Faculty Profiles - NARUSE Keiji

MISC - NARUSE Keiji

Division display >> ／ All the affair displays 1 - 111 of about 111

11th Asian-Pacific Conference on Medical and Biological Engineering

Shiraishi Y, Sakuma I, Naruse K, Ueno A

IFMBE Proceedings 82 2021

第59回日本生体医工学会大会開催報告

成瀬恵治

岡山医学会雑誌 132 110 - 111 2020.8

Mechanomedicine.

Naruse K

Biophysical reviews 2018.9

特集：宇宙の極限環境から生命体の可塑性をさぐる--1.重力変動の生理機能への影響細胞の重力応答機構--

高橋賢, 佐々並三紗, 長田仁, 成瀬恵治

生体の科学 69 ( 2 ) 106 - 109 2018.4

MECHANOMEDICINE: applications of mechanobiology to medical sciences and next-generation medical technologies.

Naruse K

Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 54 83 - 90 2018

特集新しい医療を拓くメカノバイオロジー--11．メカノ生殖補助医療の展開--

成瀬恵治

医薬ジャーナル 53 ( 6 ) 1489 - 1494 2017.6

Application of mechanobiological engineering to regenerative and reproductive medicine Invited

Takahashi K, Oh H, Iribe G, Matsuura K, Naruse K

Trans JSMBE 55 ( 4PM-Abstract ) 340 - 340 2017

Language：Japanese Publishing type：Research paper, summary (national, other academic conference) Publisher：Japanese Society for Medical and Biological Engineering

<p>Recent advancement of mechanobiological research contributes to understanding and cure of diseases, leading to the birth of mechanomedicine. Here we introduce innovative mechano-medical technologies that pursue clinical use. In dermal regenerative medicine, we performed co-culture of dermal keratinocytes and fibroblasts with stretch stimulus, and found thickening of dermal layer and facilitated basal membrane formation. In cardiac regenerative medicine, we found that exosomes released from stem cells in response to mechanical stimulus excrete paracrine factors and micro RNAs, and thus enhance therapeutic effect of cell therapy in vivo. In reproductive medicine, we applied mechanical stimulus to fertilized eggs using a tilting embryo culture system, and confirmed enhancement of blastocyst development rate. Exhaustive gene analysis suggested that the enhancement is due to alteration of gene expression at epiblast. We continue to reveal the mechanisms of biological response to mechanical stimulus, and pursue clinical application of mechano-medical therapy.</p>

DOI： 10.11239/jsmbe.55Annual.340

CiNii Article

researchmap

【メカノバイオサイエンス〜力の科学と医療の最前線〜】力学刺激に応答する循環器系の恒常性

高橋賢, 成瀬恵治

Clinical Calcium 26 ( 12 ) 1671 - 1676 2016.11

メカノメディスン：メカノ生殖補助医療

成瀬恵治

医学のあゆみ 257 ( 10 ) 1058 - 1062 2016.6

メカノメディスン

成瀬恵治

呼吸と循環 64 ( 2 ) 177 - 185 2016.2

力学刺激に応答する循環器系の恒常性 Invited

高橋賢, 成瀬恵治

Clinical Calcium 26 ( 12 ) 21 - 26 2016

Mechanosensitive ion channels

Ken Takahashi, Yusuke Matsuda, Keiji Naruse

AIMS Biophysics 3 ( 1 ) 63 - 74 2016

Language：English Publishing type：Book review, literature introduction, etc. Publisher：American Institute of Mathematical Sciences

Cell surface receptors are involved in numerous important biological processes including embryogenesis, tissue differentiation, and cellular homeostasis. Among them, mechanosensitive ion channels play an essential role in cellular functions of every cell including neurons, cardiomyocytes, and osteocytes. Here, we discuss types, roles, structures, and biophysical factors that affect the functions of mechanosensitive ion channels.

DOI： 10.3934/biophy.2016.1.63

Scopus

researchmap

iPS治療とメカニカルストレス

高橋賢, 成瀬恵治

ファルマシア 51 ( 11 ) 1038 - 1041 2015.11

メカノメディスン：メカノ医工学を用いた医学研究・次世代医療技術への展開

成瀬恵治

日本機械学会誌 118 ( 1161 ) 91 - 93 2015.8

Mechanomedicine : Applications of Mechanobiology to Medical Sciences and Next-generation Medical Technologies

NARUSE Keiji

Journal of the Japan Society of Mechanical Engineers 118 ( 1161 ) 533 - 535 2015.8

心臓・血管の組織工学と再生医療.

高橋賢, 成瀬恵治

人工臓器 43 ( 3 ) 206 - 208 2014.12

Disease-Specific Induced Pluripotent Stem Cells Identify the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 During Cardiac Development of Hypoplastic Left Heart Syndrome

Junko Kobayashi, Masashi Yoshida, Suguru Tarui, Shuta Ishigami, Michihiro Okuyama, Yusuke Nagai, Shingo Kasahara, Keiji Naruse, Hiroshi Ito, Shunji Sano, Hidemasa Oh

CIRCULATION 130 2014.11

生殖医療・育種デバイス

松浦宏治, 成瀬恵治

生物工学会誌 92 ( 4 ) 30 - 33 2014.3

Involvement of TRPC in the Slow Force Response Observed in Mouse Ventricular Myocytes

Yohei Yamaguchi, Toshiyuki Kaneko, Keiji Naruse, Gentaro Iribe

BIOPHYSICAL JOURNAL 106 ( 2 ) 772A - 772A 2014.1

生殖医療・育種デバイス(<特集>マイクロバイオ技術の潮流と展望～動物細胞の培養・計測・評価技術への応用～)

松浦宏治, 成瀬恵治

生物工学会誌 : seibutsu-kogaku kaishi 92 ( 4 ) 180 - 183 2014

Patient-specific Induced Pluripotent Stem Cells For Modeling Hypoplastic Left Heart Syndrome

Junko Kobayashi, Masashi Yoshida, Suguru Tarui, Masataka Hirata, Ken Takahashi, Shingo Kasahara, Keiji Naruse, Hiroshi Ito, Shunji Sano, Hidemasa Oh

CIRCULATION 126 ( 21 ) 2012.11

Factors-based Human Cardiomyocytes Differentiation Exhibits Defective Maturation and Excitation Through Aberrant Calcium Handling Proteins

Suguru Tarui, Junko Kobayashi, Masataka Hirata, Ken Takahashi, Gentaro Iribe, Keiji Naruse, Shingo Kasahara, Shunji Sano, Hidemasa Oh

CIRCULATION 126 ( 21 ) 2012.11

Investigation of an automated pH measurement system for the development of medicine

YAMADA A., MOHRI S., NAKAMURA M., NARUSE K.

14 ( 3 ) 426 - 427 2012.10

Actuators in the Medical Field

NARUSE Keiji

The Machine Design and Tribology Division meeting in JSME 2012 ( 12 ) 3 - 5 2012.4

生体ライブイメージングを用いた骨組織中における自律性細胞内カルシウムオシレーションの検討

石原嘉人, 菅原康代, 上岡寛, 川邉紀章, 黒坂寛, 成瀬恵治, 山城隆

日本矯正歯科学会大会プログラム・抄録集 70回 225 - 225 2011.10

細胞伸展培養

高橋賢, 成瀬恵治

Surgery Frontier 18 ( 2 ) 59 - 63 2011.6

703 Experimental study behaviors of motile sperm in fluid flow

TACHIBANA Towa, TAKI Keishi, OHNISHI Takaya, HYAKUTAKE Toru, YANASE Shinichiro, MATSUURA Koji, NARUSE Keiji

2011 ( 49 ) 171 - 172 2011.2

Essential Role For Microtubule Dynamics In Cyclic Stretch-Induced Cell Alignment In Human Airway Smooth Muscle Cells

S. Ito, H. Parameswaran, M. Morioka, K. Naruse, M. Kondo, M. Sokabe, B. Suki, Y. Hasegawa

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 183 2011

Embryo development and the mechanisms behind the improvements in In Vitro dynamic culture systems

Koji Matsuura, Keiji Naruse

Journal of Mammalian Ova Research 28 ( 4 ) 174 - 179 2011

Language：Japanese Publisher：Japanese Society of Mammalian Ova Research

Mammalian embryo culture is influenced by autocrine and paracrine effects and the diffusion of harmful byproducts. The physiological development of the embryo occurs in the Fallopian tube under dynamic conditions. To obtain high quality embryos in in vitro culture, dynamic culture systems (DCSs) have been developed which mimic the dynamic physiological conditions. In this review, embryo culture using DCSs in vitro and their culture results are discussed. From the culture results of DCSs that move the medium and embryos, we deduced that an increase in the diffusion rate is one of the reasons for an improvement in embryo development. Diffusion around the embryos could be investigated by monitoring pH changes in the medium during embryo culture. Application of moderate mechanical stimuli to embryos using DCSs would induce improvement in embryo development. To understand mechanosensing of mammalian embryos, mechanical stimuli and intracellular calcium concentrations in the embryos should be quantitatively evaluated. Finally, strategies to apply these insights and technologies to human embryo development are briefly discussed.

DOI： 10.1274/jmor.28.174

Scopus

researchmap

Microfluidic sperm sorter内流体中における精子運動の共集点蛍光顕微観察

松浦宏治, 成瀬恵治

生体医工学 : 日本エム・イー学会誌 = Transactions of the Japanese Society for Medical and Biological Engineering : BME 48 ( 6 ) 625 - 626 2010.12

新しい伸展刺激負荷方法を用いたメカノトランスダクション研究

片野坂友紀, 成瀬恵治

血管医学 11 ( 4 ) 301 - 306 2010.12

Musculoskeletal rehabilitation and bone. A novel approach to mechanotransduction using cell-adhesion-patterned cells

Katanosaka Y, Naruse K

Clin Calcium 20 ( 4 ) 514 - 519 2010.4

0236 Mechanobiology of Reproductive Cells and Device Applications

Matsuura Koji, Naruse Keiji

2009 ( 22 ) 220 - 220 2010.1

0234 Mechanosensor in Cardiovascular System

2009 ( 22 ) 218 - 218 2010.1

0820 Cell stimulation and response analysis using microfluidics

YAMADA Akira, KATANOSAKA Yuki, MOHRI Satoshi, NARUSE Keiji

2009 ( 22 ) 315 - 315 2010.1

The Generation of a Novel Animal Model of Inducible Hypertrophy: Overexpression of NCX1 in the Murine Heart Using the Doxycycline-Dependent Promoter

Yuki Katanosaka, Keiichiro Iwasaki, Satoshi Mohri, Keiji Naruse

BIOPHYSICAL JOURNAL 98 ( 3 ) 551A - 551A 2010.1

Stretch-Sensitivity of Stretch-Activated BKCa Channels in Post-Hatch Chick Ventricular Myocytes

Gentaro Iribe, Keiji Naruse

BIOPHYSICAL JOURNAL 98 ( 3 ) 335A - 335A 2010.1

Mechanobiology and Medicine

Naruse K

Nano bio-Interfaces in Relation to Molecular Mobility 79 - 88 2010

動的環境における胚培養成績上昇機構に関する考察

松浦宏治, 黒田ユカ, 舟橋弘晃, 成瀬恵治

日本生殖医学会雑誌 55 ( 3 ) 97 - 97 2010

マイクロ空圧駆動型人工卵管で負荷される力学的刺激

李井春, 松浦宏治, 兒玉美恵子, 黒田ユカ, 舟橋弘晃, 成瀬恵治

化学とマイクロ・ナノシステム研究会講演要旨集 21st 2010

Ischemia-induced Angiogenesis is Impaired in Aminopeptidase-A deficient Mice with Decreased Stability of HIF-1 alpha

Ryuji Kubota, Yasushi Numaguchi, Masakazu Ishii, Keiji Naruse, Kenji Okumura, Toyoaki Murohara

CIRCULATION 120 ( 18 ) S1151 - S1152 2009.11

ROLE OF STRETCH-ACTIVATED BKCA CHANNELS ON STRETCH-INDUCED ARRHYTHMIAS IN ISOLATED CHICK VENTRICLE

G. Iribe, H. Jin, K. Naruse

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 20 S64 - S64 2009.10

Effects of bepridil on stretch-induced arrhythmia in isolated chick ventricles

G. Iribe, H. Jin, K. Naruse

EUROPEAN HEART JOURNAL 30 32 - 32 2009.9

304 A study to improve the separation efficiency of a sperm sorter using a microfluidic system

SHIMAMURA Yutaka, SUZUKI Yusuke, HASHIMOTO Yuki, HYAKUTAKE Toru, YANASE Shinitirou, MATSUURA Kouji, NARUSE Keiji

2008 ( 21 ) 99 - 100 2009.1

602 Modeling of motile sperm in microchannel flow

HASHIMOTO Yuki, TACHIBANA Towa, SHIMAMURA Yutaka, SUZUKI Yusuke, HYAKUTAKE Toru, YANASE Shinichiro, MATSUURA Koji, NARUSE Keiji

2008 ( 21 ) 235 - 236 2009.1

MOTILITY AND [Ca2+](i) DISTRIBUTION OF SPERMS IN FLOW CONDITION

Koji Matsuura, Keiji Naruse

JOURNAL OF PHYSIOLOGICAL SCIENCES 59 365 - 365 2009

STRETCH-INDUCED UP-REGULATION OF SOC ACTIVITIES IN HUVEC

Yuki Katanosaka, Keiji Naruse

JOURNAL OF PHYSIOLOGICAL SCIENCES 59 500 - 500 2009

MECHANICAL STRETCH STIMULATES GLUCOSE UPTAKE THROUGH A MECHANISM DISTINCT FROM THAT OF INSULIN-LIKE GROWTH FACTOR 1 IN SKELETAL MUSCLE CELLS

Masahiro Iwata, Shigeyuki Suzuki, Kimihide Hayakawa, Takayuki Inoue, Keiji Naruse

JOURNAL OF PHYSIOLOGICAL SCIENCES 59 206 - 206 2009

PDMSの物性を利用した生殖細胞操作デバイスの作製

松浦宏治, 松浦宏治, 黒田ユカ, 黒田ユカ, 舟橋弘晃, 成瀬恵治

化学とマイクロ・ナノシステム研究会講演要旨集 20th 2009

傾斜培養によるマウス胚の培養成績とそのマイクロ空間制御

黒田ユカ, 黒田ユカ, 松浦宏治, 松浦宏治, 舟橋弘晃, 成瀬恵治

化学とマイクロ・ナノシステム研究会講演要旨集 20th 2009

E11 Modeling of motile sperm in microchannel flow

2008 183 - 184 2008.10

E02 A study to improve the separation efficiency of a sperm sorter using a microfluidic system

2008 165 - 166 2008.10

Development of in vitro fertilized thawed human embryo by Tilting Embryo Culture System

TAKIUE Chisato, MATSUURA Koji, HIRATA Rei, AOI Yoko, YOSHIOKA Nanako, HABARA Toshihiro, HAYASHI Nobuyoshi, NARUSE Keiji

25 ( 2 ) S60 2008.4

メカニカルストレスに対する細胞応答の解析技術 Invited

片野坂友紀, 竹内崇, 成瀬恵治

次世代医療のための高分子材料工学 158 - 167 2008

揺動培養によるマウス胚盤胞到達率の上昇

黒田ユカ, 松浦宏治, 片野坂友紀, 毛利聡, 舟橋弘晃, 成瀬恵治

日本生体医工学会大会プログラム・論文集(CD-ROM) 47th 2008

Hydrogen peroxide plays a crucial role in coronary microvascular vasodilation with increased oxidative stress in right ventricles of pulmonary hypertensive rats

Masahito Kajiya, Yousulke Inai, Taro Morimoto, Tatsuo Iwasaki, Kousuke Endo, Satoshi Mohri, Toyotaka Yada, Keiji Naruse, Tohru Ohe, Fumihiko Kajiya

CIRCULATION 116 ( 16 ) 228 - 229 2007.10

岡山大学大学院医歯薬学総合研究科生体機能制御科学専攻・機能制御学システム循環生理学教室(研究室・研究施設紹介)

毛利聡, 片野坂友紀, 入部玄太郎, 成瀬恵治

生体医工学 : 日本エム・イー学会誌 45 ( 3 ) 227 - 228 2007.9

FRS-041 Coronary Microvascular Endothelial Dysfunction with Decreased Glycocalyx Thickness and Increased Reactive Oxygen Species in Spontaneously Hypertensive Rats(Vascular Biology in Endothelial Cells (basic), The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Hirota Masanori, Inai Yousuke, Kajiya Masahito, Morimoto Taro, Mohri Satoshi, Naruse Keiji, Ohtsuka Aiji, Tsujioka Katsuhiko, Kajiya Fumihiko

Circulation journal : official journal of the Japanese Circulation Society 71 126 - 126 2007.3

The role of TRP channels in mechanotransduction of HUVEC

Yuki Katanosaka, Tomohiko Suemori, Keiji Naruse

BIOPHYSICAL JOURNAL 291A - 291A 2007.1

細胞力覚とロボティクス

成瀬恵治

日本ロボット学会誌 25 ( 2 ) 25 - 31 2007

ソフトリソグラフィーを用いた細胞研究・医療用チップの開発

成瀬恵治

表面科学 28 ( 4 ) 204 - 210 2007

細胞研究・医療チップ

成瀬恵治

バイオインダストリー 24 ( 2 ) 25 - 36 2007

ヒト臍帯血血管内皮細胞（HUVEC）のストレッチ刺激に対する細胞応答

片野坂友紀, 成瀬恵治

医学のあゆみ 223 ( 6 ) 469 - 473 2007

Coronary microvascular endothelial dysfunction with decreased glycocalyx thickness and increased reactive oxygen species in spontaneously hypertensive rats possible compensatory role of EDHF

Masanori Hirota, Yousuke Inai, Masahito Kajiya, Taro Morimoto, Kae Hashiba, Satoshi Mohri, Juichiro Shimizu, Aiji Ohtsuka, Katsuhiko Tsujioka, Keiji Naruse, Takeo Tedoriya, Shunji Sano, Fumihiko Kajiya

CIRCULATION 114 ( 18 ) 77 - 78 2006.10

Development of a flow-through type pH/CO_2 sensor system based on ISFET for evaluation of cellular function

MOHRI Satoshi, NAKAMURA Michihiro, NARUSE Keiji

IEICE technical report 106 ( 162 ) 1 - 4 2006.7

Language：Japanese Publisher：The Institute of Electronics, Information and Communication Engineers

We developed a pH/CO_2 sensor system using two ion sensitive field effect transistors (ISFETs) to evaluate the metabolic activity of cultured cells. ISFETs were placed in a flow-through chamber with a window to be attached to a glass-plate on which cells were cultured. Measurements were performed with a baseline solution of low buffer capacity. In the quantitative estimation of cellular products, we assumed that cells secreted CO_2, lactic acid, and sodium bicarbonate (NaHCO_3), and then lactic acid and NaHCO_3 proceeded to the neutralization reaction to form sodium lactate and additional CO_2. We applied this system to evaluate the metabolic activity of bovine aortic endothelial cells and rabbit aortic smooth muscle cells.

CiNii Article

CiNii Books

researchmap

Other Link： http://search.jamas.or.jp/link/ui/2007008183

ソフトリソグラフィーを駆使したメカノトランスダクションの研究

成瀬恵治

蛋白質核酸酵素 51 ( 6 ) 705 - 714 2006

ISFETセンシングシステムによる迅速細胞機能評価法の開発

毛利聡, 中村通宏, 成瀬恵治

医学のあゆみ 218 ( 2 ) 145 - 148 2006

微小流体技術による体外受精

二井信行, 成瀬恵治, Gary D. Smith, 高山秀一

医学のあゆみ 218 ( 2 ) 159 - 163 2006

メカノバイオロジー-基礎から臨床まで-

成瀬恵治

岡山医学会雑誌 118 23 - 31 2006

気道平滑筋細胞に対するメカニカルストレッチの影響：ストレッチ活性型Ca2+チャネルの役割

伊藤理, 久米裕昭, 伊藤康, 近藤征史, 武田直也, 岩田晋, 長谷川好規, 下方薫, 成瀬恵治

呼吸 25 ( 2 ) S18 - S19 2006

Stretch-sensitive mechanism of SAKCA channel

K Naruse, QY Tang, M Sokabe

BIOPHYSICAL JOURNAL 88 ( 1 ) 292A - 292A 2005.1

STREX Exon makes Ca2+-activated big K channels mechanosensitive

K Naruse, QY Tang, M Sokabe

BIOPHYSICAL JOURNAL 86 ( 1 ) 545A - 545A 2004.1

A new mechanosensitive channel SAKCA and a new MS channel blocker GsTMx-4

Masahiro Sokabe, Keiji Naruse, Qiong-Yao Tang

Folia Pharmacologica Japonica 124 ( 5 ) 301 - 310 2004

Language：Japanese Publishing type：Book review, literature introduction, etc.

Cells can respond to a variety of mechanical stimuli such as tension, pressure, and shear stress. However, the mechanisms of mechanotransduction are largely unknown. The major reason for this lies in the ambiguity of the molecular entity of cell mechanosensors. Currently only MS (mechanosensitive) channels conform to an established class of mechanosensors due to the firm and detailed analyses by electrophysiolgy. Although molecular structures of MS channels are known for limited members, higher order structures of bacterial MS channels have been resolved and their detailed structure-function studies are in progress. In contrast, molecular and biophysical analyses of eukaryote MS channels, which may attract much attention, are yet not well-studied. Although many candidate molecules have been proposed as the cell mechanosensor, currently only 2-pore-domain K channels (TREK/TRAAK) and SAKCA, a new class of MS channel introduced here, may be the subjects eligible for rigorous electrophysiological analyses. On the other hand, lack of specific blockers to MS channels is another reason why the progress in this field is slow. Gadolinium (Gd 3+) has been extensively used as a potent blocker of MS channels, but its nonspecific actions have limited its usefulness. Very recently, a promising 35 mer peptide, which can be more specific for MS channels, named GsMTx-4 has been isolated from spider venom. This peptide is interesting because it inhibits stretch-induced atrial fibrillation, which may involve MS channel activation and thus can be used as a basis for developing a new class of drugs to cure heart failure. This short review deals with recent progresses in MS channel studies and the structure-function of SAKCA, a recently cloned MS channel from heart, as well as its interaction with the new MS channel blocker GsMTx-4.

DOI： 10.1254/fpj.124.301

Scopus

PubMed

researchmap

ソフトリソグラフィーとメカノバイオロジー

成瀬恵治

血管医学 5 ( 4 ) 405 - 413 2004

Structure-Function of a cloned Stretch-Activated 13K Channel (SAKCaC) from hearts and hunting its blockers

M Sokabe, K Naruse, QY Tang

JOURNAL OF PHARMACOLOGICAL SCIENCES 94 68P - 68P 2004

Ionic amphipaths affect the gating of a stretch activated BK channel (SAK(Ca)) cloned from chick heart

Z Qi, K Naruse, M Sokabe

BIOPHYSICAL JOURNAL 84 ( 2 ) 234A - 234A 2003.2

Stretch-induced morphological response in endothelial cells.

M Sokabe, K Kawakami, K Naruse

JOURNAL OF PHARMACOLOGICAL SCIENCES 91 66P - 66P 2003

内皮細胞の伸展依存性リモデリングー分子から形へのインターフェースを見るー

曽我部正博, 河上敬介, 早川公英, 成瀬恵治, 辰巳仁史

血管医学 4 237 - 244 2003

Mechanism of hypertrophy in the nonembolized lobe after portal vein embolization.

M Kawai, K Naruse, S Komatsu, M Nagtno, Y Nimura, M Sokabe

HEPATOLOGY 32 ( 4 ) 475A - 475A 2000.10

Report clarification

M Kanzaki, M Nagasawa, Kojima, I, C Sato, K Naruse, M Sokabe, H Iida

SCIENCE 288 ( 5470 ) 1347 - 1347 2000.5

Stretch-induced intracellular calcium releases in endothelial cells.

K Murase, K Okumura, K Naruse, M Sokabe

BIOPHYSICAL JOURNAL 78 ( 1 ) 472A - 472A 2000.1

機械刺激による細胞のリモデリング：SAチャネルと接着斑蛋白質チロシンリン酸化

曽我部正博, 成瀬恵治, 河上敬介, 辰巳仁史

生体の科学 51 549 - 555 2000

内皮細胞における形態知覚と形態形成の分子機構

曾我部正博, 成瀬恵治, 宮津, 井上真澄美

医学のあゆみ 192 1201 - 1205 2000

Stretching Cells : Stretch-Induced Morphological Changes and Its Intracellular Signaling in Human Umbilical Vein Endothelial Cells

NARUSE Keiji

10 ( 1 ) 79 - 83 1999.2

細胞を引っ張る

成瀬恵治

日本血栓止血学会誌 10 79 - 83 1999

真核生物のCa²⁺透過性機械受容チャネルその発見,性質,機能

飯田秀利, 神崎展, 長沢雅裕, 小島至, 佐藤主税, 成瀬恵治, 曽我部正博

日本細胞生物学会大会講演要旨集 52nd 17 1999

Prostacyclin synthase gene transfer inhibits neointimal formation after balloon injury with acceleration of re-endothelialization

Y Numaguchi, K Naruse, M Harada, H Osanai, Y Toki, K Okumura, T Ito

CIRCULATION 98 ( 17 ) 670 - 670 1998.10

Prolonged reduction of systemic blood pressure by prostacyclin synthase gene transfer in spontaneously hypertensive rats

Y Numaguchi, K Naruse, M Harada, H Osanai, K Murase, Y Toki, K Okumura, T Ito

CIRCULATION 98 ( 17 ) 670 - 670 1998.10

Calcium response induced by mechanical stretch in vascular endothelial cells.

Murase K., Naruse K., Sokabe M.

Biophysics 38 ( 2 ) S48 1998.9

Effect of glucose and aldose reductase inhibition on PDGF-induced proliferation of cultured aortic smooth muscle cells

Y Kasuya, J Nakamura, N Koh, Y Hamada, K Naruse, K Kato, N Hotta

DIABETES 47 A366 - A366 1998.5

The mechanism of cell alignment change elicited by cyclic stretch.

K Kada, K Yasui, K Naruse, J Toyama

BIOPHYSICAL JOURNAL 74 ( 2 ) A361 - A361 1998.2

伸展刺激と血管内皮細胞−伸展刺激の方法と細胞応答の解析法−

成瀬恵治, 蔡暁蕊, 山田恭子, 村瀬吉郎

医用電子と生体工学 36 287 - 292 1998

伸展刺激に対する血管内皮細胞の反応とカルシウムイオン

曽我部正博, 成瀬恵治, 河上敬介, 小畑秀一

Clinical Calcium 8 1316 - 1322 1998

心・血管系のメカノトランスダクション

成瀬恵治

現代医学 45 529 - 535 1998

ストレッチ刺激に対する内皮応答

成瀬恵治, 宮津真寿美, 村瀬吉郎, 曽我部正博

血管と内皮 8 271 - 278 1998

Involvement of protein tyrosine kinase src in orienting reaction of fibroblasts in response to uni-axial cyclic stretch

Sai, X, K Naruse, M Sokabe

MOLECULAR BIOLOGY OF THE CELL 8 770 - 770 1997.11

Suppression of PP120FAK inhibits morphological changes of human endothelial cells in response to cyclic stretch.

K Naruse, M Sokabe

BIOPHYSICAL JOURNAL 72 ( 2 ) TU296 - TU296 1997.2

伸展刺激による血管内皮細胞リモデリングの分子機構

曽我部正博, 成瀬恵治

医学のあゆみ 182 309 - 313 1997

pp60src is responsible for stretch-dependent tyrosine phosphorylation of focal proteins in human endothelial cells

K Naruse, M Sokabe

MOLECULAR BIOLOGY OF THE CELL 7 1999 - 1999 1996.12

Stretch dependent nitric oxide (NO) production in human umbilical endothelial cells

Y Asano, K Naruse, M Sokabe

MOLECULAR BIOLOGY OF THE CELL 7 3866 - 3866 1996.12

Cyclic stretch induced morphological change involves protein tyrosine phosphorylation in human umbilical endothelial cells.

K Naruse, M Sokabe

BIOPHYSICAL JOURNAL 70 ( 2 ) TU495 - TU495 1996.2

SAチャネルは細胞の機械センサーか？

曽我部正博, 成瀬恵治, 嶽本和久

蛋白・核酸・酵素 41 2 - 13 1996

機械刺激

成瀬恵治, 曽我部正博

組織培養 22 22 - 29 1996

PROTEIN-TYROSINE PHOSPHORYLATION IN ENDOTHELIAL-CELLS SUBJECTED TO CYCLIC MECHANICAL STRETCH

K NARUSE, M SOKABE

MOLECULAR BIOLOGY OF THE CELL 6 2205 - 2205 1995.11

機械刺激に対する内皮細胞のCa2+応答と形態応答

曽我部正博, 成瀬恵治, 山田恭子, 井上真寿美, 浅野久木

脈管学 34 989 - 994 1994

血管内皮細胞の機械受容チャネルと細胞応答

曽我部正博, 成瀬恵治, 山田恭子, 嶽本和久

血管と内皮 4 ( 1 ) 29 - 38 1994

心・血管系の機械応答とＳＡチャネル

成瀬恵治, 曽我部正博

日本臨床 51 ( 7 ) 193 - 200 1993

Stretch activated ion channels in cardiovascular system

Sokabe Masahiro, Naruse Keiji, Soga Hiroyuki, Hasegawa Noboru, Yamamori Kimiko

Shinzo 25 ( 2 ) 211 - 214 1993

GD3+ SENSITIVE [CA2+]I INCREASE BY STRETCH IN HUMAN ENDOTHELIAL-CELLS

K NARUSE, M SOKABE

FASEB JOURNAL 6 ( 1 ) A513 - A513 1992.1

膜伸展によって活性化されるイオンチャネル

曽我部正博, 成瀬恵治, 曽我浩之

心臓 24 ( 3 ) 333 - 343 1992

機械変形に応ずる膜チャネル

曽我部正博, 野村一史, 成瀬恵治, 加藤隆司, 伊藤文雄

動物生理 5 168 - 176 1988

　 PREV - NEXT 　

< NARUSE Keiji >

MISC - NARUSE Keiji