSN neurons contain muscarinic acetylcholine receptors. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

    DOI： 10.1016/j.neulet.2011.05.029

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  • Cevimeline enhances the excitability of rat superior salivatory neurons Reviewed

    Hirotaka Ueda, Yoshihiro Mitoh, Hiroyuki Ichikawa, Motoi Kobashi, Takashi Yamashiro, Ryuji Matsuo

    Journal of Medical Investigation   56 ( 1 )   267 - 269   2009

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    Cevimeline, a therapeutic drug for xerostomia, is an agonist of muscarinic acetylcholine receptors (mAChRs), and directly stimulates the peripheral mAChRs of the salivary glands. Since cevimeline is distributed in the brain after its oral administration, it is possible that it affects the central nervous system. However, it is unknown how cevimeline affects the superior salivatory (SS) neurons, which control submandibular salivation. In the present study, we examined the effects of cevimeline on the SS neurons using the whole-cell patch-clamp technique in brain slices. In Wistar rats (6-10 days), the SS neurons were retrogradely labeled by Texas Red applied to the chorda-lingual nerve. Two days after injection, whole-cell recordings were obtained from the labeled cells, and miniature excitatory postsynaptic currents (mEPSCs) were examined. Cevimeline induced the inward currents dose-dependently and increased the frequency of mEPSCs. Therefore, it is suggested that cevimeline enhances the excitability via post- and presynaptic muscarinic receptors in the rat SS neurons. In conclusion, cevimeline may enhance the excitability of the SS neurons.

    DOI： 10.2152/jmi.56.267

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  • . Reviewed

    Harumi Ota, Mitsuhiro Hoshijima, Yasuyuki Nakanishi, Hirotaka Ueda, Satoru Hayano, Hiroshi Kamioka

    The Journal of Okayama Dental Society   40 ( 2 )   19 - 24   2021.12

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  • 岡山大学大学院歯科矯正学分野研究室における過去15年間および2013年から2016年の4年間の岡山大学の学生および職員に対する矯正相談の実態調査 Reviewed

    田中智代, 村上隆, 片岡伴記, 石原嘉人, 植田紘貴, 早野暁, 星島光博, 中村政裕, 川邉紀章, 上岡寛

    岡山歯学会雑誌   36 ( 2 )   45 - 51   2018

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  • 歯科矯正用アンカースクリューを併用して非抜歯治療を行った骨格性II級ハイアングル症例の一治験例 Reviewed

    植田紘貴, 迫口陽子, 宮脇正一

    九州矯正歯科学会雑誌   11 ( 1 )   10‐16 - 16   2016

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    Authorship：Lead author   Language：Japanese   Publisher：九州矯正歯科学会  

    患者は初診時年齢21歳2ヵ月の女性で、前歯部が噛み合わないことを主訴に来院した。初診時に両側下顎頭の吸収が疑われたため、1年間の経過観察を行い、22歳2ヵ月時に下顎の位置が初診時と変化していないことを確認し、上顎前突を伴うアングルI級、骨格II級ハイアングル症例と診断した。クワドヘリックス装置による上顎の拡大と、バイヘリックスによる下顎の拡大後、歯科矯正用アンカースクリューによる上下顎大臼歯の圧下と上顎大臼歯の遠心移動を併用してマルチブラケット装置により前歯部被蓋を改善した。動的治療期間は4年10ヵ月であった。上顎臼歯部の遠心移動によって口唇の突出感が緩和され、側貌の改善が認められた。保定開始後5年1ヵ月が経過し、安定した咬合と下顎位が維持されている。(著者抄録)

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  • Psychological State and Concerns of Guardians of Patients with Cleft Lips and Alveoli with/without Cleft Palates while Undergoing Orthodontic Treatment Reviewed

    福重雅美, 前田綾, 上原沢子, 植田紘貴, 帆北友紀, 中村典史, 宮脇正一

    日本口蓋裂学会雑誌   40 ( 1 )   13 - 22   2015.4

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    Language：Japanese   Publisher：(一社)日本口蓋裂学会  

    本研究の目的は、矯正治療中の口唇顎裂もしくは口唇口蓋裂を伴う患者の保護者における心理状態や関心事を明らかにすることである。鹿児島大学医学部・歯学部附属病院矯正歯科を受診した口唇顎裂もしくは口唇口蓋裂を伴う未成年患者の保護者86名を対象とし、歯科衛生士による質問紙調査を行った。VAS法を用いた質問では、保護者を患者の発達段階により5群(幼児期、学童期・小学校低学年、学童期・小学校高学年、青年前期・中学生、青年中期以降)に分類し、VAS値の差を統計学的に検討した。質問紙調査の結果、矯正治療の必要性を知った時は、「悲しみと怒りおよび不安」の心理状態を示した保護者が最も多く、そのほとんどが「矯正治療が長期に及ぶ」ことによる「不安」であった。また、保護者は「顔貌」などの審美的項目に対して特に高い関心を示し、「社会生活の不安」についても関心が高かった。一方、「矯正治療の期間」や「矯正歯科での1回の診療時間」において、青年中期以降群の保護者は、幼児期や学童期群の保護者と比較して、VAS値が有意に高く、保護者は長期間の矯正治療と長い診療時間に関して負担に感じていた。「矯正装置のトラブル」においては、学童期・小学校高学年群の保護者は、小学校低学年群と比較して、有意にVAS値が高く、トラブルが多いと回答した。使用中の矯正装置の種類は、ほぼ同じであることから、治療が長期化することで、保護者はトラブルの負担を感じやすいことが示唆された。以上から口唇顎裂もしくは口唇口蓋裂を伴う患者の保護者は、特に審美的な問題について関心が高く、矯正治療の期間や診療時間が長いことに対する不安や負担の程度は、患者の発育段階によって異なることが明らかとなった。(著者抄録)

    DOI： 10.11224/cleftpalate.40.13

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  • 従来の固定式大臼歯遠心移動装置とスケレタルアンカレッジ装置の臼歯部と前歯部への治療効果に関する系統的レビュー Reviewed

    八木孝和, 菅真有, 植田紘貴, 友成博, 大牟禮治人, 宮脇正一

    九州矯正歯科学会雑誌   9 ( 1 )   1 - 16   2013

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    従来の固定式大臼歯遠心移動装置とスケレタルアンカレッジ装置の臼歯部と前歯部への治療効果について検討した。日英4つの電子的データベースを用いて、包含条件を含む文献を検索し、セファロメトリックな方法で調査された治療前後のデータを含む各排除項目を満たす文献に選別し、さらに9項目に及ぶ質的な条件を満たしたものをメタ・アナリシスに供した。スクリーニングで45件の文献を抽出し、さらに質的解析によって8文献を抽出した。大臼歯の遠心移動に対して、歯科矯正期アンカースクリューを用いたスケレタルアンカレッジ装置は、従来の固定式大臼歯遠心移動装置と比較して、前歯部への影響がなく効果的にかつ効率的に歯を動かしたが、ペンデュラム装置は、大臼歯の遠心傾斜を誘発した。約1年間の大臼歯遠心移動で、従来の固定式大臼歯遠心移動装置では3〜4mm、スケレタルアンカレッジ装置で4〜5mm程度の遠心移動が期待できた。

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  • ミニスクリューを用いて重度の前歯部開咬を改善した症例 Reviewed

    冨田奈緒, 上岡寛, 植田紘貴, 加野小奈美, 山城隆

    中・四矯正歯誌   24 ( 1 )   63 - 71   2012

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  • 岡山大学病院矯正歯科における来院患者の実態調査 Reviewed

    白賀のり子, 上岡寛, 片岡伴記, 植田紘貴, 安藤涼子, 石原嘉人, 柳田剛志, 村上隆, 黒坂寛, 菅原康代, 本城正, 川邉紀章, 山城隆

    岡山歯学会雑誌   28 ( 2 )   107 - 114   2009.12

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  • ラット上唾液核ニューロンにおけるセビメリンの興奮性作用に関する電気生理学的解析 Reviewed

    植田 紘貴

    岡山歯学会雑誌   28 ( 1 )   1 - 16   2009.6

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    ラットを使用し、顎下腺・舌下腺の唾液分泌の副交感神経の起始核である上唾液核ニューロンに対するセビメリンの影響を電気生理学的に検討した。さらに、免疫組織化学的実験により上唾液核ニューロンに存在するムスカリン様アセチルコリン受容体のサブタイプを検討した。セビメリンは上唾液核ニューロンの興奮性を促進した。全ての上唾液核ニューロンのシナプス後膜にムスカリン様アセチルコリン受容体が存在し、約60%のニューロンにおいては、シナプス前膜においてもムスカリン様アセチルコリン受容体が存在した。上唾液核ニューロンに存在するムスカリン様アセチルコリン受容体はM1およびM3受容体で、M1受容体を介した反応が大きかった。顎下腺・舌下腺の唾液分泌の中枢である上唾液核ニューロンにはM1受容体およびM3受容体が存在し、そのうち、セビメリンは主にM1受容体を介して上唾液核ニューロンの興奮性を促進する可能性が示唆された。

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  • 植田紘貴、上岡 寛、川邉紀章、山城 隆, 外傷性咬合ならびに歯周疾患を伴う成人下顎前突症例 Reviewed

    植田紘貴, 上岡 寛, 川邉紀章, 山城 隆

    中・四矯正歯誌   21   47 - 53   2009

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  • Hormonal, pH, and calcium regulation of Connexin 43-mediated dye transfer in osteocytes in chick calvaria Reviewed International journal

    Yoshihito Ishihara, Hiroshi Kamioka, Tadashi Honjo, Hirotaka Ueda, Teruko Takano-Yamamoto, Takashi Yamashiro

    JOURNAL OF BONE AND MINERAL RESEARCH   23 ( 3 )   350 - 360   2008.3

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    Gap junctional intercellular communication among osteocytes in chick calvaria, their natural 3D environment, was examined using FRAP analysis. Cell-cell communication among osteocytes in chick calvaria was mediated by Cx43 and was regulated by extracellular pH(o) extracellular calcium ion concentration, and PTH.
    Introduction: The intercellular network of communication among osteocytes is mediated by gap junctions. Gap junctional intercellular communication (GJIC) is thought to play an important role in integration and synchronization of bone remodeling. We hypothesized that extracellular pH (pH.) and extracellular calcium ion concentration ([Ca2+](e)), both of which are dynamically altered by osteoclasts during bone remodeling, affect GJIC among osteocytes. Using fluorescence replacement after photobleaching (FRAP) analysis, we examined the effect of changes in pH(o) and [Ca2+](e) and addition of PTH on GJIC in osteocytes in chick calvaria. Additionally, we examined the role of intracellular calcium on the regulation of GJIC among osteocytes.
    Materials and Methods: Anti-Connexin43 (Cx43) immunolabeling was used to localize gap junctions in chick calvaria. GJIC among osteocytes in chick calvariae was assessed using FRAP.
    Results: Cx43 immunoreactivity was detected in most of the osteocyte processes. FRAP analysis showed dye-coupling among osteocytes in chick calvariae. In untreated osteocytes, fluorescence intensity recovered 43.7 +/- 2.2% within 5 min after photobleaching. Pretreatment of osteocytes with 18 alpha-GA, a reversible inhibitor of GJIC, significantly decreased fluorescence recovery to 10.7 +/- 2.2%. When pH(o) was decreased from 7.4 to 6.9, fluorescence recovery significantly decreased from 43.3 +/- 2.9% to 19.7 +/- 2.3%. Conversely, when pH(o) was increased from 7.4 to 8.0, fluorescence recovery was significantly increased to 61.9 +/- 4.5%. When [Ca2+](e) was increased from 1 to 25 mM, fluorescence recovery was significantly decreased from 47.0 +/- 6.1% to 16.1 +/- 2.1%. In bone fragments exposed to 1.0-10 nM rPTH for 3 h, replacement of fluorescence was significantly increased to 60.7 +/- 7.2%. Chelating intracellular calcium ions affected GJIC regulation by [Ca2+](e) and PTH.
    Conclusions: Our study of cell-cell communication between osteocytes in chick calvaria showed for the first time that GJIC among osteocytes is regulated by the extracellular environment and by hormonal stimulation during bone remodeling. This method may be more biologically relevant to living bone than current methods.

    DOI： 10.1359/JBMR.071102

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  • メビウス症候群の口腔・顎顔面形態の臨床所見について

    小見山裕司, 植田紘貴, 上岡寛

    第4回せとうち臨床遺伝研究会抄録集   19 - 19   2024.3

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  • A case of connective tissue graft for a moderate crowding with gingival recession Reviewed

    HASHIMOTO M, UEDA H, OKUBO K, KAMIOKA H

    261 - 261   2023.11

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  • Trial of PLP for patients with submucosal cleft palate using an oral scanner Reviewed

    KOZAKI G, UEDA H, KAMIOKA H

    265 - 265   2023.11

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  • 合指による自力清掃困難なアペール症候群患者に対して口腔衛生習慣の確立を目指した1症例 Reviewed

    西山由夏, 植田紘貴, 高橋麻里子, 小倉早妃, 三浦留美, 谷崎沙織, 上岡寛

    日本歯科衛生学会 第18回学術大会 抄録集   2023.9

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  • . Reviewed

    Yuri Yoshikawa, Hirotaka Ueda, Yuki Arimura, Seiji Iida, Hiroshi Kamioka

    2023.7

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  • 顎関節症状を伴う顔面非対称症例に対して Le FortI型骨切り術とIVSRO を施行した一治験例 Reviewed

    田中敦子, 植田紘貴, 石田朋子, 中辻和樹, 森谷徳文, 飯田征二, 上岡寛

    第33回日本顎変形症学会総会・学術大会プログラム・抄録号   33 ( 2 )   208 - 208   2023.5

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  • 岡山大学病院口唇裂・口蓋裂総合治療センターにおける受診患者の臨床統計的調査 Reviewed

    吉川友理, 植田紘貴, 中西泰之, 有村友紀, 妹尾貴矢, 木股敬裕, 飯田征二, 上岡寛

    日本口蓋裂学会雑誌抄録号   48 ( 2 )   194 - 194   2023.5

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  • 上顎骨の著しい狭窄と交叉咬合を伴う両側性唇顎口蓋裂症例に骨延長術を施行した一治験例 Reviewed

    竹本史子, 植田紘貴, 中西泰之, 岡直毅, 岩本悠希, 三上彩可, 兵藤藍子, 有村友紀, 飯田征二, 上岡寛

    日本口蓋裂学会雑誌抄録号   48 ( 2 )   184 - 184   2023.5

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  • 早期開口訓練により下顎枝垂直骨切り術後のcondylar sagの改善を図った骨格性下顎前突症の一治験例 Reviewed

    石田朋子, 植田紘貴, 有村友紀, 森谷徳文, 飯田征二, 上岡寛

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  • 複合的な要因を有する骨格性下顎骨後退症例に対して下顎骨前方移動術を施行し機能的改善を認めたー治験例 Reviewed

    中西泰之, 植田紘貴, 吉岡徳枝, 伊原木 聰一郎, 上岡寛

    第33回日本顎変形症学会総会・学術大会プログラム・抄録号   33 ( 2 )   2023.5

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  • 上顎骨のカントを伴う下顎骨偏位症例において非外科的に咬合を確立し良好な長期的予後を得た一治験例 Reviewed

    中逵 敬太, 植田 紘貴, 村上 隆, 上岡 寛

    日本矯正歯科学会大会プログラム・抄録集   81回   217 - 217   2022.10

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  • NSAIDs系鎮痛薬の常用による歯の移動の遅延を認めた上下顎前突症例の一治験例 Reviewed

    中西 泰之, 植田 紘貴, 星島 光博, 井澤 俊, 上岡 寛

    日本矯正歯科学会大会プログラム・抄録集   81回   229 - 229   2022.10

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  • 外科的矯正治療を行なった症候群性頭蓋縫合早期癒合症患者の長期経過を追った3症例 Reviewed

    河野 加奈, 村上 隆, 植田 紘貴, 片岡 伴記, 川邉 紀章, 原 規子, 大住 隆太, 上岡 寛

    日本矯正歯科学会大会プログラム・抄録集   81回   232 - 232   2022.10

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  • Intraoral and Perinasal Digital Impression to create PNAM in a Neonate with Unilateral Cleft Lip and Palate Reviewed

    Hirotaka Ueda, Shigetomo Tsuji, Masahiro Nakamura, Hiroshi Kamioka

    14th International Cleft Congress (CLEFT 2022)   2022.7

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  • . Reviewed

    Mitsuhiro Hoshijima, Harumi Ota, Yasuyuki Nakanishi, Hirotaka Ueda, Satoru Hayano, Hiroshi Kamioka

    2022.4

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  • Perinasal and intraoral digital impression to provide PNAM appliance Reviewed

    辻重智, 植田紘貴, 中村政裕, 中村政裕, 上岡寛, 上岡寛

    日本口蓋裂学会雑誌   47 ( 2 )   2022

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  • Surgical orthodontic approach for the case of BCLP with severe damaged incisal bone using DO Reviewed

    兵藤藍子, 有村友紀, 植村亜由美, 薬師寺翔太, 安富成美, 三上彩可, 大久保(田畑)香織, 植田紘貴, 上岡寛, 飯田征二

    日本口蓋裂学会雑誌   47 ( 2 )   162 - 162   2022

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  • A case of cleft palate treated by maxillary distraction osteogenesis with evaluation using nasometer Reviewed

    岡直毅, 植田紘貴, 中逵敬太, 中西泰之, 三上彩可, 兵藤藍子, 安富成美, 薬師寺翔太, 有村友紀, 古西隆之, 飯田征二, 上岡寛

    日本口蓋裂学会雑誌   47 ( 2 )   127 - 127   2022

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  • A case of UCLP on the left side with midline deviation, a congenital missing tooth on the right side Reviewed

    太田明美, 植田紘貴, 中西泰之, 安富成美, 有村友紀, 飯田征二, 上岡寛

    日本口蓋裂学会雑誌   47 ( 2 )   149 - 149   2022

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  • A case of long-term prognosis of skeletal mandibular protrusion involving condylar angle rotation after IVRO Reviewed

    穴田理嵯, 植田紘貴, 森谷徳文, 松村達志, 飯田征二, 上岡寛

    日本顎変形症学会雑誌   32 ( 2 )   173 - 173   2022

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  • A case of orthognathic surgery for skeletal mandibular retrognathia with temporomandibular joint disorder Reviewed

    岡直毅, 植田紘貴, 森谷徳文, 松村達志, 飯田征二, 上岡寛

    日本顎変形症学会雑誌   32 ( 2 )   172 - 172   2022

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  • Comparison of hard-soft tissue changes after MASDO and mandibular osteotomy in patients with CLP Reviewed

    安富成美, 有村友紀, 薬師寺翔太, 植田紘貴, 上岡寛, 飯田征二

    日本口蓋裂学会雑誌   47 ( 2 )   160 - 160   2022

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  • Long term stability after re-bone graft during adult period in a patient with UCLP on the left side Reviewed

    植田紘貴, 植田紘貴, 谷崎沙織, 岡直毅, 飯田征二, 飯田征二, 木股敬裕, 木股敬裕, 山城隆, 上岡寛, 上岡寛

    日本口蓋裂学会雑誌   46 ( 2 )   118 - 118   2021

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  • Patient distribution managed by Orthodontics in Okayama University Hospital Advanced CLCP Center Reviewed

    植田紘貴, 植田紘貴, 岡直毅, 中村政裕, 中村政裕, 有村友紀, 有村友紀, 徳山英二郎, 徳山英二郎, 妹尾貴矢, 妹尾貴矢, 松村達志, 松村達志, 木股敬裕, 木股敬裕, 飯田征二, 飯田征二, 上岡寛, 上岡寛

    日本口蓋裂学会雑誌   46 ( 2 )   136 - 136   2021

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  • A case of growing patient with occlusal cant and facial asymmetry associated with ocular torticollis Reviewed

    植田紘貴, 難波裕生, 山城隆, 上岡寛

    日本顎変形症学会雑誌   31 ( 2 )   134 - 134   2021

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  • A functional cross-bite with restricted maxillary arch and midline deviation improved by rapid maxillary expansion Reviewed

    植田紘貴, 難波裕生, 岡直毅, 山城隆, 上岡寛

    日本矯正歯科学会大会プログラム・抄録集   80th   226 - 226   2021

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  • Clinical attempt to wear Hotz appliance at first consultation day Reviewed

    植田紘貴, 植田紘貴, 国富陽介, 中西泰之, 村上隆, 徳山英二郎, 徳山英二郎, 上岡寛, 上岡寛

    日本口蓋裂学会雑誌   45 ( 2 )   147 - 147   2020.5

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  • Clinical investigation of patients with cleft lip and palate treated by Maxillary Anterior Segmental Distraction Osteogenesis (MASDO) Reviewed

    岡本成美, 岡本成美, 松村達志, 藤田佑貴, 有村友紀, 有村友紀, 薬師寺翔太, 植田紘貴, 植田紘貴, 上岡寛, 上岡寛, 飯田征二, 飯田征二, 飯田征二

    日本口蓋裂学会雑誌   45 ( 2 )   164 - 164   2020.5

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  • A mandibular prognathism with resolved TMJ clicking and increased anterior, lateral condyle movement after IVRO Reviewed

    植田紘貴, 岡直毅, 森谷徳文, 松村達志, 飯田征二, 上岡寛

    日本顎変形症学会雑誌   30 ( 2 )   159 - 159   2020

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  • 頭蓋骨形成術、Le Fort III型骨切り術、Le Fort I型骨切り術を含む治療を行ったApert症候群の一例 Reviewed

    大住 隆太, 川邉 紀章, 植田 紘貴, 片岡 伴記, 本城 正, 上岡 寛

    中・四国矯正歯科学会雑誌   31 ( 1 )   60 - 60   2019.8

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  • スプリントによる下顎位確認後に下顎枝垂直骨切り術を行い偏位側への側方滑走運動が改善した顔面非対称症例 Reviewed

    植田 紘貴, 岡 直毅, 上岡 寛

    日本顎変形症学会雑誌   29 ( 2 )   192 - 192   2019.5

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  • 岡山大学病院口唇裂・口蓋裂総合治療センター開設後の受診患者の実態調査 Reviewed

    植田 紘貴, 国富 陽介, 中西 泰之, 片岡 伴記, 村上 隆, 木股 敬裕, 飯田 征二, 上岡 寛

    日本口蓋裂学会雑誌   44 ( 2 )   147 - 147   2019.4

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  • 下顎枝垂直骨切り術後に偏位側顎関節の非復位性関節円板前方転位の改善を認めた顔面非対称症例の一治験例 Reviewed

    植田紘貴, 国富陽介, 岡直毅, 村上隆, 佐々木朗, 山城隆, 上岡寛

    日本矯正歯科学会大会プログラム・抄録集   78th   251 - 251   2019

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  • 重度の歯のフッ素症に対し歯面処理効果を確認した上顎前突症例 Reviewed

    田畑 香織, 植田 紘貴, 石本 和也, 村上 隆, 上岡 寛

    日本矯正歯科学会大会プログラム・抄録集   77回   324 - 324   2018.10

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  • 過去3年間における岡山大学病院口唇裂・口蓋裂総合治療センター受診患者の実態調査 Reviewed

    国富 陽介, 植田 紘貴, 中西 泰之, 片岡 伴記, 村上 隆, 上岡 寛

    中・四国矯正歯科学会雑誌   30 ( 1 )   72 - 72   2018.8

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  • 重度の歯肉退縮および叢生を伴う骨格性III級症例の長期保定 Reviewed

    植田紘貴, 岡直毅, 村上隆, 上岡寛

    日本矯正歯科学会大会プログラム・抄録集   77th   343 - 343   2018

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  • 内臓感覚と唾液分泌および嚥下反射の関係 Reviewed

    菅 真有, 植田 紘貴, 八木 孝和, 宮脇 正一

    九州矯正歯科学会雑誌   12 ( 1 )   77 - 77   2017.3

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  • 重度の叢生を伴うMarfan症候群の一治験例 Reviewed

    菅真有, 植田紘貴, 大石章仁, 宮脇正一

    日本矯正歯科学会大会プログラム・抄録集   76th   289 - 289   2017

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  • 唾液分泌と嚥下の調節機構における内臓感覚の役割 Reviewed

    植田紘貴, 菅真有, 八木孝和, 楠本郁恵, 柏谷英樹, 桑木共之, 宮脇正一

    日本生理学雑誌(Web)   79 ( 1 )   26 - 26   2017

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  • 再生医療のこれまでとこれから 内臓感覚が唾液分泌と嚥下機能に果たす役割 Invited

    植田 紘貴, 菅 真有, 八木 孝和, 楠本 郁恵, 柏谷 英樹, 桑木 共之, 宮脇 正一

    日本再生歯科医学会誌   14 ( 1 )   40 - 40   2016.12

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  • 唾液分泌および嚥下反射の誘発に内臓感覚の賦活化が及ぼす影響 Reviewed

    植田 紘貴, 菅 真有, 八木 孝和, 宮脇 正一

    日本矯正歯科学会大会プログラム・抄録集   75回   171 - 171   2016.11

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  • 歯科矯正用アンカースクリューを用いた骨格性III級前歯部反対咬合症例の1治験例 Reviewed

    植田紘貴, 菅真有, 宮脇正一

    日本顎変形症学会雑誌   26 ( 2 )   119 - 119   2016

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  • 上下顎前突と下顎第三大臼歯の近心傾斜を伴う骨格性II級症例の一治験例 Reviewed

    植田 紘貴, 菅 真有, 北嶋 文哲, 宮脇 正一

    日本矯正歯科学会大会プログラム・抄録集   74回   316 - 316   2015.11

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  • 鹿児島大学歯学部学生のKolbの学習スタイルについて Reviewed

    植田 紘貴, 宮脇 正一, 菅 真有, 池森 宇泰, 田口 則宏

    日本歯科医学教育学会総会・学術大会プログラム・抄録集   34回   107 - 107   2015.7

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  • 唾液分泌はいかに制御されるか? 内臓感覚と胃酸分泌抑制剤ニザチジンの新たな関係 Reviewed

    植田 紘貴, 菅 真有, 八木 孝和, 大賀 泰彦, 宮脇 正一

    九州矯正歯科学会雑誌   10 ( 1 )   36 - 36   2014.12

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  • 従来の大臼歯遠心移動装置とスケレタルアンカレッジ装置の治療効果の検討 系統的レビュ Reviewed

    八木 孝和, 菅 真有, 植田 紘貴, 友成 博, 大牟禮 治人, 宮脇 正一

    日本矯正歯科学会大会プログラム・抄録集   73回   235 - 235   2014.10

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  • 胃酸分泌抑制と唾液分泌促進の二相性効果について H2受容体拮抗薬による自律神経活動の促進 Reviewed

    植田 紘貴, 菅 真有, 八木 孝和, 宮脇 正一

    日本矯正歯科学会大会プログラム・抄録集   73回   179 - 179   2014.10

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  • 【酸蝕症を考える(1)総論編】 酸蝕症とブラキシズム Invited Reviewed

    小児歯科臨床   19 ( 5 )   38 - 42   2014.5

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  • 顎変形症患者の心理 顎変形症患者の心理と行動変容プロセスについて Invited

    植田 紘貴

    日本顎変形症学会雑誌   24 ( 2 )   98 - 98   2014.5

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  • International partnership between the Faculty of Dentistry, Kagoshima University and the Faculty of Dentistry, Airlangga University (1) Reviewed

    MIYAWAKI Shouichi, UEDA Hirotaka, YAGI Takakazu, YAMAMOTO Yoshitake, TOMONARI Hiroshi, MAEDA Aya, KAMIMURA Hiroki, NAGAYAMA Kunihiro, KUNINORI Takaharu, TAKADA Hiroko, UEHARA Sawako, YOSHIDA Reiko, SHIMADA Kazuyuki

    34   79 - 82   2014

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  • 臨床教育部会報告 鹿児島大学歯学部における臨床教育-現状と今後の方向性について- Reviewed

    田口則宏, 中村典史, 西村正宏, 嶺崎良人, 岩崎智憲, 糀谷淳, 山口泰平, 作田哲也, 武内博信, 門川明彦, 丸山浩美, 今村晴幸, 大河内孝子, 深水篤, 植田紘貴, 末永重明, 諏訪素子

    鹿児島大学歯学部紀要   34   103 - 106   2014

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  • A report of international symposium of globalization in dental medical education and research Reviewed

    Hirotaka UEDA

    鹿児島大学歯学部紀要   34   133 - 135   2014

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  • Report of curriculum improvement working group in Kagoshima University Faculty of Dentistry Reviewed

    MIYAWAKI Shouichi, UEDA Hirotaka, MATSUYAMA Takashi, SATO Tsuyoshi, TOKUDA Masayuki, YAMANAKA Atsushi, MINE Kazuharu, OHNISHI Tomokazu, KAWADA-MATSUO Miki, YAMAGUCHI Taihei, IWASAKI Tomonori, SAKOGUCHI Kenji, KAMASHITA Yuji, NITTA Tetsuya, HIJIOKA hiroshi, KOHJITANI Atsushi, NISHIMURA Masahiro, KUKUCHI Masafumi, TAGUCHI Norihiro, SATO Tomoaki

    鹿児島大学歯学部紀要   34   107 - 111   2014

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  • 胃食道逆流モデルラットを用いた胃酸分泌抑制剤の唾液分泌促進作用の解明 Reviewed

    菅 真有, 植田 紘貴, 八木 孝和, 宮脇 正一

    九州矯正歯科学会雑誌   9 ( 1 )   61 - 61   2013.12

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  • 胃酸分泌抑制剤ニザチジンの唾液分泌促進剤としての可能性 中枢への作用と内臓感覚との関連 Reviewed

    植田 紘貴, 菅 真有, 八木 孝和, 宮脇 正一

    日本矯正歯科学会大会プログラム・抄録集   72回   157 - 157   2013.10

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  • 胃酸分泌抑制剤ニザチジンの唾液分泌促進作用について Reviewed

    植田 紘貴, 菅 真有, 八木 孝和, 宮脇 正一

    Journal of Oral Biosciences Supplement   2013   153 - 153   2013.9

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  • 唇顎口蓋裂を伴う矯正患者の保護者における心理状態と関心事 Reviewed

    福重 雅美, 帆北 友紀, 前田 綾, 植田 紘貴, 上原 沢子, 下田平 貴子, 宮脇 正一

    日本歯科衛生学会雑誌   8 ( 1 )   129 - 129   2013.8

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  • Research activity report - Department of Orthodontics -

    Miyawaki Shouichi, Ohmure Haruhito, Yagi Takakazu, Sakaguchi Katsuyoshi, Yamamoto Yoshitake, Tomonari Hiroshi, Maeda Aya, Kamimura Hiroki, Nagayama Kunihiro, Ueda Hirotaka

    33   71 - 73   2013.3

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  • 増える逆流性食道炎 ご存知ですか?口腔内疾患との密接な関係 PART3 逆流性食道炎と歯科とのかかわり Invited

    宮脇正一, 植田紘貴, 前田綾

    歯科衛生士   37 ( 6 )   80 - 83   2013

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  • 矯正治療を受けている唇顎口蓋裂を伴う児童の保護者の心理状態と関心事の解明. Reviewed

    前田 綾, 植田 紘貴, 上原 沢子, 宮脇 正一

    かごしま口腔保健協会会報   31   6 - 7   2013

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  • 胃酸分泌抑制剤ニザチジンの唾液分泌促進作用について Reviewed

    植田紘貴, 菅真有, 八木孝和, 宮脇正一

    Journal of Oral Biosciences Supplement (Web)   2013   2013

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  • 唾液分泌と迷走神経の関連性 Reviewed

    植田 紘貴, 八木 孝和, 菅 真有, 宮脇 正一

    九州矯正歯科学会雑誌   8 ( 1 )   89 - 89   2012.12

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  • 歯科矯正学に関する1回の講義が学生のボディーイメージに及ぼす影響について 理系学生と文系学生の比較 Reviewed

    植田 紘貴, 宮脇 正一, 上原 沢子, 菅 真有, 池森 宇泰, 佐藤 友昭, 田口 則宏

    日本矯正歯科学会大会プログラム・抄録集   71回   202 - 202   2012.9

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  • 内臓感覚は唾液分泌および顎舌骨筋のリズミカルな筋活動を誘発する Reviewed

    植田 紘貴, 八木 孝和, 菅 真有, 宮脇 正一

    日本矯正歯科学会大会プログラム・抄録集   71回   148 - 148   2012.9

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  • 唾液分泌動態は迷走神経の一過性の刺激により促進される Reviewed

    植田 紘貴, 八木 孝和, 菅 真有, 宮脇 正一

    日本矯正歯科学会大会プログラム・抄録集   70回   214 - 214   2011.10

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  • 歯周病原性因子存在下の培養ヒト歯根膜線維芽細胞への物理的刺激による細胞内シグナル伝達系の動態検討 Reviewed

    八木孝和, 前田綾, 植田紘貴, 菅真有, 宮脇正一

    日本矯正歯科学会大会プログラム・抄録集   70th   248 - 248   2011

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  • 小・中学生の問題行動と睡眠、胃食道逆流症状に関する因子の検討 Reviewed

    坂口 勝義, 兼松 恭子, 齋藤 陽子, 永山 邦宏, 植田 紘貴, 大牟禮 治人, 宮脇 正一

    日本矯正歯科学会大会プログラム・抄録集   69回   220 - 220   2010.9

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  • 【子どもの歯ぎしり】 睡眠時ブラキシズムに対する考え方 Invited

    宮脇 正一, 永山 邦宏, 植田 紘貴, 大牟禮 治人, 坂口 勝義

    小児歯科臨床   15 ( 8 )   12 - 26   2010.8

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  • 小児における問題行動と睡眠障害;睡眠時ブラキシズムおよび胃食道逆流との関連について Reviewed

    93 ( 672 )   8 - 10   2010

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  • 口腔乾燥症治療薬セビメリンはラット上唾液核ニューロンの興奮性を促進する Reviewed

    植田 紘貴, 美藤 純弘, 市川 博之, 小橋 基, 山城 隆, 松尾 龍二

    日本矯正歯科学会大会プログラム・抄録集   68回   144 - 144   2009.11

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  • ラット上唾液核ニューロンに対するセビメリンの興奮性作用に関する電気生理学的および免疫組織化学的解析 Reviewed

    植田 紘貴, 美藤 純弘, 市川 博之, 小橋 基, 山城 隆, 松尾 龍二

    Journal of Oral Biosciences   51 ( Suppl. )   151 - 151   2009.8

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  • CEVIMELINE ENHANCES THE EXCITABILITY IN THE RAT SUPERIOR SALIVATORY NUCLEUS NEURONS Reviewed

    Hirotaka Ueda, Yoshihiro Mitoh, Hiroyuki Ichikawa, Motoi Kobashi, Takashi Yamashiro, Ryuji Matsuo

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   142 - 142   2009

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    Authorship：Lead author   Language：English   Publishing type：Research paper, summary (international conference)   Publisher：SPRINGER TOKYO  

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  • セビメリンはラット上唾液核ニューロンの興奮性を促進する Reviewed

    植田 紘貴, 藤井 昭仁, 美藤 純弘, 兒玉 直紀, 小橋 基, 山城 隆, 松尾 龍二

    Journal of Oral Biosciences   50 ( Suppl. )   144 - 144   2008.9

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  • 骨芽細胞株MC3T3-E1細胞において流体剪断応力はMAPKを介してCTGFの発現を増大させる Reviewed

    本城正, 植田紘貴, 上岡寛, 山城隆, 山本照子

    日本矯正歯科学会大会プログラム・抄録集   66th   147 - 147   2007

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  • 術前矯正にチタンスクリューを用いて下顎右側第二、第三大臼歯を近心移動した骨格性下顎前突症例 Reviewed

    福永 智広, 黒田 晋吾, 植田 紘貴, 山本 照子

    日本矯正歯科学会大会プログラム・抄録集   65回   290 - 290   2006.9

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▼display all

Presentations

  • Intraoral and Perinasal Digital Impression to create PNAM in a Neonate with Unilateral Cleft Lip and Palate

    Hirotaka Ueda, Shigetomo Tsuji, Masahiro Nakamura, Hiroshi Kamioka

    14th International Cleft Congress (CLEFT 2022)  2022.7.11 

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    Event date： 2022.7.11 - 2022.7.15

    Language：English   Presentation type：Poster presentation  

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  • メビウス症候群の口腔・顎顔面形態の臨床所見について

    小見山裕司, 植田紘貴, 上岡寛

    第4回せとうち臨床遺伝研究会（岡山市）  2024.3.10 

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    Event date： 2024.3.10

    Language：Japanese   Presentation type：Poster presentation  

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  • A case of connective tissue graft for a moderate crowding with gingival recession

    HASHIMOTO M, UEDA H, OKUBO K, KAMIOKA H

    The 82nd Annual Meeting of the Japanese Orthodontic Society  2023.11.2 

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    Event date： 2023.11.1 - 2023.11.3

    Language：Japanese   Presentation type：Poster presentation  

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  • Trial of PLP for patients with submucosal cleft palate using an oral scanner

    KOZAKI G, UEDA H, KAMIOKA H

    The 82nd Annual Meeting of the Japanese Orthodontic Society  2023.11.2 

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    Event date： 2023.11.1 - 2023.11.3

    Language：Japanese   Presentation type：Poster presentation  

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  • .

    The18th annual meeting of The Japan Society for Dental Hygiene  2023.9.17 

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    Event date： 2023.9.16 - 2023.9.18

    Language：Japanese   Presentation type：Poster presentation  

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  • A statistical study of the patients in Okayama University Hospital Advanced CLCP Treatment Center

    Yuri Yoshikawa, Hirotaka Ueda, Yuki Arimura, Seiji Iida, Hiroshi Kamioka

    2023.7.1 

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    Event date： 2023.7.1 - 2023.7.2

    Language：Japanese   Presentation type：Poster presentation  

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  • 顎関節症状を伴う顔面非対称症例に対して Le FortI型骨切り術とIVSRO を施行した一治験例

    田中敦子, 植田紘貴, 石田朋子, 中辻和樹, 森谷徳文, 飯田征二, 上岡寛

    第33回日本顎変形症学会総会・学術大会  2023.6.9 

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    Event date： 2023.6.8 - 2023.6.9

    Language：Japanese   Presentation type：Poster presentation  

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  • 早期開口訓練により下顎枝垂直骨切り術後のcondylar sagの改善を図った骨格性下顎前突症の一治験例

    石田朋子, 植田紘貴, 有村友紀, 森谷徳文, 飯田征二, 上岡 寛

    第33回日本顎変形症学会総会・学術大会  2023.6.8 

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    Event date： 2023.6.8 - 2023.6.9

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 複合的な要因を有する骨格性下顎骨後退症例に対して下顎骨前方移動術を施行し機能的改善を認めたー治験例

    中西泰之, 植田紘貴, 吉岡徳枝, 伊原木聰一郎, 上岡寛

    第33回日本顎変形症学会総会・学術大会  2023.6.8 

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    Event date： 2023.6.8 - 2023.6.9

    Language：Japanese   Presentation type：Poster presentation  

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  • 上顎骨の著しい狭窄と交叉咬合を伴う両側性唇顎口蓋裂症例に骨延長術を施行した一治験例

    竹本史子, 植田紘貴, 中西泰之, 岡直毅, 岩本悠希, 三上彩可, 兵藤藍子, 有村友紀, 飯田征二, 上岡寛

    第47回日本口蓋裂学会総会・学術集会  2023.5.25 

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    Event date： 2023.5.25 - 2023.5.26

    Language：Japanese   Presentation type：Poster presentation  

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  • 岡山大学病院口唇裂・口蓋裂総合治療センターにおける受診患者の臨床統計的調査

    吉川友理, 植田紘貴, 中西泰之, 有村友紀, 妹尾貴矢, 木股敬裕, 飯田征二, 上岡寛

    第47回日本口蓋裂学会総会・学術集会  2023.5.25 

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    Event date： 2023.5.25 - 2023.5.26

    Language：Japanese   Presentation type：Poster presentation  

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  • NSAIDs系鎮痛薬の常用による歯の移動の遅延を認めた上下顎前突症例の一治験例

    中西 泰之, 植田 紘貴, 星島 光博, 井澤 俊, 上岡 寛

    第81回日本矯正歯科学会  2022.10.6 

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    Event date： 2022.10.5 - 2022.10.7

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  • 外科的矯正治療を行った症候群性頭蓋縫合早期癒合症患者の長期経過を追った3症例

    河野 加奈, 村上 隆, 植田 紘貴, 片岡 伴記, 川邉 紀章, 原 規子, 大住 隆太, 上岡 寛

    第81回日本矯正歯科学会  2022.10.6 

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    Event date： 2022.10.5 - 2022.10.7

    Language：Japanese   Presentation type：Poster presentation  

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  • 上顎骨のカントを伴う下顎骨偏位症例において非外科的に咬合を確立し良好な長期的予後を得た一治験例

    中逵 敬太, 植田 紘貴, 村上 隆, 上岡 寛

    第81回日本矯正歯科学会  2022.10.6 

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    Event date： 2022.10.5 - 2022.10.7

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  • A case of mandibular retrognathia with complex factors treated by mandibular advancement.

    Yasuyuki Nakanishi, Hirotaka Ueda, Masahiro Nakamura, Hiroshi Kamioka

    65th Chu-Shikoku Orthodontic Society Annual Meeting  2022.7.2  Chu-Shikoku Orthodontic Society

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    Event date： 2022.7.2 - 2022.7.3

    Language：Japanese   Presentation type：Poster presentation  

    Venue：Fukuyama, Hiroshima   Country：Japan  

  • .

    Risa Anada, Hirotaka Ueda, Norifumi Moritani, Tatsushi Matsumura, Seiji Iida, Hiroshi Kamioka

    The 32nd Annual Meeting of the Japanese Society for Jaw Deformities  2022.6.8 

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    Event date： 2022.6.8 - 2022.6.10

    Language：Japanese   Presentation type：Poster presentation  

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  • A case of orthognathic surgery for skeletal mandibular retrognathia with temporomandibular joint disorder

    Naoki Oka, Hirotaka Ueda, Norifumi Moritani, Tatsushi Matsumura, Seiji Iida, Hiroshi Kamioka

    The 32nd Annual Meeting of the Japanese Society for Jaw Deformities  2022.6.8 

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    Event date： 2022.6.8 - 2022.6.10

    Language：Japanese   Presentation type：Poster presentation  

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  • Comparison of hard-soft tissue changes after MASDO and mandibular osteotomy in patients with CLP

    2022.5.26 

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    Event date： 2022.5.26 - 2022.5.27

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 術前後にナゾメーターで鼻咽腔閉鎖機能を評価して上顎骨仮骨延長術を施行した口蓋裂症例の一治験例

    岡直毅, 植田紘貴, 中逵敬太, 中西泰之, 三上彩可, 兵藤藍子, 安富成美, 薬師寺翔太, 有村友紀, 古西隆之, 飯田征二, 上岡寛

    第46回日本口蓋裂学会  2022.5.26 

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    Event date： 2022.5.26 - 2022.5.27

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 健側の上顎右側側切歯の先天性欠如と上顎歯列正中の一歯分の右方偏位を伴う左側唇顎口蓋裂症例の一治験例

    太田明美, 植田紘貴, 中西泰之, 安富成美, 有村友紀, 飯田征二, 上岡寛

    第46回日本口蓋裂学会  2022.5.26 

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    Event date： 2022.5.26 - 2022.5.27

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 著しい成長障害を生じた中間顎を有する両側性唇顎口蓋裂患者に対して骨延長術を用いた外科矯正的アプローチ

    兵藤藍子, 有村友紀, 植村亜由美, 薬師寺翔太, 安富成美, 三上彩可, 大久保(田畑)香織, 植田紘貴, 上岡寛, 飯田征二

    第46回日本口蓋裂学会  2022.5.26 

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    Event date： 2022.5.26 - 2022.5.27

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 鼻部と口蓋の一体的な光学印象を活用したPNAM作製の試みについて

    辻重智, 植田紘貴, 中村政裕, 上岡寛

    第46回日本口蓋裂学会  2022.5.26 

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    Event date： 2022.5.26 - 2022.5.27

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 岡山大学病院矯正歯科における永久歯先天性欠如の調査

    星島 光博, 出射 明美, 中西 泰之, 植田 紘貴, 早野 暁, 上岡 寛

    第二回せとうち臨床遺伝研究会  2022.4.10 

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    Event date： 2022.4.10

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  • A functional cross-bite with restricted maxillary arch and midline deviation improved by rapid maxillary expansion

    Hirotaka Ueda, Yuki Namba, Naoki Oka, Takashi Yamashiro, Hiroshi Kamioka

    The 80th Annual Meeting of the Japanese Orthodontic Society  2021.11.4 

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    Event date： 2021.11.3 - 2021.11.5

    Language：Japanese   Presentation type：Poster presentation  

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  • 眼性斜頸を伴う上顎咬合平面の傾斜及び顔面非対称を呈した成長期患者の一治験例

    植田 紘貴、難波 裕生、山城　隆、上岡　寛

    第31回日本顎変形症学会総会・学術大会  2021.6.11 

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    Event date： 2021.6.11 - 2021.6.12

    Language：Japanese   Presentation type：Poster presentation  

  • 岡山大学病院口唇裂・口蓋裂総合治療センター矯正歯科にて咬合管理を開始した患者動態について

    植田 紘貴 、岡　直毅、中村 政裕、有村 友紀、徳山 英二郎、妹尾 貴矢、松村 達志、木股 敬裕、飯田 征二、上岡　寛

    第45回日本口蓋裂学会総会・学術集会  2021.5.20 

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    Event date： 2021.5.20 - 2021.5.21

    Language：Japanese   Presentation type：Poster presentation  

  • 成人期に顎裂部に再骨移植術を行い咬合の長期安定性を認めた左側唇顎口蓋裂を伴う下顎前突症の一治験例

    植田 紘貴、谷崎 沙織、岡　直毅、飯田 征二、木股 敬裕、山城　隆、上岡　寛

    第45回日本口蓋裂学会総会・学術集会  2021.5.20 

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    Event date： 2021.5.20 - 2021.5.21

    Language：Japanese   Presentation type：Poster presentation  

  • Patient distribution managed by Orthodontics in Okayama University Hospital Advanced CLCP Center

    植田紘貴, 植田紘貴, 岡直毅, 中村政裕, 中村政裕, 有村友紀, 有村友紀, 徳山英二郎, 徳山英二郎, 妹尾貴矢, 妹尾貴矢, 松村達志, 松村達志, 木股敬裕, 木股敬裕, 飯田征二, 飯田征二, 上岡寛, 上岡寛

    2021.5.20  Japanese Cleft Palate Association

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    Event date： 2021.5.20 - 2021.5.21

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

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  • 下顎枝垂直骨切り術後に下顎頭の前方・側方滑走運動量の増加と関節雑音の消退を認めた骨格性下顎前突症例

    植田 紘貴、岡 直毅、森谷 徳文、松村 達志、飯田 征二、上岡 寛

    第30回日本顎変形症学会総会・学術大会  2020.6.24 

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    Event date： 2020.7.9

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  • ホッツ床の即日装着の試みについて

    植田 紘貴, 国富 陽介, 中西 泰之, 片岡 伴記, 村上 隆, 徳山 英二郎, 上岡 寛

    第44回日本口蓋裂学会総会・学術集会  2020.6.4 

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    Event date： 2020.6.4 - 2020.6.5

    Language：Japanese   Presentation type：Poster presentation  

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  • Clinical investigation of patients with cleft lip and palate treated by Maxillary Anterior Segmental Distraction Osteogenesis (MASDO)

    Narumi Okamto, Tatsushi Matsumura, Yuki Arimura, Shouta Yakushiji, Hirotaka Ueda, Hiroshi Kamioka, Seiji Iida

    The 44th Annual Meeting of Japanese Cleft Palate Association  2020.6.4  Japanese Cleft Palate Association

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    Event date： 2020.6.4 - 2020.6.5

    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

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  • Psychological status of patients with jaw deformities Invited

    Hirotaka Ueda

    The 24th Annual Meeting of the Japanese Society for Jaw Deformities  2014.6.11 

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    Event date： 2014.6.10 - 2014.6.11

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

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  • Facial asymmetry with irreducible anterior disc displacement on the mandibular deviated side treated by IVRO

    Hirotaka Ueda

    Japanese Orthodontic Society  2019.11.20 

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  • A case report of patient with Apert syndrome treated with Le Fort I osteotomy, Le Fort III osteotomy after skull angioplasty

    2019.7.7 

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  • スプリントによる下顎位確認後に下顎枝垂直骨切り術を行い偏位側への側方滑走運動が改善した顔面非対称症例

    植田 紘貴, 岡 直毅, 上岡 寛

    第29回日本顎変形症学会総会・学術大会（東京都千代田区）  2019.6.8 

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  • A statistical study of the patients in Okayama University Hospital Advanced CLCP Center

    2019.5.30 

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  • 重度の歯のフッ素症に対し歯面処理効果を確認した上顎前突症例

    田畑香織, 植田紘貴, 石本和也, 上岡 寛

    第77回日本矯正歯科学会学術大会（神奈川県横浜市）  2018.11.1 

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  • 重度の歯肉退縮および叢生を伴う骨格性III級症例の長期保定

    植田紘貴, 岡 直毅, 村上隆, 上岡 寛

    第77回日本矯正歯科学会学術大会（神奈川県横浜市）  2018.11.1 

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  • 過去3年間における岡山大学病院口唇裂・口蓋裂総合治療センター受診患者の実態調査

    国富陽介, 植田紘貴, 中西泰之, 片岡伴記, 村上隆, 上岡寛

    第61回中・四国矯正歯科学会大会（岡山県岡山市）  2018.7.7 

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  • 重度の叢生を伴うMarfan症候群の一治験例

    菅 真有, 植田紘貴, 大石章仁, 宮脇正一

    第76回日本矯正歯科学会学術大会（北海道札幌市）  2017.10.18 

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  • 内臓感覚と唾液分泌および嚥下反射の関係

    菅真有, 植田紘貴, 八木孝和, 宮脇正一

    九州矯正歯科学会雑誌  2017.3.31 

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  • 唾液分泌と嚥下の調節機構における内臓感覚の役割

    植田紘貴, 菅真有, 八木孝和, 楠本郁恵, 柏谷英樹, 桑木共之, 宮脇正一

    日本生理学雑誌(Web)  2017.2 

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  • 唾液分泌および嚥下反射の誘発に内臓感覚の賦活化が及ぼす影響

    植田紘貴, 菅真有, 八木孝和, 宮脇正一

    日本矯正歯科学会大会プログラム・抄録集  2016.11 

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  • 内臓感覚が唾液分泌と嚥下機能に果たす役割

    植田紘貴, 菅真有, 八木孝和, 楠本郁恵, 柏谷英樹, 桑木共之, 宮脇正一

    日本再生歯科医学会シンポジウム要旨集  2016.7.18 

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  • 歯科矯正用アンカースクリューを用いた骨格性III級前歯部反対咬合症例の1治験例

    植田紘貴, 菅真有, 宮脇正一

    日本顎変形症学会雑誌  2016.5.25 

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  • 上下顎前突と下顎第三大臼歯の近心傾斜を伴う骨格性II級症例の一治験例

    植田紘貴, 菅真有, 北嶋文哲, 宮脇正一

    日本矯正歯科学会大会プログラム・抄録集  2015.11 

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  • 鹿児島大学歯学部学生のKolbの学習スタイルについて

    植田紘貴, 宮脇正一, 菅真有, 池森宇泰, 田口則宏

    日本歯科医学教育学会総会・学術大会プログラム・抄録集  2015.7 

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  • 唾液分泌はいかに制御されるか?―内臓感覚と胃酸分泌抑制剤ニザチジンの新たな関係―

    植田紘貴, 菅真有, 八木孝和, 大賀泰彦, 宮脇正一

    九州矯正歯科学会雑誌  2014.12.31 

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  • 胃酸分泌抑制と唾液分泌促進の二相性効果について-H2受容体拮抗薬による自律神経活動の促進-

    植田紘貴, 菅真有, 八木孝和, 宮脇正一

    日本矯正歯科学会大会  2014.10.20  (公社)日本矯正歯科学会

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    Country：Japan  

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  • 従来の大臼歯遠心移動装置とスケレタルアンカレッジ装置の治療効果の検討-系統的レビュー-

    八木孝和, 菅真有, 植田紘貴, 友成博, 大牟禮治人, 宮脇正一

    日本矯正歯科学会大会プログラム・抄録集  2014.10.20  (公社)日本矯正歯科学会

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    Venue：千葉県千葉市   Country：Japan  

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  • 従来の大臼歯遠心移動装置とスケレタルアンカレッジ装置の治療効果の検討―系統的レビュー―

    八木孝和, 菅真有, 植田紘貴, 友成博, 大牟禮治人, 宮脇正一

    日本矯正歯科学会大会プログラム・抄録集  2014.10 

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  • 胃酸分泌抑制と唾液分泌促進の二相性効果について―H2受容体拮抗薬による自律神経活動の促進―

    植田紘貴, 菅真有, 八木孝和, 宮脇正一

    日本矯正歯科学会大会プログラム・抄録集  2014.10 

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  • 顎変形症患者の心理と行動変容プロセスについて

    植田紘貴

    日本顎変形症学会雑誌  2014.5.15 

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  • 胃食道逆流モデルラットを用いた胃酸分泌抑制剤の唾液分泌促進作用の解明

    菅真有, 植田紘貴, 八木孝和, 宮脇正一

    九州矯正歯科学会雑誌  2013.12.31 

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  • 胃酸分泌抑制剤ニザチジンの唾液分泌促進作用について

    植田 紘貴, 菅 真有, 八木 孝和, 宮脇 正一

    Journal of Oral Biosciences Supplement  2013.9 

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  • 唇顎口蓋裂を伴う矯正患者の保護者における心理状態と関心事

    福重雅美, 帆北友紀, 前田綾, 植田紘貴, 上原沢子, 下田平貴子, 宮脇正一

    日本歯科衛生学会雑誌  2013.8.10 

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  • 胃酸分泌抑制剤ニザチジンの唾液分泌促進剤としての可能性-中枢への作用と内臓感覚との関連-

    植田紘貴, 菅真有, 八木孝和, 宮脇正一

    日本矯正歯科学会大会プログラム・抄録集  2013  (公社)日本矯正歯科学会

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  • 唾液分泌と迷走神経の関連性

    植田紘貴, 八木孝和, 菅真有, 宮脇正一

    九州矯正歯科学会雑誌  2012.12.31 

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  • 内臓感覚は唾液分泌および顎舌骨筋のリズミカルな筋活動を誘発する

    植田紘貴, 八木孝和, 菅真有, 宮脇正一

    日本矯正歯科学会大会プログラム・抄録集  2012.9 

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  • 歯科矯正学に関する1回の講義が学生のボディーイメージに及ぼす影響について 理系学生と文系学生の比較

    植田 紘貴, 宮脇 正一, 上原 沢子, 菅 真有, 池森 宇泰, 佐藤 友昭, 田口 則宏

    日本矯正歯科学会大会プログラム・抄録集  2012.9 

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  • 歯周病原性因子存在下の培養ヒト歯根膜線維芽細胞への物理的刺激による細胞内シグナル伝達系の動態検討

    八木孝和, 前田綾, 植田紘貴, 菅真有, 宮脇正一

    日本矯正歯科学会大会プログラム・抄録集  2011.10 

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  • 唾液分泌動態は迷走神経の一過性の刺激により促進される

    植田紘貴, 八木孝和, 菅真有, 宮脇正一

    日本矯正歯科学会大会プログラム・抄録集  2011.10 

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  • 歯列後方部の萌出スペースを考慮した治療計画の立案

    上村裕希, 友成博, 植田紘貴, 兼松恭子, 北嶋文哲, 迫口陽子, 上原沢子, 菅真有, 宮脇正一

    第6 回九州矯正歯科学会  2011.2 

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  • 小・中学生の問題行動と睡眠・胃食道逆流症状に関する因子の検討

    坂口勝義, 兼松恭子, 齋藤陽子, 永山邦宏, 植田紘貴, 大牟禮治人, 宮脇正一

    日本矯正歯科学会大会プログラム・抄録集  2010.9 

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  • ラット顎下腺・舌下腺支配の上唾液核ニューロンに対するセビメリンの作用機序

    美藤純弘, 植田紘貴, 市川博之, 藤田雅子, 山城 隆, 小橋 基, 松尾龍二

    第19 回神経行動薬理若手研究者の集い  2010.3 

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  • 口腔乾燥症治療薬セビメリンはラット上唾液核ニューロンの興奮性を促進する

    植田紘貴, 美藤純弘, 市川博之, 小橋基, 山城隆, 松尾龍二

    日本矯正歯科学会大会プログラム・抄録集  2009.11 

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  • ラット上唾液核ニューロンに対するセビメリンの興奮性作用に関する電気生理学的および免疫組織化学的解析

    植田紘貴, 美藤純弘, 市川博之, 小橋基, 山城隆, 松尾龍二

    J Oral Biosci  2009.8.10 

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  • Cevimeline enhances the excitability in the rat superior salivatory nucleus neurons International conference

    Hirotaka Ueda, Yoshihiro Mitoh, Hiroyuki Ichikawa, Motoi Kobashi, Takashi Yamashiro, Ryuji Matsuo

    The 36th Congress of the International Union of Physiological Sciences（IUPS2009）  2009.7 

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  • Cevimeline enhances the excitability in the rat superior salivatory neurons International conference

    Hirotaka Ueda, Yoshihiro Mitoh, Hiroyuki Ichikawa, Motoi Kobashi, Takashi Yamashiro, Ryuji Matsuo

    The 11th International Symposium on Exocrine Secretion  2009.7 

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  • セビメリンはラット上唾液核ニューロンの興奮性を促進する

    植田紘貴, 藤井昭仁, 美藤純弘, 兒玉直紀, 小橋基, 山城隆, 松尾龍二

    J Oral Biosci  2008.9.10 

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  • 骨芽細胞株MC3T3-E1細胞において流体剪断応力はMAPKを介してCTGFの発現を増大させる

    本城正, 植田紘貴, 上岡寛, 山城隆, 山本照子

    日本矯正歯科学会大会プログラム・抄録集  2007 

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  • 術前矯正にチタンスクリューを用いて下顎右側第二,第三大臼歯を近心移動した骨格性下顎前突症例

    福永智広, 黒田晋吾, 植田紘貴, 山本照子

    日本矯正歯科学会大会プログラム・抄録集  2006.9 

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Awards

  • 2016〜2017, Best researchoder award（Kagoshima University

    2017.9  

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  • 口腔先端科学教育研究センター若手研究者優秀賞 （鹿児島大学大学院医歯学総合研究科）

    2016.12   『迷走神経の求心性刺激は唾液分泌と嚥下様運動を誘発する』

    植田 紘貴

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  • 優秀ポスター発表賞

    2013.10   日本矯正歯科学会   『胃酸分泌抑制剤ニザチジンの唾液分泌促進剤としての可能性ー中枢への作用と内臓感覚との関連ー』

    植田 紘貴

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  • 生理学部門優秀ポスター発表賞

    2008.9   歯科基礎医学会   『セビメリンはラット上唾液核ニューロンの興奮性を促進する』

    植田 紘貴

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Research Projects

  • 非侵襲的な耳介迷走神経刺激は唾液分泌の促進とGERDとブラキシズムの抑制に有効か

    Grant number：23K09420  2023.04 - 2026.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    宮脇 正一, 植田 紘貴, 前田 綾, 大賀 泰彦, 中川 祥子, 丸谷 佳菜子, 井戸 章雄, 上村 修司

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    Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）

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  • Principal Investigator

    Grant number：22K10246  2022.04 - 2025.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    植田 紘貴

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    Grant amount：\4290000 （ Direct expense: \3300000 、 Indirect expense：\990000 ）

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  • Elucidation of mechanosensor function acquisition process of osteocytes using 3D-volumetric image data

    Grant number：19H03859  2019.04 - 2023.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    上岡 寛, 植田 紘貴, 早野 暁, 亀尾 佳貴, 原 徹

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    Grant amount：\17160000 （ Direct expense: \13200000 、 Indirect expense：\3960000 ）

    本年度は、骨細管内の構造解析から得られた流体-構造連成解析を進めて流体応力が骨細胞の表面にどのように変形を与えているかを、共同研究者である亀尾佳貴先生を中心としたグループが国際誌Biomechanics and Modeling in Mechanobiologyに発表した。本研究では、骨細管壁と骨細胞突起を結ぶテザリングエレメントが骨細管内を流れる体液の移動で引っ張られ、細胞突起に付着する膜部位で10％を超える細胞膜変形を生じることが確認できた。この変形はメカニカルストレスにより細胞内カルシウム上昇などを生じるには十分な細胞膜変形量であることから、これら細胞突起周辺の微細構造が骨細胞の細胞突起をメカノセンサーとして重要な役割を果たしていることが示唆された。また、新たにFIB-SEM(Focused Ion Beam-Scanning Electron Microscopy)で取得した高解像度連続断層写真を用いて、これまでより広域の細胞突起の3次元形態解析を行った。得られた断層画像から細胞突起、骨細管壁を自動抽出するために機械学習を初めて応用することができた。結果、DSC(dice similarity coefficient)は、83%となり、人が手動で抽出する同等の程度まで精度を上げることができた。これにより抽出した3次元画像から形態計測を行い骨細管の微細構造を数値化することにも成功した。以上の結果をJournal of Bone and Mineral Metabolismに報告した。また、これまでの研究の成果を第80回日本矯正歯科学会学術大会で行われた日本学術会議歯学委員会臨床系歯学分科会主催の公開シンポジウム「進化・発生・メカニカルストレスから探る顎顔面形成・維持機構最先端」でシンポジストとして発表した。

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  • Principal Investigator

    Grant number：19K10405  2019.04 - 2022.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    植田 紘貴, 石原 嘉人, 亀田 雅博, 内部 健太, 上岡 寛

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    Grant amount：\4290000 （ Direct expense: \3300000 、 Indirect expense：\990000 ）

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  • Epigenetic analysis of new bone remodeling mechanism in the dentofacial region.

    Grant number：18H03011  2018.04 - 2022.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Izawa Takashi

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    Grant amount：\17290000 （ Direct expense: \13300000 、 Indirect expense：\3990000 ）

    It remains unclear whether the AhR signaling affects the TMJ. The aim of this study was to investigate possible mechanisms of bone loss in the TMJ due to the epigenetic alteration such as smoking. In particular, whether benzo[a]pyrene (B[a]P) induces expression of Cyp1a1 in the mandible. Possible functions of an endogenous ligand FICZ were investigated in a TMJ-OA mouse model. B[a]P was administered orally to mice and bone metabolism was examined. TMJ-OA was induced in WT mice with forceful opening of the mouth, and therapeutic functions of FICZ were detected. Exposure to B[a]P accelerated bone loss in the mandible. This bone loss manifested with osteoclastic bone resorption. In a TMJ-OA model, FICZ exhibited a dose-dependent rescue of subchondral bone loss by repressing osteoclast activity. Pretreatment with FICZ reduced RANKL-mediated osteoclastogenesis. B[a]P regulates subchondral bone metabolism via the Cyp1a1. FICZ can prevent TMJ-OA by regulating osteoclast differentiation.

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  • Considering the effects of nerves on maxillofacial formation-elucidation of the etiology of hemifacial atrophy and hemifacial hypertrophy-

    Grant number：18K09832  2018.04 - 2021.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kawanabe Noriaki

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    Grant amount：\4420000 （ Direct expense: \3400000 、 Indirect expense：\1020000 ）

    In this study, we conducted experiments to clarify the effects of the trigeminal nerve and facial nerve on the morphology of the maxillofacial region during growth. As a result of nerve activity blocking experiments and nerve activity activation experiments of the trigeminal nerve and facial nerve of rats, a decrease in the formation rate of cut teeth, calcification of the pulp, and disorder of the arrangement of ameloblasts and odontoblasts were observed. It was. In addition, as a result of analyzing Sonic hedgehog (Shh) gene-deficient mice and Shh gene-expressing mice, changes in bone and tooth morphology that are thought to be the effect of Shh on long-term maxillofacial morphogenesis were observed. As a result of conducting an experiment using fluorescence bioimaging, no characteristic stem cell dynamics were observed with or without nerve activity blocking / activation.

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  • Relationship between survey of "Stomatognathic sarcopenia" caused by malocclusion and factors of endocrine and immune system

    Grant number：16K11791  2016.04 - 2020.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Maeda-Iino Aya

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    Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）

    Recent studies have focused on the relationship between masticatory function such as MOF and body function such handgrip strength (HS). On the other hand, maximum occlusal force (MOF) is associated with maxillofacial morphology, such as high mandibular plane (Mp) angle, and with malocclusion such as open bite, posterior crossbite and scissor bite. However, the relationships between maxillofacial morphology/malocclusion and HS remain unclear. Furthermore, there is no one investigating simultaneously the relation between maxillofacial morphology, malocclusion, MOF, and HS. In this study, we found that the subjects with a large gonial angle and a small overbite or a crossbite/scissor bite in the molar section had low HS, which is related with MOF.

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  • Relationship between oral function including salivation and cognitive function: Animal model and optogenetics

    Grant number：15K20603  2015.04 - 2018.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Ueda Hirotaka

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    Grant amount：\3900000 （ Direct expense: \3000000 、 Indirect expense：\900000 ）

    Vagal afferent stimulation significantly increased salivation and swallowing-like events in a frequency-dependent manner. A muscle relaxant, vecuronium bromide, diminished the swallowing-like response but did not affect salivation. Moreover, the tissue blood flow rate of the body surface increased according to the frequency of the vagus nerve stimulation. These results indicate that visceral sensation induces salivation and swallowing-like events in anesthetized rodents through vagal afferent activation.
    These findings might contribute a new application of vagus nerve stimulation as to enhancing oral function.

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  • Elucidation of the relationship between the stress adjustment and the stomatognathic function by the hypothalamic-pituitary-adrenal axis and the brain-gut interactions

    Grant number：15K11349  2015.04 - 2018.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YAGI Takakazu

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    Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）

    In order to elucidate the relationship between stress and the stomatognathic function, this study investigated the effect of the stomatognathic function caused by modulating the hypothalamus - pituitary - adrenal axis (HPA axis). As a result, the activity of the masticatory muscle electromyogram remarkably decreased from several hours immediately after administering a stress factor, adrenocorticotropin releasing factor (CRF: 1.0 nM (10 μL)) into the lateral cerebral ventricle during the light period. After this response, EMG activity showed a tendency of strong hyperactivity on the contrary. And it showed that the total EMG activity for 24 hours after administration increased relative to control group administrated the artificial cerebrospinal fluid. It also suggested that the administration of CRF into the lateral cerebral ventricle could have affected the sleep-wake rhythm.

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  • Evaluation of hypothesis which a malocclusion is caused by perception disorder and hypokinesia of pharynx, esophagus and stomach

    Grant number：25670879  2013.04 - 2015.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    MIYAWAKI Shouichi, MAEDA Aya, NAGAYAMA Kunihiro, OOMURE Haruhito, YAGI Takakazu, UEDA Hirotaka, UEHARA Sawako

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    Grant amount：\3770000 （ Direct expense: \2900000 、 Indirect expense：\870000 ）

    Clinical research: we evaluated the relationship between a stomatognathic function, which closely relate with gastrointestinal function, and a malocclusion. In the patients with scissors-bite, the chewing pattern and activities of both the temporalis and the masseter muscles were significantly narrower and lower, respectively. In the patients with molar cross-bite, the reverse chewing pattern during deliberate unilateral mastication was significantly more frequently observed. Those results suggest that gastrointestinal function in patients with scissors-bite or cross-bite malocclusion may be low.
    Basic research: we focused on the vagal nerve dominating the visceral sensation. As a result of cervical vagal stimulation, it was observed the rhythmic muscle activity of mylohyoid which means swallowing with salivary secretion. From this study, it was suggested that visceral sensation is involved in activation of stomatognathic functions including salivation and swallowing.

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  • Physiological study on oral function activated by visceral sensation: brain-gut model and PET imaging

    Grant number：24792299  2012.04 - 2015.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    HIROTAKA Ueda

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    Grant amount：\4290000 （ Direct expense: \3300000 、 Indirect expense：\990000 ）

    Gastroesophageal Reflux (GER) is a disease featured by reflux of stomach contents into the esophagus, causing chest pain and nausea by stimulation to the esophagus. Its therapy is mainly performed by acid reducer. We focused on the vagal afferent pathway mediating visceral sensation to brain. First, we investigated whether experimental stimulation affect oral function involving salivation. Next, we investigated whether acid reducer affect salivation. The present study suggested that vagal afferent stimulation evoked salivation, but also a kind of acid reducer increased salivation evoked by vagal afferent stimulation. Therefore, it was suggested that visceral sensation related to oral function involving salivation.

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  • The study of the mechanism of the stomatognathic function activated by the brain and the gastrointestinal peptide

    Grant number：24593103  2012.04 - 2015.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    YAGI Takakazu, MIYAWAKI Shouichi, INUI Akio, KAMIMURA Hiroki, UEDA Hirotaka

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    Grant amount：\5330000 （ Direct expense: \4100000 、 Indirect expense：\1230000 ）

    This study focused on the relationship of stress and the stomatognathic function. As peripheral stimulation, we performed the acid stimulation to upper part gastrointestinal tract and, as central stimulation, we used corticotropin release factor where related stress. Recording procedure was mainly electromyogram (EMG: masseter muscle activity), electroencephalogram (EEG), and electrocardiogram (ECG). The result is that EMG increased after peripheral and central stimulation in comparison with before stimulation. In addition, quality of the sleep decreased, and it was suggested that the stimulation influenced the autonomic nervous system. On the other hand, in the gene expression of the stimulation on the upper gastrointestinal tract, ASIC3 and TRPV1 gained expression. It was suggested that peripheral stimulation was transmitted through the sense of pain related tract.
    Therefore, stress has close to the relations with the stomatognathic dysfunction.

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  • The association between stmatognathic function and the sensation of the stomach and esophagus via brain activity

    Grant number：24390464  2012.04 - 2015.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    MIYAWAKI Shouichi, OHMURE Haruhito, YAGI Takakazu, UEDA Hirotaka, NAGAYAMA Kunihiro, MAEDA Aya, UEHARA Sawako, TSUBOUCHI Hirohito, IDO Akio, SAKIYAMA Toshio

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    Grant amount：\18200000 （ Direct expense: \14000000 、 Indirect expense：\4200000 ）

    In the present study, we hypothesized that there is a strong correlation between stmatognathic function and the motility function of the stomach and esophagus. (1) Initial gastric emptying is suppressed by mastication, and that the suppression is caused by mastication-induced inhibition of gastric activity. (2) Esophageal-derived autonomic nervous system modulation induces masseter muscle activity, irrespective of the presence of subjective gastrointestinal symptoms. (3) By administering proton pump inhibitor to the patients with sleep bruxism, masseter muscle activity during sleep significantly decreased. (4) Involuntary teeth clenching is related to regional brain activity in the insula and anterior cingulate cortex. These studies suggest that the function and sensation of the stomach and esophagus may be closely related with a stmatognathic function via brain activity.

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  • コミュニケーションツールが青少年の睡眠、消化器疾患および顎発育に及ぼす影響の解明

    Grant number：24600015  2012.04 - 2013.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    坂口 勝義, 八木 孝和, 植田 紘貴, 吉田 礼子, 永山 邦宏, 宮脇 正一

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    Grant amount：\5460000 （ Direct expense: \4200000 、 Indirect expense：\1260000 ）

    本年度は、小中学生を対象に、以下の調査。解析を行った。概要は次の通り。研究背景：小・中学生における問題行動が学校および社会における大きな問題と言われている。一方、小・中学生の睡眠に関する様々な問題も、学校生活や日常生活に影響を及ぼすとされ、問題視されてきている。睡眠障害を引き起こす原因のひとつに睡眠時の微小覚醒を生じさせる胃食道逆流症(GERD)があると言われている。本研究では、問題行動に関し、睡眠の動態とGERDの症状がどのように関連しているのかを検討するため、小・中学生を対象に問題行動と睡眠動態およびGERD症状を調査・解析したので報告する。対象は鹿児島県内在住の小・中学校の生徒30名(男子16名、女子14名、年齢10歳‐15歳）とその保護者である。方法：生徒の基本的属性と生活および睡眠に関する質問項目について、記入式で回答を得た。問題行動についてはPediatric Symptoms Checklist（PSC、日本語版）を用いて、GERD症状についてはFrequency Scale for the Symptoms of GERD(FSSG)を用いて回答を得た。睡眠動態についてはActiwatch2（米国フィリップスレシプロニクス社）を用いて、一夜の睡眠時間、入眠潜時、REM睡眠時間、non-REM睡眠時間、REM睡眠時間/睡眠時間、中途覚醒を記録し、解析した。PSCを基準に問題行動群と正常行動群に分け、生活および睡眠に関する事項、GERD症状ならびに睡眠動態を比較した。
    結果：小・中学生では、全体の15％に問題行動が見られた。問題行動を呈する者では食事習慣と睡眠に特徴がみられ、GERD症状が多く、睡眠に関して睡眠中の動態に乱れが見られた。問題行動とGERD症状、睡眠の乱れには関連があることが示唆された。以上の解析結果を英文にまとめ、現在、国際誌に投稿中である。

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  • Relationships among pediatric sleep problems, problem behavior, gastroesophageal reflux and oral parafunctions

    Grant number：21610016  2009 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    SAKAGUCHI Katsuyoshi, MIYAWAKI Shouichi, OHMURE Haruhito, NAGAYAMA Kunihiro, UEDA Hirotaka, YAGI Takakazu

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    Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）

    We ivestigated the sleep disturbances, problem behavior, and symptoms of the gastroesophageal reflux of primary school children and junior high school children(total : 6087, boys : 3017, girls : 3070, age : 6-15 years old). In the problem behavior group, the symptoms of GERD and sleep disturbances were significantly more observed. Also, skipping breakfast, taking supper with part of their family, and shorter conversation at or after the supper and bruxism and clenching during sleep were significantly more observed than in the normal behavior group. It was suggested that the problem behavior has associations with dietary habit, sleep bruxism and clenching, and GERD symptoms.

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  • Influences of the occlusion on gastroesophageal reflux disease and acid clearance in oral cavity, pharynx and esophagus during sleep

    Grant number：20390524  2008 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    MIYAWAKI Shouichi, OHMURE Haruhito, SAKAGUCHI Katsuyoshi, TSUBOUCHI Hirohito, UEDA Hirotaka, NAGAYAMA Kunihiro

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    Grant amount：\18980000 （ Direct expense: \14600000 、 Indirect expense：\4380000 ）

    In the present study, we hypothesized that good occlusion increases the acid clearance in the oral cavity, pharynx and esophagus, leading to the prohibition of the gastroesophageal reflux disease(GERD).
    (1) The results of the investigation of masticatory functions in patients with skeletal Class III malocclusion suggested that GERD symptoms were observed more often than in normal subjects.
    (2) The results of the investigation of the effects of intra-esophageal infusions of 5-mL acidic solution(0.1 N HCl) or saline to the healthy adults suggested that sleep bruxism episodes were induced by esophageal acidification.
    (3) Bruxism patients(n=7) had high frequency of GERD with a mild esophagitis.
    These researches show good occlusion has associations with esophageal acidification, suppression of upper gastrointestinal disease.

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  • Electrophysiological and immunohistological study of the inhibitory inputs from the forebrain and brainstem to the superior salivatory nucleus in rats

    Grant number：19890133  2007 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (Start-up)

    FUJII Akihito, MATSUSHIMA Ayumi, UEDA Hirotaka

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    Grant amount：\3085000 （ Direct expense: \2680000 、 Indirect expense：\405000 ）

    唾液は脳幹(下位中枢)を介し反射性に分泌されるだけでなく、前脳(上位中枢)からの入力によっても制御されている。しかし、その制御機構は基礎および臨床研究においても、未だ具体的に明らかにされていない。本研究課題では、免疫組織学および電気生理学的手法を用い、唾液分泌に対する上位および下位中枢からの抑制性制御機構について調ベた。
    その結果、全ての上唾液核細胞は上位中枢から抑制性入力を受けていることが明らかとなった。このことから、唾液分泌は興奮性入力のみならず、上位中枢からの下行性抑制性入力によっても調節されていることが示唆された。

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