Faculty Profiles - NARUSE Keiji

MISC - NARUSE Keiji

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11th Asian-Pacific Conference on Medical and Biological Engineering

Shiraishi Y, Sakuma I, Naruse K, Ueno A

IFMBE Proceedings 82 2021

第59回日本生体医工学会大会開催報告

成瀬恵治

岡山医学会雑誌 132 110 - 111 2020.8

Mechanomedicine.

Naruse K

Biophysical reviews 2018.9

特集：宇宙の極限環境から生命体の可塑性をさぐる--1.重力変動の生理機能への影響細胞の重力応答機構--

高橋賢, 佐々並三紗, 長田仁, 成瀬恵治

生体の科学 69 ( 2 ) 106 - 109 2018.4

MECHANOMEDICINE: applications of mechanobiology to medical sciences and next-generation medical technologies.

Naruse K

Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 54 83 - 90 2018

特集新しい医療を拓くメカノバイオロジー--11．メカノ生殖補助医療の展開--

成瀬恵治

医薬ジャーナル 53 ( 6 ) 1489 - 1494 2017.6

Application of mechanobiological engineering to regenerative and reproductive medicine Invited

Takahashi K, Oh H, Iribe G, Matsuura K, Naruse K

Trans JSMBE 55 ( 4PM-Abstract ) 340 - 340 2017

Language：Japanese Publishing type：Research paper, summary (national, other academic conference) Publisher：Japanese Society for Medical and Biological Engineering

<p>Recent advancement of mechanobiological research contributes to understanding and cure of diseases, leading to the birth of mechanomedicine. Here we introduce innovative mechano-medical technologies that pursue clinical use. In dermal regenerative medicine, we performed co-culture of dermal keratinocytes and fibroblasts with stretch stimulus, and found thickening of dermal layer and facilitated basal membrane formation. In cardiac regenerative medicine, we found that exosomes released from stem cells in response to mechanical stimulus excrete paracrine factors and micro RNAs, and thus enhance therapeutic effect of cell therapy in vivo. In reproductive medicine, we applied mechanical stimulus to fertilized eggs using a tilting embryo culture system, and confirmed enhancement of blastocyst development rate. Exhaustive gene analysis suggested that the enhancement is due to alteration of gene expression at epiblast. We continue to reveal the mechanisms of biological response to mechanical stimulus, and pursue clinical application of mechano-medical therapy.</p>

DOI： 10.11239/jsmbe.55Annual.340

CiNii Article

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【メカノバイオサイエンス〜力の科学と医療の最前線〜】力学刺激に応答する循環器系の恒常性

高橋賢, 成瀬恵治

Clinical Calcium 26 ( 12 ) 1671 - 1676 2016.11

メカノメディスン：メカノ生殖補助医療

成瀬恵治

医学のあゆみ 257 ( 10 ) 1058 - 1062 2016.6

メカノメディスン

成瀬恵治

呼吸と循環 64 ( 2 ) 177 - 185 2016.2

力学刺激に応答する循環器系の恒常性 Invited

高橋賢, 成瀬恵治

Clinical Calcium 26 ( 12 ) 21 - 26 2016

Mechanosensitive ion channels

Ken Takahashi, Yusuke Matsuda, Keiji Naruse

AIMS Biophysics 3 ( 1 ) 63 - 74 2016

Language：English Publishing type：Book review, literature introduction, etc. Publisher：American Institute of Mathematical Sciences

Cell surface receptors are involved in numerous important biological processes including embryogenesis, tissue differentiation, and cellular homeostasis. Among them, mechanosensitive ion channels play an essential role in cellular functions of every cell including neurons, cardiomyocytes, and osteocytes. Here, we discuss types, roles, structures, and biophysical factors that affect the functions of mechanosensitive ion channels.

DOI： 10.3934/biophy.2016.1.63

Scopus

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iPS治療とメカニカルストレス

高橋賢, 成瀬恵治

ファルマシア 51 ( 11 ) 1038 - 1041 2015.11

メカノメディスン：メカノ医工学を用いた医学研究・次世代医療技術への展開

成瀬恵治

日本機械学会誌 118 ( 1161 ) 91 - 93 2015.8

Mechanomedicine : Applications of Mechanobiology to Medical Sciences and Next-generation Medical Technologies

NARUSE Keiji

Journal of the Japan Society of Mechanical Engineers 118 ( 1161 ) 533 - 535 2015.8

心臓・血管の組織工学と再生医療.

高橋賢, 成瀬恵治

人工臓器 43 ( 3 ) 206 - 208 2014.12

Disease-Specific Induced Pluripotent Stem Cells Identify the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 During Cardiac Development of Hypoplastic Left Heart Syndrome

Junko Kobayashi, Masashi Yoshida, Suguru Tarui, Shuta Ishigami, Michihiro Okuyama, Yusuke Nagai, Shingo Kasahara, Keiji Naruse, Hiroshi Ito, Shunji Sano, Hidemasa Oh

CIRCULATION 130 2014.11

生殖医療・育種デバイス

松浦宏治, 成瀬恵治

生物工学会誌 92 ( 4 ) 30 - 33 2014.3

Involvement of TRPC in the Slow Force Response Observed in Mouse Ventricular Myocytes

Yohei Yamaguchi, Toshiyuki Kaneko, Keiji Naruse, Gentaro Iribe

BIOPHYSICAL JOURNAL 106 ( 2 ) 772A - 772A 2014.1

生殖医療・育種デバイス(<特集>マイクロバイオ技術の潮流と展望～動物細胞の培養・計測・評価技術への応用～)

松浦宏治, 成瀬恵治

生物工学会誌 : seibutsu-kogaku kaishi 92 ( 4 ) 180 - 183 2014

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